证 券 研 究 报 告 药明合联（02268.HK）深度研究报告 推荐（首次） 蓄势待发，全球领先的 XDC CRDMO 有望 进入商业化收获期 ❖ 蓄势待发，全球领先的 XDC CRDMO 有望进入商业化收获期。药明合联凭借 端到端一体化生物偶联药物 CRDMO 服务能力与行业领先的技术平台，持续 巩固并夯实全球生物偶联药物 CRDMO 领域的领先地位。 站在当前时点，公司在手项目数量稳步攀升，尤其是商业化验证前期关键环节 的 PPQ（工艺验证）项目持续增加，充分印证公司 IND 后管线正加速向商业 化阶段转化。随着公司逐步进入商业化项目收获期，收入体量与利润规模有望 实现中长期快速增长。 ❖ 从 ADC 到 XDC，生物偶联药物行业高速发展。ADC 药物作为生物偶联药物 中最主要的一类，以 2024 年销售额计已出现 6 款"重磅炸弹"药物；此外， 以双抗 ADC 和双载荷 ADC 为代表的新型 ADC 商业化在即。据 Frost & sullivan 统计及预测，全球 ADC 药物有望于 2030 年达到 662 亿美元。除了 ADC，载 体和有效载荷还可以替换为其他形式的药物，并且有望拓展肿瘤以外的多 ...

Core Viewpoint - WuXi XDC has announced a significant revenue growth forecast for 2025, alongside a cash offer to acquire Dongyao Pharmaceutical, indicating a strategic move to enhance its capacity and market position in the ADC CDMO sector [2][3]. Financial Performance - WuXi XDC expects a revenue increase of over 45% year-on-year for 2025, with gross profit growth exceeding 70% and adjusted net profit (excluding interest income) also projected to rise over 45% [2]. - Dongyao Pharmaceutical reported a revenue exceeding 1 billion RMB for 2024, marking a 41% year-on-year increase, with sales revenue from core products growing by 39% [5]. Acquisition Rationale - The acquisition of Dongyao Pharmaceutical aims to enhance WuXi XDC's operational capacity in China, broaden its project pipeline, and strengthen business synergies [3][4]. - Dongyao's existing production facilities and compliance qualifications will allow WuXi XDC to quickly utilize these resources, significantly reducing the time needed to ramp up production capacity [5][8]. Market Context - The ADC market is experiencing rapid growth, with the global ADC drug market expected to reach approximately $17.2 billion by 2025, and a compound annual growth rate (CAGR) of 30.6% projected from 2023 to 2032 [6]. - The ADC outsourcing service market is also anticipated to grow significantly, reaching $11 billion by 2030, with a CAGR of 28.4% from 2022 to 2030 [6]. Competitive Landscape - WuXi XDC's acquisition is seen as a strategic move to alleviate capacity constraints and enhance its competitive position in the ADC CDMO market, which is characterized by increasing consolidation among leading firms [9]. - The acquisition is expected to facilitate rapid capacity release, allowing WuXi XDC to take on more mid-to-late stage and commercial projects, thereby supporting sustained high growth in performance [9]. Strategic Implications - The acquisition reflects a broader trend of consolidation in the ADC CDMO industry, with larger firms leveraging mergers to enhance scale and efficiency, potentially increasing competitive pressure on smaller CDMO companies [9]. - WuXi XDC's strategy of acquiring established production capabilities is crucial for meeting the fast-paced commercialization demands of the ADC sector, which is currently facing a mismatch between expanding clinical pipelines and short-term production capacity [10][11].

香 港 交 易 及 結 算 所 有 限 公 司 及 香 港 聯 合 交 易 所 有 限 公 司 對 本 公 告 的 內 容 概 不 負 責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部 或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 WUXI XDC CAYMAN INC. （於開曼群島註冊成立的有限公司） 藥 明 合 聯 生 物 技 術 有 限 公 司* （股份代號：2268） 內幕消息 2026年醫療健康年會簡報 本公司股東及有意投資者應避免過分倚賴簡報所載的資料，且務請於買賣本公司 證券時審慎行事。 承董事會命 藥明合聯生物技術有限公司* 執行董事兼首席執行官 李錦才博士 香港，2026年1月14日 於本公告日期，本公司董事會包括(i)執行董事李錦才博士、張靖偉先生及席曉捷 先生；(ii)非執行董事陳智勝博士、顧繼傑博士及施明女士；及(iii)獨立非執行董 事Ulf GRAWUNDER博士、Kenneth Walton HITCHNER III先生及Hao ZHOU先生。 * 僅供識別 – 2 – 本 公 告 由 藥 明 合 聯 生 物 技 術 有 限 公 司 ...

Summary of WuXi AppTec Conference Call Company Overview - WuXi AppTec is a leading global contract research, development, and manufacturing organization (CRDMO) specializing in antibody-drug conjugates (ADCs) [2][3] Industry Insights - The ADC drug market is experiencing a surge in research and development activity, with Chinese companies holding a significant competitive advantage in the industry [2][5] - Chinese firms rank second globally in terms of publications and patent authorizations related to ADCs and dominate global ADC transactions [2][5] Key Financial Metrics - The company has maintained a high growth trajectory post-IPO, with a projected compound annual growth rate (CAGR) of 102% in revenue from 2022 to 2024 [2][3] - Revenue forecasts for 2025, 2026, and 2027 are estimated at 6 billion, 8.1 billion, and 10.7 billion RMB respectively, with net profits expected to reach 1.6 billion, 2.2 billion, and 2.9 billion RMB [4][7] Capital Expenditure Plans - WuXi AppTec plans to invest approximately 1.56 billion RMB in capital expenditures in 2025, with 900 million RMB allocated for the Singapore facility and 450 million RMB for the expansion of the Wuxi facility [5] - Total capital expenditures are expected to exceed 7 billion RMB by 2029 to expand production capacity in response to increasing project demands [2][5] Production Strategy - The company is implementing a dual-factory production strategy to enhance global supply chain capabilities, with the Singapore facility expected to complete machinery installation by mid-2025 and commence GMP production in 2026 [2][3] Technological Advancements - WuXi AppTec is enhancing its core competitiveness through proprietary technology platforms, including the Wuxi Da X conjugation technology platform, which supports the development of various conjugated drugs [6] - The company has accumulated extensive experience in linker and payload synthesis, which supports the development of new bioconjugate drugs and improves R&D efficiency [6] Profitability Drivers - Key drivers for profitability growth include increased production capacity from the Wuxi facility and the phased production launch of the Singapore facility, leading to improved capacity utilization and gross margin [4][7] - The company maintains reasonable growth in sales and management expenses while increasing R&D investments, contributing to overall growth [7]

Core Insights - The CXO (Contract Research Organization) sector is showing positive signals, with WuXi Biologics (2269.HK) and its spin-off WuXi AppTec (2268.HK) reporting strong growth in their H1 2025 performance [2][3] - WuXi Biologics achieved revenue of 9.95 billion yuan, a year-on-year increase of 16.1%, while WuXi AppTec reported revenue of 2.701 billion yuan, up 62.6% [2][3] Financial Performance - WuXi Biologics' IFRS gross profit grew by 27.0% to 4.25 billion yuan, with a gross margin of 42.7% [2] - WuXi AppTec's gross profit increased by 82.2% to 975 million yuan, with a gross margin of 36.1% [2] - EBITDA for WuXi Biologics rose by 50.5% to 4.22 billion yuan, with an EBITDA margin of 42.4% [2] Growth Drivers - WuXi AppTec raised its full-year revenue growth forecast from 35% to over 45%, reflecting strong confidence in its growth potential [3] - The growth is attributed to several factors, including leading technology platforms, expanded service offerings, and improved capacity utilization [4][5] Market Trends - The CXO industry is entering an upward phase, driven by demand recovery, supply-side adjustments, and improved external conditions [3] - The ADC (Antibody-Drug Conjugates) and bispecific/multispecific antibodies are key growth areas, with significant market potential projected [7][8] Order Backlog and Capacity - WuXi Biologics has a substantial order backlog of $20.34 billion, with unfulfilled service orders and potential milestone payments [5][6] - WuXi AppTec's iCMC project count reached 225, with a historical high of 37 new iCMC projects signed in H1 2025 [5][6] Industry Outlook - The ADC market is expected to grow significantly, with projections indicating a market size of $64.7 billion by 2030 [8] - The competitive landscape in the CXO sector is intensifying, with companies needing to innovate and adapt to maintain market share [9]

Core Viewpoint - WuXi AppTec (02268) has demonstrated strong growth and strategic positioning, raising its 2025 revenue growth forecast from 35% to over 45% based on order backlog and capacity release [1][10] Financial Performance - In the first half of 2025, WuXi AppTec achieved revenue of 2.701 billion RMB, a year-on-year increase of 62.2% [2] - Adjusted net profit reached 733 million RMB, with a growth rate of 69.6% [2] - Gross margin improved by 4 percentage points to 36.1%, while net profit margin stood at 27.6%, indicating enhanced profitability [2] Strategic Execution - The company's growth is attributed to the deep execution of its "empower, follow, and win molecules" strategy, with a total of 225 iCMC projects, including a record 37 new projects signed in the first half of 2025 [3] - WuXi AppTec secured 11 PPQ projects and 1 commercialization project, indicating steady progress in its project pipeline [3] Global Market Presence - International revenue accounted for 82% of total income, reflecting the effectiveness of the company's global strategy [5] - The acceleration of overseas market revenue is driven by clients advancing their pipelines and the trend of Chinese innovative drugs going global [5] Industry Dynamics - The upward revision of performance guidance is supported by multiple favorable factors, including sustained industry growth, robust order reserves totaling $1.329 billion (up 57.9% year-on-year), and accelerated project progress [7] - The company is positioned as a leader in the bioconjugate drug CRDMO sector, with over 2,300 early-stage research projects completed in the first half of the year [9] Client Base Expansion - As of June 30, WuXi AppTec served 563 clients, with 64 new additions since the end of 2024, including 13 of the top 20 global pharmaceutical companies [11] - The company's market share increased from 9.9% in 2022 to 22.2% currently, reflecting its strong position in the industry [11] Future Outlook - WuXi AppTec is expected to continue benefiting from the booming ADC market, with a projected compound annual growth rate of 31% from 2024 to 2030 [11] - The company is well-positioned to achieve a market capitalization of 100 billion RMB in the near future [11]

Core Viewpoint - WuXi AppTec (02268) has demonstrated exceptional performance in the bioconjugate drug CRDMO sector, with a revenue growth of 62.2% in the first half of 2025, significantly surpassing annual growth guidance, and achieving a compound annual growth rate (CAGR) of 98% from the first half of 2022 to the first half of 2025, solidifying its leading position in the industry [1][2][4]. Financial Performance - The company's revenue for the first half of 2025 reached 2.701 billion yuan, a year-on-year increase of 62.2%, with a gross profit of 975 million yuan, up 82.2%, and a gross margin of 36.1%, reflecting a 5.5 percentage point increase from the full year of 2024 [2][4]. - Adjusted net profit, excluding interest income and expenses, was 733 million yuan, representing a 69.6% year-on-year growth [2]. Market Position and Growth - WuXi AppTec's market share in the bioconjugate drug CRDMO sector has surged from 9.9% in 2022 to approximately 22% in the first half of 2025, indicating strong market penetration and growth [7][11]. - The company signed a record 37 new iCMC projects in the first half of 2025, with a focus on innovative ADC molecules, including bispecific ADCs and multi-load ADCs [4][12]. Client Engagement and International Expansion - The number of global clients increased to 563, with 64 new clients added in the first half of 2025, including 13 of the top 20 global pharmaceutical companies [4][11]. - Approximately 82% of the company's revenue in the first half of 2025 came from international markets, highlighting its role as a preferred partner for overseas pharmaceutical companies [11]. Production Capacity and Infrastructure - The new DP3 production facility in Wuxi has been successfully GMP released, with an annual capacity of 7 million bottles, increasing the overall DP capacity to 15 million bottles [15][19]. - The company is also advancing its global strategy with a new production base in Singapore, expected to achieve GMP release by the first half of 2026 [19][22]. Technological Advancements - WuXi AppTec has made significant investments in technology, launching new payload linker technologies, WuXiTecan-1 and WuXiTecan-2, to enhance its service offerings [29]. - The company has advanced 1,000 molecules in early research for XDC, with a focus on high-difficulty ADC types, ensuring a robust pipeline for future growth [25][29]. Conclusion - WuXi AppTec's strong project reserves, efficient capacity construction, and strategic focus on innovative ADC and bioconjugate drug development position it as a leader in the CRDMO sector, driving sustained high growth [32].

Group 1 - The company reported a revenue of RMB 2.7 billion for the six months ending June 30, 2025, representing a year-on-year increase of 62.19% [1] - The net profit attributable to the company's owners was RMB 746 million, an increase of 52.74% year-on-year, with basic earnings per share of RMB 0.62 [1] - The revenue growth was driven by the active development of the global antibody-drug conjugate (ADC) and broader bioconjugate markets, leading to an increase in both customer and project numbers [1] Group 2 - The CRDMO business showed strong momentum in the first half of 2025, with increasing global demand for its services, having empowered a total of 563 global clients [2] - The company has successfully secured 11 process validation (PPQ) projects and one commercial stage project [2] - The company has been recognized as the "Best CDMO" at the World ADC awards for 2023 and 2024, highlighting its leading position in providing technology-driven comprehensive services for ADCs and bioconjugates [2] Group 3 - The company is expanding its production capacity and attracting talent to prepare for the growing demand for bioconjugate CRDMO services [2] - The GMP release of the XDP3 formulation workshop and the expansion of the Wuxi base, including the ongoing construction of the XDP5 formulation workshop, are progressing as planned [2] - The completion of these expansions will provide additional monoclonal antibody, drug substance (DS), and drug product (DP) production lines, laboratories, and office space [2]

Core Insights - WuXi AppTec (02268) reported a revenue of RMB 2.7 billion for the six months ending June 30, 2025, representing a year-on-year increase of 62.19% [1] - The net profit attributable to the company's owners was RMB 746 million, up 52.74% year-on-year, with basic earnings per share of RMB 0.62 [1] - The revenue growth was driven by the active development of the global antibody-drug conjugates (ADC) and broader bioconjugates market, leading to an increase in both client and project numbers [1] Group Performance - The CRDMO business exhibited strong momentum in the first half of 2025, with a continuous positive expansion and increased global demand for its services [2] - As of June 30, 2025, the company has empowered a total of 563 global clients through its comprehensive CRDMO capabilities and "one-stop" facilities from drug discovery to commercialization [2] - The company has successfully secured 11 PPQ (Process Performance Qualification) projects and one commercial stage project [2] Industry Recognition - The company was awarded the "Best CDMO" title by World ADC for 2023 and 2024, highlighting its excellence in providing technology-driven comprehensive services for ADCs and broader bioconjugates [2] - The company continues to enhance its production capacity and attract talent to prepare for expanding its market share and meet the growing global demand for bioconjugate CRDMO services [2] - Ongoing projects include the GMP release of the XDP3 formulation workshop, expansion of the Wuxi base, and the construction of a new facility in Singapore, which will increase production lines and laboratory space upon completion [2]

香 港 交 易 及 結 算 所 有 限 公 司 及 香 港 聯 合 交 易 所 有 限 公 司 對 本 公 告 的 內 容 概 不 負 責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部 或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 WUXI XDC CAYMAN INC. （於開曼群島註冊成立的有限公司） 藥 明 合 聯 生 物 技 術 有 限 公 司* （股份代號：2268） 內幕消息 2025年中期業績簡報 本公 告由藥 明合 聯生物 技術有 限公司 *（「本 公司」）根據香 港聯 合交易 所有限 公司 證 券 上 市 規 則（「 上 市 規 則 」）第 13.09 條 以 及 香 港 法 例 第 571 章 證 券 及 期 貨 條 例 第 XIVA部項下的內幕消息條文（ 定義見上市規則 ）而刊發。 為使本公司股東及有意投資者能夠更深入、更全面地了解其2025年中期業績及業 務 營 運 ， 本 公 司 將 於 2025 年 8 月 19 日 上 午 八 時 三 十 分 及 下 午 八 時 三 十 分（ 香 港 時 間 ）召 開 電 話 會 議 ， 屆 時 將 就 ...