Core Viewpoint - The company, Innovent Biologics (09969.HK), has announced that it will hold a board meeting on August 19, 2025, to consider and approve its interim results for the six months ending June 30, 2025 [1] Summary by Relevant Categories - **Company Announcement** - Innovent Biologics will hold a board meeting on August 19, 2025 [1] - The meeting will focus on considering and approving the interim results for the six months ending June 30, 2025 [1]

FF301 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 諾誠健華醫藥有限公司（於開曼群島註冊成立的有限公司） 呈交日期: 2025年8月5日 I. 法定/註冊股本變動 FF301 II. 已發行股份及/或庫存股份變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 09969 | 說明 | | | | | | | | | 已發行股份（不包括庫存股份）數目 | | 庫存股份數目 | | 已發行股份總數 | | | 上月底結存 | | | 1,494,598,235 | | 1,686,000 | | 1,496,284,235 | | 增加 / 減少 (-) | | | | | | | | | 本月底結存 | | | 1,494,598,235 | | 1,686,000 | | 1,496,28 ...

（股份代號：9969） 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或 因依賴該等內容而引致的任何損失承擔任何責任。 InnoCare Pharma Limited 諾誠健華醫藥有限公司 （ 於 開 曼 群 島 註 冊 成 立 的 有 限 公 司 ） 諾誠健華醫藥有限公司 主席兼執行董事 崔霽松博士 香港，2025年8月5日 董事會召開日期 於本公告日期，董事會包括主席兼執行董事崔霽松博士；執行董事趙仁濱博士；非執行董事 施一公博士及謝榕剛先生；以及獨立非執行董事胡蘭女士、董丹丹博士及及管坤良教授。 諾誠健華醫藥有限公司（「本公司」）董事會（「董事會」）謹此宣佈，本公司將於 2025年8月19日（星期二）舉行董事會會議，藉以（其中包括）考慮並批准本公司 及其附屬公司截至2025年6月30日止六個月中期業績及其發佈。 承董事會命 ...

港股三大指数延续昨日反弹行情，南下资金净买入港股超220亿港元！截止收盘，恒生指数涨0.68%， 国企指数涨0.65%，恒生科技指数涨0.73%。盘面上，大型科技股走势分化，其中，快手涨近3%，腾讯 涨1.64%，网易涨1.55%，小米、阿里巴巴、百度、美团仍旧飘绿；生物医药股再度迎来大涨行情，君 实生物尾盘快速拉升大幅上涨近34%表现十分抢眼，康诺亚、复宏汉霖、诺诚健华、药明康德皆走强； 纸企龙头发起新一轮涨价潮，纸业股拉升明显，晨鸣纸业大涨近15%刷新阶段新高；近期行业利好袭 来，脑机接口概念股普遍上涨，南京熊猫电子盘中涨至8%，钢铁股、苹果概念股、濠赌股、核电股、 重型机械股、航空股、保险股、内银股、煤炭股多数表现活跃。另一方面，7月新能源车销量成绩单发 布，汽车股涨跌不一，蔚来汽车、零跑汽车、比亚迪股份全天表现低迷，半导体股午后走低，中芯国际 转跌近1%，锂电池股、教育股、石油股少部分走低。(格隆汇) ...

Group 1 - The core viewpoint of the articles highlights the significant growth and activity in the Hong Kong innovative drug sector, with the Hong Kong Innovative Drug 50 ETF (513780) experiencing a year-to-date increase of approximately 100% [1] - Notable individual stocks in the innovative drug sector include Ascentage Pharma-B, which rose over 10%, and others like CanSino Biologics and Lepu Biopharma-B, which increased by more than 7% [1] - The net inflow of funds into the Hong Kong Innovative Drug 50 ETF has been substantial, with a total net inflow of 526 million yuan over the last nine trading days and over 800 million yuan in the past three months, indicating accelerated capital deployment [1] Group 2 - The top ten constituents of the CSI Hong Kong Stock Connect Innovative Drug Index account for a cumulative weight of 70.19%, including high-quality A-share companies like Innovent Biologics and CSPC Pharmaceutical Group [2] - The innovative drug sector in China is at a new historical starting point, with domestic companies enhancing their competitiveness and expanding overseas, while industry revenue is rapidly growing and moving towards a profit-driven new cycle [2] - Strong policy support is crucial for the development of the innovative drug industry, providing a favorable environment for growth and investment opportunities [2]

（文章来源：每日经济新闻） 每经AI快讯，港股创新药板块继续走强，亚盛医药-B涨逾10%，康诺亚-B、乐普生物-B涨逾7%，诺诚 健华、信达生物涨超5%。 ...

Group 1 - The Hong Kong biotechnology stocks collectively rose, with notable increases in several companies' stock prices [1][2] - Beihai Kangcheng-B saw a rise of nearly 19%, while other companies like Gilead Sciences-B and Ascentage Pharma-B also experienced significant gains of over 15% and 9% respectively [1][2] - The overall trend indicates a positive sentiment in the biotechnology sector, with multiple companies achieving gains of over 5% [1][2] Group 2 - Specific stock performance includes: Beihai Kangcheng-B at 18.99% increase, Gilead Sciences-B at 15.30%, and Ascentage Pharma-B at 9.48% [2] - The market capitalization of these companies varies significantly, with Gilead Sciences-B at approximately 11.477 billion and Ascentage Pharma-B at about 29.86 billion [2] - Other notable performers include Jiahua Bio-B and Beikang Medical-B, both showing increases of over 7% [1][2]

Group 1 - The Hong Kong biotechnology stocks experienced a collective increase, with Beihai Kangcheng-B rising nearly 19% [1] - Gilead Sciences-B surged over 15%, while Ascentage Pharma-B increased by more than 9% [1] - Other notable gainers include Jiahe Biopharma-B up over 8%, and Beikang Medical-B, Fuhong Hanlin, and Kangnuo Ya-B each rising over 7% [1] Group 2 - Huakang Biomedical, Basilea Pharmaceutica-B, Lepu Biopharma-B, and Hualing Pharmaceutical-B all saw increases of over 6% [1] - Yiming Anke-B, Nocera Health, Zai Lab, and CanSino Biologics rose by more than 5% [1]

Summary of Ascentage Pharma's Conference Call Company Overview - **Company**: Ascentage Pharma - **Key Products**: Lisatoclax (2,575) and Olverembatinib (Aurebatinib) Industry Insights - **Market Focus**: Hematological malignancies, specifically targeting CLL (Chronic Lymphocytic Leukemia), MDS (Myelodysplastic Syndromes), and MM (Multiple Myeloma) [2][6] - **Competitive Landscape**: The market for BCL-2 inhibitors is competitive, with Lisatoclax being the second BCL-2 inhibitor globally approved, following Venetoclax [19] Core Points and Arguments - **Lisatoclax Development**: - Submitted for CLL indication in China and plans to expand into MDS and MM, which have less competition [2][6] - Expected to leverage safety advantages to capture market share [2] - Clinical trial data presented at ASCO 2025 showed an ORR of 83.3% in AML patients and 43% in difficult-to-treat AML patients [23] - **Olverembatinib Performance**: - Achieved sales of 241 million RMB in 2024, with expectations to double in 2025 [3] - Positioned as a third-generation TKI targeting T315I resistant patients, showing significant safety advantages over competitors [11][15] - **Collaboration with Takeda**: - A $1.3 billion licensing agreement was reached, with Takeda expected to exercise options post-2026 [5] - This partnership indicates recognition of Chinese-developed drugs by international firms [5] - **Research and Development Focus**: - Future R&D investments will prioritize overseas registration and domestic indication expansions for Lisatoclax [4] - Cash flow is projected to support these initiatives [4] Additional Important Insights - **Market Potential**: - Lisatoclax's peak sales potential is estimated between $3 billion to $4 billion globally [19] - Olverembatinib's peak sales in overseas markets could reach $2 billion to $3 billion, with domestic sales expected to approach 2 billion RMB [18] - **Competitive Advantages**: - Lisatoclax offers better safety and faster dose escalation compared to Venetoclax, enhancing patient compliance [19] - The strategic approach of entering the market with a cautious clinical trial design allows for quicker market capture [22] - **Management and Shareholder Structure**: - Led by Dr. Yang Dajun, with a strong management team experienced in drug development [7] - Takeda is a significant shareholder, reflecting confidence in Ascentage's capabilities [8] - **Future Outlook**: - Plans to expand into ALL (Acute Lymphoblastic Leukemia) with Philadelphia chromosome-positive patients, which could significantly boost sales [14] - The company is also exploring new product pipelines targeting solid tumors and hematological malignancies [9] This summary encapsulates the key insights from Ascentage Pharma's conference call, highlighting the company's strategic direction, product performance, and market opportunities.

Core Viewpoint - The Hong Kong innovative drug sector is experiencing active performance, with significant increases in various stocks and a notable inflow into the Hang Seng Innovative Drug ETF [1] Group 1: Market Performance - As of 10:40, the Hang Seng Innovative Drug Index rose by 0.6%, with notable stock increases: Lepu Biotech-B up 5.1%, Innovent Biologics up 3.3%, Ascentage Pharma-B up 2.8%, and CStone Pharmaceuticals up 2.7% [1] - The Hang Seng Innovative Drug ETF (159316) recorded a trading volume exceeding 250 million yuan, with a net subscription of 35 million units [1] Group 2: Future Outlook - Looking ahead to the second half of 2025, major academic conferences such as the World Conference on Lung Cancer (WCLC), European Society for Medical Oncology (ESMO), American College of Rheumatology (ACR), and American Association for the Study of Liver Diseases (AASLD) are expected to continuously catalyze the innovative drug sector [1] Group 3: Index Revision - The Hang Seng Innovative Drug Index has announced a revision to its compilation scheme, explicitly excluding CXO companies, with the new rules set to take effect on August 11 [1] - This index will become one of the first "pure" innovative drug indices with 100% purity among ETF-tracked indices, enhancing its appeal to investors [1]