Exhibit 99.1 BeOne Medicines Announces Third Quarter 2025 Financial Results and Business Updates SAN CARLOS, Calif. – November 6, 2025 – BeOne Medicines Ltd. (NASDAQ: ONC; HKEX: 06160; SSE: 688235), a global oncology company, today announced financial results and corporate updates from the third quarter of 2025. "These strong financial results reinforce our position as a global oncology leader with exceptional topline growth and a strong balance sheet," said John V. Oyler, Co-Founder, Chairman and CEO at Be ...

Core Viewpoint - The article discusses the ongoing price negotiation process for innovative drugs under the 2025 National Medical Insurance (NMI) negotiations, highlighting the participation of various pharmaceutical companies and the significance of the commercial insurance innovative drug directory [2][12]. Group 1: Price Negotiation Process - On November 2, 2025, a total of 10 companies participated in the price negotiation for 11 drug products, including 2 products from BeiGene [2][4]. - The negotiation process is divided into two groups, with each group negotiating separately with representatives from the National Medical Insurance Administration and commercial insurance companies [4][6]. - The first company completed its negotiation in 45 minutes, indicating a generally positive atmosphere among participants [6][7]. Group 2: CAR-T Drugs - CAR-T drugs, known for their high prices, are receiving attention in the commercial insurance innovative drug directory, with one product priced at 999,000 yuan per dose, making it the lowest-priced CAR-T drug in China [7][11]. - Multiple CAR-T drugs received unanimous approval during the expert review phase prior to the negotiations, indicating strong interest from the commercial insurance sector [11]. Group 3: Expectations and Concerns - Companies are primarily focused on the potential patient access to drugs rather than just price reductions, expressing uncertainty about how the innovative drug directory will facilitate market access [12][13]. - A representative mentioned that the National Medical Insurance Administration suggested a price reduction expectation of 15% during pre-negotiation discussions [12]. - There is a notable interest in the innovative drug directory as it allows companies to recover substantial R&D costs without necessitating significant price cuts [13].

Core Insights - The 2025 National Medical Insurance Negotiation has entered its fourth day, focusing on the price negotiation for innovative drugs, with 121 drugs passing the initial review and 24 entering the price negotiation phase [1][2] Group 1: Price Negotiation Process - A total of 10 companies participated in the price negotiation for 11 drugs, including major players like BeiGene and Huyuan Bio [1] - The negotiation process is divided into two groups, with each group negotiating separately with representatives from the National Medical Insurance Administration and insurance companies [3] Group 2: CAR-T Drug Negotiations - CAR-T drugs, known for their high prices, are receiving attention in the innovative drug directory negotiations, with several companies reporting positive experiences during negotiations [4][5] - The price of Huyuan Bio's CAR-T drug, previously set at 999,000 yuan per dose, is expected to be a focal point in the negotiations [5][6] Group 3: Expectations and Concerns - Companies are primarily concerned about the potential patient access to drugs through the innovative drug directory, rather than just price reductions [8][9] - There is uncertainty regarding the implementation and market access of the innovative drug directory, as companies are still exploring the commercial insurance payment mechanisms [8][9]

Company Overview - BeOne Medicines Ltd. is a global oncology company based in Switzerland, focused on discovering and developing innovative cancer treatments that are more accessible to patients worldwide [2] - The company has a diverse pipeline of novel therapeutics targeting both hematology and solid tumors, supported by internal capabilities and collaborations [2] - BeOne has a workforce of over 11,000 employees across six continents, emphasizing its commitment to improving access to medicines for cancer patients [2] Upcoming Events - BeOne Medicines will participate in two investor conferences: the Guggenheim Second Annual Healthcare Innovation Conference on November 10, 2025, and the Jefferies Global Healthcare Conference in London on November 17, 2025 [5] - Live webcasts of these events will be available on the company's investor relations website, with archived replays accessible afterward [1][5] Financial Information - BeOne Medicines is scheduled to announce its third quarter 2025 financial results on November 6, 2025, before the financial markets open [8] - Following the financial results release, the company will host a live webcast with management at 8:00 a.m. ET [8] Recent Developments - BeOne presented new data on its PD-1 inhibitor, TEVIMBRA, at the European Society of Medical Oncology 2025 Congress, showcasing benefits from two pivotal Phase 3 trials [9][10] - The U.S. FDA granted Breakthrough Therapy Designation for sonrotoclax, a next-generation BCL2 inhibitor, for treating adult patients with relapsed or refractory mantle cell lymphoma [11]

Core Points - BeOne Medicines Ltd. is set to report its third quarter 2025 financial results on November 6, 2025, before the financial markets open [1] - Following the financial results release, the company will host a live webcast with management at 8:00 a.m. ET [1] - The live webcast can be accessed from the investors section of the company's website [1]

Summary of the Conference Call for BeiGene Company Overview - **Company**: BeiGene - **Date**: October 20, 2025 - **Industry**: Biotechnology, specifically focusing on hematology and oncology Key Points and Arguments Financial Performance - **Revenue Guidance**: For 2025, BeiGene's revenue is projected to be between $4.9 billion and $5.3 billion, with an upward adjustment from the initial guidance of $4.9 billion to $5.3 billion made during the mid-year report [3][4] - **Gross Margin**: Expected gross margin is between 80% and 90%, with operating profit remaining positive throughout the year [3][4] Product Performance - **Zebutinib**: - Global sales reached $1.3 billion in 2023, expected to double to $2.6 billion in 2024, and exceed $3.5 billion in 2025, particularly strong growth in the U.S. market [2][6] - Sales in the first half of 2025 reached $1.74 billion, with $1.25 billion from the U.S. alone [6][9] - **PD-1**: - Projected domestic sales of $621 million (approximately 4.5 billion RMB) in 2024, with commercialization in the U.S. starting in October 2025, expected to enhance overseas contributions [2][6] Research and Development Achievements - **R&D Capabilities**: BeiGene has a robust R&D framework, rapidly advancing molecular drugs through global clinical trials, particularly in hematology [4][12] - **Combination Therapies**: The combination of BTK inhibitors with BCL-2 inhibitors and BDKC degraders has shown an overall response rate (ORR) exceeding 90% and a complete response (CR) rate of 70% to 80% [10][11] Strategic Initiatives - **Global Expansion**: Plans to strengthen the global team and optimize sales efficiency through a combination of self-developed products and agency models [5][7] - **Market Listings**: Intent to list on U.S., Hong Kong, and STAR Market to secure funding for ongoing R&D [8][12] Future Development Strategies - **Hematology Focus**: Continued emphasis on blood cancers, with plans for head-to-head clinical trials for new therapies [9][11] - **Solid Tumors**: Initiating Phase III clinical trials for CDK4/6 inhibitors in breast cancer and advancing ADC development to address drug resistance and efficacy issues [12][13] Additional Insights - **Market Dynamics**: The decline in ibrutinib market share due to patent expiration is noted, highlighting the competitive landscape [2][6] - **Patient-Centric Approach**: The company aims to address diverse patient needs through innovative drug development across multiple therapeutic areas [2][4] This summary encapsulates the critical insights from the conference call, focusing on BeiGene's financial outlook, product performance, R&D achievements, strategic initiatives, and future development plans.

SAN CARLOS, Calif.--(BUSINESS WIRE)---- $ONC #BeOne--BeOne Medicines Ltd. (Nasdaq: ONC; HKEX: 06160; SSE: 688235), a global oncology company, today announced the presentation of data from two pivotal Phase 3 trials – RATIONALE-307 and 312 – offering new evidence of the benefits of its PD-1 inhibitor, TEVIMBRA® (tislelizumab), at the European Society of Medical Oncology 2025 Congress (ESMO 2025) in Berlin, Germany, October 17-21. The results reinforce TEVIMBRA's consistent and durable efficacy across lung ca ...

Group 1 - The article discusses the Biotech Analysis Central service, which provides in-depth analysis of pharmaceutical companies and offers a model portfolio of small and mid-cap stocks [1][2] - The service includes over 600 biotech investing articles and live chat features to assist healthcare investors in making informed decisions [2] - A promotional offer is available for new subscribers, including a two-week free trial and a discounted annual subscription price [1] Group 2 - The author of the article has no current stock or derivative positions in any mentioned companies and does not plan to initiate any within the next 72 hours [3] - The article expresses the author's personal opinions and is not compensated beyond the Seeking Alpha platform [3] - Seeking Alpha clarifies that past performance does not guarantee future results and that the views expressed may not reflect the platform's overall stance [4]

Summary of BeiGene Conference Call Company Overview - **Company**: BeiGene - **Industry**: Biotechnology and Pharmaceuticals Key Points and Arguments 1. **Global Commercialization Strategy**: BeiGene adopts a global commercialization strategy, leveraging Chinese patient resources and efficient clinical execution to reduce costs and accelerate global clinical trials, collaborating with international pharmaceutical companies like Novartis and Amgen [2][3] 2. **Core Product - Zanubrutinib**: Zanubrutinib has been approved in over 70 countries globally, becoming the leading BTK inhibitor for new patients in the U.S., surpassing the first-generation BTK inhibitor ibrutinib, significantly driving revenue growth for the company [2][5] 3. **Expansion into Solid Tumors**: BeiGene has made significant progress in the solid tumor field, with upcoming data releases for ADC, ProTech, and CDK, marking the company's transition from a focus on hematological malignancies to a broader oncology treatment approach [2][5] 4. **Clinical Trial Efficiency**: The company utilizes the cost and efficiency advantages of clinical trials in China, with 25% of global clinical patients from China and over 40% from Europe and North America, supporting simultaneous domestic and international product registrations [2][7] 5. **Upcoming Milestones**: Key milestones in the coming years include data readouts for ADC, ProTech, and CDK, as well as the submission of a BCL-2 inhibitor for U.S. market approval, which is expected to enhance the cure rate for frontline lymphoma patients [2][8] 6. **Unique Position in Chinese Innovation Drug Industry**: BeiGene is the only independent innovative drug company with global R&D and commercialization capabilities, making it a rare entity in the A-share and Hong Kong markets [3] 7. **Comprehensive Treatment Landscape**: In hematological malignancies, BeiGene has established a complete treatment portfolio including BTK, CDK, and BCL-2 inhibitors, with zanubrutinib expected to capture over 50% of the U.S. market share for CLL [4][12] 8. **BCL-2 Inhibitor Development**: The company is developing a new generation BCL-2 inhibitor, which is expected to achieve significant sales, potentially reaching $3 to $5 billion, and is currently undergoing global Phase III clinical trials [14][22] 9. **CDK Inhibitor Market**: BeiGene's CDK4/6 inhibitors are crucial in breast cancer treatment, with the global market exceeding $13 billion and projected to reach $16 to $18 billion [17][21] 10. **Broad Oncology Pipeline**: The company is actively developing treatments for various solid tumors, including lung and gastrointestinal cancers, with multiple products in clinical stages [20] Other Important but Overlooked Content 1. **Zanubrutinib's Competitive Edge**: Zanubrutinib's success is attributed to its superior product profile, showing better progression-free survival (PFS) and safety compared to ibrutinib, and being included in treatment guidelines [11][12] 2. **Impact of IRA Legislation**: The IRA legislation may have long-term effects on drug pricing, but currently, zanubrutinib has not faced price pressure, and its annual price has increased [13] 3. **Market Positioning**: BeiGene's international management team and shareholder structure, including significant overseas funds, support its global operations and strategic positioning [6][22] This summary encapsulates the critical insights from the conference call, highlighting BeiGene's strategic initiatives, product developments, and market positioning within the biotechnology industry.

Core Insights - BeOne Medicines Ltd. has received Breakthrough Therapy Designation from the FDA for sonrotoclax, a next-generation BCL2 inhibitor aimed at treating adult patients with relapsed or refractory mantle cell lymphoma [1] Company Summary - BeOne Medicines Ltd. is a global oncology company focused on developing innovative treatments for cancer [1] - The FDA's acceptance of BeOne's request indicates a significant step forward in the development of sonrotoclax for a challenging patient population [1]