本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者 重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 证券代码：603948 证券简称：建业股份 公告编号：2025-024 浙江建业化工股份有限公司 2025 年前三季度主要经营数据公告 根据上海证券交易所《上市公司自律监管指引第 3 号—行业信息披露：第十三 号—化工》有关规定，现将浙江建业化工股份有限公司（以下简称"公司"）2025 年 前三季度主要经营数据披露如下： | 一、主要产品的产量、销量及收入实现情况 | | --- | | 主要产品 | 2025 年 1-9 月 产量（吨） | 2025 年 1-9 月 销量（吨） | 2025 年 1-9 月 销售金额（万元） | | --- | --- | --- | --- | | 低碳脂肪胺 | 86728.56 | 86339.32 | 99498.41 | | 增塑剂 | 32311.72 | 32609.25 | 22680.95 | | 乙酸酯 | 30258.75 | 30755.23 | 18884.3 | | 电子化学品 | 5119.18 | 4201 ...

Core Viewpoint - The research reveals a novel metabolic interaction between tumor-associated macrophages (TAM) and hepatocellular carcinoma (HCC) cells, identifying TAM as a source of acetate that drives HCC metastasis through the synthesis of acetyl-CoA [2][3][4]. Group 1: Research Findings - TAM secretes acetate, which is then taken up by HCC cells to support their acetate accumulation [3]. - Lactate produced by HCC cells activates lipid peroxidation-ALDH2 pathways in TAM, promoting the secretion of acetate [3]. - In a mouse model of HCC, knocking out the ALDH2 gene in TAM reduces acetate levels in HCC cells and decreases lung metastasis of HCC [3][4]. Group 2: Implications - The study positions TAM as a critical acetate supply source that drives HCC metastasis, suggesting potential intervention targets in the tumor microenvironment [2][4].

Core Viewpoint - The recent U.S. sanctions on nine Indian entities involved in Iranian oil trade have caused turmoil in the Indian petrochemical market, exacerbated by insufficient domestic demand following the anticipated post-Diwali replenishment period [1] Group 1: Impact of U.S. Sanctions - The U.S. Treasury's Office of Foreign Assets Control (OFAC) has imposed sanctions on several Indian petrochemical trading companies, which may disrupt related trade activities [1] - Major Indian petrochemical importers are included in the sanctions list, leading to significant concerns about potential chaos in the Indian chemical market [2] - Traders fear that goods sold to sanctioned entities or en route to India may result in unrecoverable payments, causing substantial losses [2] Group 2: Domestic Market Conditions - Domestic prices in India are expected to rise due to the sanctions, with all quotations currently on hold [3] - The anticipated pre-Diwali replenishment has not materialized, leading to weak demand for products like polyethylene (PE), acetic acid, vinyl acetate monomer (VAM), and methyl isobutyl ketone (MIBK) [3] - Factors contributing to weak demand include high inventory levels, prolonged monsoon season, and adjustments to the Goods and Services Tax (GST) policy [3] Group 3: Price Trends and Market Sentiment - The Indian PE market is experiencing a significant downturn, with high-density polyethylene (HDPE) and linear low-density polyethylene (LLDPE) prices hitting near five-year lows, while low-density polyethylene (LDPE) prices are at a two-year low [4] - Despite expectations for demand recovery post-Diwali, the market remains cautious due to various disruptions, including the extended monsoon and GST adjustments [4] - The PVC market is also sluggish, with low purchasing willingness among companies due to uncertainty regarding the effective date of anti-dumping duties [4] Group 4: Global Trade Dynamics - The implementation of anti-dumping duties and U.S. sanctions is altering global trade flows, with Indian producers seeking alternative markets in Southeast Asia, the Middle East, and Africa [5] - The Indian market is shifting towards importing ethylene glycol from the U.S. while reducing purchases from countries under anti-dumping investigation [5] - Current Asian ethylene glycol spot prices have fallen below $500 per ton, with expectations of continued low demand until the end of 2025 [5]

Core Viewpoint - INEOS Group plans to reduce its workforce at the acetyls plant in Hull, UK, by 20% due to high energy prices and anti-competitive trade practices [1] Group 1: Company Actions - The company is calling for the UK government and the EU to urgently implement anti-dumping duties on imports from China and the US to protect the chemical industry [1] - INEOS stated that the surge in energy costs and anti-competitive trade practices have directly led to the loss of 60 technical positions [1] - The CEO of INEOS Acetyls, David Brooks, emphasized the priority of supporting affected employees and ensuring the long-term viability of the plant [1] Group 2: Product Information - INEOS Acetyls primarily produces acetic acid, acetic anhydride, and ethyl acetate [1]

Core Insights - The third-generation biorefining technology aims to utilize one-carbon molecules and renewable energy for "negative carbon" production of fuels and chemicals, addressing climate change and food shortages [1] - Acetic acid, derived from syngas fermentation, is increasingly recognized as a viable non-food carbon source in the biosynthesis of bulk chemicals [1] - 3-Hydroxypropionic acid (3-HP) is a renewable bulk chemical with a projected market size exceeding 3.6 million tons per year and a value surpassing $10 billion annually [1] Summary by Sections - **Engineering Achievements**: A research team from East China University of Science and Technology successfully constructed an engineered E. coli strain (ZWR18(MDA)) that synthesizes 3-HP from acetic acid via the propanoyl-CoA pathway, achieving a yield of 5.53 g/L and a conversion rate of 0.732 g/g, which is 97.60% of the theoretical yield [2][6] - **Cell-Catalyzed Production**: Under whole-cell catalysis conditions, the engineered strain can produce 23.89 g/L of 3-HP with a yield of 0.734 g/g, reaching 97.87% of the theoretical yield. When using acetic acid sourced from syngas, the strain still achieves 18.87 g/L of 3-HP with a yield of 0.58 g/g [2][6] - **Metabolic Pathway Insights**: The study outlines the metabolic pathway for converting acetic acid to 3-HP, highlighting the competition between fatty acid synthesis and 3-HP synthesis for propanoyl-CoA. The transcription factor FadR plays a crucial role in fatty acid metabolism, and the use of the antifungal antibiotic can further direct carbon flow towards 3-HP production [5][6] - **Publication Reference**: The research findings were published in "ACS Synthetic Biology" under the title "High-Yield Biosynthesis of 3‑Hydroxypropionic Acid from Acetate in Metabolically Engineered Escherichia coli" [3]

Core Viewpoint - The successful commissioning of the world's first 3000 tons/year ethane oxidative dehydrogenation (EDH) pilot plant at PetroChina Liaoyang Petrochemical Company marks a significant advancement in ethylene production technology, offering a more efficient and environmentally friendly alternative to traditional methods [1] Group 1: Technology and Innovation - The EDH technology, developed in collaboration with the Dalian Institute of Chemical Physics, eliminates the reliance on high-temperature steam cracking, using ethane and oxygen as primary raw materials [1] - The innovative process allows for the precise and efficient conversion of ethane into high-purity polymer-grade ethylene, while also co-producing high-value chemical products like acetic acid, significantly enhancing resource utilization and economic efficiency [1] - The high-performance catalyst developed by the company is crucial for achieving breakthroughs in activity, selectivity, and long-term stability, which are essential for low-temperature, efficient, and directional ethane conversion [1] Group 2: Environmental Impact - The EDH technology is viewed as a strong competitor for next-generation ethylene production due to its significantly lower energy consumption and production costs compared to traditional steam cracking processes [1] - The inherent characteristics of the oxidative dehydrogenation pathway and mild reaction conditions provide a substantial advantage in reducing carbon dioxide emissions, making it a viable option for the petrochemical industry to achieve carbon neutrality goals [1] Group 3: Future Plans - Liaoyang Petrochemical has established a comprehensive production plan that includes equipment debugging, operational procedure development, emergency response drills, and enhanced training for operators to ensure safe, stable, and efficient trial operations [2] - The company aims to lead with independent innovation by forming a cross-disciplinary team focused on optimizing operational parameters and verifying long-term operational stability, thereby addressing technical barriers for industrial-scale implementation [2]

证券代码：603948 证券简称：建业股份 公告编号：2025-007 浙江建业化工股份有限公司 2025 年一季度主要经营数据公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者 重大遗漏，并对其内容的真实性、准确性和完整性承担个别及连带责任。 1 三、主要原材料价格变动情况 | 原材料 | 2025 年 1-3 月不含税 平均价格（元/吨） | 2024 年 1-3 月不含税 平均价格（元/吨） | 变动比率（%） | | --- | --- | --- | --- | | 液氨 | 2523.17 | 2888.61 | -12.65 | | 乙醇 | 4822.40 | 5894.59 | -18.19 | | 正丙醇 | 7417.32 | 6568.07 | 12.93 | | 异丙醇 | 6327.02 | 7378.48 | -14.25 | | 正丁醇 | 6455.42 | 7791.89 | -17.15 | | 异丁醇 | 6665.77 | 7524.44 | -11.41 | | 苯酐 | 6111.51 | 6637.17 | -7.92 | | 乙酸 | ...