Core Viewpoint - The partnership between Sangfor Biopharma and Pfizer marks a significant milestone in the biopharmaceutical industry, with a total agreement value of up to $60.5 billion for the global development, production, and commercialization rights of SSGJ-707, a dual-target PD-1/VEGF antibody, excluding mainland China [2][5][6]. Group 1: Agreement Details - Sangfor Biopharma retains the rights for SSGJ-707 in mainland China and grants Pfizer an option for commercialization in that region based on agreed financial terms [5][6]. - The agreement includes a non-refundable upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion based on development, regulatory approval, and sales [5][6]. - Additionally, Sangfor will receive a tiered percentage of sales revenue from the licensed regions and Pfizer will purchase $100 million worth of common stock from Sangfor upon the agreement's effective date [6][5]. Group 2: Product and Clinical Insights - SSGJ-707 is developed using Sangfor's proprietary CLF2 platform and targets both PD-1 and VEGF, showing promising results in clinical trials for non-small cell lung cancer (NSCLC) with high objective response rates (ORR) and disease control rates (DCR) [7]. - The drug has received breakthrough therapy designation from the National Medical Products Administration (NMPA) for first-line treatment of PD-L1 positive locally advanced or metastatic NSCLC and has also gained IND approval from the FDA [7]. Group 3: Company Overview and Financial Performance - Sangfor Biopharma is a leading biopharmaceutical company with over 100 national invention patents and more than 40 marketed products across various therapeutic areas [9]. - The company reported a revenue of 9.11 billion yuan in 2024, a year-on-year increase of 16.5%, with a net profit of 2.09 billion yuan, up 35% [9]. - Key products include the recombinant human thrombopoietin (rhTPO) product, which generated approximately 5.06 billion yuan in sales, reflecting a 20.4% increase [9]. Group 4: Strategic Collaborations and Future Prospects - In 2024, Sangfor has achieved multiple collaborations, including partnerships in the oncology sector to enhance the accessibility of innovative chemotherapy drugs [10]. - The company is focused on leveraging its rich pipeline and early investments in blood, oncology, and autoimmune disease sectors, indicating a promising future as it approaches the NDA (New Drug Application) phase [12].

消息面上，5月20日，港股创新药企三生制药与海外辉瑞公司签订重大许可协议，授予辉瑞在全球（不 包括中国内地）独家开发、生产及商业化双抗的权利。根据协议，三生制药将获得12.5亿美元首付款， 并可能获得高达48亿美元的里程碑付款，以及双位数百分比的销售提成。这一交易再次刷新了国产创新 药出海首付款金额纪录。近期创新药行业利好不断。2025年第一季度，中国创新药license-out交易已有 41起，总金额达369.29亿美元，仅3个月已接近2023年全年水平。 相关产品：港股创新药ETF（159567）、创新药ETF（159992） 大而全：创新药ETF（159992）跟踪创新药指数，该指数布局创新药产业链龙头企业，既汇聚全球CXO 龙头企业，又包含国内仿创药企龙头，有望同时受益于AI赋能创新药、国产创新药出海、针对高价创 新药的医保丙类目录出台等。 国元证券认为，上周医药板块受特朗普宣布将推动美国处方药价格与"其他发达国家"对标政策影响，创 新药细分领域出现回调。特朗普提出行政令计划，旨在使美国药价下降30%-80%，并允许患者直接从制 造商购买药物，绕过中间商。然而，分析指出该政策实施难度较大，美国医药市场 ...

三生国健双抗新药授权辉瑞 科创板药企再次刷新国产创新药出海首付款纪录 金十数据5月20日讯，5月20日，科创板创新药企业三生国健宣布，公司及关联方三生制药和沈阳三生共 同授予辉瑞PD-1/VEGF双特异性抗体SSGJ-707在全球（不包括中国大陆）的独家开发、生产、商业化 权利。辉瑞保留通过支付额外付款获得在中国大陆商业化许可产品的权利。根据协议，辉瑞将支付12.5 亿美元不可退还且不可抵扣的首付款，最高可达48亿美元的开发、监管批准和销售里程碑付款，以及根 据授权地区产品销售额计算得到的两位数百分比的梯度销售分成。该笔授权交易的"12.5亿美元首付 款"再次刷新国产创新药出海首付款金额纪录，也标志着科创板创新药企业的研发实力再次获得国际顶 尖医药公司认可，达成国内药企迈向全球市场的又一里程碑。 （上证报） ...

Group 1 - Several innovative pharmaceutical companies have reached a profitability turning point or continued to narrow losses in Q1, driven primarily by self-sustaining growth from the continuous expansion of main products [1] - In Q1, Innovent Biologics achieved revenue of 380 million yuan, a year-on-year increase of 129.9%, with a net profit of 14 million yuan. BeiGene reported revenue of 8.048 billion yuan, a year-on-year increase of 50.2%, with losses narrowing from 1.908 billion yuan to 94.503 million yuan [1] - The Hong Kong innovative drug sector has seen high profitability continue to digest valuations, with the Hong Kong innovative drug index's price-to-earnings ratio dropping from 64 times on February 21 to 25 times on May 19, highlighting significant value for current investments [1] Group 2 - The Hong Kong innovative drug ETF (159567) tracks the Guozheng Hong Kong Stock Connect Innovative Drug Index, with 90% of its weight in innovative drug companies, positioning it to benefit from trends such as AI-enabled drug development and the expansion of domestic innovative drugs overseas [2] - The innovative drug ETF (159992) tracks an index that includes leading companies in the innovative drug industry chain, benefiting from advancements in AI, the export of domestic innovative drugs, and the introduction of new insurance policies for high-priced innovative drugs [2] - Huaxin Securities believes the innovative drug sector currently exhibits significant investment value, with Chinese companies establishing technological advantages in cutting-edge fields and attracting attention from large multinational pharmaceutical companies [2]

Group 1 - BeiGene reported Q1 2025 revenue of 8.048 billion yuan, a 50.2% increase from 5.359 billion yuan in the same period last year, with a net loss of 94.503 million yuan, significantly reduced from a loss of 1.908 billion yuan year-on-year [1] - Innovent Biologics disclosed Q1 2025 revenue of 381 million yuan, a year-on-year increase of 129.92%, with a net profit of 18 million yuan, up 112.62% year-on-year, marking a turnaround to profitability [1] - The Hong Kong innovative drug sector shows improving fundamentals, with the Hong Kong innovative drug index's P/E ratio dropping from 64 times on February 21 to 24 times on May 16, indicating a strong value proposition for investors [1] Group 2 - The Hong Kong innovative drug ETF (159567) tracks the National Index of Hong Kong Innovative Drugs, with a 90% weight in innovative drug companies, poised to benefit from trends such as AI-enabled drug development and the expansion of domestic innovative drugs [2] - The innovative drug ETF (159992) tracks a broader innovative drug index, including leading companies in the innovative drug industry chain, expected to benefit from AI advancements and new healthcare policies [2] Group 3 - CICC believes the innovative drug sector demonstrates strong investment value despite market pressures from U.S. tariff policies, as it relies on a knowledge-based payment model, making it less susceptible to short-term impacts [3] - The pricing logic of innovative drugs is centered around long-term product launch and sales expectations rather than current operational fundamentals, providing resilience during market fluctuations [3] - Upcoming international academic conferences, such as ASCO, are expected to boost sentiment in the innovative drug sector, making it a focus for investors from May to June [3]

中邮证券表示，受益于海外投融资市场的率先复苏，需求端逐步恢复，CXO&上游公司订单增速提升， 行业拐点已过。CXO板块收入端恢复良好增长态势，盈利能力持续修复，利润端改善趋势更为显著， 基本面已呈现向上趋势。优质、高效、低成本的产品及服务为核心壁垒，我国制药业优势持续巩固，有 望在全球市场占据更高市场份额。中国创新药经过数十年发展，正在进入收获期，叠加政策友好性和市 场流动性提升，国内创新药市场前景光明。建议重点关注肿瘤、自免、减重、阿尔兹海默症、NASH、 脱发、乙肝等领域。 甬兴证券表示，百济神州凭借泽布替尼在欧美市场份额的提升保持收入规模的增长、恒瑞医药也多次实 现创新药的对外授权，我们认为国产创新药的竞争力正在持续提升，看好国产创新药的出海前景。 （本文机构观点来自持牌证券机构，不构成任何投资建议，亦不代表平台观点，请投资人独立判断和决 策。） 5月14日港股低开低走，医药生物板块逆市走强。热门ETF方面，港股创新药ETF（159567）盘中震荡 走高，截至发稿涨1.01%。换手率超7%，成交额快速突破1亿元，交投活跃。 成分股方面，三生制药涨超4%，康希诺生物、凯莱英涨超3%，晶泰控股、再鼎医药、科 ...

Group 1 - The core viewpoint highlights the evolution of Chinese innovative pharmaceutical companies over the past decade, transitioning from rule followers to challengers and finally to rule makers, with 2015 marking the start of the shift from generic to innovative drugs [1] - The Hong Kong innovative drug sector has seen a significant reduction in valuation, with the Hong Kong innovative drug index's price-to-earnings ratio dropping from 64 times on February 21 to 25 times on May 9, indicating a strong value proposition for current investments [1] - On May 12, the Hong Kong market experienced a V-shaped rebound in the innovative drug sector, with notable gains in stocks such as Far East Pharmaceutical rising over 7%, and others like Rongchang Bio and Dongyangguang Changjiang Pharmaceutical increasing over 2% [1] Group 2 - The innovative drug ETF (159992) tracks an index that includes leading companies in the innovative drug industry, benefiting from trends such as AI-enabled drug development and the introduction of a new insurance category for high-priced innovative drugs [2] - Pacific Securities forecasts a recovery in global healthcare financing, projecting a 1% year-on-year increase to $58.2 billion in 2024, reflecting restored market confidence [2] - The ongoing rise of the domestic innovative drug index is expected to enhance the investment environment for innovative drug research and development companies, supported by a favorable macroeconomic backdrop including a loosening of liquidity due to the Federal Reserve's interest rate cuts [2]

市场期待DeepSeek-R2大模型5月发布。年初DeepSeek爆火带动AI概念扩散至创新药。据了解，目前AI 算法在临床前药物发现阶段已经有深入应用，海外头部临床CRO公司在临床试验中已经布局AI多年， 完全由AI研发的新药有望在1～2年内成功上市。而且，AI可以赋能药物研发的全流程，相关的企业有 望通过AI技术缩短研发周期、降低成本、提高效率。 大而全：创新药ETF（159992）跟踪创新药指数，该指数布局创新药产业链龙头企业，既汇聚全球CXO 龙头企业，又包含国内仿创药企龙头，有望同时受益于AI赋能创新药、国产创新药出海、针对高价创 新药的医保丙类目录出台等。 信达证券认为，创新药板块在2025年第二季度展现出较高的投资价值，这主要得益于一系列积极的行业 动态和政策支持。首先，随着医保谈判、医保丙类目录落地预期以及多个重要肿瘤药临床会议等事件的 催化，创新药市场有望迎来新的增长点。其次，随着医疗整顿负面影响的逐步消化，院内市场的恢复将 为创新药的销售提供更稳定的环境。综上所述，创新药板块在多重利好因素的共同作用下，具备较高的 投资吸引力。 相关产品：港股创新药ETF（159567）、创新药ETF（15 ...

Group 1 - The global innovative drug investment and financing environment is recovering, with significant growth in sub-sectors like peptides and ADCs, which is expected to boost the CXO industry's performance [1] - WuXi AppTec reported Q1 2025 revenue of approximately 9.655 billion yuan, a year-on-year increase of 20.96%, and a net profit of about 3.672 billion yuan, up 89.06% year-on-year [1] - The Hong Kong innovative drug sector is experiencing a significant valuation correction, with the Hong Kong innovative drug index's P/E ratio dropping from 64 times to 27 times in less than two months, indicating attractive investment opportunities [1] Group 2 - The Hong Kong innovative drug ETF (159567) tracks the National Securities Hong Kong Stock Connect Innovative Drug Index, which has a 90% weight in innovative drug companies, positioning it to benefit from trends like AI-enabled drug development and the expansion of domestic innovative drugs [2] - The innovative drug ETF (159992) tracks an index that includes leading companies in the innovative drug industry chain, benefiting from AI advancements and new healthcare policies aimed at supporting innovative drugs [2] - Policies from Beijing and Shenzhen are promoting the development of innovative drugs and devices, focusing on R&D innovation, clinical trials, and regulatory approvals, which will enhance the competitiveness of innovative drug companies [2]

Group 1 - WuXi AppTec, a leading player in the CXO sector, reported better-than-expected performance with double-digit growth in both revenue and net profit, maintaining a revenue guidance of RMB 41.5 billion to RMB 43 billion for 2025 [1] - In 2024, WuXi AppTec generated RMB 16.64 billion from the top 20 global pharmaceutical companies, highlighting its significant role in the global CXO market [1] - The Hong Kong innovation drug index saw a significant drop in P/E ratio from 64 times on February 21 to 27 times on April 28, indicating a strong value proposition for investors [1] Group 2 - The innovation drug ETF (159992) tracks an index that includes leading companies in the innovation drug industry, benefiting from trends such as AI-enabled drug development and the international expansion of domestic innovative drugs [2] - According to Insight database, there were 79 new drug license-out transactions in 2024, with 24 transactions completed in the first five months of 2025, totaling over USD 2 billion, showcasing the growing international recognition of Chinese innovative drugs [2] - Chinese pharmaceutical companies are demonstrating strong competitiveness in the global market through high-standard R&D, particularly in areas like antibodies and ADCs [2]