#SynBio团队 | 以色列魏茨曼科学研究院 【SynBioCon】 获 悉 ， 以色列魏茨曼科学研究院科学家在新一期《自然》杂志发表文章称：他们利用基于酶工 作原理的计算机新算法设计出高效人工合成酶。这种新型酶不仅能催化天然蛋白质无法完成的化学反应， 其效率 更达到人工智能（AI）设计酶的100倍 ，标志着"按需定制"高效酶的新阶段即将来临。 传统计算机算法辅助设计的酶往往效率低下，需要耗费大量时间进行实验室优化。为突破这一瓶颈，研究团队独 辟蹊径，选择"肯普消除"（一种涉及从特定底物碳原子上移除质子的非天然化学反应）作为验证案例。 过去十年，AI蛋白质设计大行其道，但其工作机制主要模仿现有酶。相比之下，新算法的工作机制是基于物理原 理来构建酶。研究团队表示，AI在处理某些蛋白质设计时确实无可替代，但对于复杂催化反应仍力不从心。未来 需要将两种方法优势互补，才能设计出更完美的酶。 通过算法设计的一种酶（白色）将底物（红色、黄色和蓝色）包裹于其活性位点内。图片来源：《自然》网站 ▌ 参考信息： 本文部分 素 材 来 自全网 。由 作 者重新 编写，系作者个人观点，本平台发布仅为了传达一种不同观点，不代表对该 ...

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period, highlighting innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizers and Highlights - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Key highlights include forums on biomanufacturing trends, youth innovation sharing, project roadshows, and participation from leading enterprises, top universities, and investment institutions [4]. Group 3: Agenda and Special Activities - The first day features a closed-door high-level seminar focusing on the development trends and growth points of biomanufacturing, with 30 industry leaders and experts invited [7]. - The second and third days will include a macro forum on biomanufacturing, covering the overall trends and progress in the industry [10]. Group 4: Specialized Forums - Specialized forums will cover topics such as green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. - The forums will discuss various aspects of biomanufacturing, including the development of bio-based chemicals, green manufacturing technologies, and the application of AI in industrial processes [11]. Group 5: Project Roadshows and Talent Engagement - The conference will feature project roadshows aimed at connecting head parks and investment institutions with innovative biomanufacturing projects [10]. - A youth forum will be held to discover potential teams and technologies in biomanufacturing, providing a platform for efficient talent and collaboration exchanges [10].

Core Viewpoint - The company plans to implement a Biomanufacturing Center construction project with an estimated total investment of 502.25 million yuan to enhance its biotechnology research and industrialization process [1][2]. Project Overview - The project was approved by the company's board of directors with unanimous support during the third meeting of the Strategic and Sustainable Development Committee [1]. - The project requires further approval from the shareholders' meeting after the board's approval [2]. - The project is not classified as a related party transaction or a major asset restructuring [2]. Basic Project Details - The construction area is 27,687.65 square meters, including two underground levels and 297 parking spaces [2]. - The project will involve the acquisition of equipment for strain selection, cell factory construction, intelligent fermentation, separation and purification, and analysis and testing [2]. - The project will utilize existing water and electricity supplies from the company headquarters and will implement an integrated wastewater treatment system [2]. Environmental Protection - The project will adhere to sustainable development principles and comply with national environmental protection regulations [2]. - Wastewater, domestic waste, and construction waste will be handled according to standards, and new systems will be installed following relevant building and fire safety laws [2]. Necessity Analysis - The project aims to integrate resources to accelerate the research and application of new technologies and processes, transitioning the company's biomanufacturing from traditional to intelligent, green, and high-end models [3]. - It aligns with the company's strategic goal of becoming a leading global yeast enterprise and a first-class international biotechnology company [3]. Impact on the Company - The project aligns with the company's 14th Five-Year Plan and is expected to significantly enhance its technological innovation capabilities in biomanufacturing [4]. - It will further strengthen the company's sustainable profitability and overall competitiveness, contributing to stable development without harming the interests of the company and its shareholders [4].

Core Viewpoint - The company Angel Yeast (600298.SH) plans to implement a biomanufacturing center construction project with an estimated total investment of 502.25 million yuan, funded by the company's own resources. This project aims to enhance the company's biomanufacturing technology innovation capabilities and aligns with its strategic goals [1][3]. Project Details - The project will consist of a 7-story above-ground structure and a 2-story underground facility, covering a total building area of approximately 44,115.97 square meters, including 27,687.65 square meters above ground and 16,427.32 square meters underground, with 297 parking spaces [3]. - The site is located on the south side of the company's headquarters R&D complex, occupying about 23 acres [3]. - The construction period is expected to last 24 months, with plans for completion and operational use in the second half of 2027, subject to actual conditions [3]. - The total estimated investment for the project is 502.25 million yuan, with funding sourced from the company's own capital [3]. Company Performance - Angel Yeast is the largest yeast company in Asia and the second largest globally, holding nearly 60% of the domestic market share and close to 20% of the global market share [3]. - From 1998 to 2024, the company's revenue grew from 138 million yuan to 15.2 billion yuan, a 110-fold increase, with consistent year-on-year growth. Net profit increased from 30.78 million yuan to 1.325 billion yuan, a 43-fold increase [3]. - In the first quarter of 2025, the company's revenue reached 3.794 billion yuan, representing a year-on-year growth of 8.95%, while net profit was 370 million yuan, up 16.02% year-on-year [3].

生物制造领域有哪些 "潜力股" 团队、技术和产品值 得关注？ 为发掘合成生物学和生物制造科研团队创新成果、 促进生物制造领域优秀科研工作者成果交流和产业方对接， 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 同期将举办特色专场——" 生物制造青年论坛 "，于8月20日在浙江宁波举办。 助力行业 15分钟了解一个方向 ，重点阐述研究领域存在的科学问题、解决思路、成果、放大可行性以及未来发展方向。 欢迎高校、科研院所申报分享！ 扫码报名，请选择参会形式 报名请选择：青年论坛、科技成果展示 SynBioCon 2 025 8月20-22日，浙江·宁波 SynBioCon 大会 | 生物制造青年论坛 特色专场 生物制造青年论坛 8月20日，浙江·宁波 01 论坛信息 时 间： 8月20日（周三） 席 位 ： 仅 30 席！ 报告时间： 第一场：13:30-17:30； 第二场：19:00-20:30 报名须知 ：扫描以上二维码，会务组将第一时间与您确认，并对接报告信息表等； 02 科技成果展示与对接专场 （同期活动） SynBioCon 2025 将设置 「科技成果展示与对接」专场 （ ...

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that can sustain the industry's vitality [1]. Group 2: Organizing Institutions - The conference is organized by Ningbo Detai Zhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. Group 3: Highlights of the Conference - The conference will feature forums and closed-door activities to gain insights into the development trends of biomanufacturing during the 14th Five-Year Plan, exploring new products, technologies, and collaborations [4]. - There will be over 100 financing project roadshows to discover new cooperation opportunities [4]. - Key industry players, top universities, and capital from various sectors will gather to discuss advancements in biomanufacturing [4]. Group 4: Special Activities and Agenda - The first day will include a closed-door seminar focusing on the development trends and growth points of biomanufacturing, inviting 30 industry leaders and experts for in-depth discussions [7]. - The second and third days will feature a macro forum on biomanufacturing, covering the development trends and progress of policies related to the industry [10]. Group 5: Specialized Forums - The conference will host specialized forums on various topics, including green chemicals and new materials, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. - Each forum will address specific themes such as the development of bio-based chemicals, green manufacturing technologies, and the application of AI in biomanufacturing processes [11].

Group 1 - The event showcased 240 major scientific achievements, focusing on the urgent needs in key areas such as artificial intelligence, high-end equipment manufacturing, and advanced new materials in Guangxi [1][2] - A total of 25 projects reached cooperation intentions, with a total signed amount of 88.75 million yuan, including 21 key projects that were signed on-site [1] - 65 cutting-edge scientific achievements were selected for physical display, while 240 achievements were simultaneously released online, providing new ideas and technical support for the development of Guangxi's advantageous and characteristic industries [1] Group 2 - The event was co-hosted by the Guangxi Zhuang Autonomous Region Science and Technology Department and the Guangzhou Branch of the Chinese Academy of Sciences, themed "CAS Enters Guangxi, Creating a Future" [2] - The aim was to deepen the scientific and technological innovation cooperation between the Chinese Academy of Sciences and Guangxi, injecting more innovative vitality into the high-quality development of industries [2]

Core Viewpoint - The K&K team from Nanjing University of Technology has successfully industrialized over 500,000 tons per year of high-performance bio-based materials, showcasing the potential of bio-based materials in various applications and their advantages over petroleum-based materials [1][2]. Group 1: Advantages of Bio-based Materials - Bio-based materials allow for precise structural tuning, overcoming the limitations of traditional petrochemical materials which have a single structure and are difficult to modify [4][5]. - The natural endowment of raw materials, such as amino acids and lignin, provides significant advantages over petrochemical raw materials, enabling more efficient polymerization processes [6]. - Bio-based materials contribute to a closed-loop resource cycle, enhancing sustainability [6]. Group 2: K&K Team's Successful Strategies - The K&K team emphasizes integrated research rather than isolated studies, focusing on fundamental research to explore micro-scale effects and overcome engineering bottlenecks, resulting in over 300 published SCI papers [7][8]. - They have developed common technologies and engineering equipment, securing over 20 international patents and completing the application transformation of more than 60 patents [8][9]. - The team has achieved significant cost reductions of over 65% in production through technological innovations in multi-component processes and polymerization [9]. Group 3: Product Applications and Achievements - The K&K team has established a comprehensive product system based on common biomass raw materials, achieving over 500,000 tons per year of bio-based materials [10][11]. - Notable products include bio-based polyurethane (50,000 + 150,000 tons/year), bio-based plasticizers, and bio-based spandex, with several products receiving global bio-based material certifications [13][17]. - These materials have been applied in major engineering projects, including the Belt and Road Initiative and various infrastructure developments [14][16].

眉山未来产业基金正式启动，基金规模为5亿元，由眉山市产业引导基金、四川省科技创新投资集团和彭 山区共同发起设立，主要投资低空经济、新型储能、生物制造等前沿产业领域。当前，眉山市依托交通 区位优势、优越的空域条件、丰富的旅游资源，成功跻身四川省低空经济试点城市。 榜单： 「2025投资机构软实力排行榜」评选启动 峰会： 「2025母基金年度论坛」盛大启幕：汇聚中国力量！ 热文： 一纸新规，炸出一级市场的管理费焦虑 热文： 今年，上市公司热衷做并购基金 此次未来基金的设立，正是锚定低空经济赛道，抢抓低空经济产业密集创新和高速增长的战略机遇，基 金将聚焦空域试点、低空制造业和人才培养三大领域，助力低空经济产业项目在眉落地生根，打造西南 地区低空制造协同配套高地，加快提升我市低空经济竞争力。 未来，眉山产投私募基金公司将进一步发挥基金撬动作用，引导更多社会资本支持眉山战略性新兴行业 和未来产业发展，持续培育壮大新兴产业和加快布局未来产业，推动低空经济等未来产业在眉山实现技 术突破、应用场景拓展和产业集群发展。 来源：眉山投资控股集团 对接需求请扫码 每日｜荐读 ...

Group 1 - The event held in Nanning, Guangxi, focused on the transformation of significant scientific achievements from the Chinese Academy of Sciences, with 21 key projects signed to enhance the high-quality development of Guangxi's industries [1][3] - The theme "Chinese Academy of Sciences Enters Guangxi, Creating a Future" highlights the collaboration between the Guangxi Science and Technology Department and the Guangzhou Branch of the Chinese Academy of Sciences, addressing urgent needs in artificial intelligence, high-end equipment manufacturing, and advanced new materials [3][5] - A total of 65 cutting-edge technological achievements were showcased at the event, with an additional 240 achievements released online, demonstrating the strong momentum technology provides for industrial upgrades in Guangxi [3][5] Group 2 - Four Guangxi enterprises and four research institutes from the Chinese Academy of Sciences presented their major technological achievements in fields such as artificial intelligence, biomanufacturing, new materials, and marine medicine, fostering deeper industry-academia-research collaboration [5] - The Guangxi Technology Achievement Transformation Fund was promoted at the event, aiming to provide financial support for the transformation of scientific achievements into production, thereby injecting momentum into Guangxi's industrial development [5]