Group 1 - AbbVie received a "buy" rating from Morgan Stanley analyst Terrence Flynn, with a target price of $250 [1] - For Q1 FY2025, AbbVie reported adjusted diluted EPS of $2.46, a year-over-year increase of 6.5%, and net revenue of $13.343 billion, reflecting an 8.4% growth rate [1] - The company is expected to announce Q2 FY2025 earnings on July 31, 2025, with projected revenue of $14.9667 billion and EPS of $1.527 [1] Group 2 - AbbVie's immunology segment showed strong performance, with sales of Skyrizi and Rinvoq reaching $3.43 billion and $1.72 billion, respectively, representing year-over-year increases of approximately 70% and 57% [1] - The company is focusing on early business development opportunities in oncology and neuroscience to drive growth over the next eight years [1] Group 3 - AbbVie made significant progress in its R&D pipeline, showcasing early-stage developments at the 2025 AACR annual meeting, including new ADC ABBV-969 and CCR8-targeting antibody ABBV-514 [2] - CEO Robert Michael stated that AbbVie plans to invest $10 billion in U.S. manufacturing over the next decade to mitigate impacts from U.S. tariff policies and drug pricing proposals [2] - AbbVie remains competitive among the top ten global pharmaceutical companies, facing competition from Johnson & Johnson, Novartis, and Merck, but is expected to maintain its leading position due to its innovation in immunotherapy and ongoing investment in new drug development [2]

Group 1: Marketing Reform and Sales Performance - The company initiated a direct sales reform pilot in 9 provinces starting in 2022, achieving significant results with steady profit growth in these regions [1] - The direct sales reform has been completed in 15 provinces, covering major OTC markets, which is expected to enhance sales efficiency and profitability [1] - The marketing reform introduced new performance metrics such as per capita efficiency and store efficiency, moving away from solely focusing on growth rates [1] Group 2: Financial Indicators and Profitability - The company is experiencing positive feedback from its marketing reform, with good completion rates for sales and payment indicators [2] - The company aims to exceed previous net profit levels, supported by steady growth of existing products and new drug development projects [2] - The company plans to enhance its profit margin to meet or exceed the industry average, ensuring long-term stable development [2] Group 3: New Drug Development - The Huanglian Jiedu Wan is the first "general" syndrome-type traditional Chinese medicine new drug in China, with clinical trials involving 840 cases [3] - The project employs a unique evaluation method combining "syndrome types + biomarkers," which could set a precedent for the evaluation standards of syndrome-type traditional Chinese medicine [3] - If approved, Huanglian Jiedu Wan will provide new treatment options for numerous diseases related to heat toxin syndrome [3] Group 4: Investment in Subsidiaries - Chengdu Zeling Biopharmaceutical Technology Co., Ltd. is a subsidiary in which the company holds a 17.6926% stake, making it the second-largest shareholder [3] - The subsidiary focuses on innovative drug research and has completed multiple rounds of financing [3]

Core Insights - The 2024 "Annual Report on Progress of New Drug Registration Clinical Trials in China" indicates a significant increase in drug clinical trial registrations, reaching 4,900, a year-on-year growth of 13.9% [2] - The report highlights that domestic pharmaceutical companies are actively engaged in clinical research, with 92.8% of the new trials initiated by domestic sponsors [2] Summary by Categories Overall Clinical Trial Registration - In 2024, the total number of drug clinical trial registrations in China reached 4,900, with new drug trials accounting for 2,539, representing 51.8% of the total [2] - The efficiency of clinical trial registration and implementation has improved compared to 2023, with average registration times for new drug trials reduced to 67.4 days [6] Drug Types and Categories - Chemical drugs dominate the clinical trials, making up over 70% of the total, while biological products account for 21.1% [4] - Among new drug trials, Class I registered drugs constitute 68.3%, with Phase I trials representing 46.92% of the total [4] Focus Areas in Clinical Trials - Antitumor drugs have the highest representation in clinical trials, with chemical drugs accounting for 24.7% and biological products for 43.1% [7] - The report indicates a notable increase in clinical trials for cell and gene therapies, with a growth rate exceeding 40% for newly registered trials [9][11] Pediatric and Rare Disease Drug Development - The number of clinical trials for pediatric and rare disease drugs has increased, with pediatric trials totaling 249, representing 9.8% of the new drug trials [14] - Rare disease drug trials reached 121, with a focus on blood system diseases, neurological diseases, and antitumor drugs, which together accounted for 63.6% of the total [16]

Core Viewpoint - Shanghai Yizhong is facing significant performance pressure as its second-largest shareholder, Shanghai Kaibao, plans to reduce its stake amid high stock prices and declining earnings [2][9]. Shareholder Actions - On July 16, Shanghai Kaibao announced plans to sell up to 6.2011 million shares of Shanghai Yizhong, currently holding 24.7035 million shares, representing 11.95% of the company [2][4]. - This marks the second time Shanghai Kaibao has reduced its stake, having previously sold 1.0476 million shares in 2022 for approximately 97.2716 million yuan [2][8]. - As of July 17, Shanghai Yizhong's stock price was 67.9 yuan per share, reflecting a 70% increase year-to-date, with the current market value of Shanghai Kaibao's holdings around 1.677 billion yuan [4][9]. Company Performance - Shanghai Yizhong reported a revenue of 71.0322 million yuan in Q1 2025, a year-on-year increase of 3.39%, but net profit fell by 51.38% to 14.186 million yuan [3][10]. - The company experienced a significant decline in performance in 2024, with revenues dropping to 174 million yuan, a decrease of 51.83%, and net profit down 95.68% [10]. - The core product, paclitaxel micelles, was not included in the medical insurance directory until November 2024, impacting market access and sales performance [9][10]. Financial Metrics - In 2024, Shanghai Yizhong's sales and R&D expenses were 115 million yuan and 37.2037 million yuan, respectively, reflecting increases of 8.28% and 65.71% [10]. - For Q1 2025, sales and R&D expenses were 28.2088 million yuan and 9.2766 million yuan, accounting for 39.7% and 13.06% of total revenue [10].

Core Viewpoint - Recently, Buchang Pharma (603858.SH) announced that its subsidiary, Zhejiang Tianyuan Biopharmaceutical Co., Ltd., has received the drug registration certificate for the quadrivalent influenza virus split vaccine from the National Medical Products Administration, making it the 9th certified company for this vaccine in China [1] Group 1: Vaccine Approval and Market Potential - The quadrivalent influenza vaccine is a key step in Buchang Pharma's strategy to expand from traditional Chinese medicine into biopharmaceuticals and vaccines [1] - Research indicates that approximately 84 million to 144 million people in China contract influenza annually, highlighting the significant market potential for vaccination [1] - The current vaccination rate for influenza in China is low, indicating substantial room for growth [1] Group 2: Timing and Production Advantages - The approval of the vaccine is timely, as the peak influenza season occurs from November to March, and vaccination requires 2-4 weeks to develop protective antibodies [1] - The vaccine was approved in July, allowing ample time for production and market distribution to meet the upcoming vaccination peak [1] Group 3: Product Details - The quadrivalent influenza virus split vaccine contains 15μg of each type of influenza virus hemagglutinin per 0.5ml dose, and is classified as a prescription biological product [3][4] - The vaccine is manufactured by Zhejiang Tianyuan Biopharmaceutical Co., Ltd., located in Hangzhou, Zhejiang Province [3][4] Group 4: R&D Investment and Commitment - As of June 30, 2025, Buchang Pharma has invested approximately 126 million yuan in the vaccine project, reflecting its commitment to new drug development [7] - The company emphasizes strict quality control throughout the drug development, manufacturing, and sales processes, showcasing its technical capabilities [7] Group 5: Shareholder Returns and Corporate Responsibility - Buchang Pharma has consistently returned value to shareholders through cash dividends and share buybacks, having paid out a total of 9.183 billion yuan since its listing [8] - The company plans to reduce its registered capital by repurchasing 44.8536 million shares, which is expected to enhance per-share value and stabilize stock prices [8] - Buchang Pharma has contributed over 32 billion yuan in taxes since its establishment, demonstrating its commitment to social responsibility and local economic development [8]

Group 1 - The core patent of Dongyangguang Pharmaceutical's invention "Bridge cyclic compound as a hepatitis C inhibitor and its preparation method" has won the second Hubei Patent Gold Award, highlighting the company's innovation and core competitiveness in new drug development [1][5][12] - The hepatitis C virus (HCV) infection rate in China is approximately 10 million, with new reported cases around 200,000 per year, indicating a significant public health challenge due to low diagnosis and treatment rates [6][7] - Dongyangguang Pharmaceutical established its research goal in 2010 to develop hepatitis C drugs tailored for the Chinese market, aiming to provide effective treatment options for the large patient population [6][7] Group 2 - The drug, Phosphoric acid imetavine, was developed over ten years and became the first domestically developed hepatitis C NS5A inhibitor in China, receiving approval in 2020 [7][8] - Phosphoric acid imetavine has a high overall cure rate of 99.8% when used in combination with Sofosbuvir, and it was included in the national medical insurance directory in December 2021, significantly reducing the cost for patients [7][8] - The patent strategy for Phosphoric acid imetavine includes a comprehensive layout that began in 2013 and has expanded to cover various aspects of the drug, enhancing its market competitiveness and protecting its innovations [10][11] Group 3 - Since its establishment in 2001, Dongyangguang Pharmaceutical has focused on R&D, applying for over 2,400 invention patents and holding more than 1,400 authorized patents, making it a leader in patent filings among domestic pharmaceutical companies [12] - The company has built a complete innovation chain from basic research to clinical transformation, with 150 approved drugs globally and over 100 in development, including nearly 50 first-class innovative drugs [12] - Dongyangguang Pharmaceutical aims to continue driving development through innovation, enhancing its core competitiveness, and contributing to the high-quality development of the pharmaceutical industry [12]

Core Insights - The company has made significant progress in the development of its innovative drug SYN045, which has received approval for Phase I clinical trials in three different dosages from the National Medical Products Administration of China [1] - The results from the completed clinical trials indicate favorable pharmacokinetic characteristics, enhanced safety, and tolerability compared to similar drugs, supporting the potential for long-term oral administration [1] - The company has submitted a total of 18 invention patents related to the SYN045 project, including 5 international patents and 13 domestic patents, with some already granted [1] Group 1: SYN045 Development - SYN045 is a highly selective PGI2 receptor agonist showing significant anti-pulmonary arterial hypertension effects in animal studies [1] - The company plans to conduct Phase IIa clinical trials based on the final results of Phase I to determine the dose-response relationship and explore efficacy and safety in patients [1] Group 2: Other Drug Developments - The company is developing an innovative anti-epileptic drug targeting the potassium ion channel KCNQ2/3, currently in the compound screening phase and preparing for toxicity evaluation [2] - An innovative drug for diabetic peripheral neuropathic pain is also under development, targeting AAK1, with compound screening currently underway [2] - The company is working on three new drug reformulation projects, with two completing pharmacokinetic-based formulation studies and one planned for IND submission within the year [2]

Investment Rating - The report maintains an investment rating of "Outperform the Market - A" for the biopharmaceutical sector [7]. Core Insights - The National Healthcare Security Administration has initiated the adjustment work for the 2025 National Basic Medical Insurance, Maternity Insurance, and Work Injury Insurance Drug Catalog, which is expected to include multiple new drugs for negotiation [2]. - From July 1, 2024, to June 30, 2025, approximately 19 oncology drugs and 23 non-oncology drugs are anticipated to be approved and may participate in the 2025 medical insurance negotiations [2]. Summary by Sections 1. Weekly New Drug Market Review - From June 30, 2025, to July 4, 2025, the top five companies in the new drug sector by stock price increase were: - Zai Lab (45.00%) - Sanofi (36.30%) - Frontier Biopharma (30.60%) - Micron Biomedicine (30.50%) - Kangfang Biopharma (25.50%) - The top five companies with the largest declines were: - Oconview (-12.90%) - Kexin Pharmaceuticals (-9.10%) - Dongyao Pharmaceuticals (-6.70%) - Lepu Biopharma (-6.40%) - Yifang Biopharma (-3.60%) [1][16]. 2. Weekly New Drug Industry Analysis - The adjustment work for the 2025 medical insurance catalog has begun, allowing new generic drugs approved between January 1, 2020, and June 30, 2025, to apply for inclusion [2]. - The expected new drugs for negotiation in 2025 will primarily be those approved between July 1, 2024, and June 30, 2025 [2]. 3. Weekly New Drug Approval & Acceptance Status - This week, 22 new drugs or new indications received approval for market entry, while one new drug application was accepted [3][26]. 4. Weekly New Drug Clinical Application Approval & Acceptance Status - A total of 46 new drug clinical applications were approved this week, and 31 new drug clinical applications were accepted [4][32]. 5. Key Domestic Market Events - Key events included the approval of a MET inhibitor by Hutchison China MediTech for treating advanced non-squamous non-small cell lung cancer and the approval of an anti-IL-1β monoclonal antibody by Junshi Biosciences for treating acute attacks of gouty arthritis [5][12]. 6. Key Overseas Market Events - Notable overseas events included Moderna's positive progress in its seasonal flu mRNA vaccine study, Regeneron's accelerated approval of a dual antibody for multiple myeloma, and Pfizer's announcement of a significant reduction in bleeding rates in hemophilia patients [13].

香 港 交 易 及 結 算 所 有 限 公 司 及 香 港 聯 合 交 易 所 有 限 公 司 對 本 公 告 的 內 容 概 不 負 責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部 或任何部份內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 Laekna, Inc. 來凱醫藥有限公司 （於開曼群島註冊成立之有限公司） （股份代號：2105） 自願公告 LAE103向美國食品藥品監督管理局(FDA) 遞交新藥臨床試驗(IND)申請 本 公 告 由 來 凱 醫 藥 有 限 公 司（「 本 公 司 」， 連 同 其 附 屬 公 司 統 稱「 本 集 團 」）自 願 作 出，以告知本公司股東及潛在投資者本集團最新業務進展。 關於LAE103 LAE103是一款Act RIIB選擇性抗體。本集團正積極推動該候選藥物進入臨床研究 階段，旨在為肌少性肥胖症及肌肉相關疾病提供創新療法。 – 1 – 風險提示 LAE103最終不一定能夠成功開發及商業化。本公司股東及潛在投資者於買賣本公 司證券時務請審慎行事。 公司董事（「董事」）會（「董事會」）欣然宣佈，本集團已就自主研發的LAE103（ 一 ...

Group 1: Company Overview - The company achieved a revenue of 72.11 million yuan in 2024, representing a year-on-year growth of 20.8%, while the net profit attributable to shareholders was -45.18 million yuan, a reduction in losses compared to the same period in 2023 [1] - In Q1 2025, the company reported a revenue of 16.42 million yuan, a year-on-year increase of 1.85%, with a net profit of -0.77 million yuan, marking a 37.01% reduction in losses compared to the previous year [1] - The company has not yet launched any new drugs, but its ophthalmic products are the core revenue source, continuously supporting new drug development [1] Group 2: Clinical Progress - The company's NL003 project, a recombinant human hepatocyte growth factor naked plasmid injection, has made significant progress, with both the ulcer group and resting pain group of the Phase III clinical trials completing unblinding [2] - The primary endpoint of the NL003 resting pain group showed a significant improvement over the placebo group, with a p-value of less than 0.0001, indicating statistical significance [2] - NL003 successfully passed registration inspection in September 2024, with its production process meeting GMP standards, establishing a stable and controllable production and quality management system [2] Group 3: Production and Commercialization - The company's biopharmaceutical industrialization project in Tongzhou, Beijing, has achieved important milestones, including the completion of municipal power capacity approval and design for various facilities [3] - The completion of this project is expected to significantly enhance the company's production capacity in the biopharmaceutical field, providing strong support for the commercialization of innovative drugs [3] - In October 2024, the company opened a branch in Shanghai, further facilitating its commercialization efforts [3] Group 4: Financial Forecast - The company forecasts revenues of 88 million yuan, 185 million yuan, and 371 million yuan for 2025, 2026, and 2027 respectively, with corresponding EPS of -0.19, -0.01, and 0.30 yuan [4] - The current stock price corresponds to PE ratios of -114.7, -2402.2, and 70.6 times for the years 2025, 2026, and 2027 respectively, with an initial coverage rating of "buy" [4]