2)虹软科技(金鹰基金参与公司业绩说明会&电话会议) 调研纪要：虹软科技在2025年上半年的机构调研中，详细介绍了公司在手机业务、AI眼镜、智能辅助驾驶等多个领域的进展。手机业务方面，Q2 收入波动主要因客户项目验收延迟，但全年仍看好移动智能终端业务成长性。AI眼镜业务已与5-6个品牌签约，未来将从1.0音频眼镜发展到3.0带 屏幕AR眼镜，解决对焦、成像质量等核心问题。智能辅助驾驶产品方面，智能停车辅助系统和智能辅助驾驶系统完成技术验证，L2级解决方案进 入商业化落地阶段。毛利率下滑因智能汽车业务软硬一体产品出货，未来将转向纯软件授权，目标毛利率90%。研发人员数量保持稳定，下半年 不会大幅增加。手机业务增长逻辑包括智能芯片和硬件升级、扩大渗透率、开发影像和视觉相关应用，降低硬件成本。 调研纪要：捷捷微电2025年半年度报告显示，公司实现营业收入160,047.70万元，同比增长26.77%。晶闸管、防护器件和MOSFET为主要收入来 源，分别占主营业务收入的17.94%、34.31%和47.75%。2025年第二季度，晶闸管、防护器件和MOSFET的营收分别为1.51亿、3.15亿和4.25亿。毛 利率下 ...

Company Overview - WuXi AppTec (02268.HK) has raised its revenue growth forecast for 2025 from 35% to over 45%, driven by strong order backlog, accelerated project progress, and capacity release [1][2] - The company reported a revenue of 2.701 billion yuan and a net profit of 746 million yuan for the first half of the year, with 82% of revenue coming from overseas markets [1][2] Project and Capacity Development - As of June 2025, the total number of iCMC (integrated Chemistry, Manufacturing, and Control) projects has reached 225, with 37 new projects signed in the first half of 2025, marking a historical high [2] - The company completed over 2,300 early-stage research projects for bioconjugated drugs, including dual-antibody ADCs and novel conjugated drugs [2] - WuXi AppTec is advancing its capacity layout under the "global dual-plant production" strategy in Wuxi and Singapore to prepare for commercial production next year [2] Market Position and Growth - The company's market share has increased from 9.9% in 2022 to 22.2% currently [3] - The ADC (Antibody-Drug Conjugate) market is experiencing explosive growth, with a projected compound annual growth rate (CAGR) of 34% from 2020 to 2024 and 31% from 2024 to 2030 [4] - The global ADC outsourcing service market is expected to reach $11 billion by 2030, growing over 300% from 2024 [4] Industry Trends - The demand for integrated CRDMO (Contract Research, Development, and Manufacturing Organization) services is increasing among global pharmaceutical giants and innovative drug companies, benefiting WuXi AppTec as a leading ADC CRDMO provider [4][5] - The number and value of domestic innovative drug BD (business development) transactions have reached new highs, with 52 transactions involving Chinese innovative drugs going overseas, including 18 transactions exceeding $1 billion [4]

Core Viewpoint - The article discusses the emergence of NewCo transactions in China's innovative pharmaceutical sector, highlighting a shift where Chinese investment firms, such as Sequoia China, are becoming buyers in these deals, leveraging China's clinical efficiency and cost advantages to enhance the global market value of targeted drugs [1][3][6]. Group 1: NewCo Transactions Overview - NewCo transactions have seen a significant increase in China, with 14 similar deals occurring since the beginning of 2024, primarily involving both large and small pharmaceutical companies [2][6]. - The first NewCo transaction led by a Chinese fund involved a $10 million upfront payment to Lepu Biopharma, marking a notable shift in the buyer landscape from predominantly foreign funds to domestic investors [2][4][6]. Group 2: Investment Strategy and Market Impact - Sequoia China's investment strategy focuses on identifying differentiated assets, particularly in the T-cell engager (TCE) space, which has limited competition in solid tumors compared to blood cancers [6][7]. - The transaction structure allows Lepu Biopharma to retain a 10% stake in the new company, Excalipoint, and potentially earn up to $848 million in milestone payments and sales royalties, indicating a strategic approach to funding and asset management [7][10]. Group 3: Clinical Development and Cost Efficiency - The new company will conduct Phase I clinical trials in China, utilizing local resources to expedite development, contrasting with previous models that prioritized overseas clinical trials [12][13]. - The cost of conducting clinical trials in China is significantly lower than in the U.S., with estimates suggesting a cost difference of five to seven times, which enhances the feasibility of early-stage drug development [13]. Group 4: Management and Operational Considerations - The success of NewCo transactions relies heavily on the experience of the management team, with a focus on ensuring seamless integration of core technologies and research strategies [9][10]. - The article emphasizes the importance of strong relationships with potential buyers and understanding their pipeline needs, which is crucial for the successful exit of NewCo assets [16]. Group 5: Market Perception and Future Outlook - Despite some skepticism regarding the low upfront payments typical of NewCo deals, they remain a vital funding avenue for innovative pharmaceutical companies facing financial pressures [17]. - The article suggests that as the market for innovative drugs recovers, more NewCo transactions are likely to emerge, providing opportunities for companies to secure funding while maintaining involvement in their drug pipelines [17].

证券研究报告·公司点评报告·医药生物 新诺威（300765） 2025 年中报点评：持续加码研发，EGFR ADC 下半年有望启动首个海外注册临床 买入（维持） | [Table_EPS] 盈利预测与估值 | 2023A | 2024A | 2025E | 2026E | 2027E | | --- | --- | --- | --- | --- | --- | | 营业总收入（百万元） | 2,539 | 1,981 | 2,392 | 2,765 | 3,294 | | 同比（%） | (3.34) | (21.98) | 20.76 | 15.59 | 19.13 | | 归母净利润（百万元） | 434.44 | 53.73 | 57.30 | 58.91 | 128.17 | | 同比（%） | (40.18) | (87.63) | 6.66 | 2.80 | 117.57 | | EPS-最新摊薄（元/股） | 0.31 | 0.04 | 0.04 | 0.04 | 0.09 | | P/E（现价&最新摊薄） | 171.36 | 1,385.60 | 1,299.09 | 1,263.68 | ...

Investment Rating - The industry investment rating is "Positive" (maintained) [1] Core Insights - The report highlights the transformation of China's medical insurance system from a "single basic coverage" model to a "basic insurance + commercial insurance supplementary" dual-track system, marked by the introduction of the commercial insurance innovative drug directory [5][13] - The commercial insurance innovative drug directory primarily focuses on high-value innovative drugs in oncology, immunology, and rare diseases, providing a new pathway for these drugs to gain market access [6][20] - The report indicates that the inclusion of innovative drugs in both the basic and commercial insurance directories is expected to lead to rapid revenue growth for related companies, benefiting patients and driving growth for innovative pharmaceutical firms [6][29] Summary by Sections Section 1: National Drug Review and Commercial Insurance Directory - The announcement of the national drug review results and the debut of the commercial insurance innovative drug directory occurred on August 12, 2025, indicating a significant policy shift [5][13] - The commercial insurance directory includes 121 drugs, focusing on those with high clinical value and significant patient benefits, particularly in oncology and rare diseases [20][27] - The report emphasizes that the commercial insurance directory allows for a more flexible pricing mechanism, which does not count towards hospital drug expenditure ratios, thus facilitating the market entry of high-value innovative drugs [28][24] Section 2: Market Performance and Trends - In August 2025, the pharmaceutical and biotechnology sector saw a 3.08% increase, outperforming the CSI 300 index by 0.7 percentage points [2][10] - The medical research outsourcing sector experienced the highest growth, while the offline pharmacy sector faced declines [10][12] - The report notes that the inclusion of over 20 traditional Chinese medicines in the 2025 basic medical insurance directory, primarily unique products, reflects a growing recognition of traditional medicine [6][29] Section 3: Recommended Stocks and Beneficiaries - Recommended stocks in the pharmaceutical and biotechnology sector include companies such as Heng Rui Medicine, East China Medicine, and Innovent Biologics, among others [7] - The report also highlights potential beneficiaries in the CXO sector, including WuXi AppTec and Tigermed, as well as companies in the medical device and service sectors [7][29]

Core Viewpoint - 康宁杰瑞制药-B (09966)预计在截至2025年6月30日的六个月内实现利润不少于人民币2000万元，相较于2024年同期的亏损约人民币4490万元，显示出公司在财务上的显著改善 [1] Financial Performance - 康宁杰瑞制药-B在最新公告中提到，报告期内公司实现了转亏为盈，主要得益于三项授权合作的里程碑收入和商业化产品的销售收入 [1] Technology and Pipeline - 广发证券指出，康宁杰瑞制药-B在抗体药物偶联物（ADC）、双特异性抗体和多功能蛋白质工程方面拥有完善的专有技术平台，内部管线高度差异化，涵盖处于不同研发阶段的抗肿瘤药物 [1] - 公司差异化的生物大分子平台以及已展现初步临床疗效的ADC药物的发展潜力受到看好 [1]

Core Viewpoint - 康宁杰瑞制药-B expects to achieve a profit of no less than RMB 20 million for the six months ending June 30, 2025, compared to a loss of approximately RMB 44.9 million in the same period of 2024, indicating a turnaround from loss to profit driven by milestone revenues from three licensing collaborations and sales from commercialized products [1][1][1] Group 1 - Following the announcement, 康宁杰瑞制药-B's stock rose over 3%, currently trading at HKD 9.42 with a transaction volume of HKD 10.1093 million [1][1] - 广发证券 highlights the company's robust proprietary technology platform in ADC, bispecific antibodies, and multifunctional protein engineering, suggesting a strong differentiation in its internal pipeline [1][1] - The company’s pipeline includes various anti-tumor drugs at different stages of development, showcasing its potential for growth in the biopharmaceutical sector [1][1]

Core Viewpoint - The investment value of innovative drugs is not a short-term pulse but a long-term industrial dividend, with optimal solutions for sharing this dividend through index tools in golden tracks [1] Group 1: Performance of Innovative Drug Indices - Since July, the National Index for Hong Kong Stock Connect Innovative Drugs and the China Securities Innovative Drug Industry Index have reached new highs, with year-to-date increases of 106.7% and 32.3% respectively as of July 31 [2] - The impressive performance of these indices reflects a decade-long transformation of China's innovative drug industry from "follower" to "leader" [2] - Recent inflows into ETFs tracking innovative drug indices have been significant, with a net inflow of 4.26 billion yuan from August 4 to August 8 and over 16 billion yuan since June [2] Group 2: Index Adjustments and Sensitivity - The recent upgrade of the Hong Kong Stock Innovative Drug Index aims to enhance its focus by excluding CXO companies and increasing adjustment frequency from semi-annual to quarterly, effective August 12 [3][4] - This adjustment allows the index to better capture the core drivers of the innovative drug industry, focusing on pharmaceutical companies that lead drug development and hold key patents [3] - The increased adjustment frequency enhances the index's sensitivity, enabling it to quickly identify emerging growth companies in a rapidly evolving market [4] Group 3: Policy Support for Innovative Drugs - The innovative drug industry has received significant policy support this year, with the State Council's 2025 strategic goal to create a globally competitive innovation ecosystem [5] - Multiple regulatory bodies have introduced supportive measures, including optimizing review processes and reopening IPO channels for unprofitable companies [6] - The 2024 medical insurance fund expenditure on innovative drugs is projected to be 3.9 times that of 2020, with an annual growth rate of 40% [7] Group 4: Market Dynamics and Future Outlook - By the end of 2024, China is expected to have 3,575 original innovative drugs in clinical trials, surpassing the U.S. and becoming the global leader [7] - The proportion of first-in-class (FIC) drugs has increased from less than 10% in 2015 to 24% in 2024, indicating a significant enhancement in original innovation capabilities [7] - The innovative drug market in China currently accounts for less than 10% of the total pharmaceutical market, indicating substantial growth potential compared to over 20% in other G20 countries [9] Group 5: Investment Opportunities in Innovative Drugs - The China Securities Innovative Drug Industry Index has shown a year-to-date increase of 32.3%, with significant upside potential remaining [8] - The long-term growth of the innovative drug market is supported by an aging population and increasing demand for treatments for chronic diseases and rare diseases [8] - Investing in ETFs that track the innovative drug sector provides a way to mitigate risks associated with individual stock investments while capitalizing on overall industry growth [9]

Core Viewpoint - The chairman of Maiwei Biotech, Liu Datao, has been penalized for short-term trading of the company's stock, violating securities laws, and must return related profits to the company [2][6]. Company Overview - Liu Datao has served as the general manager and director of Maiwei Biotech since June 1, 2020, and became chairman on June 1, 2023, earning a total salary of 7.4 million yuan over the past three years [5]. - Under Liu's leadership, Maiwei Biotech has made significant progress in product research and development, focusing on innovative drugs and biosimilars, with a portfolio that includes antibodies, ADC drugs, and recombinant proteins [6]. Financial Performance - Since its establishment in 2017, Maiwei Biotech has consistently reported losses, with a cumulative net loss exceeding 6 billion yuan as of the first quarter of 2025, primarily due to substantial R&D investments totaling over 4.425 billion yuan [8]. - The company has faced cash flow challenges, with 1.119 billion yuan in cash on hand against 1.073 billion yuan in short-term loans and 210 million yuan in current non-current liabilities, alongside 962 million yuan in long-term debt [8]. Product Pipeline and Market Strategy - As of the first quarter of this year, Maiwei Biotech has 16 core products in various stages of development, including 12 innovative drugs and 4 biosimilars, with 3 products already on the market [6]. - The company is rapidly advancing its international strategy, having secured formal agreements for its products in multiple countries, including submissions for market approval in Pakistan and Indonesia [6].

Summary of Jiuzhou Pharmaceutical Conference Call Company Overview - **Company**: Jiuzhou Pharmaceutical - **Industry**: Pharmaceutical Contract Development and Manufacturing Organization (CDMO) Key Points CDMO Business Growth - Jiuzhou Pharmaceutical's CDMO business is experiencing steady growth with a rich project pipeline, including 38 projects that have been launched and 90 in Phase III clinical trials, along with over 1,000 projects in Phase I and II [2][4][5] - The company serves over 80 global clients, covering more than 100 active projects, including innovative drugs, generics, and high-barrier formulations [2][4] Emerging Business Segments - Rapid growth in emerging businesses such as peptides and pentavalent vaccines, with over 20 new clients acquired, and orders nearing $10 million [2][6] - Successful delivery of over ten projects in these segments, indicating significant future growth potential [2][6] Generic Drug Business - Steady progress in the generic drug sector, with two specialty raw materials and two generic formulations approved in the first half of the year [2][7] - A total of 22 projects in the generic pipeline, with 8 approved and 9 under review [2][7] Financial Performance - For the first half of 2025, Jiuzhou Pharmaceutical reported revenue of 2.87 billion yuan, a year-on-year increase of 3.86%, and a net profit of 526 million yuan, up 10.7% [3] - The company has strengthened relationships with major clients, particularly in the Japanese and Korean markets, leading to significant project growth [3] Capacity Utilization and Profit Margins - CDMO capacity utilization is steadily increasing, with optimistic gross margin expectations for the next two to three years due to process optimization and a higher proportion of high-value products [2][10] - The gross margin for the first half of 2025 was approximately 41%, with expectations for stability throughout the year [12] New Factory Developments - The new factory in Taizhou has completed validation for five CDM raw material projects and is attracting numerous follow-up projects due to high management standards and successful FDA inspections [2][13] - The factory's capacity utilization is expected to continue increasing in the coming years [13] Market Trends and Client Structure - The client structure remains predominantly large pharmaceutical companies, accounting for 70-75% of business, with significant growth in the U.S. market [14][15] - The company anticipates an increase in collaboration with large pharmaceutical firms, driven by successful partnerships and potential acquisitions of biotech clients [15] Future Plans and Capital Expenditure - Jiuzhou Pharmaceutical plans to enhance global R&D capabilities and expand advanced production capacity, with a multi-functional GMP production line expected to be operational by late 2025 [9][21] - The company has approximately 3 billion yuan in cash reserves for strategic investments and acquisitions [21] International Expansion - The company has made significant inroads into the Japanese market, becoming a supplier for over half of the top ten pharmaceutical companies in Japan, with a growth rate of 30-40% annually [22] - Plans for further expansion into Europe and the U.S. are underway, focusing on small molecule production lines [17] New Product Development - Jiuzhou Pharmaceutical is focusing on new business areas such as small nucleic acids and ADCs, with expectations for significant contributions in the next two to three years [23][24][26] - The company is also expanding its peptide production capacity to meet growing demand, with a new facility set to produce 800 kg annually [25] Overall Confidence - The company expresses strong confidence in continued growth across all business segments, particularly in overseas client expansion and recovery in industry cycles [31]