公司于 2023 年 7 月 17 日召开第一届董事会第二十五次会议审议通过了《关 于回购公司股份方案的议案》，同意公司使用自有资金以集中竞价交易方式回购 公司部分已发行的人民币普通股股份，用于员工持股计划或股权激励（以下简称 "第一期回购"）。本次用于回购股份的资金总额不低于人民币 1,500 万元且不超 过人民币 3,000 万元（均包含本数）。 证券代码：301080 证券简称：百普赛斯 公告编号：2025-068 北京百普赛斯生物科技股份有限公司 关于变更部分回购股份用途并注销的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 北京百普赛斯生物科技股份有限公司（以下简称"公司"）于 2025 年 10 月 28 日召开第二届董事会第二十二次会议，审议通过了《关于变更部分回购股份用途 并注销的议案》，根据《深圳证券交易所上市公司自律监管指引第 9 号——回购 股份》（以下简称《自律监管指引》）的规定以及公司《关于回购公司股份的回 购报告书》（公告编号：2023-033），公司拟将回购专用证券账户中第一期回购 的部分股份用途由"用于员工持股计划或股权激 ...

Core Viewpoint - The company, Baipusais (301080.SZ), announced plans to initiate the process for issuing H-shares and listing on the Hong Kong Stock Exchange, aiming to enhance its international strategy and expand its overseas business presence [1] Group 1 - The meeting to review the proposal is scheduled for October 28, 2025 [1] - The initiative is intended to broaden financing channels and improve international visibility and overall competitiveness [1] - Details regarding the proposal are not yet finalized and will require approval from the company's board, shareholders, and relevant government and regulatory bodies [1]

Core Insights - The company reported third-quarter revenue of 226 million, representing a year-over-year increase of 37.50% [1] - Net profit for the third quarter was 48.62 million, showing a year-over-year growth of 81.46% [1] - For the first three quarters, total revenue reached 613 million, reflecting a year-over-year increase of 32.26% [1] - Net profit for the first three quarters amounted to 132 million, with a year-over-year growth of 58.61% [1]

Core Viewpoint - The company plans to change the purpose of the remaining 57,803 shares from the first phase of the buyback from "for employee stock ownership plan or equity incentives" to "for cancellation and corresponding reduction of registered capital" [1] Group 1 - The company will also proceed with the cancellation of 612,700 shares from the second phase of the buyback [1] - A total of 670,500 shares will be canceled as part of the first and second phase buyback plans [1] - Following the cancellations, the company's total share capital will decrease from 168 million shares to 167 million shares [1]

北京百普赛斯生物科技股份有限公司 2025 年第三季度报告 证券代码：301080 证券简称：百普赛斯 公告编号：2025-067 北京百普赛斯生物科技股份有限公司 2025 年第三季度报告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记载、误导性陈述或重大遗漏。 重要内容提示： 1.董事会及董事、高级管理人员保证季度报告的真实、准确、完整，不存在虚假记载、误导性陈述或重大遗漏，并承担 个别和连带的法律责任。 2.公司负责人、主管会计工作负责人及会计机构负责人(会计主管人员)声明：保证季度报告中财务信息的真实、准确、 完整。 3.第三季度财务会计报告是否经过审计 □是 否 1 北京百普赛斯生物科技股份有限公司 2025 年第三季度报告 一、主要财务数据 （一） 主要会计数据和财务指标 公司 2025 年 1-9 月因股份支付影响当期损益的金额为 8,321,702.80 元，扣除股份支付影响后归属于母公司上市股东的 净利润为 140,748,079.80 元。 公司报告期末至季度报告披露日股本是否因发行新股、增发、配股、股权激励行权、回购等原因发生变化且影响所有者 权益金额 是 □否 | ...

Investment Rating - The report maintains an "Overweight" rating for several pharmaceutical companies including Jiangsu Heng Rui Medicine, Hansoh Pharmaceutical Group, 3SBio, and Jiangsu Nhwa Pharmaceutical, with related targets such as CSPC Innovation Pharmaceutical [6][28]. Core Insights - The innovative drug sector is experiencing high prosperity, and the report continues to recommend innovative drugs and their industry chain. It highlights the recent global strategic collaboration between Innovent Biologics and Takeda, which is expected to catalyze the innovative drug market [6][29]. - The report notes that the A-Shares pharmaceutical sector underperformed the market in the fourth week of October 2025, with the SW Pharmaceutical and Biological index rising only 0.6% compared to a 2.9% increase in the SHCOMP [8][30]. - In the same period, the Hong Kong pharmaceutical sector also underperformed, while the U.S. pharmaceutical sector performed in line with the market [31][19]. Summary by Sections Continuous Recommendation of Innovative Drugs and Industry Chain - The report emphasizes the ongoing recommendation of innovative drugs and the industry chain, maintaining "Overweight" ratings for various companies including Heng Rui Medicine, Hansoh Pharmaceutical, 3SBio, and Nhwa Pharmaceutical. It also recommends Biopharma/Biotech companies with innovative pipelines and increasing performance, maintaining "Overweight" ratings for Innovent Biologics, Xiamen Amoytop Biotech, and others [6][28]. Performance of A-Shares Pharmaceutical Sector - In the fourth week of October 2025, the A-Shares pharmaceutical sector's performance was weaker than the overall market, with a 0.6% increase compared to the SHCOMP's 2.9% rise. The medical service, pharmaceutical commerce, and medical equipment sub-sectors showed relatively better performance [8][30]. Performance of Hong Kong and U.S. Pharmaceutical Sectors - The Hong Kong pharmaceutical sector underperformed the market with a decline of 0.8%, while the U.S. pharmaceutical sector matched the market performance with a 1.9% increase. Notable stock movements included significant gains for companies like WuXi AppTec and declines for Alphamab Oncology in Hong Kong [31][19].

Investment Rating - The report maintains a "Positive" investment rating for the pharmaceutical and biotechnology industry [1] Core Insights - The report highlights significant advancements in innovative drugs, particularly in the context of recent clinical trial results presented at the 2025 ESMO conference, showcasing the potential for new treatment options in various cancer types [12][19] - The report emphasizes the emergence of domestic drugs that have achieved notable efficacy in treating conditions such as NSCLC and HER2-positive breast cancer, indicating a shift in the competitive landscape [13][17] Summary by Sections 1. New Drug Developments - **2L EGFR Mutant NSCLC**: The drug Lukanosumab (sac-TMT) is the first to demonstrate both overall survival (OS) and progression-free survival (PFS) benefits in patients with TKI-resistant NSCLC, with mPFS of 8.3 months compared to 4.3 months for chemotherapy [13][14] - **HER2 Positive Breast Cancer**: The drug Ruikang Trastuzumab shows longer mPFS of 30.6 months compared to 8.3 months for the chemotherapy combination, indicating a promising new option for patients [17][18] - **T-Bren for Breast Cancer**: Early data from the T-Bren trial shows a clinical overall response rate (cORR) of 82.2% in HER2-positive patients, with mPFS of 18.0 months [19][20] - **2L HER2 Positive Gastric Cancer**: Anniotuzumab combined with chemotherapy shows significant improvements in mPFS (7.1 months vs 2.7 months) and mOS (19.6 months vs 11.5 months), suggesting a potential shift in treatment paradigms [21][24] 2. Market Performance - The pharmaceutical and biotechnology sector saw a 0.58% increase in October, underperforming the CSI 300 index by 2.67 percentage points, ranking 25th among 31 sub-industries [25][30] - The medical research outsourcing sector experienced the highest growth, up 5.47%, while other bioproduct sectors faced declines [30][34]

Core Viewpoint - The company, Beijing Baipusais Biotechnology Co., Ltd., has shown significant growth in revenue and profit, driven by its innovative biotechnological products and services, particularly in the fields of recombinant proteins and CAR-T cell therapy [9][10]. Group 1: Company Performance - On October 24, the company's stock rose by 4.89%, with a trading volume of 198 million yuan and a turnover rate of 2.51%, bringing the total market capitalization to 10.628 billion yuan [1]. - For the first half of 2025, the company achieved a revenue of 387 million yuan, representing a year-on-year growth of 29.38%, and a net profit attributable to shareholders of 83.804 million yuan, up 47.81% year-on-year [9]. - The company has distributed a total of 432 million yuan in dividends since its A-share listing, with 312 million yuan distributed over the past three years [10]. Group 2: Product Development and Market Position - The company has developed a range of high-quality recombinant proteins targeting various diseases, which supports the research and production needs of biopharmaceuticals [2]. - It has launched a specific antibody targeting the CD19 antigen, enhancing the detection methods for CAR-T cell therapy, and is expanding its product line related to cell and gene therapy [2]. - The company has initiated product development in response to the monkeypox virus, with multiple recombinant proteins, antibodies, and test kits already available [3]. Group 3: Industry Recognition and Financial Impact - The company has been recognized as a "specialized and innovative" small giant enterprise, which is a prestigious title in China, indicating its strong market position and innovation capabilities [3]. - As of the 2024 annual report, overseas revenue accounted for 66.46% of total revenue, benefiting from the depreciation of the Chinese yuan [4]. - The company operates in the pharmaceutical and biotechnology sector, specifically in the bioproducts category, and is involved in various concept sectors including artificial intelligence and biomedicine [9].

Core Insights - The collagen market is experiencing significant growth driven by increasing consumer focus on efficacy and ingredients, with two main growth drivers: professional skin care and aesthetic injection applications [1][3] - The collagen market in China is projected to exceed 16 billion yuan at the raw material level and approach 270 billion yuan at the retail level by 2030 [1] - The industry is currently in a phase of policy refinement, accelerated technological iteration, and tight collaboration across the supply chain [1] Industry Structure - The collagen industry has a high degree of integration between raw material supply and end product manufacturing, with upstream suppliers, midstream manufacturers of recombinant collagen, and downstream sales channels [2] - The market is characterized by significant growth potential, high technological barriers, and intense competition [2] End-User Applications - The demand for professional skin care products that combine medical safety and cosmetic efficacy is rapidly increasing, particularly in the aesthetic medicine sector [3] - Applications of collagen products are expanding from traditional moisturizing and nourishing functions to include core roles in aesthetic injection materials [3] Recommended Companies - Companies to watch include: Giant Bio (02367), Jinbo Bio (920982.BJ), Marubi Bio (603983.SH), Huaxi Bio (688363.SH), Fulejia (301371.SZ), Novozymes (688105.SH), Baipusais (301080.SZ), and Betaini (300957.SZ) [4]

Investment Rating - The report maintains a positive outlook on the innovative drug and medical device industry, highlighting key targets for investment [5][24]. Core Insights - The innovative drug sector is experiencing high growth, with a focus on companies such as Jiangsu Heng Rui Medicine, Hansoh Pharmaceutical Group, and others. The report emphasizes the potential for value re-evaluation in these firms [5][24]. - Recent business development (BD) deals in the innovative drug sector are expected to catalyze market activity, with notable transactions including Jiangsu Heng Rui Medicine's agreement with Kite for a $1.20 billion upfront payment, potentially reaching $15.20 billion in total [5][24]. - The A-share pharmaceutical sector underperformed the broader market in the third week of October 2025, with the Shanghai Composite Index falling by 1.5% and the SW Biopharma index declining by 2.5% [7][18]. Summary by Sections 1. Continuous Focus on Innovative Drugs and Medical Devices - The report emphasizes the high growth potential in innovative drugs, with key investment targets including Jiangsu Heng Rui Medicine, Hansoh Pharmaceutical Group, and others. Related targets include CSPC Innovation Pharmaceutical [5][24]. 2. A-Share Pharmaceutical Sector Performance - In the third week of October 2025, the A-share pharmaceutical sector saw a decline of 2.5%, underperforming the Shanghai Composite Index, which fell by 1.5%. The report notes that the sector's premium relative to all A-shares is currently at a normal level, with a relative premium rate of 74.5% [7][14][21]. 3. Hong Kong and U.S. Pharmaceutical Sector Performance - The report indicates that the Hong Kong and U.S. pharmaceutical sectors also underperformed, with the Hang Seng Healthcare index dropping by 5.8% and the S&P 500 Healthcare index increasing by only 0.7% during the same period [18][24].