2026 年 1 月 8 日，南方科技大学 董哲 副教授、 余沛源 助理教授作为共同通讯作者，在国际顶尖学术期刊 Science 上发表了题为： Leveraging triatropic rearrangements for stereoselective skeletal reshuffling 的研究论文。 这项研究提出了一种新型周环反应—— 三向重排 （ triatropic rearrangement） ，实现了对饱和碳环骨架的高选择性编辑，三向重排不仅兼具高立体控制与广泛 适用性，还能与经典反应模块化组合 ， 为 复杂环 戊烷及天然产物骨架的精准编辑提供了全新路径。 编辑丨王多鱼 排版丨水成文 周环反应 （ Pericyclic reaction ） 能够以精妙的立体控制将简单前体转化为结构复杂的产物，使其成为合成化学的核心工具。 在这项最新研究中，研究团队报道了一类称为 三向重排 （ triatropic rearrangement） 的新型周环反应，该反应在单一过渡态中同时断裂三个 σ 键并形成两个 σ 键与一个 π 键。在此机理框架下，环氧化物中的碳-氧键可通过有机硼试剂介导，立体选择性地转 ...

该研究由华东理工大学费林加诺贝尔奖科学家联合研究中心完成。2019年，研究团队在参观上海中心大 厦时受到启发。该大厦于2016年建成，是目前中国第一高楼、世界第三高楼，以多项创新技术在超高层 建筑史上具有里程碑意义。研究团队特别注意到，其独特的内外双层螺旋外观不仅赋予建筑独特的空气 动力学稳定性，也令人联想到生命体系中的螺旋结构，如DNA和某些蛋白质。由此，研究团队提出一 个科学设想：能否在非生物体系中，通过化学合成手段构建具有类似几何特征和动态功能的人工高分 子？ 生物体内的螺旋高分子承担着信息存储、结构支撑或催化等关键功能，其精密构型被认为是"生命密 码"的物理载体。然而，数十年来，化学家虽然能合成出螺旋结构高分子，但往往基于难降解、难回收 的刚性骨架，不具备天然螺旋高分子一样的动态功能。 此次研究团队从最基础的小分子出发，尝试将氨基酸、二硫键等天然的、与生物相容的"分子积木"，通 过动态可逆的化学键连接起来，构筑出稳定的螺旋构象。不过，早期设计的分子仅靠氢键等弱相互作用 维持螺旋，一旦受热或环境变化，结构便迅速"坍塌"。 螺旋聚合物和上海中心大厦结构示意图。 资料图片 近期，中国与荷兰科学家合作完成的一 ...

Core Idea - The article highlights the innovative contributions of Barry Sharpless, a two-time Nobel Prize-winning chemist, particularly focusing on his philosophy of simplicity in chemistry, exemplified by his development of click chemistry, which has transformed the field by emphasizing functional molecular synthesis over complex structures [5][6]. Group 1: Background and Personal Journey - Barry Sharpless's early experiences as a child fishing in New Jersey shaped his curiosity and passion for discovering new biological entities, which he likens to his pursuit of interesting chemical reactions [2]. - Despite losing vision in one eye due to a laboratory accident at age 29, Sharpless continues to explore the field of chemistry with resilience, believing in the potential of serendipitous discoveries [2][4]. Group 2: Click Chemistry - Click chemistry, introduced by Sharpless in 1998, aims to simplify chemical synthesis by focusing on functional outcomes rather than complex structures, challenging the prevailing academic belief that complexity equates to advancement [5][6]. - Sharpless faced initial rejection from top journals for his click chemistry papers, but the concept eventually gained recognition, leading to his second Nobel Prize in Chemistry in 2022, validating its impact on the field [5][6]. Group 3: Academic Philosophy and Approach - Sharpless emphasizes a practical and straightforward approach to research, often discarding ideas that do not yield results quickly, which he believes fosters innovation [4][5]. - He expresses disdain for the competitive nature of academic publishing, preferring to focus on the completion of research rather than the politics of authorship [3][4]. Group 4: International Collaboration and Influence - Over the past decade, Sharpless has established strong academic ties with China, frequently visiting Shanghai to collaborate on research and promote international scientific cooperation [8][9]. - He has been instrumental in mentoring Chinese students and researchers, contributing to the development of a new generation of chemists in China, who are now shaping the future of the field [9].

此次会议经无记名投票选举，中山大学教授侯仰龙当选为首届主任委员，中国科学院院士、中国科学院 长春应用化学研究所研究员陈学思和浙江大学教授李志波、福州大学教授杨黄浩、武汉大学教授袁荃当 选为副主任委员。会议还选举产生了首届委员会委员共56人。委员会聘任北京大学王術人为秘书长。 首届主任委员侯仰龙介绍了专委会下一步的工作计划。随后，与会委员就专委会的组织建设、未来发展 和学术活动进行了讨论并提出了多项建议。 (陈菲) 中化新网讯 11月22日，中国化学会生物医用材料化学专业委员会成立大会在深圳召开。此次会议采用 线下和线上相结合的方式，来自科研院所、高等院校、医院等单位的40余位代表参加了成立大会。 ...

Core Viewpoint - The article discusses a significant advancement in the asymmetric synthesis of N-chiral compounds, highlighting a collaborative research effort that successfully achieved the first catalytic asymmetric synthesis of these compounds, which is crucial for future studies in this area [4][5]. Group 1: Research Background - The research was conducted by a team from Southern University of Science and Technology and UCLA, focusing on controlling pyramidal nitrogen chirality through asymmetric organocatalysis [4]. - The study addresses the challenges associated with the instability of nitrogen stereocenters and the limited success in asymmetric synthesis of non-cyclic N-chiral compounds [5][7]. Group 2: Methodology and Findings - The team proposed a method to synthesize challenging non-cyclic N-chiral chlorohydroxylamines through asymmetric chlorination reactions, capturing unstable chiral intermediates to obtain more stable N-chiral molecules [7]. - A significant breakthrough was achieved using a chiral phosphoric acid catalyst, leading to the successful synthesis of 21 N-stereocenters with high enantioselectivity [8]. - The research demonstrated that introducing a rigid bicyclic structure near the nitrogen atom significantly improved the stability of the configuration, reducing racemization [10]. Group 3: Mechanism and Results - The study confirmed that the key step for stereoselectivity was the chlorination reaction, followed by an intramolecular nucleophilic substitution that adhered to the S N 2 mechanism, ensuring effective transfer of chirality [10]. - The final products exhibited enantiomeric excess values greater than 90%, showcasing the method's effectiveness and broad applicability [10].

Core Viewpoint - The research team led by Zhang Xiaoheng from the University of Chinese Academy of Sciences has developed a groundbreaking method for direct deamination functionalization using N-nitrosamines, which challenges the traditional industrial processes that have been in use for 140 years [1] Summary by Relevant Sections Research Breakthrough - The new method allows for the direct transformation of aromatic amines into various C-X bonds (including carbon-halogen, carbon-oxygen, carbon-nitrogen, and carbon-carbon bonds) through the in-situ formation of N-nitrosamine intermediates under nitric acid mediation, followed by the removal of dinitrogen oxide [1] Industrial Implications - This innovative approach addresses several issues associated with the traditional stepwise strategy, such as the instability and explosive hazards of diazonium salts, significant copper consumption, and limited substrate compatibility [1] Practical Application - The research team has also developed a one-pot deamination cross-coupling strategy, enabling multiple cross-coupling reactions to be completed within the same reaction system by simply adding the corresponding coupling reagents to the deamination intermediate [1] Scalability - The new method can efficiently achieve kilogram-scale synthesis of target products using common laboratory reagents, making it applicable in pharmaceutical and materials manufacturing sectors [1]

Core Viewpoint - The article discusses a groundbreaking research published in Nature, which introduces a new method for direct deaminative functionalization using N-nitroamines, providing a safer and more efficient alternative to traditional aromatic amine transformations that rely on hazardous diazonium salts [1][2]. Group 1: Research Breakthrough - The research presents a novel approach that allows for the direct conversion of inert aromatic carbon-nitrogen (C-N) bonds into various important chemical bonds, including carbon-halogen, carbon-oxygen, carbon-nitrogen, and carbon-carbon bonds [1][2]. - This method utilizes common laboratory reagents and enables kilogram-scale synthesis, challenging the traditional processes that have been in use for 140 years [2][3]. Group 2: Industrial Implications - The new strategy is expected to have broad applications in critical fields such as pharmaceuticals and materials manufacturing, offering a safe and economical alternative to the widely used but hazardous aryl diazonium chemistry [2][3]. - The direct deaminative functionalization method simplifies the synthesis process and subsequent functionalization by combining deaminative functionalization with transition metal-catalyzed arylation [2][3]. Group 3: Mechanism and Advantages - Mechanistic studies indicate that the reactivity of the aromatic carbon cation equivalent during the deamination process is typically dominant, highlighting the potential of this method in synthetic chemistry [3]. - The direct deamination approach provides a significant advantage over other deaminative functionalization methods, as it is applicable to a wide range of drug-relevant heteroaryl amines with varying electronic and structural properties [2][3].

Core Insights - The article discusses the introduction of the Reac-Discovery semi-autonomous digital platform by the research team from IMDEA Materials Institute in Spain, which addresses the lack of a unified model for geometric parameters in reactor design, enhancing the speed and precision of catalytic reactor development [1][2]. Group 1: Platform Overview - Reac-Discovery integrates design, manufacturing, and optimization modules in a closed-loop system, allowing for parallel evaluation of multiple reactors while incorporating real-time NMR monitoring and machine learning for process optimization [2][6]. - The platform utilizes periodic open pore structures (POCs) to improve performance, reaction efficiency, and material consumption, while enhancing system versatility [2][6]. Group 2: Research Highlights - The integration of mathematical modeling, machine learning, and automated experimental systems allows for a comprehensive approach to catalytic reactor design, from geometric design to experimental optimization [3]. - The platform incorporates topological parameters into the optimization space, overcoming the limitations of traditional methods that focus on single variables like temperature and flow rate [3]. - A neural network-based performance prediction model has been developed, significantly improving experimental efficiency and resource utilization through rapid evaluation iterations [3]. Group 3: Data Generation and Modules - The research team generated an internal multidimensional dataset during experiments, covering geometric structures, printability, and reaction performance, without relying on external datasets [3][4]. - The Reac-Discovery platform consists of three functional modules: Reac-Gen for geometric modeling, Reac-Fab for manufacturing, and Reac-Eval for experimental validation and optimization [6][12]. Group 4: Experimental Validation - The platform's effectiveness was validated through two typical multiphase catalytic reactions: the hydrogenation of phenylacetone and CO₂ cycloaddition, demonstrating robustness, stability, and repeatability in self-optimization and topological reconstruction [15][20]. - In the phenylacetone hydrogenation experiments, the platform successfully identified optimal process conditions from over one million parameter combinations, significantly reducing experimental exploration costs [16][20]. Group 5: Industry Implications - The rapid integration of artificial intelligence in flow chemistry and reactor engineering is establishing self-driving laboratories as a new paradigm in chemical research, enhancing precision, efficiency, and scalability in reaction processes [22][23]. - The potential for self-driving laboratories to replace certain research roles while creating new opportunities highlights the transformative impact of automated systems in scientific exploration [23].

Group 1 - The core achievement in the field of chemistry is the successful design of metal-organic frameworks (MOFs) with large cavities, enabling the ordered combination of metal ions and organic molecules, which provides new methods for synthesizing compounds with controllable spaces [3] - The discovery is seen as a significant advancement that could help address major challenges related to resources, energy, and environmental issues [3] - The work of the award-winning researchers has led to the development of various flexible MOFs that can change shape when filled or emptied of different substances, showcasing their potential applications [1][3] Group 2 - The stable material MDF-5, constructed by Yaghi in 1999, can hold an area equivalent to a football pitch with just a couple of grams, highlighting the efficiency and utility of MOFs [1] - The ongoing research in this area is focused on leveraging the properties of MOFs to find solutions for pressing global challenges [3]

Core Insights - Clarivate announced the 2025 Citation Laureates, recognizing 22 distinguished scholars from 8 countries, including Zhang Tao from China for his pioneering work in single-atom catalysis, making him the first scientist from mainland China to receive this award [1][3]. Group 1: Award Significance - The Citation Laureates award is based on a comprehensive evaluation of multidimensional data, including citation performance, originality and breakthrough of research, identification of core contributors, and peer recognition [5]. - Since its establishment in 2002, 83 Citation Laureates have eventually won Nobel Prizes, highlighting the award's significance in identifying impactful researchers [5]. Group 2: Zhang Tao's Contributions - Zhang Tao and his team proposed the concept of single-atom catalysis in 2011, advancing heterogeneous catalysis research to an atomic precision scale, laying the scientific foundation for precise control in catalytic processes [3]. - The systematic research conducted by Zhang's team not only advanced the field of catalysis but also had a broad impact on various interdisciplinary fields such as energy chemistry, materials science, and biomedicine [3]. - Single-atom catalysis has influenced both academia and industrial applications, with new processes achieving industrial-scale implementation, supporting green chemistry and carbon neutrality goals [3].