第三代生物炼制技术旨在利用一碳分子和可再生能源，实现燃料与化学品的"负碳"生产，以应对日益严峻的气候变化和粮 食短缺问题。由合成气发酵制得的乙酸，作为一种可行的非粮碳源，近来在大宗化学品的生物合成中地位日益凸显。 3-羟基丙酸（3-HP）是一种可再生的大宗化学品，可通过氧化还原反应衍生出丙烯腈、1,3-丙二醇、丙烯酰胺、丙二酸和 丙烯酸等多种高值产品。据预测，其市场规模将突破360万吨/年，产值超过100亿美元/年。 SynBio团队 | 吴辉 【SynBioCon】 获 悉 ， 华东理工大学生物工程学院上海生物制造技术协同创新中心生物反应器工程国家重点实验室 的吴辉老 师团队 通过丙二酰 -CoA 途径，在大肠杆菌中成功构建了以乙酸为原料合成 3- 羟基丙酸（ 3-HP ）的工程菌 株。最终，工程菌株 ZWR18(M DA) 的 3-HP 产量达到 5.53 g/L ，得率为 0.732 g/g ，占理论得率的 97.60% 。在全 细胞催化条件下，该菌株可产 23.89 g/L 3-HP ，得率为 0.734 g/g ，达到理论得率的 97.87% 。以合成气来源的乙酸 为底物进行全细胞催化时， ZWR1 ...

Core Viewpoint - The successful commissioning of the world's first 3000 tons/year ethane oxidative dehydrogenation (EDH) pilot plant at PetroChina Liaoyang Petrochemical Company marks a significant advancement in ethylene production technology, offering a more efficient and environmentally friendly alternative to traditional methods [1] Group 1: Technology and Innovation - The EDH technology, developed in collaboration with the Dalian Institute of Chemical Physics, eliminates the reliance on high-temperature steam cracking, using ethane and oxygen as primary raw materials [1] - The innovative process allows for the precise and efficient conversion of ethane into high-purity polymer-grade ethylene, while also co-producing high-value chemical products like acetic acid, significantly enhancing resource utilization and economic efficiency [1] - The high-performance catalyst developed by the company is crucial for achieving breakthroughs in activity, selectivity, and long-term stability, which are essential for low-temperature, efficient, and directional ethane conversion [1] Group 2: Environmental Impact - The EDH technology is viewed as a strong competitor for next-generation ethylene production due to its significantly lower energy consumption and production costs compared to traditional steam cracking processes [1] - The inherent characteristics of the oxidative dehydrogenation pathway and mild reaction conditions provide a substantial advantage in reducing carbon dioxide emissions, making it a viable option for the petrochemical industry to achieve carbon neutrality goals [1] Group 3: Future Plans - Liaoyang Petrochemical has established a comprehensive production plan that includes equipment debugging, operational procedure development, emergency response drills, and enhanced training for operators to ensure safe, stable, and efficient trial operations [2] - The company aims to lead with independent innovation by forming a cross-disciplinary team focused on optimizing operational parameters and verifying long-term operational stability, thereby addressing technical barriers for industrial-scale implementation [2]