Group 1 - The core point of the article is that XuanZhu Bio-B (02575) saw its stock price rise over 5%, reaching a high of 71.9 HKD, approaching its historical peak of 72 HKD, following the inclusion of its innovative drug, Pyrocilin, in the national basic medical insurance drug list [1] - The inclusion of Pyrocilin in the insurance list is expected to enhance its affordability and accessibility for patients, thereby promoting the drug's market penetration and sales growth, which will positively impact the long-term operational development of XuanZhu Bio [1] - Pyrocilin, a new CDK2/4/6 inhibitor, has shown strong efficacy in inhibiting tumor cell proliferation and was approved by the National Medical Products Administration of China for specific types of advanced or metastatic breast cancer patients in May 2025 [1] Group 2 - Both approved indications for Pyrocilin have been included in the 2025 national basic medical insurance directory, and an application for its use in first-line treatment in combination with aromatase inhibitors is currently under review [1]

消息面上，基石药业宣布，公司普吉华(普拉替尼胶囊，100mg)已被纳入中国国家医疗保障局公布的最 新版《国家基本医疗保险、生育保险和工伤保险药品目录》，该目录将于2026年1月1日起正式实施。 此外，香港联交所最新资料显示，12月4日，非执行董事胡正国增持基石药业100万股，每股作价5.7546 港元，总金额为575.46万港元。增持后最新持股数目为347.1万股，持股比例为0.24%。 基石药业-B(02616)现涨超4%，截至发稿，涨3.93%，报5.82港元，成交额2498.41万港元。 ...

Core Viewpoint - UBS reports that Innovent Biologics (01801) has six new products and a new indication for sintilimab included in the latest National Basic Medical Insurance, Maternity Insurance, and Work Injury Insurance Drug List (2025) [1] - Innovent Biologics has been officially included in the Hang Seng Index as of today [1] - UBS maintains a "Buy" rating with a target price of HKD 137.4 [1] Group 1 - The new products targeting IGF-1R, EGFR, BTK, ROS1, KRAS G12C, and RET are expected to see rapid sales growth by 2026 [1] - The inclusion of teriparatide for diabetes in the insurance list positively impacts the expected launch of masitinib in 2026, although price adjustments need to be monitored [1] - Inclusion in the Hang Seng Index is anticipated to further enhance liquidity for the company's stock [1]

Major Events - GuoXia Technology (02655) plans to conduct an IPO from December 8 to December 11, offering 33.85 million H-shares and introducing cornerstone investors such as Huikai Hong Kong [1] - Basilea Pharmaceutica AG (02616) has its drug Pujihua® (Pralsetinib Capsules) included in the National Medical Insurance Directory for 2025 [1] - Four Seasons Pharmaceutical (00460) sees its innovative drug XuanYueNing® included in the National Basic Medical Insurance Drug List for the first time [1] - Shanghai Pharmaceuticals (02607) successfully negotiates and includes Amisulpride Orally Disintegrating Tablets in the National Medical Insurance Directory [1] - Hansoh Pharmaceutical (03692) has its innovative drug Amelotex® approved for two new indications in the updated 2025 National Medical Insurance Directory [1] - Xiansheng Pharmaceutical (02096) sees EnzeShu® and EnDu® included in the updated National Medical Insurance Drug List [1] - Hutchison China MediTech (00013) has its drug Tazverik® included in the first edition of the National Commercial Health Insurance Innovative Drug List [1] - XuanZhu Biotechnology (02575) has its innovative drug XuanYueNing® included in the National Basic Medical Insurance Drug List for the first time [1] - Yino Pharmaceutical (02591) has its H-shares included in the list of eligible securities for the Shanghai-Hong Kong and Shenzhen-Hong Kong Stock Connect [1] - China Metallurgical Group (01618) and its subsidiaries plan to sell non-core business assets for approximately 60.68 billion yuan, focusing on core businesses in metallurgical engineering, non-ferrous metals, and mining engineering [1] - Cambridge Technology (06166) intends to invest a total of 405 million yuan to acquire and subscribe for shares in the Yangzhong Happiness Home Venture Capital Partnership Fund [1] Operating Performance - Dongfeng Motor Group (00489) reports cumulative automobile sales of 1.697 million units in the first 11 months, a year-on-year decrease of approximately 0.3% [2] - New天绿色能源 (00956) achieves a cumulative power generation of 1,336.89 million MWh in the first 11 months, an increase of 8.04% year-on-year [2] - Longyuan Power (00916) reports a cumulative power generation of approximately 6,909.64 million MWh in the first 11 months, a year-on-year growth of 0.41% [2] - Baolong Real Estate (01238) records a total contract sales of approximately 6.666 billion yuan in the first 11 months, a year-on-year decline of 43.2% [2]

智通财经APP讯，基石药业-B(02616)发布公告，公司普吉华®(普拉替尼胶囊，100 mg)已被纳入中国国 家医疗保障局公布的最新版《国家基本医疗保险、生育保险和工伤保险药品目录》，该目录将于2026年 1月1日起正式实施。 美国食品药品监督管理局(FDA)批准其以商品名为GAVRETO®上市销售，适应症分别为：用于治疗经 FDA批准的检测方法检测证实为转移性RET融合阳性NSCLC的成人患者;需要系统性治疗且放射性碘难 治(如适用)的晚期或转移性RET融合阳性甲状腺癌成人和 12岁及以上儿童患者。 普吉华®由基石药业合作伙伴Blueprint Medicines公司(已于2025年7月被赛诺菲收购)开发。基石药业拥 有普吉华®在大中华地区(包括中国大陆、中国香港、中国澳门和中国台湾地区)的独家开发和商业化权 利。2023年11月，基石药业将普吉华®在中国大陆区域的独家商业化推广权授予上海艾力斯医药科技股 份有限公司。 普吉华®是一种口服、每日一次的靶向治疗药物。中国国家药品监督管理局(NMPA)已批准普吉华®用于 治疗RET基因融合阳性的局部晚期或转移性非小细胞肺癌(NSCLC)成人患者，需要系统性治疗 ...

（股份代號：2575） 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致之任何損失承擔任何責 任。 Xuanzhu Biopharmaceutical Co., Ltd. 軒竹生物科技股份有限公司 （一家於中華人民共和國註冊成立的股份有限公司） 吡 洛 西 利 片（商 品 名：軒 悅 寧®）作 為 新 型CDK2/4/6抑 製 劑，具 有 獨 特 的 多 靶 點 協 同 作 用 機 制，具 有 強 效 抑 制 腫 瘤 細 胞 增 殖，顯 著 降 低 傳 統CDK4/6抑製劑常見的 血 液 學 毒 性 等 優 勢。吡 洛 西 利 已 於 二 零 二 五 年 五 月 獲 得 中 國 國 家 藥 品 監 督 管 理局批准與氟維司群聯合用於既往接受內分泌治療後出現疾病進展的激素受 體陽性(HR+)、人 表 皮 生 長 因 子 受 體2陰 性(HER2-)（「HR+╱HER2-」）晚 期 或 轉 移 性 乳 腺 癌 患 者；單 藥 ...

Core Viewpoint - The stock of Innovent Biologics (01801) has experienced a significant decline of over 6%, currently trading at 87 HKD with a transaction volume of 1.86 billion HKD, despite the inclusion of seven innovative products in the new medical insurance directory [1] Group 1: Product Developments - Innovent Biologics has successfully included seven innovative products, including the PD-1 inhibitor Tyvyt (sintilimab injection), in the new medical insurance directory, expanding the indications for mature products [1] - With the recent additions, all eight approved indications for Tyvyt are now covered by medical insurance, which may enhance market access and patient affordability [1] Group 2: Financial Transactions - The company has completed a share issuance to Takeda Pharmaceutical, issuing 6.9138 million shares, which represents approximately 0.4% of the total issued share capital, raising nearly 780 million HKD in net proceeds [1] - There have been significant large transactions in the market, involving approximately 13.0734 million shares at an average price of 92 HKD per share, totaling over 1.2 billion HKD [1]

Core Viewpoint - Haichuang Pharmaceutical's drug, Deuteroenzalutamide soft capsule, has been included in the 2025 National Medical Insurance Drug List, effective from January 1, 2026, following successful negotiations with the National Healthcare Security Administration and the Ministry of Human Resources and Social Security [2][6]. Drug Information - The drug's generic name is Deuteroenzalutamide soft capsule, marketed as Hainan An, classified as a Category B drug under the medical insurance system, with an agreement validity from January 1, 2026, to December 31, 2027 [3]. - Deuteroenzalutamide is a first-class new drug developed for the treatment of metastatic castration-resistant prostate cancer (mCRPC) and is a second-generation androgen receptor (AR) inhibitor, supported by the National Major New Drug Creation Technology Major Project [3]. - Clinical data from Phase III trials showed that Deuteroenzalutamide significantly extended progression-free survival (PFS) by reducing the risk of disease progression or death by 42% compared to the control group (HR=0.58, 95% CI: 0.439-0.770; p=0.0001) [3]. - The drug is the first domestically approved innovative treatment for adult patients with mCRPC who have progressed after receiving abiraterone acetate and chemotherapy, and it demonstrates superior safety by significantly reducing the incidence of central nervous system adverse events [3]. Market Context - Prostate cancer ranks as the second most common malignancy among men globally, with 1.467 million new cases reported in 2022, and in China, the incidence reached 134,000 new cases in the same year [4]. - The market for prostate cancer treatments in China is projected to reach 50 billion yuan by 2030, with the second-generation anti-androgen drug market expected to exceed 4 billion yuan by 2024 [4]. - Endocrine therapy remains the recommended first-line treatment for metastatic castration-resistant prostate cancer [4]. Company Impact - The inclusion of Deuteroenzalutamide in the National Medical Insurance Drug List reflects the recognition of its clinical value and innovation, facilitating market promotion and reducing patient medication costs [6]. - The company plans to actively support the implementation of insurance policies and expand hospital access to meet patient needs [6].

Major Events - Chuangsheng Group-B (06628) announced updated efficacy data for osemitamab triple therapy as a first-line treatment for gastric or gastroesophageal junction adenocarcinoma at ESMO Asia [1] - Strength Development (01277) plans to acquire 100% equity of Taiyuan Shidi for approximately 384 million yuan and acquire Dongzhimen property for a total of 86.33 million yuan [1] - Innovent Biologics (01801) completed a global strategic collaboration with Takeda Pharmaceutical and issued 6.9138 million shares under general authorization [1] - Ascentage Pharma-B (06855) received FDA and EMA approval for global registration of a Phase III clinical trial for Nilotinib as a first-line treatment for Ph+ ALL [1] - Baiao Saitou-B (02315) announced that its business partner IDEAYA received IND approval from the FDA for IDE034 [1] - Jinfang Pharmaceutical-B (02595) initiated a registration clinical trial for GFH375, the world's first oral KRAS G12D inhibitor in a controlled chemotherapy Phase III study [1] - Xixiangfeng Group (02473) signed a business cooperation agreement with Hello Car Rental to develop car rental services in designated cities under a "co-branded store" model [1] - International Commercial Settlement (00147) signed a computer chip sales agreement with Hong Kong Antarctic Light to seize growth opportunities in the IC chip market [1] - CSPC Pharmaceutical Group (01093) received clinical trial approval in the U.S. for a GLP-1/GIP receptor dual agonist injection [1] - MIRXES-B (02629) plans to collaborate with Crystal Technology to build an AI-enabled integrated "diagnosis and treatment" research and industrialization platform [1] - Zhengtong Automobile (01728) intends to invest approximately 816 million yuan to acquire Xiamen Xinda 4S dealership and automotive sales and export business [1] - Guorui Life (00108) plans to acquire 78.3% of Beijing Chunyu Tianxia Software for 269 million yuan [1] - Innovent Biologics (01801) successfully included seven innovative products (including new indications) in the 2025 National Medical Insurance Drug List [1] - Peijia Medical-B (09996) had its registration application for the TaurusNXT® "non-aldehyde cross-linked" transcatheter aortic valve replacement system accepted by the National Medical Products Administration [1] - Fosun Pharma (02196) had new drugs included in the National Medical Insurance Directory and commercial insurance innovative drug directory [1] - Junshi Biosciences (01877) had Tuoyi® new indications and Junshida® included in the National Medical Insurance Directory [1] - Valiant Biotech-B (09887) presented clinical data for LBL-034 at the 67th ASH Annual Meeting [1] - Canfite BioPharma (09926) had all approved indications for five marketed drugs successfully included in the latest National Medical Insurance Drug List [1] - Fuhong Hanlin (02696) had Fuzhuoning® (Citrus Acid Vovizili Capsules) included in the National Medical Insurance Drug List [1] - Green Leaf Pharmaceutical (02186) successfully included five new products in the 2025 National Medical Insurance Drug List or commercial insurance innovative drug directory [1] - Yinnuo Pharmaceutical-B (02591) had its core products included in the National Medical Insurance Drug List [1] Operating Performance - Poly Real Estate Group (00119) reported a contract sales amount of approximately 47.7 billion yuan for the first 11 months, a year-on-year decrease of 8.45% [2] - GAC Group (02238) reported November automobile sales of approximately 179,700 units, a year-on-year decline of 9.72% [2] - Xiehe New Energy (00182) reported an equity power generation of 697.23 GWh in November, a year-on-year increase of 7.77% [2]

Core Viewpoint - Heng Rui Medicine announced the inclusion of several drugs in the national medical insurance directory, which is expected to positively impact sales, although the exact effect on the company's performance is currently indeterminate [1] Group 1: Drug Inclusion in National Medical Insurance - The following drugs have been newly included in the national medical insurance directory: injection of Rukang Qumatuozhuzhantang, Appleseed Famitinib capsules, injection of Funachizhu single antibody, and several others [1] - New indications for injection of Karilizhu single antibody, Fluorozolpali capsules, and Fumaric acid Tejilidin injection have also been successfully added to the national medical insurance directory [1] - The renewal of the following drugs has been successful, allowing them to remain in the national medical insurance directory: Malate Pyrotinib tablets, Hecoropag Ethanolamine tablets, and several others [1] Group 2: Financial Impact - The total sales revenue for the aforementioned drugs is estimated to be approximately 8.66 billion yuan for the year 2024 [1] - For the first three quarters of 2025, the estimated sales revenue for these drugs is around 7.55 billion yuan [1] - The inclusion of these drugs in the national medical insurance directory is expected to facilitate sales, although the specific impact on the company's operational performance remains uncertain [1]