医药生物行业 行业研究 | 动态跟踪 创新领航，春华秋实 ——医药生物 2024 年报及 2025 年一季报综述 核心观点 ⚫ 投资建议与投资标的 风险提示 国家/地区 中国 行业 医药生物行业 报告发布日期 2025 年 05 月 06 日 | 伍云飞 | wuyunfei1@orientsec.com.cn | | --- | --- | | | 执业证书编号：S0860524020001 | | | 香港证监会牌照：BRX199 | | 傅肖依 | fuxiaoyi@orientsec.com.cn | | | 执业证书编号：S0860524080006 | 坚守院内，创新担纲：——医药生物 2024 年三季报综述 2024-11-11 回归正常成长，坚守院内：——医药生物 2023 年报&2024 一季报综述 2024-05-15 有关分析师的申明，见本报告最后部分。其他重要信息披露见分析师申明之后部分，或请与您的投资代表联系。并请阅读本证券研究报告最后一页的免责申明。 ⚫ 看好（维持） ⚫ 上市公司：板块分化持续加深，化学制药表现亮眼。全行业 24 年营收增速同比- 0.6%，为近年来首次增速同比下 ...

证券研究报告 | 行业周报 2025 年 05 月 06 日 医药 本周医药板块上涨 0.49%，百济神州 BCL-2 抑制剂申报上市 | 股票 | 股票 | 投资 | EPS（元） | | PE | | | --- | --- | --- | --- | --- | --- | --- | | 代码 | 名称 | 评级 | 2025E | 2026E | 2025E | 2026E | | 002755.SZ | 奥赛康 | 买入 | 0.2 | 0.28 | 93.95 | 67.11 | | 01952.HK | 云顶新耀 | 买入 | -0.94 | 0.58 | - | - | | 600079.SH | 人福医药 | 增持 | 1.59 | 1.86 | 13.13 | 11.22 | | 688192.SH | 迪哲医药 | 增持 | -1.33 | -0.08 | -43.54 | -723.88 | | 688315.SH | 诺禾致源 | 买入 | 0.53 | 0.62 | 26.53 | 22.68 | | 688321.SH | 微芯生物 | 增持 | 0.05 | 0.23 | 3 ...

[Table_Tag] [Table_Summary] 投资要点 2025 年 05 月 05 日 证券分析师 朱国广 执业证书：S0600520070004 zhugg@dwzq.com.cn 证券研究报告·公司点评报告·生物制品 百济神州-U（688235） 2024 年年报点评：营收大幅增长，2025 年将 迎来 GAAP 经营性利润转正 买入（维持） | [Table_EPS] 盈利预测与估值 | 2023A | 2024A | 2025E | 2026E | 2027E | | --- | --- | --- | --- | --- | --- | | 营业总收入（百万元） | 17,423 | 27,214 | 35,855 | 43,743 | 53,367 | | 同比（%） | 82.13 | 56.19 | 31.75 | 22.00 | 22.00 | | 归母净利润（百万元） | (6,715.86) | (4,978.29) | 403.50 | 3,592.88 | 6,748.76 | | 同比（%） | 50.77 | 25.87 | 108.11 | 790.43 | 87. ...

板块总结及投资逻辑 总体来看，除创新药板块业绩和股价表现强势走出独立行情以外，医药板块在 2024 年和 202501 景气度仍有待复苏。 在整体医保支付环境压力、医疗行业秩序整顿、海外贸易不确定性、消费环境变化等因素的影响下，2024 年和 2025 年 q1 医药板块整体业绩持续承压，利润端持续下滑。除了创新药板块走出独立行情以外，其他板块的整体股价表现 也相对较弱。 但考虑到政策端、基本面、和市场面的压制因素已经基本出清，同时 2024 年医药业绩基数前高后低，基数压力逐季 度下降，我们非常看好 2025 年下半年医药板块成功实现景气度反转，业绩端增速止跌回升，回到增长趋势。在这一 根本性的变化基础上，医药板块股价表现也有望整体性走强。 药品板块：创新药龙头商业销售和 BD 业绩持续兑现，走出独立行情。创新药龙头创新药营收与创新资产 BD 收入持续 上行兑现。随着临床推进和数据读出，中国创新药企业肿瘤、自免及慢病领域潜力大单品预期不断增强，给细分赛道 领先公司的成长空间和估值修复提供了有力支撑。全球领先的创新品种逐步进入业绩放量兑现期，同时国际领先的临 床突破或 BD（授权引进或出海）不断涌现。看好本土 ...

公司报告 | 季报点评 科兴制药（688136） 证券研究报告 2025Q1 海外收入持续增长，创新平台进入收获期 事件 近日，公司发布 2024 年年报和 2025 年第一季度报告。公司 2024 年全年 营业收入为 14.07 亿元，同比增长 11.75%，归母净利润为 0.31 亿元，同比 增长 116.54%。2025 年第一季度，公司实现营业收入 3.54 亿元，同比下降 1.97%，外销收入增长 84.33%，归母净利润为 2558 万元，同比增长 106%。 创新平台渐入收获期，靶点创新度大，具有出海潜力 公司针对 GDF-15 靶点候选在研药物 GB18 关于治疗肿瘤恶病质的临床试 验已经获得 NMPA 受理。已正式发表的临床前研究数据显示其在恶病质小 鼠模型上可以有效地缓解体重减轻情况并恢复身体机能。根据 WHO 数据 显示，2022 年全球新发肿癌症病例数 2000 万，约半数患者为晚期，其中 50-80%的患者受到恶病质影响，约 900 万目标患者，市场空间大。 GDF-15 靶点在研药物的肿瘤恶病质适应症已 POC，临床获益初步确认。 目前辉瑞制药的 Ponsegromab 于 ESM ...

公司报告 | 季报点评 科兴制药（688136） 证券研究报告 2025Q1 海外收入持续增长，创新平台进入收获期 2024 年海外收入 2.24 亿元，同比增长约 61.96%。根据股权激励，2025 年 海外收入相较 2023 年的目标增速为 200%-400%，预计为 4.15-6.92 亿元。 科兴制药海外销售渠道已经覆盖七十多个国家和地区，在巴西、墨西哥、 新加坡、德国、越南、埃及等地设立了子公司，覆盖欧州、中南美、东南 亚、中东北非等区域。目前已引进 10 余款重磅药物的海外商业化权益， 近期，引进的产品阿达木单抗和贝伐珠单抗已分别获得沙特和巴西等地的 GMP 证书。公司于 2024 年引进的九源基因的司美格鲁肽生物类似物，其 有望于 2025 年在国内获批上市，科兴制药已同步开展海外上市准入的准 备工作，预计于 2025 年向巴西 ANVISA 递交 NDA。近期，公司与科伦药 业、海创药业等公司签署战略合作，进一步扩大公司海外业务拓展基础。 事件 近日，公司发布 2024 年年报和 2025 年第一季度报告。公司 2024 年全年 营业收入为 14.07 亿元，同比增长 11.75%，归母净利 ...

Core Viewpoint - The A-share pharmaceutical and biotechnology sector demonstrated resilience in 2024 despite a complex external environment, with innovative drugs entering a phase of realization and development progress catalyzing growth, unaffected by trade wars, positioning it as a key investment theme for 2025 [1][8]. Overall Performance - A-share pharmaceutical and biotechnology companies reported stable performance, with total revenue in 2024 reaching 2.47 trillion yuan, slightly down from 2.50 trillion yuan in 2023, and a net profit attributable to shareholders of 140.26 billion yuan [2][3]. Revenue Breakdown - The overall sector had 499 companies, with a total revenue of 24,651.04 billion yuan in 2024, reflecting a year-on-year decrease of 1.50%. The first quarter of 2025 saw total revenue of 6,037.04 billion yuan, down 6.14% year-on-year [3]. - Sub-sectors such as chemical pharmaceuticals, pharmaceutical commerce, and medical devices achieved positive revenue growth in 2024, while only the medical services sector showed positive growth in Q1 2025 [4]. Individual Company Performance - Among the companies, 234 reported revenue growth in 2024, with 59 companies exceeding a 20% increase. In terms of net profit, 231 companies saw growth, with 140 exceeding 20% [5]. - Shanghai Pharmaceuticals achieved revenue of 275.25 billion yuan in 2024, up 5.75%, with a net profit of 4.55 billion yuan, a 20.82% increase. The company also reported a significant increase in R&D investment [5]. - Jiuzhoutong reported revenue of 151.81 billion yuan in 2024, a 1.11% increase, driven by stable growth in its pharmaceutical distribution business and rapid growth in emerging sectors [6]. Market Attention - The pharmaceutical and biotechnology sector has garnered significant market attention since April, with many companies receiving institutional research interest, particularly those involved in innovative drugs [7]. - Huadong Medicine's recent annual report and Q1 performance attracted considerable institutional investor interest, focusing on product development and future industry trends [7]. Investment Outlook - Analysts remain optimistic about innovative drugs, overseas expansion, and the clearing of procurement policies, suggesting that the sector is entering a growth phase with potential in insulin, orthopedics, and certain generic drug companies [8]. - The market is expected to see increased activity in mergers and acquisitions as the pharmaceutical market undergoes a phase of concentration [8].

沃森生物（300142）公告，2025年4月30日，公司董事会收到董事黄镇先生的书面辞职报告。黄镇先生 因个人原因辞去公司第五届董事会董事职务，辞职自报告送达董事会时生效。黄镇先生不再担任公司及 子公司其他职务。截至公告披露日，黄镇先生持有公司股份1769.87万股。黄镇先生辞职不会导致董事 会成员低于法定最低人数，不会对公司董事会的正常运作产生重大影响。 ...

Core Viewpoint - The stock of Olin Bio (688319) shows a strong overall score of 57.61, indicating a robust performance in the market [1]. Price and Cost Analysis - The current main cost is 15.98 CNY, with a 5-day average cost of 15.83 CNY, a 20-day average of 15.34 CNY, and a 60-day average of 14.15 CNY [1]. - The stock has not experienced any limit-up or limit-down events in the past year [1]. Northbound Capital Data - The holding amount is 422,200 shares, accounting for 0.1% of the circulating shares [1]. - The net purchase yesterday was 48,200 shares, with a daily increase ratio of 0.012% [1]. - The 5-day increase ratio is 0.005%, while the 20-day increase ratio is -0.028% [1]. Technical Analysis - The short-term resistance level is at 15.99 CNY, while the short-term support level is at 15.58 CNY [2]. - The mid-term resistance level is at 16.39 CNY, and the mid-term support level is at 12.79 CNY [2]. - The current short-term and mid-term trends are unclear, awaiting direction from main capital [2]. K-Line Patterns - The K-line pattern indicates a "friend attack" and a bottom reversal, suggesting potential upward movement [2]. - However, the presence of a long upper shadow indicates significant resistance at higher price levels, suggesting that upward momentum may be hindered [2]. Fund Flow Data - As of April 30, 2025, the net outflow of main capital was 1.277 million CNY, representing -3% of the total transaction amount [2]. - There was a net inflow of 1.6169 million CNY from large orders, while large orders saw a net outflow of 2.894 million CNY [2]. - Retail investors experienced a net outflow of 461,900 CNY [2]. Financial Data - The latest financial report shows an earnings per share of -0.017 CNY and an operating profit of -0.07 billion CNY [2]. - The price-to-earnings ratio is not available, but the sales gross margin is reported at 93.43% [2]. - The net profit stands at -7,041,533.34 CNY [2]. Related Industries/Concepts - The stock is associated with sectors such as bioproducts (0.60%), biovaccines (0.43%), innovative drugs (0.52%), and western development (0.47%) [2].

Core Viewpoint - The company reported a revenue of 303 million yuan in 2024, a year-on-year increase of 0.64%, but faced a net loss of 44.74 million yuan, marking its first loss since going public due to intensified competition in the animal health industry and declining vaccine prices [1] Group 1: Financial Performance - The company achieved a revenue of 303 million yuan in 2024, reflecting a growth of 0.64% compared to the previous year [1] - The net profit attributable to shareholders was a loss of 44.74 million yuan, which is the first loss since the company was listed [1] - The decline in gross margin was attributed to increased competition and lower prices for vaccine products, despite an increase in product sales [1] Group 2: Product Development and Market Strategy - The company is focused on expanding its market share in the government procurement sector and enhancing its presence in the pig vaccine market while also developing the ruminant vaccine market and improving its pet biological product offerings [1] - In the pig vaccine segment, several products are in the approval process, including vaccines for porcine infectious pleuropneumonia and porcine reproductive and respiratory syndrome [1] - The company has made significant progress in developing new pet biological products, including a long-acting recombinant canine alpha interferon and mRNA vaccines [2] Group 3: Research and Development - The company invested 85.99 million yuan in R&D in 2024, with a notable acceleration in the conversion of research results, filing 28 national patent applications and obtaining 2 new veterinary drug registration certificates [2] - The company’s animal inactivated vaccine workshop has passed GMP certification, and the construction of production lines for live vaccines and mRNA vaccines is progressing steadily [2] Group 4: Expansion into Human Medicine - The company is leveraging its technology platform to explore opportunities in the human medicine sector, establishing a subsidiary focused on innovative drugs and investing in a company specializing in human monoclonal antibodies [3] - The company plans to commercialize the sale of experimental pigs to support its product development efforts [3]