团队表示，除多通路协同抗癌，该平台还突破了当前细胞疗法在时间、工艺与成本方面的限制。现有疗 法需采集患者自身细胞，送往专门设施进行数周改造，再回输体内，而自然杀伤T细胞与人体免疫系统 天然兼容，不会引发严重排斥反应，因此可利用捐献的血液干细胞实现规模化生产。 为突破这些障碍，研究团队调用了自然杀伤T细胞。通过为其配备靶向胰腺癌细胞蛋白"间皮素"的嵌合 抗原受体，这些细胞能同时启动多种攻击机制，对肿瘤展开全方位围剿。 在针对胰腺原位肿瘤及肝转移瘤（最常见且致命的转移类型）的严苛动物模型中，CAR-NKT细胞展现 出强大的肿瘤清除能力。即便在高度炎性的肿瘤微环境中，治疗细胞仍保持抗癌活性，且不易出现衰 竭。 美国加州大学洛杉矶分校科研团队开发出一种新型嵌合抗原受体-自然杀伤T细胞（CAR-NKT）免疫疗 法。即便癌细胞已转移至其他器官，该疗法也能精准识别并摧毁胰腺癌细胞。相关论文发表于新一期 《美国国家科学院院刊》。 此前，嵌合抗原受体-T（CAR-T）细胞疗法虽在部分血癌治疗中取得突破，却难以应对胰腺癌等实体 瘤。胰腺肿瘤外围包裹着致密的结缔组织与抑制性免疫细胞，形成一道天然屏障，阻碍治疗细胞进入。 更棘手的是 ...

近期，价格百万的"抗癌针"屡屡登上热搜，有网友称，注射"抗癌针"后癌细胞被完全清除了。不少人惊呼，癌症真的要被攻克了吗？所谓 的"抗癌针"到底是怎么回事？真能清除癌细胞吗？ 北京大学人民医院血液科副主任医师 吕萌：CAR-T细胞之所以目前来说比较稀有，因为它是一个个性化定制的过程，每一个患者所接受的这 份CAR-T都是用自己的细胞培养了全世界独一无二的药品。 "CAR-T疗法"目前在国内研发的上市产品价格从几十万元到一百多万元价格不等，如此昂贵的原因除了高度定制化、生产工艺复杂外，还包括 漫长的研发成本以及更加严格的监管与供应链等。 "扩增"：在体外大量扩增这些"超级杀手"CAR-T细胞。 "回输"：将它们像输血一样回输到患者体内。 CAR-T并非万能 仅对部分血液肿瘤有效 中国工程院院士 中国抗癌协会理事长 樊代明：正常人都有癌细胞，但是为什么不得癌？因为身体有强大的自然力，包括免疫力。免疫力从哪 里来？主要是从淋巴细胞来。肿瘤病人肿瘤长起来以后，淋巴细胞杀不了或者是有各种原因，要不就是不认识，要不就是力量不够。在这种情 况下，如果对淋巴细胞进行改装，让它能够认识癌细胞，而且能够杀死癌细胞，这个就是免疫细胞 ...

Core Viewpoint - Changjiang Life Science Technology (00775) has seen a significant increase of over 8%, currently trading at 1.01 HKD, with a transaction volume of 23.28 million HKD, following the presentation of its cancer immunotherapy research results at the SITC 2025 conference [1] Group 1 - The company showcased major advancements in cancer vaccine development targeting TROP2, PRAME, and PD-L1, highlighting their potential to inhibit tumor growth [1] - Dr. Du Jianming, Vice President and Chief Scientific Officer of the company, expressed optimism about the results of the cancer vaccine candidates targeting TROP2 and PRAME/PD-L1, indicating that these developments could accelerate the progress of effective therapeutic cancer vaccines [1] - The current goal of the company is to advance these vaccine candidates to the clinical trial stage [1]

Core Viewpoint - Changjiang Life Sciences (00775) saw a significant stock increase of 8.6%, reaching HKD 1.01, with a trading volume of HKD 23.28 million, following the presentation of its cancer immunotherapy research at the SITC 2025 conference [1] Group 1: Company Developments - Changjiang Life Sciences showcased its research advancements in cancer vaccines targeting TROP2, PRAME, and PD-L1 at the SITC 2025 conference [1] - The company’s Vice President and Chief Scientific Officer, Dr. Du Jianming, expressed optimism about the progress of the cancer vaccine candidates targeting TROP2 and PRAME/PD-L1, indicating a potential acceleration in the development of effective therapeutic cancer vaccines [1] - The current objective for the company is to advance these vaccine candidates to the clinical trial stage [1]

Core Viewpoint - Changjiang Life Science Technology (00775) has seen a significant stock increase of over 8%, currently trading at 1.01 HKD, with a transaction volume of 23.28 million HKD, following the presentation of its tumor growth inhibition research results at the SITC 2025 conference [1] Group 1: Company Developments - The company showcased major advancements in cancer vaccines targeting TROP2, PRAME, and PD-L1 at the SITC 2025 conference [1] - Dr. Du Jianming, Vice President and Chief Scientific Officer of the company, expressed optimism about the results of the cancer vaccine candidates targeting TROP2 and PRAME/PD-L1, indicating a potential acceleration in the development of effective therapeutic cancer vaccines [1] - The current goal for the company is to advance these vaccine candidates to the clinical trial stage [1]

Core Viewpoint - 长江生命科技 has demonstrated significant advancements in cancer immunotherapy, particularly in the development of innovative vaccines targeting specific cancer antigens, which has positively impacted its stock performance [1] Group 1: Stock Performance - Long江生命科技's stock rose nearly 7%, with a current increase of 6.82%, trading at 0.94 HKD, with a transaction volume of 10.43 million HKD [1] Group 2: Research and Development Achievements - The company showcased its research findings at the SITC 2025 conference, focusing on the development of cancer vaccines targeting TROP2, PRAME, and PD-L1, highlighting their potential to inhibit tumor growth [1] - Two innovative vaccines targeting TROP2 protein were disclosed, which is highly expressed in various cancers, including breast cancer, lung cancer, and colorectal cancer [1] - The company also announced the development of a vaccine that simultaneously targets PD-L1 and PRAME, with significant T-cell activation effects [1] - In a preventive lung cancer model, the vaccine demonstrated a tumor growth inhibition rate exceeding 95%, maintaining defensive capabilities even three months post-vaccination, indicating the potential for long-lasting immune memory [1]

Core Viewpoint - Changjiang Life Science (00775) experienced a nearly 7% increase in stock price, reaching 0.94 HKD, following the presentation of significant advancements in cancer immunotherapy at the SITC 2025 conference [1] Group 1: Company Developments - Changjiang Life Science showcased research results on tumor growth inhibition at the SITC 2025 conference, focusing on innovative cancer vaccines targeting TROP2, PRAME, and PD-L1 [1] - The company revealed two innovative vaccines targeting the TROP2 protein, which is highly expressed in various cancers including breast cancer, lung cancer, and colorectal cancer [1] - Additionally, the company announced the development of a vaccine that simultaneously targets PD-L1 and PRAME, with notable T-cell activation effects [1] Group 2: Research Outcomes - In a preventive lung cancer model, the vaccine demonstrated a tumor growth inhibition rate exceeding 95% after administration [1] - The vaccine maintained its defensive capability against tumor re-challenge tests three months post-vaccination, indicating the potential for inducing long-lasting immune memory [1]

Core Viewpoint - Changjiang Life Science Technology (00775) experienced a nearly 7% increase in stock price, attributed to the presentation of significant advancements in cancer immunotherapy at the SITC 2025 conference [1] Group 1: Company Developments - The company showcased research results on tumor growth inhibition, focusing on innovative cancer vaccines targeting TROP2, PRAME, and PD-L1 [1] - Two innovative vaccines targeting the TROP2 protein were disclosed, which is highly expressed in various cancers including breast, lung, and colorectal cancers [1] - The company also announced the development of a vaccine that simultaneously targets PD-L1 and PRAME, with notable T-cell activation effects [1] Group 2: Research Outcomes - In a preventive lung cancer model, the vaccine demonstrated a tumor growth inhibition rate exceeding 95% after administration [1] - The vaccine maintained its defensive capability against tumor re-challenge tests three months post-administration, indicating the potential for long-lasting immune memory [1]

Core Viewpoint - The article discusses a novel approach to enhance CD47 blockade therapy for cancer treatment by utilizing biomineralized nanoparticles that facilitate phagocytosis and mitochondrial DNA sensing, leading to improved therapeutic outcomes [2][5]. Group 1: Research Background - Antigen-presenting cells (APCs) mediate the phagocytosis of cancer cells and initiate antigen presentation through sensing mitochondrial DNA (mtDNA), which is a critical mechanism in CD47 blockade therapy [2]. - Current strategies targeting CD47 often lack regulation of mtDNA sensing, limiting their effectiveness [2]. Group 2: Research Findings - The study developed biomineralized nanoparticles ZnCO₃@BSA/siCD47 that enhance CD47 blockade therapy by promoting APC phagocytosis and mtDNA sensing, resulting in significant tumor growth inhibition [2][5]. - The nanoparticles are designed to balance the stable encapsulation of siRNA with efficient intracellular release, achieving effective CD47 silencing and Zn²⁺ overload [5][6]. - In colorectal cancer and melanoma models, ZnCO₃@BSA/siCD47 restored APC function, increased T cell infiltration, and achieved a tumor growth inhibition rate of 93% [5][6]. Group 3: Mechanism of Action - The strategy involves Zn²⁺ overload to enhance phagocytosis and STING activation, while the pH-responsive ZnCO₃@BSA matrix ensures synchronized delivery of Zn²⁺ and siRNA [6]. - The treatment induces CD47 knockdown, calreticulin exposure, and mtDNA release, which are crucial for effective immune response [6].

Core Viewpoint - The article discusses the potential of SARS-CoV-2 mRNA vaccines as broad-spectrum immune activators that can sensitize tumors to immune checkpoint inhibitors (ICIs), significantly improving survival rates in advanced cancer patients [4][10]. Group 1: Impact of mRNA Vaccines on Cancer Treatment - Recent studies indicate that systemic administration of high-immunogenic mRNA nanoparticles can reset the immune microenvironment, making resistant tumors sensitive to ICIs [2]. - The research from MD Anderson Cancer Center shows that advanced cancer patients who received the SARS-CoV-2 mRNA vaccine within 100 days before starting ICI treatment had significantly extended overall survival [8]. - Specifically, the median survival for non-small cell lung cancer patients increased from 20.6 months to 37.3 months, and for metastatic melanoma patients, it rose from 26.7 months to over 36 months [8]. Group 2: Mechanism of Action - The study found that the SARS-CoV-2 mRNA vaccine significantly increased type I interferon (IFN-I) levels and activated antigen-presenting cells, which in turn stimulated CD8+ T cells to combat tumors [10][12]. - The vaccine also enhanced PD-L1 protein expression in tumors and promoted T lymphocyte activation within the tumor microenvironment [10]. Group 3: Clinical Implications - The findings suggest that clinically available mRNA vaccines targeting non-tumor-associated antigens can serve as powerful immune modulators, making tumors sensitive to ICIs [12]. - The combination of SARS-CoV-2 mRNA vaccines with ICIs can maintain T cell responses, thereby inhibiting tumor growth and improving cancer patient survival rates [12].