Core Insights - The "Weight Management Year" initiative launched by the National Health Commission in 2025 has made weight loss a national topic of discussion, particularly among the younger generation [1] - A survey conducted by Just So Soul Research Institute revealed that nearly 80% of young respondents have weight loss intentions, with over 50% actively taking steps to lose weight [1][2] - The primary motivation for weight loss remains "appearance anxiety," but there is a growing trend towards health-focused weight loss among the youth [2][3] Group 1: Survey Findings - Approximately 60% of young people prefer exercise as a method for weight loss, with the average expenditure on weight loss being 1,487 yuan [2] - Over 20% of young individuals seek AI assistance for weight loss, while more than 60% abandon their weight loss efforts within three months [2] - The criteria for successful weight loss have shifted from merely achieving a target weight to feeling more confident and healthier [2][3] Group 2: Changing Attitudes - Young people are increasingly viewing weight loss as a means of self-management and regaining control over their lives, with 59.7% considering it a form of self-management [2][3] - The average ideal weight for women is reported to be 101.5 jin, while for men it is 133 jin, indicating a shift in perceptions of ideal body weight [3] - The focus on health and self-confidence as indicators of successful weight loss is becoming more prominent, with 44.2% prioritizing personal comfort and confidence over weight metrics [3] Group 3: Social Media Influence - Social platforms play a crucial role in providing motivation and support for weight loss, with 70% of young people engaging in social interactions to enhance their weight loss journey [4] - A significant portion of youth (34%) actively document their weight loss progress on social media, while 21.2% seek AI companionship during their weight loss efforts [4] - Young individuals are learning to balance their lifestyle, work, and health through their weight loss experiences, fostering a better relationship with their bodies [4]

Core Viewpoint - Obesity is a health condition associated with excess fat accumulation, leading to various complications and comorbidities. GLP-1 receptor agonists have been approved for treating obesity and type 2 diabetes, demonstrating effectiveness in appetite reduction and food intake decrease [2][3]. Group 1: Efficacy of GLP-1 Receptor Agonists - GLP-1 receptor agonists like semaglutide and tirzepatide have shown weight loss of 15%-20% compared to placebo after 68 and 72 weeks of treatment, respectively [3]. - Despite their effectiveness, about half of the patients discontinue treatment within the first year due to gastrointestinal side effects and high costs [3]. - A clinical trial indicated that participants who continued semaglutide lost an average of 17.3% of their weight over 68 weeks, while those who switched to placebo regained approximately 6.9% of their weight [6]. Group 2: Challenges in Weight Maintenance - One of the biggest challenges in weight loss is maintaining the results, as many individuals experience weight regain after stopping treatment. Studies show that discontinuation of GLP-1 receptor agonists often leads to weight gain [5]. - After stopping semaglutide, 18% of patients regained their previous weight, and 26% regained more than 25% of their lost weight within a year [6]. Group 3: Treatment Duration and Strategies - It is recommended to continue treatment for at least 12 weeks before assessing effectiveness, with a suggested duration of 9 months to 1 year for consolidation therapy if significant weight loss is observed [7]. - Initial weeks of semaglutide treatment may lead to increased satiety and reduced food intake, although mild side effects like nausea may occur [10][11]. Group 4: Discontinuation and Monitoring - Gradual dose reduction is advised when discontinuing semaglutide to mitigate increased hunger sensations, especially for non-diabetic patients [12]. - Patients are encouraged to monitor their appetite and weight closely after stopping medication, and to maintain healthy eating habits and regular exercise to prevent weight rebound [14]. Group 5: Strategies to Prevent Weight Regain - Key strategies to prevent weight regain include altering dietary habits by reducing high-calorie foods and increasing protein and fiber intake to enhance metabolism [15]. - Incorporating strength training alongside aerobic exercises can help maintain weight loss by increasing muscle mass and metabolic rate [17]. - Adequate sleep is crucial for metabolic regulation, with 7-9 hours of sleep recommended for optimal health [18].

Core Viewpoint - The article emphasizes the importance of sleep in relation to appetite control and successful weight loss, alongside dietary and exercise considerations [3]. Dietary Aspects - Drinking a glass of water before meals can suppress appetite and enhance metabolism through thermogenesis, while also alleviating mental stress [7]. - Changing cognitive perceptions can help prevent overeating [6]. Sleep Considerations - The article suggests that sleep is a fundamental factor influencing appetite and weight management, highlighting the need for effective sleep strategies [5].

Core Viewpoint - The article emphasizes the health risks associated with low carbohydrate diets, particularly the negative effects of insufficient carbohydrate intake on overall health and well-being [3][4][5][7][10]. Group 1: Health Risks of Low Carbohydrate Diets - Insufficient carbohydrate intake can lead to low blood sugar, metabolic dysfunction, and excessive protein consumption, negatively impacting various bodily functions [3]. - A study from March 2023 indicates that ketogenic diets can double the risk of cardiovascular diseases, including heart attacks and strokes [4]. - Participants who consume little to no staple foods have a twofold increased risk of cardiovascular diseases compared to those on regular diets [5]. Group 2: Long-term Consequences - A comprehensive study published in 2018 suggests that inadequate carbohydrate consumption may shorten lifespan, with both very low and very high carbohydrate intake associated with increased mortality risk [7]. - Regularly avoiding staple foods can impair memory and cognitive functions due to insufficient energy supply to the brain [9]. - Long-term lack of staple foods can lead to nutritional deficiencies, emotional instability, and various physical side effects such as bad breath, hair loss, and muscle loss [10][11]. Group 3: Dietary Recommendations - To effectively manage weight, it is essential to control total caloric intake while ensuring a balanced diet that includes carbohydrates [12]. - Recommended staple foods include whole grains and root vegetables, which provide satiety without high glycemic indices [14]. - According to the Chinese Dietary Guidelines, daily intake of grain foods should be 200-300 grams, including 50-150 grams of whole grains and legumes, and 50-100 grams of root vegetables [17].

Core Viewpoint - The article discusses the rising trend of weight loss among celebrities and public figures, highlighting the role of weight loss medications and social media in increasing awareness and interest in weight management solutions [4]. Group 1: Celebrity Weight Loss Stories - Sun Nan's transformation led to public astonishment, with a reported weight loss of over 20 pounds through a natural approach of healthy eating, good sleep, and moderate exercise [5][7]. - Yan Rujing successfully lost 55 pounds over six months, transitioning from a weight of 196 pounds and a BMI of 40.27 to a more fit appearance, emphasizing her rigorous training regimen of six hours daily [9][11]. - La Mu Yangzi achieved a weight loss of 20 pounds in one month through intense training and a strict low-carb diet during the filming of a reality show [12][16]. - Ma Weiwei lost 20 pounds in 45 days by adopting a low-carb diet and exercising, despite acknowledging the mental challenges associated with such a restrictive diet [17][19]. Group 2: Use of GLP-1 Medications - Celebrities like Elon Musk and Whoopi Goldberg have publicly shared their experiences with GLP-1 medications, reporting significant weight loss results, with Musk losing 30 pounds and Goldberg using medication to manage weight gained from steroid treatments [20][22]. - The effectiveness of semaglutide (Wegovy) in clinical trials shows an average weight reduction of 15% among participants, significantly outperforming previous weight loss medications [31][33]. - The STEP series of studies demonstrated that semaglutide can lead to substantial weight loss, with some participants losing over 20% of their body weight, and it has been approved by the FDA for long-term obesity management [35][34]. Group 3: Efficacy of Tirzepatide - Tirzepatide has shown promising results in clinical trials, with participants experiencing an average weight loss of up to 26.6% after a combination of lifestyle changes and medication [38][39]. - The SURMOUNT studies indicate that tirzepatide significantly reduces weight in patients with obesity or prediabetes, with a notable reduction in diabetes progression risk [36][38].

Core Viewpoint - The article emphasizes the importance of aligning meal times with the body's biological clock to effectively manage weight and reduce obesity risk, highlighting recent research on time-restricted feeding (TRF) and its effects on metabolism and energy expenditure [6][18][20]. Summary by Sections Obesity and Eating Habits - With rising living standards, the pursuit of delicious food has increased, leading to a rise in obesity rates, making weight loss a focal point of social concern and medical research [6]. Time-Restricted Feeding Research - A study published in the journal "Science" explores the biological mechanisms of time-restricted feeding in mice, indicating that eating during inactive periods (daytime) leads to significant weight gain compared to active periods (nighttime) [7][9]. - The research shows that energy consumption decreases when mice eat during inactive periods, contributing to weight gain despite similar food intake and digestion efficiency [9]. Metabolic Implications - Active period eating enhances energy expenditure by increasing glycolysis and the tricarboxylic acid cycle in fat tissues, which helps in weight management [11]. - Disruption of the biological clock due to high-fat diets affects the expression of clock genes in fat tissues, indicating that inappropriate eating times can disturb fat metabolism and increase obesity risk [13]. Genetic Factors and Thermogenesis - The study identifies key genes related to thermogenesis in fat tissues, showing that enhancing fat cell thermogenesis can help control weight gain during inactive periods [15][17]. - The absence of the ZFP423 gene promotes fat thermogenesis and improves energy metabolism, suggesting that proper meal timing can maximize fat tissue thermogenesis and minimize weight gain [17]. Practical Recommendations - To achieve effective weight loss, meal times should align with the body's biological rhythms, advocating for eating during the day when the biological clock is active and reducing or avoiding food intake at night [18][19].

Core Viewpoint - The market regulatory authorities and consumer associations in China have issued a warning to consumers about the misleading claims of ordinary food products being marketed as health supplements or having health benefits, emphasizing the importance of distinguishing between ordinary food, health food, and pharmaceuticals [1][2]. Group 1: Regulatory Framework - There is a strict legal distinction between ordinary food, health food, and pharmaceuticals in China, with laws prohibiting false advertising and claims related to disease prevention and treatment [2]. - The laws such as the Anti-Unfair Competition Law, Advertising Law, and Consumer Rights Protection Law explicitly forbid misleading commercial promotions of food products [2]. Group 2: Consumer Guidance - Consumers are advised to carefully check product labels to identify whether they are ordinary food, health food, or pharmaceuticals, and to look for the "blue hat" symbol on health food products [3]. - It is recommended to purchase health food from reputable e-commerce platforms and physical stores, avoiding unverified sources such as social media or informal groups [3].

Core Viewpoint - The article highlights the significant health risks associated with the consumption of ultra-processed foods (UPF), linking it to obesity, cardiovascular diseases, and increased mortality rates. It emphasizes the need for dietary guidelines to recommend a reduction in UPF intake due to its adverse health effects [2][3][12]. Group 1: Research Findings - A recent study published in Nature Medicine indicates that consuming UPF can hinder weight loss efforts, even when adhering to national dietary guidelines. In contrast, a diet based on minimally processed foods (MPF) may facilitate weight loss [3][6]. - The study involved 55 adults following UK dietary guidelines, where participants consumed UPF for 8 weeks and MPF for another 8 weeks. Results showed an average weight loss of 0.88 kg during the UPF phase compared to 1.84 kg during the MPF phase [11][12]. - The research found that while both diets led to weight loss, the MPF diet resulted in significant improvements in cardiovascular health indicators, such as total fat, body fat percentage, visceral fat, and triglycerides, which were not observed during the UPF diet [11][12]. Group 2: Implications of Food Processing - The study suggests that the degree of food processing affects weight management and cardiometabolic health, indicating that even healthy dietary guidelines may not mitigate the negative impacts of UPF [12][14]. - The mechanisms behind the weight changes between UPF and MPF diets remain unclear, but factors such as texture, structure, and the presence of additives in UPF may lead to increased calorie intake and delayed satiety [14]. - The research underscores the importance of considering food processing as a unique dimension of dietary quality, suggesting that policies focusing solely on reformulating processed foods to meet nutritional standards may overlook the behavioral and physiological impacts of food processing methods [14][15].

在日常生活中，许多人对"饭前喝水"的建议持怀疑态度，担心"会稀释胃液"。一项新研究显示：饭前喝水不仅有助于减肥，还能改善多种健康问题。 饭前喝杯水 有助于降糖减肥 一项研究显示，多喝水不仅能辅助减肥，还能改善糖尿病，而且，"饭前喝水"更有效。 ■ 饭前喝水有助于减肥 饭前喝点水，首先会让人因为增加饱腹感而减少进食；其次对食物的渴望会改变，因为有足够的水，身体会比较喜欢蛋白质，而不是令人发胖的碳水化合 物。 ■ 饭前喝水调节血糖 增加饮水量（尤其饭前）可显著降低空腹血糖水平。虽不能治愈糖尿病，但作为简单的生活方式调整，能积极辅助血糖管理，预防疾病发生发展。 对于"饭前喝水会稀释胃液"这种说法，北京大学公共卫生学院副研究员张娜表示，我们吃饭时，摄入的蔬菜或汤类本身也含有水分，因此正常的饮水并不 会稀释胃液，不会导致对食物的消化吸收能力降低。 适当多喝水 能改善多种健康问题 ■ 减少尿路结石、感染 很多尿路结石的发生都和饮水不足有关，多喝水有利于预防结石形成以及促使尿石排出。 此外，多喝水也会对尿路感染和膀胱过度活动产生影响。研究发现，与饮水量低于1500毫升/天相比，饮水量增至1500毫升/天与尿路感染发作次数减 ...

Core Viewpoint - The article emphasizes the importance of meal timing in weight loss, suggesting that a higher caloric intake at breakfast may lead to better appetite control and easier adherence to weight loss plans, despite similar weight loss results compared to a higher caloric intake at dinner [6][11][12]. Summary by Sections - **Study Overview**: A recent study published in *Cell Metabolism* involved 30 overweight or obese volunteers who followed two different meal timing plans for four weeks: one with a higher caloric intake at breakfast and the other with a higher intake at dinner [6][7]. - **Weight Loss Results**: Both dietary approaches resulted in an average weight loss of approximately 3.3 kg, indicating that the timing of caloric intake did not significantly affect weight loss outcomes [11]. - **Appetite Control**: Participants who consumed more calories at breakfast reported lower daily hunger levels and better appetite control, suggesting that a substantial breakfast may help mitigate feelings of hunger throughout the day [11][12]. - **Physiological Mechanisms**: A larger breakfast may slow gastric emptying and increase the secretion of satiety hormones while decreasing hunger hormone levels, which can help in appetite regulation [13][14]. - **Biological Clock Alignment**: The article notes that aligning meal timing with the body's biological clock may enhance weight loss effectiveness, as humans are naturally inclined to consume more energy during the day [15].