证券研究报告 | 医药生物 | 2026年01月31日 www.hczq.com 华创医药投资观点&研究专题周周谈 ·第161期 中国手术机器人行业近况更新 本周专题联系人：李焯娟 陈俊威 | 华创医药团队: | | | --- | --- | | 首席分析师郑辰 | 执业编号:S0360520110002邮箱:zhengchen@hcyjs.com | | 联席首席分析师刘浩 | 执业编号: S0360520120002邮箱: liuhao@hcyjs.com | | 医疗器械组组长李蝉娟 | 执业编号: S0360520110004邮箱: lichanjuan@hcyjs.com | | 中药和流通组组长高初营 | 执业编号:S0360524070002邮箱:gaochulei@hcyjs.com | | 高级分析师王宏雨 | 执业编号: S0360523080006邮箱: wanghongyu@hcyjs.com | | 高级分析师朱珂琛 | 执业编号: S0360524070007邮箱:zhukechen@hcyjs.com | | 分析师陈俊威 | 执业编号:S0360525060002邮箱:che ...

证券研究报告 | 医药生物 | 2026年1月24日 www.hczq.com | 华创医药团队： | | | --- | --- | | 首席分析师 郑辰 | 执业编号：S0360520110002 邮箱：zhengchen@hcyjs.com | | 联席首席分析师 刘浩 | 执业编号：S0360520120002 邮箱：liuhao@hcyjs.com | | 医疗器械组组长 李婵娟 | 执业编号：S0360520110004 邮箱：lichanjuan@hcyjs.com | | 中药和流通组组长 高初蕾 | 执业编号：S0360524070002 邮箱：gaochulei@hcyjs.com | | 分析师 王宏雨 | 执业编号: S0360523080006 邮箱: wanghongyu@hcyjs.com | | 分析师 朱珂琛 | 执业编号：S0360524070007 邮箱：zhukechen@hcyjs.com | 本报告由华创证券有限责任公司编制 报告仅供单创证券有限责任公司的客户使用，本公司不会因按人找到不报告而视其为客户。 华创证券的这些信息的准确性和完整也不作任何保证。报告中的内容 ...

根据《证券期货投资者适当性管理办法》及配套指引，本资料仅面向华创证券客户中的金融机构专业投资者，请勿对本 资料进行任何形式的转发。若您不是华创证券客户中的金融机构专业投资者，请勿订阅、接收或使用本资料中的信息。 本资料难以设置访问权限，若给您造成不便，敬请谅解。感谢您的理解与配合。 摘要 免责声明 具体内容详见华创证券研究所2026年1月16日发布的报 告《普蕊斯（301257）深度研究报告：行稳致远，SMO行业 领军者开启成长新周期》 法律声明 华创证券研究所定位为面向专业投资者的研究团队，本资料仅适用于经认可的专业投资者，仅供在新媒体背景下研究观 点的及时交流。华创证券不因任何订阅本资料的行为而将订阅人视为公司的客户。普通投资者若使用本资料，有可能因 缺乏解读服务而对报告中的关键假设、评级、目标价等内容产生理解上的歧义，进而造成投资损失。 SMO行业快速发展，未来格局有望进一步集中 。 SMO是临床试验不可或缺的一环，主要负责 临床试验非医学判断事务的执行与管理。随着国内创新药研发投入持续增长、临床试验数量稳步 提升，SMO行业迎来快速发展期。根据CDE数据，2024年中国药物临床试验年度登记总量为 49 ...

Core Viewpoint - The invisible orthodontics industry in China is experiencing a significant transformation, with leading manufacturers maintaining steady growth while smaller players face pressure due to pricing challenges. The market penetration of invisible orthodontics is expected to increase significantly in the coming years, driven by rising consumer awareness and demand for aesthetic solutions [12][25][31]. Market Overview - The CITIC Medical Index decreased by 0.72%, underperforming the CSI 300 Index by 0.15 percentage points, ranking 16th among 30 primary industries [7]. - The top ten stocks by growth this week included Baolait, Hualan, and Tianzhihang, while the bottom ten included Xiangrikui and 51 Changyao [7]. Industry and Stock Events - The invisible orthodontics market in China is projected to grow, with the penetration rate increasing from 11% in 2020 to an estimated 25% by 2030. The penetration rate for adults was 38.9% in 2020, while for children and adolescents, it was only 4.5% [17][24]. - The average selling price (ASP) of invisible orthodontics is under pressure due to increased competition and price wars among manufacturers, leading to a decline in market revenue growth compared to the number of cases [24][25]. - The leading companies, such as Times Angel and Invisalign, hold over 70% of the market share, with Times Angel maintaining growth in case numbers despite industry challenges [25][31]. Domestic Market Dynamics - The demand for invisible orthodontics is expanding in lower-tier cities, with the proportion of cases in third-tier and below cities rising from 22% in 2021 to 29% in 2023 [18]. - The market is witnessing a shift towards head manufacturers as smaller firms struggle to compete, leading to an accelerated market consolidation [25]. International Market Trends - The global invisible orthodontics market is expected to reach $4.8 billion by 2024, with North America dominating the market share at 56.9% [31][32]. - Chinese manufacturers are increasingly entering international markets, with Times Angel reporting a significant increase in overseas cases, which accounted for 39% of its total cases by 2024 [32]. Future Outlook - The invisible orthodontics industry is anticipated to continue its growth trajectory, with increasing consumer awareness and a shift towards aesthetic dental solutions. The market is expected to see further consolidation as smaller players exit due to competitive pressures [25][31].

Core Viewpoint - The article discusses the development and commercialization of brain-computer interface (BCI) technology, highlighting its market potential, competitive landscape, and various applications, particularly in the medical field [3][5]. Group 1: Brain-Computer Interface Overview - BCI technology establishes a direct communication pathway between the brain and external devices, with steady progress in commercialization leading to vast market opportunities [3]. - The competitive landscape in China's BCI sector is still in its early stages, with most companies being small and not yet in a saturated market [3]. - There are two main types of BCI products: invasive BCIs, which offer significant signal quality advantages, and non-invasive BCIs, which are safer and easier to operate, serving as a complement to invasive types [3]. - Current applications are primarily in the medical field, with future potential to expand into non-medical areas [3]. - The industry chain has high technological barriers at the upstream level, while the mid and downstream sectors exhibit strong agglomeration effects [3]. Group 2: Global Leader Neuralink's Path to Industrialization - Neuralink, a global pioneer in BCI, is expected to enter the industrial application phase by 2025, with 12 patients having successfully implanted devices [4]. - The company plans to scale production of BCI devices starting in 2026, transitioning from laboratory research to large-scale manufacturing [4]. - Neuralink has outlined a three-step technology iteration plan, aiming to increase the number of electrodes in implants significantly by 2028 to enable comprehensive brain connectivity [4]. - The company has identified three core product lines: Telepathy for motor function recovery, Blindsight for visual perception restoration, and Deep for neurological function recovery [4]. - Neuralink's competitive advantages include advanced electrode technology, precise implantation robotics, and low-power signal processing systems [4]. - The development of Neuralink offers insights for domestic companies, emphasizing the importance of interdisciplinary research, clinical collaboration, and gradual commercialization [4]. Group 3: Factors Driving BCI Industrialization in China - National strategies are guiding the BCI sector, with local policies being introduced to support its development [5]. - Clinical advancements are accelerating, with significant breakthroughs in various BCI applications, including invasive and semi-invasive systems [5][6]. - The financing market for BCI is thriving, with 24 financing events recorded in 2025, marking a 30% year-on-year increase [5]. - The supporting industry chain for BCI technology is rapidly forming, facilitating the practical application of BCI in medical, production, and daily life scenarios [6]. Group 4: Key Companies in the BCI Sector - Notable companies in the BCI field include: - Xinwei Medical (interventional BCI) - Maipu Medical (neurosurgical consumables) - Kefu Medical (bionic implant BCIs) - Meihua Medical (upstream BCI industry) - Sanbo Brain Science (neurological specialty medical group) - Weisi Medical (rehabilitation BCIs) - Mailande (rehabilitation BCIs) - Xiangyu Medical (rehabilitation BCIs) - Chengyitong (comprehensive BCIs) - Aipeng Medical (neuro-regulation BCIs) - Chuangxin Medical (exoskeleton BCIs) [11].

Industry Overview - The diabetes patient population is expected to reach 853 million globally by 2050, creating significant demand for diagnosis and treatment due to the chronic nature of the disease [3] - The Continuous Glucose Monitoring (CGM) market is projected to grow from $5.7 billion in 2020 to $36.5 billion by 2030, driven by technological advancements [3] - The insulin pump market, particularly patch-style devices, is rapidly developing, with the closed-loop artificial pancreas expected to become mainstream by 2026 [3] Company Profile - Weitai Medical is the only company in China with both a commercially available patch-style insulin pump and a real-time, no-calibration CGM, with the artificial pancreas expected to receive approval by 2026 [4] - The company has established itself as a leader in the domestic market, with superior product performance and a strong distribution network, achieving significant sales milestones such as being the top seller on Tmall for CGM products during the 2025 Double Eleven shopping festival [4] - Weitai Medical's overseas revenue surged to 121 million yuan in the first half of 2025, marking a 218% increase, indicating strong growth potential in international markets [5] Financial Outlook - The company is expected to turn a profit, with operating cash flow turning positive in the first half of 2025, and a projected net profit of 31 million yuan in 2025, increasing to 154 million yuan by 2027 [5] - The current market valuation is significantly undervalued, with a price-to-sales ratio of around 2 times for 2025 revenue, compared to historical valuations of comparable companies [5] - The target market capitalization is set at 5.8 billion HKD, with a target share price of 13.7 HKD, reflecting a strong buy recommendation [5]

Market Review - The CITIC Medical Index increased by 7.70%, outperforming the CSI 300 Index by 4.91 percentage points, ranking 5th among 30 primary industries [8] - The top ten stocks by increase this week include: Bibet-U, Innovation Medical, Sanbo Brain Science, and others, with significant gains [8] - The top ten stocks by decrease include: Baihua Medicine, Jinhao Medical, and others, with notable declines [8] Overall View and Investment Themes - The domestic innovative drug industry is transitioning from quantity logic to quality logic, focusing on differentiated and internationalized pipelines, with an emphasis on products that can generate profits by 2025 [11] - In the medical device sector, there is a noticeable recovery in bidding volumes for imaging equipment, with ongoing updates and acceleration in overseas expansion [11] - The innovative chain (CXO + life science services) is expected to see a rebound in overseas investment, with domestic investment stabilizing, indicating a potential bottoming out [11] - The pharmaceutical industry is anticipated to enter a new growth cycle, with cost improvements in specialty raw materials and a focus on patent expirations leading to new growth opportunities [11] Traditional Chinese Medicine - The basic drug directory is expected to be released, with unique basic drugs projected to grow faster than non-basic drugs, indicating a potential market rebound [12] - The reform of state-owned enterprises is expected to enhance the fundamental performance of companies, particularly after adjustments to the evaluation system [12] - The new medical insurance directory is expected to benefit certain companies, with a focus on OTC enterprises that cater to aging populations and have strong dividend characteristics [12] Medical Services - The anti-corruption and centralized procurement efforts are expected to purify the medical market environment, enhancing the competitiveness of private medical services [12] - The rapid expansion of commercial insurance and self-funded medical services is likely to provide more competitive advantages for private healthcare providers [12] Blood Products - The approval of plasma stations is expected to increase supply, with companies expanding their product offerings and production capacity, indicating a clear long-term growth path for the blood products industry [12]

Market Overview - The CITIC Pharmaceutical Index decreased by 2.02%, underperforming the CSI 300 Index by 1.44 percentage points, ranking 27th among 30 primary industries [8] - The top ten stocks with the highest gains this week include Duorui Pharmaceutical, Maillande, and Xiangyu Medical, while the top ten stocks with the largest declines include *ST Changyao and Shuyupingmin [8][37] Overall View and Investment Themes - The domestic innovative drug industry is transitioning from quantity logic to quality logic, emphasizing differentiated and internationalized pipelines, with a focus on products that can generate profits [11] - In the medical device sector, there is a notable recovery in bidding volumes for imaging equipment, and the home medical device market is benefiting from subsidy policies [11] - The CXO and life sciences services sector is expected to see a rebound in overseas investment and a bottoming out of domestic investment, indicating a potential upturn in the innovation chain [11] - The specialty raw materials pharmaceutical industry is anticipated to experience a new growth cycle, with a focus on the impact of patent expirations on new product volumes [11] Specific Industry Insights Innovative Drugs - The company has significantly increased its pipeline, with the number of innovative products rising from 3 to 18 since 2022, and plans to launch an average of 5 innovative products annually over the next three years [15][16] - The revenue share from innovative products is expected to exceed 50% by 2025, driven by a robust pipeline and strategic partnerships [15][16] Medical Devices - The orthopedic market is projected to grow due to aging demographics and increased surgery penetration, with domestic companies benefiting from the acceleration of local replacements [17] - The IVD market, particularly in chemiluminescence, is expected to grow rapidly, with domestic brands increasing their market share through competitive pricing and improved product offerings [18] Life Sciences Services - The life sciences services sector is recovering, with demand expected to rise in both domestic and overseas markets, driven by increased investment in biopharmaceuticals [24] - The industry is characterized by low penetration rates and a trend towards domestic substitution, with significant opportunities for growth through mergers and acquisitions [24] Traditional Chinese Medicine and Medical Services - The traditional Chinese medicine sector is expected to benefit from policy changes and an aging population, with a focus on unique therapeutic areas and high-dividend stocks [26][31] - The medical services sector is anticipated to improve due to anti-corruption measures and the expansion of commercial insurance, enhancing the competitiveness of private healthcare providers [26] Investment Recommendations - The company recommends focusing on the pharmacy sector due to the acceleration of prescription outflow and the optimization of competitive dynamics, suggesting that the pharmacy sector is poised for recovery [25] - In the medical device sector, attention is drawn to companies that are well-positioned to benefit from domestic substitution and technological advancements [19]

Core Viewpoint - Differentiated R&D capability is one of the core competitive advantages of the company, with a focus on high-end generic drug selection and project initiation supporting early growth and capital accumulation, leading to a successful breakthrough among small and mid-cap companies [3] R&D Strategy and Integration - The company has undergone a systematic R&D strategic adjustment in 2025, integrating its existing R&D system and gaining control of Shanghai Chaoyang, which is expected to enhance its R&D capabilities significantly [4] - The integrated R&D path combines "Chengdu Yuandong's controlled substances" and "Shanghai Chaoyang's oncology/immunology," allowing the company to strengthen its existing weaknesses while steadily advancing in the controlled substances field [4] Product Pipeline and Clinical Progress - HP-001, a leading candidate in the targeted protein degradation field, shows promising clinical progress with an overall response rate (ORR) of 53% in Phase I trials, and 83% in high-dose groups [5] - HP-002, a brain-penetrating BTK PROTAC, is expected to submit an IND application in early 2026, demonstrating superior degradation efficiency compared to competitors [5] - HP-003, a VAV1 molecular glue, is anticipated to become a new star in autoimmune diseases, with plans to submit an IND in the second half of 2026 [5] - The DAC platform combines antibody precision delivery with protein-targeted degradation, showcasing the company's competitive edge in the TPD and DAC fields [5] Financial Projections - The company forecasts net profits attributable to shareholders of 277 million, 316 million, and 388 million yuan for 2025, 2026, and 2027, respectively, reflecting year-on-year growth rates of 16.2%, 14.0%, and 22.9% [6] - The current stock price corresponds to price-to-earnings (PE) ratios of 38, 34, and 27 for the respective years, with a target valuation of 15.51 billion yuan for 2026, translating to a stock price of 87.6 yuan per share [6]

Core Viewpoint - The SMO (Site Management Organization) landscape is stable, and the industry is expected to enter a new growth cycle, driven by the increasing demand for clinical trials and the recovery of innovative drug development [13][20][31]. Market Review - The CITIC Pharmaceutical Index decreased by 0.19%, underperforming the CSI 300 Index by 2.14 percentage points, ranking 26th among 30 primary industries [6]. - The top ten stocks by growth this week included Hongyuan Pharmaceutical and Luyuan Pharmaceutical, with growth rates of 59.43% and 37.34% respectively [5][6]. Overall Viewpoint and Investment Themes - The innovative drug sector is transitioning from quantity to quality, emphasizing differentiated products and international pipelines, with a focus on companies that can deliver profits by 2025 [8]. - In the medical device sector, there is a notable recovery in bidding volumes for imaging equipment, and home medical devices are benefiting from subsidy policies [8]. - The CXO and life sciences services sector is expected to see a rebound in investment, with a focus on high-growth potential companies as the industry recovers from previous downturns [8]. SMO Industry Insights - The number of clinical trials in China is steadily increasing, with a projected 4,900 new drug clinical trials in 2024, reflecting a 13.9% year-on-year growth [17]. - The SMO industry is expected to reach a market size of 35 billion yuan by 2030, driven by the rising complexity of clinical trials and the demand for high-quality services [17][20]. - The introduction of AI technology in SMO processes is anticipated to enhance efficiency and reduce costs, particularly in labor-intensive tasks [25]. Investment Recommendations - The medical device sector is recommended for investment, particularly in imaging equipment and home medical devices, which are expected to see significant growth due to policy support and market recovery [46]. - The low-value consumables market is also showing signs of improvement, with domestic manufacturers experiencing a rebound in orders as inventory levels normalize [47]. - The pharmaceutical retail sector is poised for growth due to the acceleration of prescription outflow and an improving competitive landscape, particularly for listed chain pharmacies [53]. Specific Company Insights - Companies like Pusens and Tianzhong have shown resilience and growth in their operational metrics, with Pusens improving its gross margin from 16.23% in Q1 2025 to 25.58% by Q3 2025 [22]. - The domestic SMO market is still in its early stages, with the top five players holding approximately 25-30% market share, indicating potential for consolidation and growth [27]. - The life sciences service sector is expected to benefit from increased domestic and international demand, with a focus on companies that can leverage their capabilities for growth [52].