香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容所產生或因依賴 該等內容而引致的任何損失承擔任何責任。 Jiangsu Hengrui Pharmaceuticals Co., Ltd. 江蘇恒瑞醫藥股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1276） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條刊發。 根據中華人民共和國的有關法例規定，江蘇恒瑞醫藥股份有限公司（「本公司」）在 上海證券交易所網站( www.sse.com.cn )刊發了以下公告。茲載列如下，僅供參閱。 承董事會命 江蘇恒瑞醫藥股份有限公司 董事長 孫飄揚先生 中國上海 2025年8月20日 於本公告日期，董事會成員包括(i)執行董事孫飄揚先生、戴洪斌先生、馮佶女 士、張連山先生、江寧軍先生及孫杰平先生；(ii)非執行董事郭叢照女士；及(iii) 獨立非執行董事董家鴻先生、曾慶生先生、孫金雲先生及周紀恩先生。 江苏恒瑞医药股份有限公司 2025 年半年度报告 公司代码：600276 ...

Core Viewpoint - Beijing Foyou Pharma Co., Ltd. reported a decline in revenue and net profit for the first half of 2025, reflecting challenges in the pharmaceutical industry despite a supportive policy environment [1][2]. Company Overview and Financial Indicators - The company generated revenue of CNY 1,633,971,250.02, a decrease of 1.30% compared to the same period last year [2]. - The total profit was CNY 301,518,066.14, down 5.37% year-on-year [2]. - Net profit attributable to shareholders was CNY 267,867,639.64, a decline of 7.83% from the previous year [2]. - The net cash flow from operating activities decreased by 37.03% to CNY 218,031,007.68 [2]. - The company's total assets were CNY 4,690,692,171.54, down 2.61% from the end of the previous year [2]. Business Operations - The company focuses on the research, production, and sales of pharmaceuticals and medical devices, aiming to create a comprehensive competitive advantage [3][4]. - The product line includes various therapeutic areas such as cardiovascular, chronic kidney disease, dermatology, digestive system, diabetes, and gynecology [3][4]. - The company has established a strong R&D capability, with a focus on both generic and innovative drugs, and has a diverse product pipeline [9][15]. Industry Context - The pharmaceutical industry in China is experiencing a policy-driven transformation, with a focus on quality upgrades and structural adjustments [6][7]. - The implementation of new policies is expected to enhance the development of generic drugs and support innovative drug research [6][7]. - The industry is witnessing increased consolidation, with larger companies acquiring smaller firms to enhance market share and efficiency [7][8]. Competitive Position - The company holds a strong position in the market with several first-generic products and a robust sales network [8][15]. - The R&D pipeline is rich, with 63 products having passed consistency evaluations and 103 generic projects under development [15][16]. - The company has established partnerships with major pharmaceutical distributors, enhancing its market reach [15][16].

Core Viewpoint - The controlling shareholder of Xuantai Pharmaceutical, Shanghai Lianhe Investment Co., Ltd., has voluntarily committed not to reduce its shareholding for 24 months starting from August 25, 2025, to enhance investor confidence and maintain market stability [1][4] Group 1: Shareholder Commitment - The commitment not to reduce shareholding is based on confidence in Xuantai Pharmaceutical's future development and long-term value recognition [1] - On August 25, 2023, a total of 311 million shares of Xuantai Pharmaceutical will be unlocked, accounting for 68.61% of the total share capital, with Lianhe Investment holding 233 million shares, representing 75% of the unlocked shares [1] Group 2: Business Development and Competitive Edge - Xuantai Pharmaceutical's controlling shareholder is optimistic due to the robust development of the company's core strategic business and the broad industry prospects [2] - The company has established three major technology platforms for high-barrier products in the generic drug sector, including "insoluble drug solubilization technology platform," "controlled-release drug formulation R&D platform," and "fixed-dose combination formulation R&D platform" [2] - By the end of 2024, Xuantai Pharmaceutical is expected to have 16 approved products, including several first-generic products domestically and internationally [2] Group 3: CRO/CMO Performance - In the CRO/CMO sector, Xuantai Pharmaceutical has successfully assisted in the approval of multiple innovative drugs and has developed over 100 innovative drug formulations [3] - The company has established partnerships with several listed companies and well-known pharmaceutical enterprises, providing CMO services for eight approved new drug products [3] Group 4: Investor Relations and Dividends - Xuantai Pharmaceutical prioritizes cash dividends to reward shareholders, having distributed a total of 74.36 million yuan in cash dividends since its listing in 2022, with plans for mid-term dividends in 2024 [3] - The commitment from the controlling shareholder serves as a strong vote of confidence in the company's existing development strategy and management team [4]

8月6日，福建海西新药创制股份有限公司（简称"海西新药"）再次向港交所递交招股书，华泰国际和招银国际担任其联席保荐人。今年1月3日，海西新药 首次递交招股书。 与多家创新药企业在亏损状态下遵从18A制度谋求在港股上市的情况不同，海西新药拥有获得国家药监局批准的14款仿制药，并凭借仿制药的销售实现盈 利。2024年，海西新药来自VBP（即国家药品集中带量采购）计划的销售金额占总销售金额的九成。 但其主要产品瑞安妥、海慧通的VBP纳入有效期将在2025年12月31日结束。招股书提示，如果相应的产品被剔除出VBP名录或其他政府资助的医保计划， 公司的业务、运营业绩及财务状况可能会受到不利影响。而依靠仿制药"供血"的创新药研发也将遭遇危机。 靠仿制药赚钱 海西新药几乎所有的销售收入均来自销售仿制药。公司表示，未来销售收入也将主要来自仿制药。具体来看，安必力、海慧通、瑞安妥及塞西福四款入选 国家VBP计划的药物，在2024年为海西新药带来的收入分别为1.46亿元、1.87亿元、4794.9万元及4372.9万元。 | | | | 截至12月31日止年度 | | | | | 截至5月31日止五個月 | | | | --- ...

Core Viewpoint - The business cooperation between Beijing Beiyi Pharmaceutical and Peking University International Hospital is nearing completion, leading to potential risks of business cessation, personnel layoffs, and corporate transformation for Beiyi Pharmaceutical [1][2]. Group 1: Business Overview - Beijing Beiyi Pharmaceutical, a wholly-owned subsidiary of Beida Pharmaceutical, is primarily engaged in the distribution, retail, hospital procurement, and pharmacy management of third-party drugs, medical devices, and consumables [1]. - The contract between Beiyi Pharmaceutical and Peking University International Hospital, which was effective from May 2022 to May 2023, has expired, and both parties will not continue their cooperation, significantly impacting the revenue of both companies [2][4]. Group 2: Financial Impact - The loss of Peking University International Hospital as a client could lead to a significant revenue decline for Beiyi Pharmaceutical, with an estimated sales revenue reduction of approximately 600 million yuan, accounting for about 29.13% of the company's latest audited revenue [5]. - Beiyi Pharmaceutical's total revenue for 2024 is projected to be 2.06 billion yuan, with around 50% of this revenue dependent on the contract with the hospital [4][5]. - If the cooperation is completely terminated, Beiyi Pharmaceutical's profitability could shrink by nearly half, with a potential revenue decrease of about 1.027 billion yuan starting in 2026 [5]. Group 3: Market Reaction - On August 12, the stock price of Beida Pharmaceutical fell by over 9%, closing at 6.42 yuan per share, a decline of 7.36%, with a total market capitalization of 3.826 billion yuan [1]. Group 4: Industry Context - The situation reflects a typical case of over-reliance on a single major client, which can lead to severe financial consequences when the partnership ends [6]. - The healthcare industry is experiencing rapid changes, including accelerated medical reforms and centralized procurement, which may further compress traditional distribution margins [6].

随着华昊中天、派格生物、康乐卫士、美中嘉和等企业递表港交所，药企前往港股上市的热潮还在继续。 据港交所8月6日披露，福建海西新药创制股份有限公司(以下简称：海西新药)再次递表港交所主板，华泰 国际和招银国际为其联席保荐人。根据智通财经APP了解，该公司曾于1月3日向港交所递表。 据了解，海西新药已经进入商业化阶段，凭借多元化的产品组合及管线，实现了不小的增长。相比诸多处 于临床阶段的药企，海西新药发展向好性无疑是更加明显的。 5个月营收约2.5亿元最大客户贡献营收"半边天" 据招股书，海西新药是一家处于商业化阶段的制药公司，集研发、生产及销售能力于一体，具备在研创新 药的管线。公司在中国最大、增长最快的治疗领域拥有多元化的产品组合及管线，目前已就14款仿制药获 得国家药监局批准，并建立拥有四款在研创新药的管线，成为中国制药行业的主要市场参与者。 | | | | | | | 已則震化的仿劇碼中 | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 治療盟城 | 南福 | 低製糖 名稱 | | ...

Core Viewpoint - The trend of pharmaceutical companies seeking to list on the Hong Kong Stock Exchange continues, with HaiXi New Drug being a notable example, having submitted its application again after an initial attempt earlier in the year [1][2]. Company Overview - HaiXi New Drug is a commercial-stage pharmaceutical company with a diversified product portfolio and pipeline, having achieved significant growth compared to many peers still in clinical stages [1][2]. - The company has received approval for 14 generic drugs from the National Medical Products Administration and has four innovative drugs in its pipeline, positioning it as a major player in China's pharmaceutical industry [2][4]. Financial Performance - The company reported revenues of approximately 2.5 billion RMB over five months, with a significant portion of revenue coming from a major client [2][5]. - Revenue figures for the reporting period show a growth trend: 212 million RMB in 2022, 317 million RMB in 2023, and projected 467 million RMB in 2024, with profits also increasing correspondingly [5][6]. - The company heavily relies on a few major clients, with the top five clients contributing 71.7% to 85.1% of total revenue during the reporting periods [7]. Business Model - HaiXi New Drug operates a light-asset model, utilizing the Marketing Authorization Holder (MAH) system, which separates drug marketing and production licenses, allowing for outsourcing of production [5][10]. - The company has established a sales and distribution network with over 18,000 hospitals and medical institutions across China, covering all provinces and municipalities [4]. Market Strategy - The company is focusing on both generic and innovative drugs, with a particular emphasis on developing small-molecule innovative drugs that meet clear clinical needs [4][12]. - HaiXi New Drug's innovative pipeline includes a potential first-in-class oncology drug and other drugs targeting significant market needs, indicating a strategic shift towards innovation [12][14]. Industry Context - The Chinese pharmaceutical market is predominantly composed of generic drugs, with over 90% of the 4,000 pharmaceutical companies being generic drug manufacturers [11]. - The global market for breast cancer drugs is projected to grow significantly, providing a substantial opportunity for HaiXi New Drug's innovative products [12]. Future Outlook - The company is transitioning towards a heavier asset model with the construction of its own manufacturing facility, which may lead to increased operational volatility [14]. - Balancing stable income from generics with the long-term investment required for innovative drug development will be crucial for the company's future valuation [14].

Core Viewpoint - Fujian Haixi New Drug Creation Co., Ltd. has submitted its IPO application to the Hong Kong Stock Exchange, marking its second attempt after the first application lapsed in January 2025. The updated application includes financial data for 2024 and the first five months of 2025, with plans to raise funds for drug pipeline development and commercialization efforts [1][2]. Group 1: Company Overview - Established on March 27, 2012, Haixi New Drug is a commercial-stage pharmaceutical company based in Fuzhou, Fujian, focusing on R&D, production, and sales [2]. - The company has a product portfolio that includes generic drugs for various diseases, with 14 generic drugs approved by the National Medical Products Administration [2]. - Haixi New Drug has a research team of 112 members, with approximately 27% holding doctoral or master's degrees, and an average industry experience of about 19 years [2]. Group 2: Product Pipeline and Market Position - Among the approved generic drugs, four have been selected for national centralized procurement, including Anbili, Haihuitong, Ruian Tuo, and Saixifu [3]. - The company has five additional generic drugs in the ANDA stage, expected to receive market approval by 2025 or 2026 [3]. - Revenue during the reporting period primarily came from pharmaceutical product sales, with a significant portion sold to distributors for hospital distribution [3]. Group 3: Financial Performance - Revenue figures for the reporting period were approximately CNY 212 million, CNY 317 million, CNY 467 million, and CNY 249 million, with net profits of approximately CNY 69 million, CNY 117 million, CNY 136 million, and CNY 90 million [5]. - The company's gross margin during the reporting period was high, ranging from 81% to 84%, ranking second among 20 generic drug companies in the A-share market [6]. - Cash and cash equivalents as of May 31, 2025, were approximately CNY 46.26 million, a decrease of over CNY 200 million from the end of 2023 [6]. Group 4: Leadership and Management - The company is co-controlled by founders Dr. Kang Xinshan and his spouse Feng Yan, who together hold 41.17% of the shares [6]. - Dr. Kang Xinshan has over 26 years of experience in the pharmaceutical industry and has held various significant positions prior to founding Haixi New Drug [6][7]. - Feng Yan has also held prominent roles in research management and joined Haixi New Drug in 2012, later becoming the deputy general manager [7].

每经记者｜蔡鼎 每经编辑｜陈俊杰 申请文件显示，海西药业拟将募集资金用于推进管线中在研药物并丰富产品组合、提升研发能力及寻求 合作机会、增强商业化能力及扩大市场影响力、改善及优化研发和生产系统，以及营运资金及其他一般 企业用途。 14款仿制药获批，其中4款进入集采 海西新药成立于2012年3月27日，总部位于福建省福州市，是一家处于商业化阶段的制药公司，集研 发、生产及销售能力于一体，具备在研创新药的管线。截至申请文件披露日，其已商业化的产品组合主 要包括用于消化系统疾病、心血管系统疾病、内分泌系统疾病、神经系统疾病及炎症疾病的仿制药。此 外，海西新药已就14款仿制药获得国家药监局批准，并建立拥有4款在研创新药的管线。 截至申请文件披露日，海西新药的研发团队由112名研究人员组成，其中约 27%拥有博士或硕士学位， 主要成员在医药行业平均拥有约19年的经验。海西新药已建立一个包括36项专利的全球专利组合，其中 包括在美国、加拿大、澳大利亚、日本、韩国、新加坡、印度以及约29个欧洲国家等海外司法管辖区获 得的17项专利。 海西新药业务包括仿制药及在研创新药，在上述提及的已获国家药监局批准的14款仿制药当中，有4 ...

来源：新浪港股-好仓工作室 福建海西新药创制股份有限公司是一家处于商业化阶段的制药公司，正冲刺港股IPO。此次招股书展现 了公司在业务、财务等多方面的情况，其中营收增长47.4%颇为亮眼，但同时也隐藏着一些风险点，值 得投资者关注。 业务模式：双轨并行，各有千秋 仿制药：市场地位初显 公司2024年收入增长远超过中国医药市场平均增长，增长率高达47.4% 。这主要得益于仿制药入选VBP 计划带来的销量增长。从产品来看，入选国家VBP计划的几款药物贡献突出，如海慧通®、安必力® 等。 净利润：暂未披露变化情况 招股书中未明确提及净利润的具体变化数据。净利润受多种因素影响，包括成本控制、销售费用、研发 投入等。在营收增长的情况下，净利润的走向对公司盈利能力评估至关重要，投资者需后续关注相关信 息披露。 毛利率与净利率：数据待明确 海西新药通过推出一系列技术壁垒高、市场潜力大且符合监管要求的仿制药，在市场上确立了一定地 位。截至最后实际可行日期，公司已就14款仿制药获得国家药监局批准 。其中，有四款入选国家带量 采购（"VBP"）计划，四款入选省级VBP计划。像安必力®被视为通过中国一致性评价并率先进入市场 的枸橼 ...