每经AI快讯，9月29日，港交所文件显示，长春高新（000661）技术产业(集团)股份有限公司向港交所 提交上市申请书，独家保荐人为中信建投（601066）国际。 ...

Core Viewpoint - Rongchang Biopharma (09995) saw a stock increase of over 7%, reaching 109.4 HKD with a trading volume of 357 million HKD, following the announcement of its drug Taitasip being prioritized for review for treating adult patients with primary immunoglobulin A (IgA) nephropathy, significantly reducing proteinuria levels [1][1][1] Group 1: Drug Development and Clinical Trials - On September 28, the CDE announced that Taitasip is proposed for priority review for treating IgA nephropathy, which poses a risk of progression [1] - On August 27, Rongchang Biopharma reported that the Phase III study of Taitasip for IgA nephropathy achieved its primary endpoint in Stage A, showing a 55% reduction in the 24-hour urine protein-to-creatinine ratio (UPCR) compared to the placebo group after 39 weeks of treatment [1][1][1] Group 2: Mechanism of Action - Taitasip is currently the only drug that can simultaneously inhibit B lymphocyte stimulator (BLyS) and proliferation-inducing ligand (APRIL), both of which are significantly elevated in IgA nephropathy patients compared to the normal population, acting as key drivers of the disease [1] - By inhibiting these two factors, Taitasip can reduce B cell proliferation, lower plasma cell counts, and decrease the generation of abnormal immunoglobulins, thereby blocking the deposition of immune complexes and alleviating renal immune inflammatory responses [1][1][1]

Core Viewpoint - Rongchang Biologics (09995) saw a significant stock increase of over 7%, reaching HKD 109.4 with a trading volume of HKD 357 million, following the announcement of its drug Taitasip being prioritized for review for treating adult patients with primary immunoglobulin A (IgA) nephropathy [1] Group 1: Drug Development and Clinical Trials - On September 28, the CDE website indicated that Taitasip is proposed for inclusion as a priority review product for treating adult patients with IgA nephropathy at risk of progression, significantly reducing proteinuria levels [1] - Previously, on August 27, Rongchang Biologics announced that the Phase III study of Taitasip for IgA nephropathy achieved its primary endpoint in Stage A, showing a 55% reduction in the 24-hour urine protein-to-creatinine ratio (UPCR) compared to the placebo group after 39 weeks of treatment [1] Group 2: Mechanism of Action - Taitasip is currently the only drug that can simultaneously inhibit B lymphocyte stimulator (BLyS) and proliferation-inducing ligand (APRIL), both of which are significantly elevated in IgA nephropathy patients compared to the normal population, serving as key drivers of the disease [1] - By inhibiting these two factors, Taitasip can reduce B cell proliferation, lower plasma cell counts, and decrease the production of abnormal immunoglobulins, thereby blocking the deposition of immune complexes at the source and alleviating renal immune inflammatory responses [1]

Group 1 - The core point of the article highlights the recent performance of Olin Biological, which saw a 5.1% increase in stock price, reaching 26.80 yuan per share, with a total market capitalization of 10.879 billion yuan [1] - Olin Biological, established on December 11, 2009, specializes in the research, production, and sales of human vaccines, with the majority of its revenue coming from the adsorbed tetanus vaccine at 90.99% [1] - The company also generates revenue from other vaccines, including A group C group meningococcal polysaccharide conjugate vaccine (4.49%), b-type Haemophilus influenzae type b conjugate vaccine (3.99%), and others [1] Group 2 - From the perspective of fund holdings, Olin Biological is a significant investment for the Fuyong Fund, with its Fuyong Medical Health Mixed Fund A (015655) holding 17,200 shares, representing 2.06% of the fund's net value [2] - The fund has seen a floating profit of approximately 22,400 yuan from this investment, with a total fund size of 11.8186 million yuan [2] - Year-to-date, the fund has achieved a return of 14.22%, with a one-year return of 10.55%, although it has experienced a loss of 20.8% since its inception [2]

Core Viewpoint - Rongchang Biologics (09995) saw a stock increase of over 7%, reaching HKD 109.4 with a trading volume of HKD 357 million, following the announcement of its drug Taizhisip being prioritized for review for treating adult patients with primary immunoglobulin A (IgA) nephropathy [1] Company Developments - On September 28, the CDE announced that Rongchang Biologics' Taizhisip is proposed for inclusion in the priority review category for treating adult patients with IgA nephropathy at risk of progression, significantly reducing proteinuria levels [1] - On August 27, Rongchang Biologics reported that the Phase III study of Taizhisip for treating IgA nephropathy achieved its primary endpoint in Stage A, showing a 55% reduction in the 24-hour urine protein-to-creatinine ratio (UPCR) compared to the placebo group after 39 weeks of treatment [1] Drug Mechanism - Taizhisip is currently the only drug that can simultaneously inhibit B lymphocyte stimulator (BLyS) and proliferation-inducing ligand (APRIL), both of which are significantly elevated in IgA nephropathy patients compared to the normal population, serving as key drivers of the disease [1] - By inhibiting these two factors, Taizhisip can reduce B cell proliferation, lower plasma cell counts, and decrease abnormal immunoglobulin production, thereby blocking the deposition of immune complexes and alleviating renal immune inflammatory responses [1]

Core Viewpoint - Rongchang Biologics (09995) saw a stock increase of over 7%, currently at 109.4 HKD, with a trading volume of 357 million HKD, following the announcement of its drug Taitasip being prioritized for review for treating adult patients with primary immunoglobulin A (IgA) nephropathy [1] Group 1: Drug Development and Clinical Trials - On September 28, the CDE website indicated that Taitasip is proposed for inclusion in the priority review category for treating adult patients with IgA nephropathy at risk of progression, significantly reducing proteinuria levels [1] - On August 27, Rongchang Biologics announced that the Phase III study of Taitasip for treating IgA nephropathy achieved its primary endpoint in Stage A, showing a 55% reduction in the 24-hour urine protein-to-creatinine ratio (UPCR) compared to the placebo group after 39 weeks of treatment [1] Group 2: Mechanism of Action - Taitasip is currently the only drug that can simultaneously inhibit B lymphocyte stimulator (BLyS) and proliferation-inducing ligand (APRIL), both of which are significantly elevated in IgA nephropathy patients compared to the normal population, serving as key drivers of the disease [1] - By inhibiting these two factors, Taitasip can reduce B cell proliferation, lower plasma cell counts, and decrease the generation of abnormal immunoglobulins, thereby blocking the deposition of immune complexes at the source and alleviating renal immune inflammatory responses [1]

值得一提的是，国元国际指出，公司在2025年世界肺癌大会上公布IMM2510单药在晚期肺鳞状非小细 胞肺癌(sq-NSCLC)患者中的初步疗效与安全性数据，数据来源于I期临床研究的剂量递增及队列扩展阶 段。IMM2510此次公布单药治疗的ORR为35.3%，PFS为9.4个月，临床数据优秀，安全性良好。 消息面上，据动脉网报道，近日，宜明昂科自主研发的VEGF×PD-L1双特异性抗体IMM2510，已向国 家药品监督管理局药品审评中心递交两项针对不同类型肺癌的III期注册临床试验的EOP2沟通交流申 请，标志着其临床开发进入关键阶段。 据介绍，IMM2510基于"mAb-Trap"技术平台研发，通过多重机制发挥抗肿瘤作用。I期临床研究显示， IMM2510治疗经免疫治疗的晚期鳞状非小细胞肺癌客观缓解率达35.3%，疾病控制率为76.5%，中位无 进展生存期为9.4个月，安全性可控;II期初步数据显示联合化疗一线治疗NSCLC效果显著。基于积极结 果，宜明昂科计划在III期临床试验中进一步验证IMM2510的疗效和安全性。 来源：智通财经网 宜明昂科-B(01541)涨超12%，截至发稿，涨12.27%，报12 ...

据介绍，IMM2510基于"mAb-Trap"技术平台研发，通过多重机制发挥抗肿瘤作用。I期临床研究显示， IMM2510治疗经免疫治疗的晚期鳞状非小细胞肺癌客观缓解率达35.3%，疾病控制率为76.5%，中位无 进展生存期为9.4个月，安全性可控;II期初步数据显示联合化疗一线治疗NSCLC效果显著。基于积极结 果，宜明昂科计划在III期临床试验中进一步验证IMM2510的疗效和安全性。 值得一提的是，国元国际指出，公司在2025年世界肺癌大会上公布IMM2510单药在晚期肺鳞状非小细 胞肺癌(sq-NSCLC)患者中的初步疗效与安全性数据，数据来源于I期临床研究的剂量递增及队列扩展阶 段。IMM2510此次公布单药治疗的ORR为35.3%，PFS为9.4个月，临床数据优秀，安全性良好。 （原标题：港股异动 | 宜明昂科-B(01541)涨超12% IMM2510两项III期注册临床试验已递交EOP2） 智通财经APP获悉，宜明昂科-B(01541)涨超12%，截至发稿，涨12.27%，报12.72港元，成交额2390.9万 港元。 消息面上，据动脉网报道，近日，宜明昂科自主研发的VEGF×PD-L1双特异 ...

Group 1 - The stock of Yiming Oncology-B (01541) increased by over 12%, reaching HKD 12.72 with a trading volume of HKD 23.9 million [1] - Yiming Oncology has submitted two EOP2 communication requests for its self-developed VEGF×PD-L1 bispecific antibody IMM2510 to the National Medical Products Administration for Phase III clinical trials targeting different types of lung cancer, marking a critical stage in its clinical development [1] - The IMM2510 is developed based on the "mAb-Trap" technology platform and demonstrates antitumor effects through multiple mechanisms [1] Group 2 - Phase I clinical trials showed that IMM2510 achieved an objective response rate (ORR) of 35.3% and a disease control rate of 76.5% in patients with advanced squamous non-small cell lung cancer (sq-NSCLC), with a median progression-free survival (PFS) of 9.4 months and manageable safety [1][2] - Preliminary data from the Phase I clinical study presented at the 2025 World Lung Cancer Conference indicated excellent clinical data and good safety for IMM2510 as a monotherapy in advanced sq-NSCLC patients [2] - Based on positive results, Yiming Oncology plans to further validate the efficacy and safety of IMM2510 in Phase III clinical trials [1]

Core Viewpoint - The article highlights the contrasting performance and strategies of two A-share pharmaceutical companies, Shuyou Shen (舒泰神) and Zhaoyan New Drug (昭衍新药), both controlled by the same entrepreneurial couple, Feng Yuxia and Zhou Zhiwen. While Shuyou Shen focuses on innovative drug development, Zhaoyan New Drug operates as a contract research organization (CRO), providing more stable revenue streams. The article discusses their stock performance, financial results, and the implications of their business models on future growth [1][3][4]. Stock Performance - Shuyou Shen's stock price reached 33.87 CNY per share with a year-to-date increase of 357.09%, resulting in a total market capitalization of 16.18 billion CNY [2][4]. - Zhaoyan New Drug's stock price was 36.93 CNY per share, reflecting a year-to-date increase of 115.7%, with a total market capitalization of 27.68 billion CNY [2][4]. Financial Performance - Shuyou Shen reported a revenue of approximately 126 million CNY for the first half of the year, a decline of 31.14% year-on-year, and a net loss of 25 million CNY, a decrease of 619.7% year-on-year [6]. - Zhaoyan New Drug achieved a revenue of about 669 million CNY, down 21.28% year-on-year, but turned a profit with a net income of 61 million CNY, marking a turnaround from previous losses [6][7]. Business Models - Shuyou Shen is focused on developing innovative drugs, particularly a new treatment for hemophilia, which has the potential for significant market impact if successfully commercialized [8][9]. - Zhaoyan New Drug's business is closely tied to the market for laboratory monkeys, which are essential for drug research. The company's financial performance is influenced by the pricing and availability of these animals [7][10]. Management and Ownership - Feng Yuxia primarily oversees Zhaoyan New Drug, holding 22.3% of its shares, while Zhou Zhiwen is the chairman of Shuyou Shen, with the couple collectively holding over 31% of Shuyou Shen's shares through a holding company [4][11]. Regulatory and Market Challenges - Shuyou Shen has faced regulatory scrutiny due to related party transactions with Zhaoyan New Drug, which raised concerns about compliance with listing commitments [11][12]. - Both companies may face long-term challenges, including the potential impact of technological advancements that could reduce reliance on animal testing in drug development [9][10].