Core Viewpoint - The 2025 ASCO Annual Meeting will showcase significant research achievements of domestic innovative drugs, highlighting their potential in oncology treatment [1] Group 1: Innovative Drug Highlights - Several innovative drug molecules with first-in-class or best-in-class potential will present data, including IBI363 from Innovent Biologics, SKB264 from Kelun-Biotech, and others [1] - IBI363 is the world's first next-generation IO dual antibody designed with IL 2α bias, showing promising efficacy in treating IO-resistant tumors such as NSCLC, melanoma, and CRC [2] Group 2: Clinical Data and Efficacy - In a Phase I clinical study, IBI363 demonstrated an overall response rate (ORR) of 43.3% and a disease control rate (DCR) of 90.0% in squamous NSCLC patients at a 3 mg/kg dosage, with a median progression-free survival (mPFS) of 7.3 months [2] - For adenocarcinoma patients previously treated with PD-(L)1 therapy, the 3 mg/kg group showed an ORR of 76.0% and a DCR of 90.0%, with an mPFS of 4.2 months [2] Group 3: Comparative Efficacy - IBI363 exhibited significant clinical activity in IO-resistant lung squamous and adenocarcinoma patients, outperforming existing therapies such as docetaxel and various immune combination treatments [3] Group 4: Colorectal Cancer Potential - IBI363 also shows promise in late-line CRC treatment, with clinical studies indicating an overall survival (OS) of 16.1 months for patients treated with IBI363 monotherapy [5][6] - Compared to standard treatments like TAS-102 combined with bevacizumab, IBI363 demonstrated superior survival outcomes in patients with worse baseline characteristics [6]

Core Viewpoint - Zhongyin International has raised the target price for Innovent Biologics (01801.HK) to HKD 82 and maintains a "Buy" rating following positive data updates on IBI363 presented at the ASCO conference [1] Financial Projections - The revenue forecasts for Innovent Biologics for 2025, 2026, and 2027 have been increased to RMB 11.4 billion, RMB 14.2 billion, and RMB 17.9 billion respectively [1] Regulatory Developments - The US FDA has granted Fast Track designation for IBI363 for the treatment of advanced non-small cell lung cancer and melanoma, while the National Medical Products Administration has awarded it Breakthrough Therapy designation [1] Clinical Trials - The company plans to initiate two Phase III clinical trials in the second half of the year [1]

Core Insights - Innovent Biologics has received a second Breakthrough Therapy Designation (BTD) from China's NMPA for IBI363, a bispecific antibody fusion protein targeting squamous non-small cell lung cancer (sqNSCLC) [1][3] - IBI363 has also received Fast Track Designations (FTDs) from the U.S. FDA for sqNSCLC and melanoma, highlighting its potential in treating immunotherapy-resistant cancers [1][8] - The drug aims to address unmet clinical needs in patients who have progressed after anti-PD-(L)1 immunotherapy and platinum-based chemotherapy [1][4] Company Overview - Innovent Biologics is a leading biopharmaceutical company founded in 2011, focusing on developing high-quality medicines for various diseases, including oncology and autoimmune disorders [9] - The company has launched 15 products and has multiple assets in various stages of clinical trials, including 3 new drug applications under regulatory review [9] - Innovent collaborates with over 30 global healthcare companies, enhancing its research and development capabilities [9] Clinical Development - IBI363 has shown promising results in Phase 1 clinical studies, demonstrating manageable safety and encouraging efficacy in immunotherapy-resistant patients [2][6] - The drug's dual mechanism of action combines PD-1 blockade and IL-2-driven T-cell expansion, potentially reshaping the tumor microenvironment [3][5] - Innovent is accelerating global development for IBI363, with ongoing clinical studies in China, the U.S., and Australia targeting various tumor types [7]

Group 1 - The Hang Seng Index closed up 0.6%, while the Tech Index rose by 0.57% [1] - Most sectors in the market experienced gains, with significant strength in the consumer and pharmaceutical sectors [1] - Pop Mart (09992.HK) and Mixue Group (02097.HK) both saw their stock prices increase by over 5%, reaching historical highs [1] - Innovent Biologics (01801.HK) experienced a notable rise of over 14% [1]

Core Viewpoint - The Hong Kong stock market experienced a slight decline, but the innovative drug sector showed significant movement, with Innovent Biologics surging 17% in a single day, leading to a strong rebound in related ETFs [1] Group 1: Market Performance - The largest thematic ETF in the Hong Kong market, the Hong Kong Innovative Drug ETF (513120), was the most actively traded, with a turnover rate exceeding 38% and a transaction volume close to 40 billion yuan by 11:30 AM [1] - The surge in innovative drugs is attributed to multiple industry catalysts, enhancing market confidence [1] Group 2: Industry Catalysts - The China National Medical Products Administration issued 11 innovative drug approvals at the end of May, boosting expectations for commercialization among pharmaceutical companies [1] - High-quality research results from domestic innovative drugs were showcased at the American Society of Clinical Oncology (ASCO) and American College of Rheumatology (ACR) meetings, validating the value of leading pharmaceutical pipelines and business development capabilities [1] Group 3: Investment Strategy - Investors are encouraged to construct a strategy that includes the Hong Kong Innovative Drug ETF (513120), Medical ETF Leader (560260), and Pharmaceutical and Health ETF (159938) to capture opportunities across the entire innovative drug supply chain [1] - The three ETFs form a closed loop: the Hong Kong Innovative Drug ETF addresses R&D breakthroughs, the Medical ETF Leader focuses on industrialization, and the Pharmaceutical and Health ETF captures commercialization [2] Group 4: ETF Details - The Hong Kong Innovative Drug ETF (513120) tracks the China Securities Hong Kong Innovative Drug Index, with a current P/E ratio of 27 times and a valuation at the 18th percentile historically [4] - The Medical ETF Leader (560260) focuses on medical devices and services, with a P/E ratio of 31 times and a valuation at the 20th percentile historically [4] - The Pharmaceutical and Health ETF (159938) covers the pharmaceutical and health industry, with a P/E ratio of 35 times and a valuation at the 43rd percentile historically [4]

Group 1 - The Hang Seng Index increased by 0.72% during the midday trading session [1] - The Hang Seng Tech Index rose by 1.01% [1] - Innovent Biologics saw a significant increase of over 15% in its stock price [1] Group 2 - Meituan's stock price increased by over 4% [1] - Pop Mart's stock price rose by over 3% [1]

Group 1 - The Hong Kong stock market saw a broad increase in early trading, with the healthcare sector performing actively, particularly the Hang Seng Healthcare Index ETF (159557) which rose by 3.56% with a turnover rate of 8.1% [1] - Among the constituent stocks, Innovent Biologics surged over 17%, while Zai Lab and China National Pharmaceutical Group both increased by more than 8% [1] - The 2025 American Society of Clinical Oncology (ASCO) annual meeting is highlighted as a significant event, showcasing the latest research from local companies such as Diagreat Pharmaceuticals, Kelun Pharmaceutical, and China National Pharmaceutical Group, with over 70 original research presentations from Chinese researchers [1] Group 2 - Donghai Securities noted that the recent presentation of numerous domestic innovative drug projects at the ASCO meeting indicates the growing international recognition of local innovative pharmaceutical companies, suggesting that innovative drugs are a key investment theme within the healthcare sector [1] - The report emphasizes investment opportunities in sub-sectors such as medical devices, traditional Chinese medicine, chain pharmacies, and medical services [1] - Changjiang Securities pointed out that domestic innovative drugs are currently undervalued, with some products showing potential to be the best in their class globally, supporting the outlook for these drugs to gain international market presence and valuation upside [2]

Core Viewpoint - The Hong Kong innovative drug ETF fund (520700) has shown significant market activity, with a 4.00% increase and a turnover rate exceeding 55.40%, indicating strong investor interest in innovative pharmaceutical stocks [1] Group 1: Company Developments - Innovent Biologics reported promising clinical data for its first-in-class PD-1/IL-2α-bias bispecific antibody fusion protein IBI363 at the 2025 ASCO annual meeting, focusing on advanced non-small cell lung cancer [1] - IBI363 has shown controllable safety and encouraging efficacy trends in squamous non-small cell lung cancer and wild-type lung adenocarcinoma, contributing to long-term survival benefits [1] - At the ASCO conference, Innovent Biologics had a total of 8 oral presentations, accounting for approximately 2% of the total presentations at the event [1] Group 2: Market Analysis - Morgan Stanley has raised its sales forecasts for Innovent's IBI363 and IBI343, citing their significant potential and the likelihood of global development or licensing opportunities [2] - GF Securities emphasizes the value of investing in Hong Kong innovative drugs, noting a shift in market focus from traditional sectors to long-term strategic areas like the Sino-U.S. technology competition [2] - The recent emergence of the DeepSeek large model has positively influenced investor sentiment, leading to a systematic reassessment of China's potential in key technology sectors [2]

截至2025年6月4日 10:16，中证香港创新药指数(931787)强势上涨5.04%，成分股君圣泰医药-B(02511)领 涨17.44%，信达生物(01801)上涨17.14%，开拓药业-B(09939)上涨9.70%，泰格医药(03347)，再鼎医药 (09688)等个股跟涨。港股创新药ETF(513120)上涨4.56%，涨幅居全市场ETF第二！ 冲击4连涨。 流动性方面，港股创新药ETF盘中换手23.32%，成交23.69亿元，市场交投活跃。拉长时间看，截至6月 3日，港股创新药ETF近1周日均成交37.57亿元。规模方面，港股创新药ETF最新规模达98.55亿元，居 全市场港股医药类ETF第一。 信达证券表示，国产创新药板块近年来展现出强劲的投资价值和发展潜力，主要得益于政策支持、技术 进步以及资本市场对高质量医药企业的认可。随着中国创新药从"拼数量""拼速度"向"拼质量""拼创 新"的转变，行业整体的研发能力和产品差异化优势不断提升，形成了较为明确的竞争壁垒。 港股创新药ETF(513120)，（联接A:019670，联接C:019671）：紧密跟踪中证香港创新药指数，投资港 股创新药产业。值 ...

Core Viewpoint - The recent surge in the Hong Kong stock market, particularly in the innovative drug sector, is attributed to significant inflows of capital and positive developments in clinical research, indicating a robust growth trajectory for the industry [1][3][4]. Group 1: Market Performance - The Hong Kong stock market showed slight gains, with the Hong Kong Stock Connect innovative drug ETF (159570) rising by 3.88% and achieving a trading volume exceeding 5 billion yuan [1]. - The ETF experienced a net inflow of over 21 million yuan during the trading session, following a substantial inflow of over 91 million yuan the previous day [1]. Group 2: Company Developments - The constituent stocks of the Hong Kong Stock Connect innovative drug ETF saw collective gains, with notable increases such as over 15% for Innovent Biologics and over 3% for both CSPC Pharmaceutical Group and CanSino Biologics [3]. - Innovent Biologics presented promising clinical data at the 2025 ASCO annual meeting, showcasing its first-in-class PD-1/IL-2α-bias bispecific antibody IBI363 for treating advanced non-small cell lung cancer [3]. - Morgan Stanley has raised its sales forecasts for Innovent's products, indicating strong potential for IBI363 and IBI343 in both domestic and international markets [3]. Group 3: Industry Trends - The current wave of innovation in the pharmaceutical sector is seen as a natural progression of China's pharmaceutical industry, with a significant increase in the number of innovative drugs entering the market [4]. - The period from 2025 to 2028 is projected to be critical for Chinese innovative drug companies as they are expected to collectively enter a profitability phase, marking a significant shift in the industry [4]. - The ASCO conference highlighted a record number of 73 oral presentations for Chinese innovative drug assets, reflecting the growing international recognition and demand for these products [5]. Group 4: Investment Opportunities - The Hong Kong Stock Connect innovative drug ETF (159570) is noted for its high concentration in innovative drug companies, with over 72% of its top ten holdings in leading firms [9]. - The ETF is characterized by a high weight of innovative drugs (up to 85%) and a relatively low valuation compared to the market, making it an attractive investment option [9]. - The Chinese innovative drug sector is experiencing a surge in business development (BD) activities, with increasing recognition and transaction values for innovative drug assets [6][7].