中信证券股份有限公司 关于成都苑东生物制药股份有限公司 股东向特定机构投资者询价转让股份的核查报告 上海证券交易所： 中信证券股份有限公司（以下简称"中信证券"或"组织券商"）受委托担任成都 楠苑投资合伙企业（有限合伙）、成都竹苑投资合伙企业（有限合伙）、成都菊苑投资 合伙企业（有限合伙）（以下合称"转让方"）以向特定机构投资者询价转让（以下简 称"询价转让"）方式减持所持有的成都苑东生物制药股份有限公司（以下简称"公司" 或"苑东生物"）首次公开发行前已发行股份的组织券商。 经核查，中信证券就本次询价转让的股东、受让方是否符合《上海证券交易所科创 板上市公司自律监管指引第 4 号——询价转让和配售（2025 年 3 月修订）》（以下简 称"《询价转让和配售指引》"）要求，本次询价转让的询价、转让过程与结果是否公 平、公正，是否符合《询价转让和配售指引》的规定作出如下报告说明。 一、本次询价转让概况 （一）本次询价转让转让方 截至 2025 年 7 月 22 日，转让方所持公司首发前股份的数量及占公司总股本比例情 况如下： | 序号 | 股东名称 | 持股数量（股） | 持股比例 | | --- | --- ...

苑东生物(688513.SH)公告称，全资子公司硕德药业于近日收到国家药监局核准签发的《药品注册证 书》，药品名称为培哚普利氨氯地平片（Ⅲ）。该药品为复方制剂，主要用于治疗 高血压。培哚普利 氨氯地平片（Ⅲ）由法国施维雅开发，最早于2008年3月在欧盟获批上市。硕德药业该药品获批后视同 通过一致性评价。根据米内网数据，2024年该药品销售金额约4.36亿元。 ...

Core Viewpoint - Yuan Dong Bio is accelerating its transformation from generic to innovative drugs, with a strong commitment to innovation as the core driver of high-quality development [2][4]. Company Overview - Chengdu Yuan Dong Bio-Pharmaceutical Co., Ltd. was established in 2009 and listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board on September 2, 2020, with stock code 688513 [4]. - The company focuses on research and development driven by innovation, integrating the entire industry chain of chemical raw materials, high-end chemical drugs, and biological drugs [4]. - Yuan Dong Bio aims to become a leading enterprise in the global anesthesia and analgesia field, with a mission centered on patient care and human health [4]. New Quality Productivity - The core of "new quality productivity" in the biopharmaceutical industry lies in technological innovation and the transformation of results [5]. - A multi-dimensional collaborative breakthrough is essential for cultivating new quality productivity, requiring technological innovation, policy support, and a complete industrial development ecosystem [5]. Business Strategy - The company’s development strategy is based on high-end generic drugs, internationalization for growth, and innovation for the future [6]. - High-end generic drugs currently serve as the main source of revenue and profit, with a steady increase in the number of approvals over the past three years [6]. - As of the end of 2024, the company has successfully industrialized 60 high-end chemical drugs, including several first generics and special narcotic drugs [6]. International Expansion - Yuan Dong Bio is actively developing international markets while deepening its domestic market presence [6]. - By the end of 2024, the company has exported 12 raw materials to major international markets and received FDA approval for 2 high-end formulation products [6]. Innovation and R&D - The company maintains a high level of R&D investment, with over 20% of revenue allocated to R&D in recent years, exceeding the industry average [8]. - There are currently over 10 first-class new drugs in the R&D pipeline, ensuring a structured layout for industrial upgrades [7][8]. - The efficiency of R&D results transformation is continuously improving, with an increasing number of product approvals in high-end generics and several new drug pipelines at different stages of development [8]. Future Outlook - Yuan Dong Bio is committed to developing differentiated clinical advantages in innovative products and high-end formulations to enhance market competitiveness [9].

Group 1 - The preliminary transfer price for the shares is set at 42.06 yuan per share based on the inquiry conducted on July 23, 2025 [1] - A total of 12 institutional investors participated in the inquiry, including fund management companies, insurance companies, securities companies, and private equity fund managers, with a total effective subscription of 5,400,000 shares, resulting in a subscription multiple of 1.60 times the transfer base price [1] - The total number of shares to be transferred has been fully subscribed, with the preliminary number of institutional investors set to acquire the shares being 10, totaling 3,369,550 shares [2]

Group 1 - Rongzhi Rixin expects a net profit increase of 2,027.62% to 2,179.59% for the first half of 2025, with projected profits between 14 million to 15 million yuan [1] - The significant profit growth is attributed to the acceleration of digital and intelligent transformation across industries, leading to increased revenue from sectors like wind power and petrochemicals [1] - The company has improved operational management efficiency, resulting in enhanced gross margins and overall profitability [1] Group 2 - Jinzhai Food plans to repurchase shares worth between 50 million to 100 million yuan, with a maximum repurchase price of 16 yuan per share [2] - The repurchase will be funded through self-owned funds and a special loan from China Merchants Bank, with a loan commitment of up to 90 million yuan [2] Group 3 - Zhongfu Information's chairman and general manager, Wei Dongxiao, has been detained, and the board has arranged for the deputy general manager to assume his responsibilities during this period [3][4] - The company states that this situation will not significantly impact its daily operations [4] Group 4 - Shenzhen Energy plans to invest approximately 789.703 million yuan in the construction of the Honghaiwan offshore wind power project, with a portion funded through financing [6] - The company will increase its capital in its subsidiary by 153.108 million yuan to support this project [6] Group 5 - *ST Zitian faces potential delisting due to failure to rectify false financial reporting as mandated by the China Securities Regulatory Commission [8] - The company has not disclosed corrected financial reports within the required timeframe, leading to a warning of delisting risk [8] Group 6 - Watson Bio has signed a strategic cooperation framework agreement with Yuxi State-owned Capital Operation Co., aiming to establish a long-term partnership in the vaccine and bioproducts industry [10] - The collaboration is expected to enhance innovation and business expansion in the vaccine sector [10] Group 7 - Weiming Environmental reported a total power generation of 226,162.29 million kWh in the first half of 2025, representing a year-on-year increase of 7.54% [12] - The company also recorded a total waste input of 689.32 million tons, with a growth of 8.71% compared to the previous year [12]

Group 1 - The scope of "zero tariff" goods in Hainan Free Trade Port will expand to approximately 6,600 tax items, covering about 74% of all goods tax items, an increase of nearly 53 percentage points compared to before the closure [1] - A-share financing balance has exceeded 1.9 trillion yuan for two consecutive trading days, with a single-day financing purchase amount reaching 200.9 billion yuan, accounting for 10.42% of A-share trading volume [1] Group 2 - Global semiconductor equipment sales are expected to reach a record $125.5 billion in 2025, a year-on-year increase of 7.4%, driven by advanced logic, memory, and technology migration [2] - A new type of scintillation screen developed by a team from the Chinese Academy of Sciences significantly improves the spatial resolution of fast neutron imaging, enhancing its applicability in non-destructive testing of large and dense equipment [2] Group 3 - In the first half of the year, China approved 43 innovative drugs, a year-on-year increase of 59%, with many targeting major diseases such as tumors and rare diseases [3] - The coal industry may face a new round of capacity reduction and regulation due to a recent notice from the National Energy Administration aimed at stabilizing coal supply and addressing market disruptions [3] Group 4 - Weima Automobile is planning to resume production, with a goal of producing 100,000 vehicles annually by 2030, despite facing significant challenges from its investor, Baoneng Group [5] - OpenAI's CEO stated that AI has the capability to bypass most identity verification methods, indicating a potential crisis in the financial sector [5] Group 5 - The company Dalian Bojue Wedding Photography has undergone a management change, with plans to optimize its business model and reduce losses by shutting down unprofitable stores [6] - Zhongwei Semiconductor is planning to issue H-shares for listing on the Hong Kong Stock Exchange, driven by both external pressures and internal development needs [7] Group 6 - Credit Suisse Securities has been renamed Beijing Securities following a change in ownership to a state-owned entity, marking a shift from foreign-controlled to state-controlled brokerage [8] - Mindray Medical is reportedly considering a second IPO in Hong Kong, aiming to raise at least $1 billion [8] Group 7 - Yuan Dong Bio announced a preliminary transfer price of 42.06 yuan per share for its stock, attracting 12 institutional investors with a subscription multiple of 1.60 times [8] - Qidi Design won a bid for the Henan Airport Intelligent Computing Center project, with a total bid amount of 860 million yuan [9] Group 8 - Huagong Technology has received approval to issue short-term financing bonds and medium-term notes, with a registered amount of 2 billion yuan each [10] - Rongzhi Rixin expects a significant increase in net profit for the first half of the year, projecting a growth of 2027.62% to 2179.59% [11] Group 9 - The Shanghai Composite Index experienced a slight increase, with over 4,000 stocks declining, indicating a mixed market sentiment [12]

分组1 - Watson Bio signed a strategic cooperation framework agreement with Yuxi State-owned Capital Operation Company to establish a long-term partnership in the vaccine and bioproducts industry [1] - The cooperation aims to promote innovation in vaccines and synthetic biological manufacturing through various methods such as establishing equity investment funds and strategic investments [1] - Watson Bio was founded in January 2001 and focuses on the research, production, and sales of human vaccines and biotechnological drugs [2] 分组2 - Yuan Dong Bio announced a preliminary transfer price of 42.06 yuan per share for its stock, attracting 12 institutional investors with a total subscription of 540,000 shares, resulting in a subscription multiple of 1.60 times [3] - Yuan Dong Bio was established in June 2009 and specializes in the research, production, and sales of chemical raw materials, high-end chemical drugs, and biological drugs [3] 分组3 - Weiming Environmental reported a total power generation of 2.262 billion kWh in the first half of the year, representing a year-on-year increase of 7.54% [4] - The company also achieved a total online power generation of 1.863 billion kWh, with an average online electricity price of 0.569 yuan per kWh [4] - Weiming Environmental was founded in December 2001 and focuses on low-carbon environmental technology, products, and services [5] 分组4 - Qidi Design won a bid for the Henan Airport Intelligent Computing Center project with a total bid amount of 860 million yuan [6] - The project includes construction, maintenance, and operation of a computing cluster, with a construction period of 150 calendar days [6] - Qidi Design was established in March 1988 and specializes in design consulting, construction engineering, and new energy projects [7] 分组5 - Tiantan Bio's subsidiary received approval for a production site change for its product "Recombinant Human Coagulation Factor VIII" used in treating hemophilia A [8] - The new production site is located in Chengdu, Sichuan Province [8] - Tiantan Bio was founded in June 1998 and focuses on blood products using human plasma and recombinant technology [9] 分组6 - East China Pharmaceutical's HDM1002 tablet clinical trial application was approved by the FDA, aimed at weight management for overweight or obese individuals [10] - The company also received approval for a new drug abbreviated application for injectable cabozantinib, enhancing its product pipeline in the anti-infection field [10] - East China Pharmaceutical was established in March 1993 and specializes in drug research, production, and sales [10] 分组7 - Jinlong Co. plans to acquire a 29.32% stake in Shenzhen Benmao Technology Co., Ltd. [11] - Jinlong Co. was founded in April 1997 and focuses on securities company operations [11] 分组8 - Hasi Lian's injectable diltiazem hydrochloride passed the consistency evaluation by the National Medical Products Administration [12] - The drug is primarily used for treating cardiovascular diseases [12] - Hasi Lian was established in June 1996 and specializes in the research, production, and sales of chemical drug formulations [13] 分组9 - Matrix Co. reported new signed orders of 272 million yuan in the second quarter, with a total of 677 million yuan in signed but uncompleted orders [14] - Matrix Co. was founded in March 2010 and focuses on space design and soft decoration [15] 分组10 - Nanshan Aluminum plans to use up to 1 billion yuan of idle funds for low-risk financial investments [16] - Nanshan Aluminum was established in March 1993 and specializes in the development, production, processing, and sales of aluminum and aluminum alloy products [17] 分组11 - Danhua Technology received a warning letter for failing to timely disclose related party transactions [18][19] - Danhua Technology was founded in February 1994 and focuses on the production and sales of coal chemical products [20] 分组12 - Jinkong Coal Industry announced a cash dividend of 0.755 yuan per share based on a total share capital of 1.674 billion shares [21] - Jinkong Coal Industry was established in July 2001 and specializes in coal production and sales [21] 分组13 - Blue Sky Gas announced that shareholders and the secretary of the board plan to reduce their holdings by a total of 2.61 million shares [22] - Blue Sky Gas was founded in December 2002 and focuses on pipeline natural gas and urban gas services [23] 分组14 - Huagong Technology received approval for the issuance of 2 billion yuan in short-term financing bonds and medium-term notes [24] - Huagong Technology was established in July 1999 and specializes in intelligent manufacturing equipment and related technologies [25] 分组15 - Chengjian Development completed the issuance of 500 million yuan in medium-term notes with a coupon rate of 2.05% [26] - Chengjian Development was founded in December 1998 and focuses on real estate development and investment [27] 分组16 - Feilong Co. reported a net profit of 210 million yuan in the first half of the year, a year-on-year increase of 14.49% [28] - The company achieved a total revenue of 2.162 billion yuan, a year-on-year decrease of 8.67% [28] - Feilong Co. was established in January 2011 and specializes in manufacturing thermal management components for automotive and civil applications [29] 分组17 - Guanghe Technology plans to invest 30 million yuan to establish a new venture capital fund focusing on emerging industries [30] - Guanghe Technology was founded in June 2002 and specializes in the research, production, and sales of multi-layer printed circuit boards [31] 分组18 - Dongnan Network won a bid for the EPC project of Qianjiang Century City Intelligent Comprehensive Science and Technology Park with a total bid amount of 1.183 billion yuan [32] - The project has a total construction area of 273,600 square meters and a planned total investment of 3.956 billion yuan [32] - Dongnan Network was established in December 2001 and focuses on steel structures and new energy [33] 分组19 - Guangdian Measurement plans to raise no more than 1.3 billion yuan through a private placement [34] - The funds will be used for various projects including testing platforms and upgrading laboratories [34] - Guangdian Measurement was founded in May 2002 and specializes in measurement services and technical services [35] 分组20 - Wanma Co. plans to invest in a project to produce 350,000 tons of environmentally friendly polymer materials [36] - The total investment for the project is approximately 1.245 billion yuan, with a construction period from 2025 to 2030 [36] - Wanma Co. was established in December 1996 and focuses on the research, production, and sales of wires, cables, and charging equipment [37] 分组21 - Dingxin Communications plans to sell its subsidiary Haina Smart for 240 million yuan [38] - Dingxin Communications was founded in March 2008 and specializes in low-voltage power line carrier communication products [39] 分组22 - Jiayun Technology plans to transfer its wholly-owned subsidiary Jinyuan Interactive for 10 million yuan [40] - Jiayun Technology was established in May 2002 and focuses on internet marketing services [41] 分组23 - Guangsheng Nonferrous plans to publicly transfer a 3% stake in Guangdong Pearl River Rare Earth Co., Ltd. [42] - The transfer price is not less than 5.9764 million yuan, aimed at clearing unrelated assets [42] - Guangsheng Nonferrous was founded in June 1993 and specializes in rare earth mining and processing [43] 分组24 - Zhongwei Semiconductor plans to issue H-shares and apply for listing on the Hong Kong Stock Exchange [44] - Zhongwei Semiconductor was established in June 2001 and focuses on the research, design, and sales of digital and analog chips [45] 分组25 - Zhongrong Co. announced that its chairman and general manager has been released from custody and is resuming normal duties [46] - Zhongrong Co. was founded in April 1990 and specializes in the research, design, production, and sales of paper packaging products [47] 分组26 - Jiangling Motors reported a net profit of 733 million yuan in the first half of the year, a year-on-year decrease of 18.17% [48] - The company achieved total revenue of 18.092 billion yuan, a year-on-year increase of 0.96% [48] - Jiangling Motors was established in January 1997 and focuses on the production and sales of commercial vehicles and related parts [49] 分组27 - Glodon plans to reduce its holdings by up to 2.08% of the company's shares [50] - Glodon was founded in August 1998 and specializes in digital construction platform services [51] 分组28 - Olin Bio's controlling shareholder plans to reduce its holdings by up to 3% of the company's shares [52] - Olin Bio was established in December 2009 and focuses on the research, production, and sales of human vaccines [53] 分组29 - Tianrun Industrial plans to acquire 100% of Shandong Altai's shares for 135 million yuan [54] - The acquisition aims to enhance the company's capabilities in lightweight automotive components [54] - Tianrun Industrial was founded in December 1995 and specializes in the production of crankshafts and connecting rods [55] 分组30 - Goer Technology plans to acquire Mega Precision Technology and Channel Well Industrial for approximately 10.4 billion HKD [56] - The acquisition aims to enhance Goer Technology's capabilities in precision components and smart hardware [56] - Goer Technology was established in June 2001 and focuses on precision components and intelligent acoustic products [57]

证券代码：688513 证券简称：苑东生物 公告编号：2025-051 二、风险提示 （一）本次询价转让受让方及受让股数仅为初步结果，尚存在拟转让股份被 司法冻结、扣划等风险。询价转让的最终结果以中国证券登记结算有限责任公司 上海分公司最终办理结果为准。 成都苑东生物制药股份有限公司 股东询价转让定价情况提示性公告 成都楠苑投资合伙企业（有限合伙）、成都竹苑投资合伙企业（有限合伙）、 成都菊苑投资合伙企业（有限合伙）（以下合称"出让方"）保证向成都苑东生物 制药股份有限公司（以下简称"苑东生物"、"公司"）提供的信息内容不存在任 何虚假记载、误导性陈述或者重大遗漏，并对其真实性、准确性和完整性依法承 担法律责任。 本公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 重要内容提示： 根据 2025 年 7 月 23 日询价申购情况，初步确定的本次询价转让价格为 42.06 元/股。 一、本次询价转让初步定价 （一）经向机构投资者询价后，初步确定的转让价格为 42.06 元/股。 （二）参与本次询价转让报价的机构投资者家数为 12 家，涵盖了基金管理 公司、保险公司、证券公司、私募基金管理人等专业 ...

苑东生物公告，根据2025年7月23日询价申购情况，初步确定的本次询价转让价格为42.06元/股。参与 本次询价转让报价的机构投资者家数为12家，参与机构包括基金管理公司、保险公司、证券公司、私募 基金管理人等。有效认购股份数量为540万股，对应转让底价的有效认购倍数为1.6倍。本次询价转让拟 转让股份已获全额认购，初步确定受让方为10家机构投资者，拟受让股份总数为336.95万股。 ...

Group 1 - Hualing Cable recently won multiple contracts totaling approximately 557 million yuan, accounting for 13.40% of its audited revenue for 2024 [1] - The projects include contracts from Southern Power Grid, China Institute of Atomic Energy, Zijin Mining, Tianjin Rail Transit, and China Nonferrous Metal International Mining [1] Group 2 - Weisi Medical's shareholder plans to reduce its stake by up to 3%, totaling no more than 2.8731 million shares, due to personal funding needs [2] - Han Yi Co. intends to invest 102 million yuan to acquire a 39% stake in Shanghai Pidong Cultural Media, aiming to expand its IP derivative business [2] Group 3 - Zhongsheng High-Tech's controlling shareholder will change to Fuzhou Qianjing after signing a share transfer agreement, with stock resuming trading [3] - Tianli Lithium Energy plans to invest 30% in a joint venture for advanced energy research, contributing 30 million yuan [5] Group 4 - Zhenbang Intelligent plans to invest up to 11 million USD to establish a production base in Indonesia [8] - Shenhuo Co. aims to set up a 1.512 billion yuan industry fund focusing on strategic emerging industries [9] Group 5 - Shenhuo Co. intends to acquire a 14.69% stake in Shenhuo New Materials for 298 million yuan through public bidding [11] - Kema Technology plans to acquire a 73% stake in Suzhou Kaixin Semiconductor for 102 million yuan to enhance its capabilities in silicon carbide materials [13] Group 6 - China Power Construction's subsidiary won two major engineering projects with total contract values of approximately 57.52 billion yuan and 54.39 billion yuan [14] - Huaxin Environmental plans to reduce its stake by up to 1.58% due to personal funding needs [15] Group 7 - Yuandong Bio's shareholders plan to collectively reduce their stake by up to 1.91% for personal funding needs [17] - Xiangming Intelligent's controlling shareholder plans to reduce its stake by up to 3% due to personal funding needs [18] Group 8 - Sand Technology's actual controller's associates plan to reduce their stake by up to 2% for personal funding needs [19] - Beifang Changlong decided to terminate the acquisition of 51% of Henan Zhongzheng due to changes in market conditions [20] Group 9 - ST Huicheng plans to publicly transfer 30% of its subsidiary Peak Intelligent for a starting price of 5.1 million yuan [22] - Yunji Group's major shareholder plans to reduce its stake by up to 3% for personal funding needs [23] Group 10 - Shunbo Alloy plans to raise up to 600 million yuan through a private placement to enhance its main business [24] - Berry Gene's major shareholder will face judicial enforcement on 1% of its shares due to a pledge default [25] Group 11 - Guanglian Aviation's controlling shareholder is under investigation, but the company's operations remain normal [26]