编辑丨王多鱼 排版丨水成文 心脏 是人体循环系统的核心动力器官，其结构和功能的完整性对于生命和健康的维系至关重要。根据世界 卫生组织和全球健康研究数据，心血管疾病长期以来一直是人类健康的"头号杀手"。随着年龄增长，心脏逐 渐出现结构重塑、收缩与舒张功能减退以及心肌纤维化等衰老特征，显著增加了冠心病、心力衰竭、心律 失常等心脏疾病的风险，并且常常与高血压、动脉粥样硬化等疾病交织存在，进一步加重疾病负担。 然而，当前针对心脏衰老的干预手段非常有限。深入解析心脏衰老的分子机制，对于开发延缓心脏功能退 化、预防老年相关心血管疾病的新策略具有极为重要的科研意义和临床应用价值。 2025 年 4 月 29 日，国家生物信息中心 张维绮 团队联合中国科学院动物研究所 曲静 、 刘光慧 团队，首都 医科大学附属北京安贞医院 姚艳 团队，在 Nature 子刊 Nature Cardiovascular Research 上 发表了题为： ARID5A Orchestrates Cardiac Aging and Inflammation through MAVS mRNA Stabilization 的研究论文。 该研究利用 ...

Group 1 - The core viewpoint of the articles highlights the financial performance and market position of He Yuan Biological Technology Co., Ltd., a biotech company focused on gene therapy [1][2] - As of the first quarter of 2025, He Yuan reported a revenue of 52.85 million yuan, a year-on-year decrease of 11.29%, and a net loss of approximately 59.48 million yuan, representing a 41.04% decline compared to the previous year [1] - The company's gross profit margin was reported at -36.44%, indicating challenges in profitability [1] Group 2 - He Yuan's current stock price is 5.42 yuan, with a market capitalization of 3.518 billion yuan and a price-to-book ratio of 2.17 [1] - The company is among seven institutions holding shares, with a total of 83.47 million shares valued at 459 million yuan [1] - In comparison to industry averages, He Yuan's price-to-earnings ratio (TTM) is -10.37, while the industry average is 40.74 [2]

Company Overview - He Yuan Bio is a biotechnology company focused on gene therapy, providing CRO services for basic research and CDMO services for drug development [1] - The company offers products including gene therapy CRO, gene therapy CDMO, biological agents, and reagents [1] Financial Performance - For the fiscal year 2024, He Yuan Bio reported revenue of 248 million yuan, representing a year-on-year increase of 21.16% [1] - The net profit for the same period was -321.81 million yuan, showing a year-on-year decline of 151.54% [1] - The gross profit margin was reported at -37.81% [1] Shareholder Information - As of March 31, 2025, the number of shareholders for He Yuan Bio was 12,181, a decrease of 122 from the previous count [1] - The average market value of shares held by each shareholder was 352,800 yuan, with an average holding of 27,600 shares [1] Market Valuation - He Yuan Bio's closing stock price was 5.68 yuan, with a market capitalization of 3.687 billion yuan and a price-to-book ratio of 2.12 [1] - The company's PE (TTM) ratio was reported at -11.46, while the industry average PE (TTM) was 45.89 [2]

4月16日，和元生物今日收盘5.49元，下跌4.19%，最新市净率1.91，总市值35.63亿元。 股东方面，截至2024年9月30日，和元生物股东户数12482户，较上次增加370户，户均持股市值35.28万 元，户均持股数量2.76万股。 序号股票简称PE(TTM)PE(静)市净率总市值(元)11和元生物-10.96-10.961.9135.63亿行业平均 45.0541.013.36141.40亿行业中值46.9735.682.4248.61亿1普瑞眼科-185.6423.202.8062.17亿2何氏眼 科-146.8145.011.4828.60亿3光正眼科-92.66220.167.4720.38亿4迪安诊断-92.2327.771.2185.37亿5南华生 物-81.46-107.1912.1430.20亿6创新医疗-42.79-42.792.2640.20亿7国际医学-32.95-32.033.23117.99亿8嘉和 美康-26.93-26.932.2640.40亿9皓宸医疗-22.04-22.704.7821.42亿10美迪西-11.99-11.991.6137.86亿 来源：金融界 和元 ...

Company Overview - He Yuan Biological Technology (Shanghai) Co., Ltd. focuses on the gene therapy field, providing CRO services for basic research and CDMO services for drug development [1] - The company offers products including gene therapy CRO, gene therapy CDMO, biological agents, and reagents [1] Financial Performance - For the third quarter of 2024, the company reported revenue of 184 million yuan, a year-on-year increase of 34.22% [1] - The net profit for the same period was -189.77 million yuan, representing a year-on-year decline of 166.90% [1] - The sales gross margin was -21.95% [1] Market Position - As of the third quarter of 2024, 40 institutions hold shares in He Yuan Biological, with a total holding of 6.84 million shares valued at 34 million yuan [1] - The company's latest closing price was 5.43 yuan, with a market capitalization of 3.524 billion yuan and a price-to-book ratio of 1.89 [1] Industry Comparison - The average PE (TTM) for the industry is 46.28, while He Yuan Biological has a PE (TTM) of -10.84 [2] - The industry median PE (TTM) is 47.68, indicating that He Yuan Biological is significantly below industry averages [2]

Investment Rating - The report maintains an "Outperform" rating for the industry [7]. Core Insights - The report highlights the potential of gene therapy for retinal diseases, particularly focusing on the single-dose treatment that could replace long-term injections, with a specific emphasis on Kanghong Pharmaceutical [4][5]. - The global market for retinal diseases, primarily age-related macular degeneration (AMD), is approaching $20 billion and continues to grow, indicating significant unmet medical needs [4][32]. - The report identifies key players in the gene therapy space, including REGENXBIO and AbbVie, with their product ABBV-RGX-314 expected to complete critical Phase 3 clinical trials in 2025 [4][46]. Summary by Sections 1. Market Overview - The CITIC Pharmaceutical Index rose by 1.9% during the week of March 10-14, 2025, outperforming the CSI 300 Index by 0.3 percentage points [3]. - The pharmaceutical sector has shown resilience, with innovative drugs performing well and a positive market sentiment driven by policy changes and new healthcare initiatives [5]. 2. Gene Therapy for Retinal Diseases - Gene therapy is seen as an ideal solution for retinal diseases due to the unique characteristics of the eye, such as immune privilege and low treatment dosage requirements [4][26]. - Current treatments for AMD involve frequent injections, which pose challenges in patient compliance and treatment burden [36]. - Kanghong Pharmaceutical is highlighted for its advanced clinical products KH631 and KH658, which are expected to enter clinical trials in 2023 and 2024, respectively [4][26]. 3. Key Players and Products - ABBV-RGX-314, developed by REGENXBIO and AbbVie, is in Phase 3 trials and has shown promising results in reducing treatment burden by 97% for patients previously requiring frequent injections [64]. - 4DMT's product 4D-150 is designed to inhibit multiple VEGF targets and is expected to significantly reduce treatment needs for wAMD patients [77][89]. - Adverum's Ixo-vec is also entering Phase 3 trials, aiming to provide sustained effects through a single injection [99]. 4. Investment Recommendations - The report recommends focusing on innovative drugs and companies with strong growth potential, particularly those involved in gene therapy and AI applications in healthcare [5][6].