Core Viewpoint - Zhonghui Biotech-B is set to go public on the Hong Kong Stock Exchange from August 8, 2025, focusing on innovative vaccine development and commercialization in China [3][4]. Company Overview - Established in 2015, Zhonghui Biotech specializes in innovative vaccine research and commercialization, employing a dual strategy of "independent innovation + authorized introduction" to meet unmet vaccine needs [3]. - The company aims to gradually replace traditional and imported vaccines with high-end products and extend its competitive advantage to international markets [3]. Product Pipeline - As of the prospectus date, Zhonghui Biotech has a pipeline of 13 vaccine products targeting various infectious diseases, including core products and 11 candidates in different clinical stages [3][4]. - Key products include the first and only approved quadrivalent influenza subunit vaccine in China, which has shown a serum protection rate of 89.41%-97.98% against four influenza virus strains [5]. Financial Performance - The company exhibits rapid revenue growth but continues to incur losses, typical for a research-driven biotech firm [4]. - Revenue for 2023 was 0.52 billion yuan, primarily from the quadrivalent influenza vaccine, with projections for 2024 to reach 2.60 billion yuan, reflecting a 400% year-on-year increase [5]. - The net loss for 2023 was 4.25 billion yuan, narrowing to 2.59 billion yuan in 2024 due to increased revenue [5]. IPO Details - The IPO will utilize a standard offering mechanism, with subscription dates from July 31 to August 5, 2025, and pricing on August 6 [4][6]. - The share price range is set between 12.90 and 15.50 HKD, with a total issuance of approximately 33.44 million shares [6]. - The expected net proceeds of around 4.21 billion HKD will focus on advancing the product pipeline, with 63.6% allocated to core product development [6][7]. Market Sentiment - The IPO is anticipated to attract significant market interest, with early subscription rates exceeding 41 times, indicating strong short-term speculative interest [7]. - The absence of well-known institutional investors may signal weaker long-term confidence, despite the high initial market enthusiasm [7].

业绩方面，中慧生物于2023年9月才开始商业销售其首款商业化产品四价流感病毒亚单位疫苗，并自销 售该产品产生全部收入。2023年、2024年和2025年前三个月，中慧生物的营业收入分别为0.52亿、2.60 亿和41.3万元，相应的净亏损分别为4.25亿、2.59亿和0.87亿元。 而这种亏损在可见未来仍将持续，中慧元通表示，未来将继续产生大量开支及亏损，主要支出来自疫苗 研发、建造生产园区、在研疫苗商业化、团队扩充、员工激励、引进知识产权等。 自2018年至2021年，中慧生物累计进行了3轮融资，包括高特佳、国海创新资本等机构纷纷押注，累计 融资额约10亿元。在2021年完成B轮融资后，公司的投后估值达到41.89亿元。 招股书显示，中慧生物在上市前的股东架构中，安有才、江苏粜宇、何一鸣为一致行动人，上述股东为 控股股东集团，合计持股约45.55%；其他股东包括上海忆久诚、高特佳、文周投资、盈科创新、国海 创新、HLC、杭州三花弘道等。 2025年7月27日，江苏中慧元通生物科技股份有限公司（下称"中慧生物")更新了聆讯后的资料集，拟香 港主板挂牌上市。 中慧生物是一家疫苗公司，成立于2015年，致力于创新 ...

Core Viewpoint - Zhonghui Biotech-B (02627) is set to launch an initial public offering (IPO) from July 31 to August 5, 2025, aiming to issue 33.44 million H-shares globally, with 10% allocated for Hong Kong and 90% for international investors, at a price range of HKD 12.9 to HKD 15.5 per share [1] Group 1 - The company is a China-based vaccine manufacturer focused on the research, development, and commercialization of innovative vaccines and traditional vaccines using new technologies [1] - The product pipeline includes two core products: a quadrivalent influenza virus subunit vaccine and an investigational freeze-dried human rabies vaccine, along with 11 other vaccines in development [1] Group 2 - The cornerstone investors, including Jiaxing Xinyang and Huatai Capital Investment, have agreed to subscribe for shares worth USD 13 million, with an estimated total of 7.1136 million H-shares to be purchased at a midpoint price of HKD 14.20 per share [2] - This subscription represents approximately 21.3% of the total shares offered in the global sale, assuming no exercise of the over-allotment option [2] Group 3 - The net proceeds from the global offering are estimated to be around HKD 421 million after deducting underwriting fees and expenses, with approximately 63.6% allocated to the development and registration of core products [3] - Specific allocations include about 32.4% for the continued R&D and overseas registration of the quadrivalent influenza virus subunit vaccine, and about 31.2% for the Phase III clinical trials and registration of the investigational freeze-dried human rabies vaccine [3] - Additional funds will be used for the development of other investigational vaccines, enhancement of production and commercialization capabilities, and the development of various technological platforms [3]

江蘇中慧元通生物科技股份有限公司 Ab&B Bio-Tech CO., LTD. JS 全球發售 聯席保薦人、整體協調人、聯席全球協調人、聯席賬簿管理人及聯席牽頭經辦人 聯席賬簿管理人兼聯席牽頭經辦人 Ab&B Bio-Tech CO., LTD. JS 江蘇中慧元通生物科技股份有限公司 重要提示 （於中華人民共和國成立的股份有限公司） 股份代號 : 2 6 2 7 重要提示：閣下如對本招股章程的任何內容有任何疑問，應尋求獨立專業意見。 Ab&B Bio-Tech CO., LTD. JS 江蘇中慧元通生物科技股份有限公司 （於中華人民共和國成立的股份有限公司） 全球發售 全球發售項下的發售股份數目 33,442,600股H股（視發售量調整權 行使與否而定） 香港發售股份數目 3,344,400股H股（可予重新分配） 國際發售股份數目 30,098,200股H股（可予重新分配及 視發售量調整權行使與否而定） 最高發售價 每股H股15.50港元，另加1.0%經紀 佣金、0.0027%證監會交易徵費、 0.00565%聯交所交易費及 0.00015%會財局交易徵費（須於申請 時以港元繳足，多繳股款可予退還） 面值 ...

7月30日，北京科兴控股（集团）有限公司（以下简称"科兴集团"）召开"甲型和乙型肝炎防控"媒体沟 通会。 "近年来，科兴一直在产品研发、产业化等领域加大投入，不断扩展针对呼吸道疾病、肠道传染病、外 伤感染、虫媒传播疾病的疫苗和抗体产品矩阵，并同步布局多种联合疫苗开发，预计2030年前将获批上 市9款产品。"会上，科兴集团副总裁李静表示，科兴以创新产品开发为导向构建研发平台，对前沿突破 性产品、平台技术开展广泛的研发布局和持续投入。当前公司的研发管线拥有疫苗和抗体两类20多种在 研产品。 近日，科兴甲型乙型肝炎联合疫苗倍尔来福®取得了药品再注册批准通知书。对此，李静表示，该产品 最早在2005年上市。上市后该产品在全国29省市累计使用超1300万剂，获得广泛欢迎，对我国甲肝、乙 肝防控发挥了重要作用。基于乙肝、甲肝先后纳入国家免疫规划后防控成效显著，甲乙肝联苗此前也完 成了查漏补种的时代使命。 7月24日，据科兴集团官微消息，由集团旗下北京科兴生物制品有限公司自主研发的甲型乙型肝炎联合 疫苗倍尔来福®于2025年7月21日取得药品再注册批准通知书。倍尔来福®是目前国内唯一获批上市的 甲型乙型肝炎联合疫苗。 科兴 ...

Group 1: Control Change and Share Transfer - Wan Kexin Bio acquired a total of 28.46638 million shares from Wang Zhentao, Aokang Group, and Kangyue Qiming, resulting in a voting rights proportion of 29.9893% [2][3] - The controlling shareholder will change from Wang Zhentao to Wan Kexin Bio, which has no actual controller [3] - The control change requires antitrust review and compliance audit by the Shenzhen Stock Exchange, which is currently in progress [3] Group 2: Norovirus Vaccine Development - The company signed an exclusive licensing agreement with HilleVax for the development and commercialization of a six-valent norovirus vaccine outside of China [4] - Domestic clinical trial approval for the six-valent norovirus vaccine has been obtained, with ongoing efforts to expedite both domestic and international market entry [4] Group 3: Rabies Vaccine Market Situation - In 2024, there were 143 reported rabies deaths in China, highlighting the critical demand for post-exposure rabies vaccination [5] - Approximately 40 million people are exposed to rabies annually in China, with a vaccination rate of only 35%, indicating significant room for improvement [5] - Three types of rabies vaccines are approved in China, with Vero cell vaccines dominating the market, followed by human diploid and mouse kidney cell vaccines [5] Group 4: Marketing and Brand Strategy - The company aims to leverage its established product reputation and market channels to enhance brand influence and market competitiveness [6][7] - Plans include adjusting marketing management structures, expanding the marketing team, and enhancing professional training to improve collaborative capabilities [7]

Group 1 - Valiant Biotech-B's dark market saw a maximum increase of 134.28%, reflecting market recognition of its antibody drug development pipeline in oncology and autoimmune diseases [1] - The company has one core product and 13 other candidates, with 6 having successfully entered clinical stages [1] - Long-term value will depend on the commercialization capabilities of new drugs [1] Group 2 - Hengrui Medicine's subsidiary received approval for clinical trials of HRS-1893 tablets, a selective myosin inhibitor aimed at treating heart failure with preserved ejection fraction [2] - The project has accumulated R&D investment of approximately 60.67 million yuan [2] - If clinical trials proceed successfully, it could become the first drug in this unmet clinical need, enhancing the company's competitiveness [2] Group 3 - 3SBio announced the formal effectiveness of a licensing agreement with Pfizer for the global development and commercialization rights of the PD-1/VEGF bispecific antibody SSGJ-707, excluding mainland China [3] - The agreement includes a total option and exercise fee of up to 150 million USD [3] - This partnership allows 3SBio to leverage Pfizer's resources for accelerated project development and commercialization [3] Group 4 - Zhonghui Yuantong updated its prospectus, indicating that its core products have been commercialized, alongside 11 vaccines in development [4] - The company has raised a total of 999.5 million yuan through three rounds of financing from notable investors [4] - The upcoming Hong Kong listing is expected to accelerate R&D and market expansion in the vaccine sector [4] Group 5 - Eddingpharm received approval for the registration and commercialization of multi-dose diquafosol sodium eye drops in China, which contains 3% diquafosol sodium [5] - The product is intended for the treatment of dry eye syndrome [5] - This approval enhances the treatment options for dry eye disease and is expected to contribute to the company's growth in the ophthalmic market [5]

Core Viewpoint - The company Olin Bio (688319.SH) announced a plan for its controlling shareholder, Shanghai Wushan Biotechnology Co., Ltd., to reduce its stake by up to 12.178 million shares, representing no more than 3% of the total share capital, due to funding needs [1][2] Group 1: Shareholder Actions - Shanghai Wushan plans to cash out over 200 million yuan from the share reduction based on the closing price of 22.11 yuan per share on July 23 [2] - The actual controllers of Olin Bio, Fan Shaowen and Fan Fan, along with board member Chen Aimin, have committed not to participate in this reduction [1][2] - The shares to be reduced were acquired before the company's IPO, indicating a long-term holding period [2] Group 2: Financial Performance - Olin Bio's stock price has increased over 100% year-to-date, with market capitalization rising from approximately 4.3 billion yuan to about 9 billion yuan [2] - The company reported a revenue of 87.49 million yuan in Q1, a year-on-year increase of 23.6%, while the net profit attributable to shareholders was a loss of 7.07 million yuan, which has narrowed compared to the previous year [3] - For 2024, the company expects revenue and net profit to grow by 18.69% and 18.24% respectively, with a significant increase in non-recurring net profit projected at 230.01% [3] Group 3: Product Pipeline - Olin Bio's main commercial product is the adsorbed tetanus vaccine, with additional products including Hib combination vaccine and AC combination vaccine already approved for market [3] - The company is conducting a Phase III clinical trial for its recombinant pneumococcal vaccine, with 5,000 out of 6,000 planned participants already enrolled [3] - The company has also received approval for clinical trials of its oral recombinant Helicobacter pylori vaccine and trivalent and quadrivalent influenza virus vaccines [3]

Core Viewpoint - The article discusses the sale of a vaccine company by Wang Zhentao, the founder of Aokang International, highlighting the challenges faced by the vaccine market and the strategic decision to divest from a declining business [1][3][21]. Group 1: Transaction Details - Wang Zhentao and his associates sold their shares in Kanghua Biological to Shanghai Wankexin Biological for a total of 1.85 billion yuan [1]. - The acquisition involves a performance-based agreement requiring a total net profit of no less than 728 million yuan for the years 2025 and 2026, along with a minimum R&D investment of 260 million yuan [5][6]. - If performance targets are not met, Wang Zhentao and Aokang Group must compensate the difference in cash [6]. Group 2: Company Performance - Kanghua Biological's core product, the freeze-dried human rabies vaccine, has seen a significant decline in market performance, with the number of vaccine batches issued dropping over 40% in 2024 [9]. - The company's revenue for 2024 was approximately 1.43 billion yuan, a decrease of 9.23% from the previous year, while net profit fell by 21.71% to around 400 million yuan [10]. - The company’s market capitalization has shrunk to below 10 billion yuan, reflecting a broader decline in performance [10][17]. Group 3: Background of Wang Zhentao - Wang Zhentao, known as the founder of "China's first men's shoe stock," ventured into the vaccine industry with an investment of 800 million yuan, but faced challenges in this new field [2][16]. - His attempts to innovate within the vaccine sector, including the development of new vaccines, have not yielded significant results, leading to the decision to exit the business [11][13]. - Wang's financial situation is under pressure, with high levels of share pledges in both Aokang International and Kanghua Biological, indicating a need for liquidity [21][22]. Group 4: Market Context - The vaccine market has become increasingly competitive, with new technologies and production capabilities leading to a decline in Kanghua Biological's market position [9][23]. - Aokang International has also faced difficulties, with a reported cumulative loss of 683 million yuan over the past three years, contributing to Wang's decision to divest from Kanghua Biological [24][30].

Core Viewpoint - Sanofi has agreed to acquire UK biotech company Vicebio Ltd. for up to $1.6 billion, aiming to gain access to an experimental vaccine and technology that accelerates vaccine development [1] Group 1: Acquisition Details - The acquisition price for Vicebio Ltd. is up to $1.6 billion [1] - The deal will provide Sanofi with an experimental vaccine targeting multiple respiratory diseases, including respiratory syncytial virus (RSV) [1] Group 2: Strategic Intent - Sanofi's CEO, Paul Hudson, is actively seeking innovative solutions that align with the company's existing product portfolio [1] - The experimental vaccine from Vicebio is intended to complement Sanofi's new therapy, Beyfortus, which also targets RSV [1]