随着"十五五"规划建议将"生物制造"视为新的经济增长点，嘉必优已深度融入国家创新体系：入选工业 和信息化部首批生物制造中试能力建设平台，承担"微生物平行生物反应器"揭榜挂帅任务，牵头共建武 汉合成生物创新中心，更作为湖北省首家科创板企业参与地方产业政策落地。 技术创新赋能企业未来发展 作为行业领军者，嘉必优在实现业绩稳健增长的同时，也注重研发创新。上市以来，嘉必优研发投入强 度始终保持在8%以上，2024年研发投入达4790.71万元，同比增长24.12%，近三年累计投入超1.19亿 元。通过融合AI与合成生物学，公司构建起覆盖"设计-构建-测试-学习"循环的全栈式技术闭环，完成模 式菌株知识图谱搭建，实现酶理性设计自动化，打破了国外在工业菌种领域的垄断。 依托微生物发酵与合成生物学技术，公司实现了环境友好型生产，契合"双碳"战略要求。更值得关注的 是，其国家级中试平台主动向高校、科研机构开放，提供"菌种验证-工艺放大-质量控制"一站式服务， 打通从"实验室到生产线"的转化瓶颈。投入3亿元建设的武汉合成生物创新中心，形成"政产学研用 金"六位一体机制，已吸引上下游企业集聚光谷，推动区域产业集群成型。 凭借多年 ...

Core Insights - The company is showcasing its innovative transformation in the pharmaceutical industry, particularly in the ADC drug sector and synthetic biology, establishing itself as a model for innovation-driven development in Chinese pharmaceutical enterprises [1]. ADC Drug Sector - The company has emerged as a representative player in the ADC drug field, achieving significant breakthroughs in technology research and industrialization [4]. - The company's subsidiary, Kelun Biotech, developed the first domestically approved ADC drug with global intellectual property rights, Lukanasatuzumab (Jiatailai®), which received its first indication approval in November 2024 and has since gained additional approvals in March and October of this year [4]. - In collaboration with Merck, the company has initiated 15 global Phase III studies for Lukanasatuzumab, targeting prevalent cancers such as lung and breast cancer, highlighting its global innovation potential [4]. - The company has multiple ADC drug pipelines, with SKB518, SKB500, and a bispecific ADC drug SKB571 entering Phase II clinical trials, while another ADC drug, Botuzumab (HER2 ADC Shuitailai®), received NDA approval in October for HER2-positive breast cancer [4]. - Phase III studies comparing Botuzumab to the traditional standard drug T-DM1 have shown significant efficacy advantages [4]. Synthetic Biology Sector - The company is leveraging breakthroughs in synthetic biology as a crucial pillar for accelerating its innovative transformation [5]. - Utilizing a robust biological fermentation technology platform and increasing R&D investments, the company has established a commercial system around synthetic biology, successfully applying research outcomes to high-value product development [5]. - The company is embracing AI technology to enhance synthetic biology research, optimizing production processes and achieving cost reductions, thereby strengthening market competitiveness [5]. - The company has successfully brought several products, including Red Methyl Alcohol, 5-Hydroxytryptophan, Ergothioneine, Ectoine, Squalane, Inositol, Plant Sphingosine, and PHA, into production and sales, becoming one of the first domestic companies to deliver products in synthetic biology [5]. - The company's continuous innovation in biopharmaceuticals is accelerating its high-quality development across various emerging sectors, earning recognition as an innovative enterprise in the 2025 annual case study by First Financial Capital Market [5].

● 本报记者 李梦扬 近日，西安市人民政府办公厅发布《促进生物医药产业能力提升实施方案（2025—2027年）》。其中提 到，在干细胞药物、多肽药物、肝靶向创新药物、麻醉制品等领域突破一批药物研发关键核心技术。支 持企业开展Ⅰ类创新药、临床紧缺药研发及成果转化，推动企业研发立项Ⅱ类创新药，提升企业在创新 药领域的研发能力和竞争力。 值得关注的是，今年以来，北京、上海、重庆、四川等多地出台相关政策，促进医药健康产业创新，推 动创新药行业高质量发展。业内人士表示，医药行业尤其是创新药已经步入新一轮的政策支持发展新周 期。全链条鼓励创新有望带动创新药商业模式整体改善。 突破药物研发关键核心技术 具体来看，《实施方案》提出三大主要目标。产业规模方面，根据《实施方案》，到2027年，西安市生 物医药产业规模达到400亿元，其中中药、化药生物药、医疗器械、消费医疗产业链群分别达到90亿 元、120亿元、60亿元、130亿元。 在免疫细胞治疗领域，《实施方案》表示，支持企业与西安交大一附院、唐都医院等医疗机构围绕胃 癌、肝癌等领域，合作开展"CAR-T实体瘤"技术突破和临床研究，推动免疫细胞产业化。 在细胞衍生物治疗领域， ...

Core Insights - The article emphasizes the strategic importance of biomanufacturing, which is projected to create a $30 trillion market, comparable to the significance of chip manufacturing [3] - Biomanufacturing is not merely a replacement for traditional chemical processes but a transformative engine that redefines the underlying logic of industries, impacting the entire supply chain from raw materials to end products [3][4] Company Overview - Jia Bi You has been proactive in the biomanufacturing sector, establishing a robust business model that has evolved significantly since its listing on the STAR Market six years ago [4] - The company reported a revenue increase from 312 million yuan in 2019 to 555 million yuan in 2024, achieving a compound annual growth rate of 12.2% [4] Market Positioning - The implementation of new national standards for infant formula in February 2023 has created a favorable market environment for Jia Bi You, allowing it to efficiently release production capacity [10] - The expiration of DSM's core patents has enabled Jia Bi You to penetrate international markets and establish stable partnerships with major companies like Nestlé and Danone [12] Strategic Growth - Jia Bi You's revenue structure has diversified, with the human nutrition segment's share decreasing from over 95% to around 80%, while the health sector now contributes nearly 20% [13] - The company maintains a high R&D investment rate of 8%-10%, which has supported its innovation and technological advancements [15] Technological Innovation - The company has developed a comprehensive technology system based on synthetic biology, which includes bioinformatics, AI, and other interdisciplinary fields [15][16] - Jia Bi You aims to leverage AI to enhance its research and application processes, creating a specialized biological database to optimize product development and personalized nutrition solutions [18][19] International Expansion - Jia Bi You's international revenue share has increased from less than 10% to nearly 40%, with products now available in over 30 countries [24] - The company adopts a flexible internationalization strategy, focusing on technology cooperation and customized supply rather than aggressive expansion [25] ESG Commitment - Jia Bi You places significant emphasis on ESG practices, having initiated social responsibility reports since 2019 and implementing sustainable practices such as replacing coal boilers with natural gas [27][28] - The company has received recognition for its ESG efforts, highlighting its commitment to environmental, social, and governance standards [30] Future Opportunities - The upcoming "15th Five-Year Plan" presents multiple opportunities for Jia Bi You, including favorable policies for biomanufacturing and increased demand for infant nutrition products [33][34] - The company believes that its internal capabilities and technological advancements will be the primary drivers of growth, rather than external trends [35]

Core Insights - Company has focused on emerging products such as SA (Sialic Acid) and HMOs (Human Milk Oligosaccharides) while maintaining its core product line [1][2] - The company reported a revenue of 430 million yuan for the first three quarters of 2025, a year-on-year increase of 10.56%, and a net profit of 130 million yuan, up 54.18% year-on-year, indicating a significant profit growth outpacing revenue growth [1] - The company aims to expand its market presence in infant formula, animal nutrition, and personal care sectors through a strategy termed "one main and two wings" [1][2] Company Strategy - The company is enhancing its product offerings in the infant formula market by promoting algal oil DHA as a substitute for fish oil DHA and deepening cooperation on HMOs [2] - In the pet nutrition sector, the company employs a strategy of "technology research + brand marketing + supply chain management" to enhance product innovation and competitiveness [3] - In the beauty and personal care sector, the company leverages synthetic biology and innovative technologies to rapidly screen and validate new cosmetic raw materials [3] Market Position - The company is a leader in the microbial synthesis nutrient sector in China, with key products including ARA, DHA, and β-carotene, widely used in infant formula, health foods, animal nutrition, and personal care [1] - The domestic and international milk powder markets continue to provide favorable conditions for the company's stable performance [1] - The approval of HMOs as new raw materials for infant formula by the National Health Commission is expected to accelerate the application of these products in the infant nutrition sector [2]

Core Viewpoint - ST诺泰 (688076.SH) has received an administrative penalty decision, but this has not negatively impacted its current business performance, with significant revenue and profit growth reported for the first three quarters of 2025 [2] Group 1: Financial Performance - For the first three quarters of 2025, the company achieved revenue of 1.527 billion yuan, representing a year-on-year increase of 21.95% [2] - The net profit attributable to shareholders reached 445 million yuan, up 26.92% year-on-year, while the net profit excluding non-recurring items was 437 million yuan, reflecting a 23.20% increase [2] Group 2: Business Growth and Strategy - The company's peptide raw material drug business continues to grow significantly, driven by the expanding GLP-1 market, and is a core driver of its performance [2] - The company is implementing a development strategy focused on time and technology leadership, with a foundation in peptide drugs and small molecule drugs, while strategically expanding into oligonucleotide business and cutting-edge fields like synthetic biology and AI drug development [2] Group 3: Innovation and R&D - The company has made a significant breakthrough in innovative R&D, with its subsidiary, Hangzhou Nuoao Biopharmaceutical Technology Co., Ltd., receiving acceptance for a clinical trial application for the new drug Semaglutide tablets, marking a milestone in oral peptide delivery technology for weight management [2] - Currently, there are no approved oral Semaglutide formulations for weight management in the domestic and international markets, indicating a substantial market opportunity for the company [2] Group 4: Market Position and Collaborations - As a leading enterprise in the peptide raw material drug sector, the company has overcome technical bottlenecks in large-scale production of long-chain peptide drugs, achieving single-batch production of over 10 kilograms for drugs like Semaglutide and Tirzepatide [3] - The company has established collaborations with several leading generic drug companies for the raw materials and formulations of Semaglutide and Tirzepatide, maintaining high growth in peptide raw material sales [3] - The company has also announced comprehensive coverage of its GLP-1 pipeline products, with ongoing development of new targets like Retatrutide, which is set to begin development in early 2024 with an investment of approximately 5.08 million yuan [3] Group 5: Oligonucleotide and New Technologies - The company is actively involved in the oligonucleotide field, with plans for commercial production capacity expected to be completed by 2025, aiming for an annual output of 1,000 kilograms of oligonucleotides and 200 kilograms of PEG-conjugated cyclic peptides [4] - Collaborations with companies like Novogene and DeepTech in synthetic biology and AI-enabled areas are accelerating the exploration of new business fields, positioning the company for high-quality development across multiple tracks [4]

Core Viewpoint - The recent administrative penalty imposed on Nuotai Bio (688076.SH) due to past issues has not negatively impacted the company's current operational performance, with significant revenue and profit growth reported for the first three quarters of 2025. Financial Performance - For the first three quarters of 2025, the company achieved a revenue of 1.527 billion yuan, representing a year-on-year increase of 21.95% - The net profit attributable to shareholders reached 445 million yuan, up 26.92% year-on-year - The net profit excluding non-recurring items was 437 million yuan, reflecting a 23.20% year-on-year growth [1] Business Growth and Strategy - The company's peptide raw material drug business continues to grow significantly, driven by the expanding GLP-1 market, and is a core driver of its performance [1] - Nuotai Bio is committed to a development strategy focused on time and technology leadership, with a foundation in peptide drugs and small molecule drugs, while strategically expanding into oligonucleotide business and cutting-edge fields like synthetic biology and AI drug development [1] Innovation and R&D - The company has made a significant breakthrough in innovative R&D, with its subsidiary, Hangzhou Nuoao Biopharmaceutical Technology Co., Ltd., receiving acceptance for the clinical trial application of the new drug Semaglutide tablets, marking a milestone in oral peptide delivery technology for weight management [1] - Currently, there are no approved oral Semaglutide formulations for weight management in the domestic and international markets, indicating a substantial market opportunity for Nuotai Bio [1] Global Influence and Collaborations - Nuotai Bio has established itself as a leading enterprise in the peptide raw material drug sector, overcoming technical bottlenecks in large-scale production of long-chain peptide drugs, and is one of the few companies capable of producing over 10 kilograms of Semaglutide and other long-chain modified peptide drugs in a single batch [2] - The company has engaged in collaborations with several leading generic drug companies for the development of Semaglutide and other raw material drug projects, maintaining high growth in peptide raw material sales [2] Pipeline Development - The company has comprehensively covered its GLP-1 pipeline products, building on the success of first-generation Liraglutide, second-generation Semaglutide, and dual-target Teplizumab, while also developing a three-target Retatrutide, with an initial investment of approximately 5.08 million yuan [2] - In addition to peptide drugs, Nuotai Bio is advancing in the oligonucleotide field, with plans for commercial production capacity expected to be completed by 2025, aiming for an annual production of 1,000 kilograms of oligonucleotides and 200 kilograms of PEG-conjugated cyclic peptides [3] Strategic Partnerships - The company has formed partnerships with NuoVision and DeepTech in the areas of synthetic biology and AI empowerment, accelerating the exploration of new business fields [3] - With the gradual rollout of new production capacity and breakthroughs in cutting-edge technology, Nuotai Bio is positioned for high-quality development across multiple tracks, creating long-term value for investors [3]

丸美生物旗下拥有"丸美"与"恋火"两大核心品牌。弗若斯特沙利文报告显示，以2024年零售额计，丸美 品牌已连续四年位列中国国内眼部护理品牌第一，而恋火品牌则在中国国货底妆品牌中排名第三。 此次发行将助力公司把握中国抗衰护肤品市场的增长机遇。弗若斯特沙利文报告指出，抗衰护肤品是中 国护肤品行业中增速最快的细分领域。通过本次募资，公司将持续投入以重组胶原蛋白为代表的核心技 术研发，进一步巩固其技术壁垒。截至2025年9月30日，公司已在全球申请专利651项，获得授权发明专 利265项，研发实力位居国内美妆企业前列。此举将增强公司在激烈市场竞争中的差异化优势，巩固其 行业领先地位。 针对核心原料，公司已建立覆盖从基础研究到应用的闭环价值链。截至2025年9月30日，已开发出重组 双胶原蛋白、SPGβ－葡聚糖、超分子木棉花提取物、超分子弹性蛋白等80余款自有成分，其中30余款 实现规模化生产。其自有的生产基地能够开展用于重组胶原生产的高密度发酵与纯化工艺，有效衔接基 础研究与产业化生产。 公司强调，此次H股发行不会导致公司控制权发生变更，孙怀庆博士与王晓蒲仍为公司实际控制人。公 司拟通过本次发行募集资金，在扣除相关发 ...

大会名称 | 2026第四届合成生物学产业博览会（SBC2026） 大会主题 | 合成未来趋势·智造无限可能 大会时间 | 2026年4月17-18日 大会地点 | 江苏南京扬子江国际会议中心 主办单位 | 佰傲谷BioValley、生物经纬、山东大学、华东理工大学、山东大学微生物技术国家重点实验 室 支持单位 | 中国微生物学会、 中国微生物学会生化过程模型化与控制专业委员会、 华东理工大学国家 生化工程技术研究中心(上海)、北京软物质科学与工程高精尖中心、上海市微生物学会、南京生物工程 学会、华东师范大学医学合成生物学研究中心、工业生物催化教育部重点实验室 合成未来趋势·智能无限可能 扫码提前解锁观摩席位 合成生物学作为21世纪生命科学领域的颠覆性力量与全新生产力，正以DBTL循环"编程"生命，为人类 在健康、能源、环境等领域的重大挑战提供全新的解决方案，引领我们步入一个能够按需设计、改造乃 至创造生命的"生物世纪"。在我国"十五五"规划中，合成生物学与生物制造被提升至与量子科技并列的 战略高度，作为未来产业进行持续培育，目标形成万亿级产业规模。 SBC2026第四届合成生物学产业博览会 将实现科技深度与 ...

"AI正对传统农业生产方式、生产关系和治理体系带来深层变革，成为实现农业现代化、保障国家粮食 安全和推动乡村振兴的关键技术支撑。"南京农业大学党委常委、副校长丁艳锋介绍，近年来，南京农 业大学在14个学科进入ESI全球前百分之一、3个学科进入前千分之一，植物学与动物学、农业科学跻身 前万分之一的坚实基础上，进一步前瞻布局成立前沿交叉研究院，围绕农业人工智能、植物表型组学、 农业与人类健康、合成生物学等新型方向大力推动学科交叉，一批前沿成果不断涌现，为科技赋能农业 发展注入新动能。(经济日报记者蒋波) 会上，"fomo4wheat作物表型大模型""AI+遥感驱动的作物数字孪生系统""作物动态智能设计育种大模 型""大豆智慧育种平台""'药问'农药科学家智能体"等五款农业AI领域成果正式推出。fomo4wheat作物表 型大模型构建起小麦视觉感知AI底座，遥感驱动作物数字孪生系统实现"感知-建模-决策"全链路贯通， 作物动态智能设计育种大模型将育种周期缩短至少50%，大豆智慧育种平台打造全球领先的大豆育 种"超级大脑"，"药问"农药科学家智能体则将农药研发周期从十年压缩至一年，整体构建起从基础研究 到产业应用的完 ...