Group 1: Company Overview and Investment Activities - The company is Hangzhou Baicheng Pharmaceutical Technology Co., Ltd., with stock code 301096 and abbreviation Baicheng Pharmaceutical [1] - The investor relations activities include online meetings and strategy sessions held from June 9 to June 20, 2025 [2] - Key participants include the Chairman and General Manager, Lou Jinfang, and the Financial Director and Board Secretary, Cheng Dandan [2] Group 2: Drug Development Progress - The company has multiple new drug pipelines, with 2 IND approvals for Class 1 new drugs targeting areas such as the nervous system and oncology [3] - The global market for central nervous system drugs exceeded $500 billion in 2023, with China's market at approximately ¥173.4 billion, indicating significant growth potential [3] - The central nervous system drug market in China is projected to grow from about ¥40 billion in 2025 to ¥200 billion by 2030 [3] Group 3: Specific Drug Projects - BIOS-0623 is a novel pain relief drug with advantages such as rapid onset and lower effective doses, showing superior efficacy compared to pregabalin [4] - BIOS-0632 is a strong AAK1 kinase inhibitor that demonstrates faster onset and better efficacy in diabetic neuropathic pain models compared to existing treatments [4] - BIOS-0629, a potential Best-in-Class second-generation XPO1 inhibitor, shows significant anti-tumor efficacy in various cancer models [5][6] Group 4: Market Trends and Opportunities - The global market for anti-tumor drugs reached $235.7 billion in 2023, with China's market at approximately ¥280 billion, driven by increasing cancer incidence [5] - The autoimmune disease drug market is expected to grow from $113.7 billion in 2018 to $176.7 billion by 2030, with a CAGR of 3.7% globally and over 20% in China [6][7] Group 5: Improved Drug Development - The company has over 20 projects in the improved drug category, with 11 receiving clinical approval, indicating a robust pipeline [10] - The market for improved drugs in China is expected to reach ¥560 billion by 2025, suggesting a favorable investment return [11][12] Group 6: Subsidiary Development - The subsidiary, Saimer Pharmaceutical, aims to become a global supplier of raw materials and formulations, with a production area of over 260 acres and 16.3 million square meters of GMP-compliant facilities [13][14] - Saimer has successfully registered 435 projects and has 49 products approved, showcasing its strong production capabilities [14] Group 7: CRO Business Status - The CRO/CDMO industry is experiencing a downturn due to cautious investment and increased competition, leading to a decline in orders [15][16] - Recent regulatory changes are expected to positively impact the CRO/CDMO sector, potentially restoring investment enthusiasm [16][17] Group 8: International Expansion Plans - The company is accelerating its internationalization efforts, establishing partnerships to enhance global resource connectivity [19] - Saimer has obtained the EU CEP certificate for minoxidil, marking a significant step in international business expansion [19]

Core Viewpoint - The China Securities Regulatory Commission has approved the overseas listing of Bokan Vision on the Hong Kong Stock Exchange, with plans to issue up to 133 million shares. The company is a clinical-stage ophthalmic biotech firm focused on developing therapies for eye diseases [1]. Financial Performance - Bokan Vision has not yet commercialized any products and has been operating at a loss since its inception. The losses from 2021 to June 2024 are reported as $35.398 million, $66.838 million, $129 million, and $52.111 million, respectively. Cumulatively, the losses have reached $309 million as of June 30, 2024, with a loss of approximately $46.874 million in the first half of 2024 alone [1][2]. Product Pipeline - The core products of Bokan Vision include CBT-001 and CBT-009, targeting pterygium and myopia in adolescents, respectively. CBT-001 has entered Phase 3 clinical trials in the US and China, while CBT-009 completed Phase 1/2 trials and is set to submit a new drug application to the FDA in July 2024 [1][6]. Patent and Regulatory Issues - CBT-001 is a modified new drug based on the active ingredient nintedanib, which is already approved for idiopathic pulmonary fibrosis. Bokan Vision holds a patent for using nintedanib to treat pterygium, but there are concerns about potential patent disputes, particularly with competitors like Allgenesis Biotherapeutics [3][4][5]. Commercialization Agreements - Bokan Vision has entered into exclusive commercialization agreements with Yuan Da Pharmaceutical and Santen Pharmaceutical, granting them rights to develop and market CBT-001 in various regions. The company expects to receive significant milestone payments and royalties based on sales [5]. Market Competition - CBT-009 faces intense competition in the myopia treatment market, with several companies already in advanced clinical stages. The efficacy of atropine for myopia control remains controversial, which may impact the product's market acceptance [6][7]. Challenges Ahead - Bokan Vision's lack of commercialization experience and the uncertainties surrounding its patent issues and product efficacy present significant challenges for its future development [7].