（一）标的公司符合创业板定位具体说明 广州迈普再生医学科技股份有限公司董事会 关于本次交易符合《创业板上市公司持续监管办法(试行)》 第十八条、第二十一条以及《深圳证券交易所上市公司重大 资产重组审核规则》第八条规定的说明 广州迈普再生医学科技股份有限公司（以下简称"上市公司"、 "公司"）拟通过发行股份及支付现金的方式购买广州泽新医疗科技 有限公司、广州易创享投资合伙企业（有限合伙）等 10 名交易对方 合计持有的广州易介医疗科技有限公司（以下简称"标的公司"、"易 介医疗"）100%股权并募集配套资金（以下简称"本次交易"）。 一、本次交易符合《持续监管办法》第十八条和《重组审核规则》 第八条相关规定 根据《持续监管办法》第十八条和《重组审核规则》第八条的规 定，创业板上市公司重大资产重组、发行股份购买资产，标的资产所 属行业应当符合创业板定位，或者与上市公司处于同行业或者上下游。 1、标的公司紧跟介入手术国际领先的发展趋势，打造创新性的 薄壁桡动脉支撑导管 神经介入手术中，桡动脉入路将替代股动脉入路成为主流手术方 案。与股动脉入路相比，桡动脉入路的患者术后无需卧床制动并缩短 住院时间，减少下肢静脉血栓、 ...

提示性公告 证券代码：301033 证券简称：迈普医学 公告编号：2025-075 广州迈普再生医学科技股份有限公司 关于披露重组报告书暨一般风险提示性公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完 整，没有虚假记载、误导性陈述或重大遗漏。 敬请广大投资者关注后续公告，注意投资风险。 特此公告。 广州迈普再生医学科技股份有限公司 董事会 2025 年 10 月 16 日 本次交易尚需公司股东会审议通过，并经深圳证券交易所审核通 过、中国证券监督管理委员会注册后方可正式实施，本次交易能否取 得相关批准、审核通过并同意注册以及最终取得批准、审核通过并同 意注册的时间均存在不确定性。 公司将继续推进本次交易的相关工作，并严格按照有关法律、法 规的要求履行信息披露义务，所有信息均以在公司指定信息披露媒体 提示性公告 刊登的公告为准。 广州迈普再生医学科技股份有限公司（以下简称"上市公司"、 "公司"）拟通过发行股份及支付现金的方式购买广州泽新医疗科技 有限公司、广州易创享投资合伙企业（有限合伙）等 10 名交易对方 合计持有的广州易介医疗科技有限公司（以下简称"标的公司"、"易 介医疗"）100%股权并 ...

Core Viewpoint - The company plans to acquire 100% equity of Guangzhou Yijie Medical Technology Co., Ltd., which is expected not to constitute a major asset restructuring but will be classified as a related party transaction [1] Group 1: Transaction Details - The transaction was initiated on May 22, 2025, and has gone through various stages including suspension and resumption of trading [1] - As of September 30, the company is cooperating with intermediaries to conduct due diligence, which is still ongoing [1] Group 2: Approval Process - The transaction requires approval from the board of directors and shareholders, as well as review by the Shenzhen Stock Exchange and registration with the China Securities Regulatory Commission [1] - There is uncertainty regarding the completion of the transaction, and the company will disclose updates in a timely manner [1]

进展公告 证券代码：301033 证券简称：迈普医学 公告编号：2025-072 广州迈普再生医学科技股份有限公司 关于发行股份及支付现金购买资产并募集配套资金 暨关联交易事项的进展公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完 整，没有虚假记载、误导性陈述或重大遗漏。 一、本次交易概述 公司拟通过发行股份及支付现金的方式向泽新医疗等 10 名交易 对方购买广州易介医疗科技有限公司（以下简称"易介医疗"）100% 股权，并募集配套资金。本次交易预计不构成重大资产重组，构成关 联交易，不构成重组上市。 二、本次交易的历史披露情况 （一）公司因筹划本次交易事项，经向深圳证券交易所申请，公 司股票（证券简称：迈普医学，证券代码：301033）自 2025 年 5 月 22 日开市起开始停牌，停牌时间不超过 10 个交易日。具体内容详见 公司于 2025 年 5 月 22 日披露的《关于筹划发行股份及支付现金购买 资产并募集配套资金暨关联交易事项的停牌公告》（公告编号： 2025-026）。停牌期间，公司根据相关规定及时履行信息披露义务， 并于 2025 年 5 月 29 日披露了《关于筹划发行股份及支 ...

Investment Rating - The report recommends focusing on leading companies in various segments of the high-value consumables and medical device sectors, indicating a positive outlook for recovery and growth in these areas [4][30]. Core Insights - High-value consumables have begun to recover from the impacts of centralized procurement, with leading companies regaining profitability levels seen before the procurement initiatives [4][32]. - The medical device and IVD sectors are expected to show signs of recovery, with significant improvements anticipated in financial performance by Q3 2025 for device companies and by Q4 2025 for IVD companies [4][30]. - The report highlights specific high-growth segments, including vascular intervention, orthopedics, and IVD, suggesting that these areas will continue to attract investment due to their growth potential and market dynamics [4][30]. Summary by Sections Medical Devices - The medical device sector is projected to experience a revenue decline in 2024, with a further drop of -5.18% expected in the first half of 2025, but recovery is anticipated thereafter [9][12]. - Despite revenue challenges, the overall gross margin and net profit margin have remained stable, with R&D expenses increasing from approximately 7% pre-pandemic to around 10% currently [10][12]. - Companies in the imaging equipment segment are expected to see improved performance in Q3 2025 as inventory issues are resolved and new procurement projects are executed [13][18]. High-Value Consumables - The high-value consumables sector has shown revenue growth in the first half of 2025, indicating a recovery from previous declines, with profit margins returning to levels seen in 2021 [32][33]. - Specific segments such as vascular intervention and orthopedics are highlighted for their resilience and growth potential, with companies like Huatai Medical and Weigao Orthopedics showing significant revenue increases [38][43]. IVD and Other Segments - The IVD sector is expected to see improvements by Q4 2025, with overall industry recovery projected for the first half of 2026 [4][30]. - The report emphasizes the importance of innovation and market expansion for companies in the rehabilitation and home medical device sectors, with firms like Sanofi and Kefu Medical showing strong growth despite market challenges [24][26].

Core Viewpoint - The Chinese innovative drug industry is gradually catching up with Europe and the United States in terms of technology, with some targets and technical pathways already leading globally. The number and value of new drugs authorized for overseas markets continue to increase, leading to world-class pricing and non-linear investment elasticity. The domestic market is experiencing strong growth in demand, with domestic new drug sales continuing to rise, and several innovative pharmaceutical companies have turned losses into profits, entering a stable growth phase [2]. Group 1: Innovative Drugs - The innovative drug sector is witnessing a significant increase in sales driven by strong domestic demand, with a number of innovative companies achieving profitability [2]. - The trend of domestic innovative drugs going overseas is accelerating, with increasing numbers and values of new drug authorizations [2]. - The pricing power of innovative drugs is improving, reflecting the global competitiveness of Chinese pharmaceutical companies [2]. Group 2: High-Value Medical Consumables - The orthopedic sector is expected to see mild price reductions due to continued domestic substitution and accelerated overseas business progress [2]. - The neurosurgery and neurointervention fields are experiencing stable growth post-collection, with new products being launched [2]. - The high-value consumables market is expected to benefit from ongoing domestic replacement and the introduction of new products [2]. Group 3: Medical Devices - The medical device sector is seeing a recovery in bidding prices, with ongoing high-speed growth in bidding data this year [2]. - Companies are entering a phase of inventory reduction, with performance expected to improve in the second half of the year [2]. - The low-value consumables sector is experiencing product upgrades and accelerated expansion into overseas markets [2]. Group 4: Blood Products - The supply side of the blood products industry is concentrating on central state-owned enterprises, gradually clearing the competitive landscape [2]. - The demand side is expected to see continuous upgrades to new products, with industry sentiment gradually improving [2]. Group 5: API (Active Pharmaceutical Ingredients) - The API sector is benefiting from the end of a capital expenditure peak, with three growth logic points driving upward trends: new high-end market products, integrated consolidation and overseas expansion, and cost-leading CDMO [2]. - Leading companies in the API sector are expected to see explosive growth in revenue and profits [2]. Group 6: CXO (Contract Research Organization) - The CXO sector is witnessing a recovery in A+H financing activity, with multiple significant business developments enhancing market confidence [2]. - The focus is on optimizing the supply-side landscape and increasing market share for leading CRO companies [2]. Group 7: Traditional Chinese Medicine and Retail Pharmacy - The traditional Chinese medicine sector is showing signs of recovery, with friendly pricing for new drugs and ongoing observation of collection progress [2]. - The retail pharmacy sector is influenced by the pace of supply-side clearing and business model upgrades, with expectations of increased store closures in the second half of 2025 [2]. Group 8: Research and Development Services - The domestic innovative drug business development is heating up, likely driving downstream demand recovery [2]. - The overseas market presents significant growth opportunities for domestic companies, leveraging cost-effectiveness and service differentiation [2].

Market Demand and Product Development - The medical rehabilitation field has a pressing demand for brain-machine interfaces, particularly for patients with paralysis and epilepsy [2] - The company is primarily engaged in neurosurgery, offering Class III medical devices such as artificial dura mater patches and craniofacial repair systems [2] Financial Performance - In the first half of 2025, the sales revenue from dura mater products reached CNY 71.36 million, a year-on-year increase of 3.24% [3] - The sales revenue from absorbable regenerated cellulose and dura mater medical glue totaled CNY 38.32 million, marking a significant growth of 169.66% compared to the previous year [4][7] - Overseas revenue for the company reached CNY 38.10 million, reflecting a growth of 50.96% year-on-year [8] Strategic Collaborations and Innovations - The company has established deep collaborations with top research institutions like Tsinghua University, which provides a strong opportunity for entering the brain-machine interface field [2] - The company’s self-developed dura mater medical glue, Ruigu, was launched in February 2023 and has received MDR certification, allowing for legal sales in EU markets [5][7] Market Trends and Challenges - The overall market size for craniofacial repair and fixation in China reached CNY 1.75 billion in 2023, with a compound annual growth rate (CAGR) of 15.3% from 2018 to 2023, indicating significant replacement potential for traditional materials [3] - Challenges in replacing traditional titanium materials with PEEK include high technical barriers and the need for clinical acceptance [3] Future Outlook - The company plans to expand its market share in domestic and international markets by enhancing its neurosurgery solutions and increasing brand influence [8] - The company is actively pursuing the acquisition of a medical technology firm to broaden its capabilities in bio-synthetic materials [6]

Core Viewpoint - The Chinese innovative drug industry is gradually catching up with Europe and the United States in terms of technology, with some targets and technical pathways already leading globally. The number and value of new drugs authorized for overseas markets continue to increase, leading to world-class pricing and non-linear investment elasticity. The domestic market is experiencing strong growth in demand, with domestic new drug sales continuing to rise, and several innovative pharmaceutical companies have turned losses into profits, entering a stable growth phase [2]. Group 1: Innovative Drugs - The innovative drug sector is witnessing a significant increase in sales driven by strong domestic demand, with a number of innovative companies achieving profitability [2]. - The trend of domestic innovative drugs going overseas is accelerating, with increasing numbers and values of new drug authorizations [2]. - The industry is positioned for a "Davis double" effect, where both performance and valuation are expected to improve [2]. Group 2: High-Value Medical Consumables - The orthopedic sector is expected to see mild price reductions, while domestic replacements continue to grow, and overseas business progresses rapidly [2]. - The neurosurgery and neurointervention fields are stabilizing after centralized procurement, with new products expected to contribute to growth [2]. Group 3: Medical Devices - The medical device sector is experiencing a high-speed growth in bidding data, with companies entering a destocking phase, which is expected to improve performance in the second half of the year [2]. - The low-value consumables sector is seeing continuous product upgrades and accelerated expansion into overseas markets [2]. Group 4: Blood Products - The supply side of the blood products industry is increasingly concentrated among state-owned enterprises, leading to a clearer competitive landscape [2]. - The demand side is expected to upgrade towards new products, gradually improving the industry's overall health [2]. Group 5: API (Active Pharmaceutical Ingredients) - The industry is at an upward turning point due to the end of a capital expenditure peak, combined with three growth drivers: new high-end market products, integrated consolidation and overseas expansion, and cost-leading CDMO [2]. - Leading companies are expected to see explosive growth in revenue and profits in the medium term [2]. Group 6: CXO (Contract Research Organization) - The CXO sector is seeing a revival in A+H financing activity, with multiple significant business developments enhancing market confidence [2]. - The focus is on optimizing the supply-side landscape and increasing market share for leading CRO companies [2]. Group 7: Traditional Chinese Medicine and Retail Pharmacy - The traditional Chinese medicine sector is showing signs of recovery, with friendly pricing for new drugs, while the retail pharmacy sector is influenced by supply-side adjustments and business model upgrades [2]. - The performance of offline pharmacies is expected to improve in the second half of 2025, with leading chains like YaoXingTang making progress in store upgrades [2]. Group 8: Research Reports - A series of in-depth research reports on various companies and sectors within the pharmaceutical and medical device industries have been published, highlighting their growth potential and market positioning [3][4].

内容概要：人工硬脑膜是用生物材料制成人体脑膜的替代物，用于因颅脑、脊髓损伤、肿瘤及其他颅脑 疾病引起的硬脑膜或脊膜缺损的修补，防止脑脊液外漏、颅内感染、脑膨出、脑粘连和疤痕等严重并发 症，以恢复其完整性。人工硬脑膜属于植介入耗材，伴随着国民可支配收入增加、老龄化程度加深，脑 血管疾病发病率上升，神经外科介入类手术需求增加，推动人工硬脑膜的需求放量增长。但2021年以来 随着集采的稳步推进，国内人工硬脑膜产品价格下降较为明显。2024年，我国人工硬脑膜需求量从2017 年的44.63万片增长至94.61万片，产品价格从2017年的1775元/片下降至800元/片，人工硬脑膜市场规模 则从2020年的10.26亿元下降至2024年的7.57亿元。 关键词：人工硬脑膜行业政策、人工硬脑膜产业链、人工硬脑膜需求量、人工硬脑膜行业均价、人工硬 脑膜市场规模、人工硬脑膜市场竞争格局、人工硬脑膜行业发展趋势 一、人工硬脑膜行业基本概况 神经外科作为医学领域最为复杂的学科之一，是以手术为主要手段，医治中枢神经系统（脑、脊髓）、 周围神经系统和植物神经系统疾病的一门临床外科专科。作为高精尖的前沿学科之一，神经外科对应用 在手术 ...

Group 1 - The core point of the article is that Maipu Medical has announced that its research project "Absorbable Regenerative Oxidized Cellulose Hemostatic Granules" has officially entered the clinical trial phase [2] Group 2 - The announcement was made on the evening of September 16 [2] - This development indicates a significant step forward in the company's product pipeline and potential market offerings [2] - The clinical trial phase is crucial for the validation and eventual commercialization of the product [2]