Core Insights - Human fibrinogen is recognized globally for its clinical application value in regulating coagulation function, with increasing demand driven by aging populations and rising living standards [1][13] - The market size for human fibrinogen in China is projected to grow from 1.529 billion yuan in 2021 to 2.15 billion yuan in 2024, reflecting a compound annual growth rate (CAGR) of 12.0% [1][13] - The production process of human fibrinogen is expected to improve with technological advancements, leading to enhanced product quality and continuous market growth [1][13] Industry Overview - Fibrinogen is a key substrate in the coagulation and hemostasis process, essential for maintaining normal coagulation and promoting platelet aggregation [3] - Human fibrinogen is derived from healthy human plasma, processed to remove viruses, and is used as an effective replacement therapy for fibrinogen deficiency [3] - The normal concentration of fibrinogen in the human body is maintained at 2-4 g/L, and it is crucial for correcting hypofibrinogenemia and improving coagulation disorders [3] Market Dynamics - The number of blood collection stations and plasmapheresis stations in China is increasing, with 3 new stations approved and 17 new operational stations in 2024, leading to a steady rise in plasma collection [8] - The total plasma collection volume in 2024 is expected to reach 13,400 tons, a year-on-year increase of 10.94%, with major companies like Tian Tan Biological, Taibang Biological, and Shanghai Raist accounting for approximately 80% of the domestic plasma collection [8] - The growth in the number of medical institutions, driven by an aging population and increased health awareness, is expected to boost the demand for human fibrinogen [11] Competitive Landscape - The human fibrinogen industry is attracting significant attention from capital markets, with increasing competition as more companies enter the field [17] - Key players in the industry include Huaren Boya Biological Pharmaceutical Group, Shanghai Raist Blood Products, and Beijing Tiantan Biological Products, among others [17][18] Future Trends - Continuous government policy support is expected to benefit the human fibrinogen market, with initiatives aimed at improving the quality and safety of blood products [22] - Companies are focusing on optimizing production processes and enhancing plasma utilization rates, which will drive overall industry progress [23] - The expansion of medical insurance coverage and rising consumer spending on healthcare are anticipated to gradually increase the market demand for human fibrinogen [24]

据博雅生物公告，旗下子公司博雅欣和80%股权最新挂牌价为1.7亿元，较首次挂牌的2.13亿元下调近20%。这 是该股权三个月内的第三次价格调整，前两次分别以2.13亿元、1.92亿元流拍。此次若仍无受让方，价格将进 一步降至不足1.6亿元，较首次挂牌价缩水超25%，最低价格已降至原评估值的80%左右。 值得注意的是，去年8月，博雅生物刚刚完成对博雅欣和的增资，以4.87亿元自有资金获得其90.69%股权，如今 却连番降价也要将其剥离。 在这一波操作背后是博雅生物业绩波动加剧的现实压力。近年来，博雅生物营收增速下滑，核心产品营收、毛 利率承压，虽通过收购绿十字提升了采浆能力，但浆站数量不足等问题仍制约发展。 2025年的国内血制品行业面临诸多挑战，包括浆源紧张可能进一步加剧，集采范围有望扩大等因素都将压缩企 业的生存空间。对于博雅生物而言，如何在此背景下提振业绩，走出困局是其面临的紧迫问题。 股权转让的"降价困局" 作为国内血液制品领域的重要企业，"华润系"成员博雅生物近期的股权转让行为引发市场高度关注。 博雅欣和成立于2014年，经营范围包括药品、化工产品生产销售等，业务涵盖抗感染、糖尿病、心脑血管等药 品的 ...

第二次公开挂牌仍遭遇流拍后，江西博雅欣和制药有限公司（以下简称"博雅欣和"）80%股权的挂牌价 格再度面临下调。 近日，博雅生物（300294.SZ）公告拟将博雅欣和80%股权转让项目进一步降价至原评估值80%重新挂 牌，若以80%价格挂牌后仍无意向方摘牌，则再降价5.76%，以约1.58亿元进行挂牌，此价格约为原评 估值的75%。 战略发展规划，为压降高负债子公司工作，改善博雅欣和财务状况。 2023年及2024年上半年，博雅欣和均处于亏损状态，当期营收分别为1036.9万元、477.84万元，净利润 分别为-5687.42万元、-1131.58万元。2024年全年，博雅欣和亏损较2023年收窄，报告期内净利润 为-3461.87万元，负债大幅下降，净资产从2023年年末的-2.58亿元增至2024年年末的1.94亿元。 博雅生物方面披露称，博雅欣和于2018年正式投入运营，明确了以西他沙星项目、他汀类项目为核心的 原料制剂一体化发展策略，但因项目研发进度缓慢、集采降价、环保政策限制等因素影响，产品丧失竞 争优势，未能实现规模化生产，导致业绩未达预期，博雅欣和处于持续亏损状态。2024年，博雅欣和围 绕西他 ...

[Table_Summary] 事件: 3 月 19 日,公司发布 2024 年年报。2024 年，公司实现营业总收入 17.35 亿元（-34.58%），归母净利润 3.97 亿元（+67.18%）。 4 月 25 日，公司发布 2025 年一季报。2025Q1，公司实现总营业收入 5.36 亿元（+19.49%）；归母净利润 1.39 亿元（-8.25%）。 投资要点: ⚫ 采浆量稳健增长。截至 2024 年年报，公司（含绿十字（中国））现有 11 个品种 31 个规格（含进口重组Ⅷ因子）产品，涵盖白蛋白、人免疫球 蛋白和凝血因子三大类；在营浆站 20 个，在建浆站 1 个，合计 21 个。 公司 2024 年采浆量为 630.6 吨，同比增长 10.4%，其中华润博雅生物 采浆量为 522.04 吨，同比增长 11.7%，高于行业平均增速。公司通过 研发优化产品结构，提升生产工艺水平， 采浆量稳健增长，在研管线不断丰富 [Table_StockName] ——博雅生物（300294）点评报告 [Table_ReportDate] PCC 和Ⅷ因子推动血制品收入稳健增长：公司血制品业务 2024 年营业 ...

21世纪经济报道记者韩利明上海报道 几家欢喜几家愁？近期，多家血液制品企业披露2024年及2025年一季度业绩，呈现出明显的分化态势。 2024年，上海莱士（002252）、天坛生物（600161）、派林生物（000403）、卫光生物（002880）实现营收净利双增。此外，从营收来看，华兰生物 （002007）、博雅生物（300294）、博晖创新（300318）分别同比下滑18.02%、18.53%、34.58%；从归母净利润来看，华兰生物同比下滑26.57%，不过博 晖创新已成功扭亏为盈，实现归母净利润0.09亿元。 进入2025年一季度，多家血液制品企业出现业绩反转。营收上，天坛生物、华兰生物、博雅生物延续增长；但卫光生物、上海莱士、派林生物却分别出现 0.57%、2.45%、14%的下滑。利润层面，仅华兰生物实现19.62%的增长，上海莱士、天坛生物等五家企业净利润均有不同程度下跌。 其中，单季度创收10亿元以上的上海莱士和天坛生物，业绩规模处于第一梯队，但期内归母净利润降幅却分别高达25.2%、22.9%。天坛生物将归母净利润 下滑的原因归咎为"产品价格下降减少的利润大于销量增长增加的利润。" | | ...

Investment Rating - The industry investment rating is "Outperform the Market - A" [4] Core Viewpoints - The report highlights a steady growth in domestic albumin batch approvals, with a 12% year-on-year increase in Q1 2025, while imported albumin saw a 9% decline [9][10] - The report suggests a long-term growth potential in the immunoglobulin market, with a 15% year-on-year increase in intravenous immunoglobulin (IVIG) approvals in Q1 2025 [18][24] - The report identifies key companies to watch, including Tian Tan Biological, Pai Lin Biological, Bo Ya Biological, Shanghai Lai Shi, and Hua Lan Biological [3] Summary by Sections 1. Overview of Blood Product Batch Approvals in Q1 2025 - Domestic albumin approvals reached 418 batches, up 12% year-on-year, while imported albumin approvals totaled 778 batches, down 9% [9][10] - Intravenous immunoglobulin (IVIG) approvals were 324 batches, up 15%, and intramuscular immunoglobulin (IMIG) approvals were 9 batches, up 13% [9] - For specific immunoglobulins, hepatitis B immunoglobulin approvals were 11 batches (up 83%), tetanus immunoglobulin 35 batches (up 13%), and rabies immunoglobulin 34 batches (up 42%) [9] 2. Albumin Analysis - The report notes a compound annual growth rate (CAGR) of 11.4% for albumin approvals from 2011 to 2024, with domestic albumin growing at 5.9% and imported at 16.7% [11] - In Q1 2025, the total albumin approvals were 1196 batches, reflecting a slight decline of 2.4% year-on-year [11] 3. Immunoglobulin Analysis - The report indicates a CAGR of 8.4% for IVIG approvals from 2011 to 2024, with Q1 2025 showing 324 batches approved [18] - The leading companies in the IVIG market accounted for approximately 61% of the market share in Q1 2025 [24] 4. Special Immunoglobulins - The report highlights significant growth in specific immunoglobulin approvals, particularly for hepatitis B and rabies, with notable increases in batch approvals [28][29] - The market for tetanus immunoglobulin is also growing, with a 13% increase in approvals [28] 5. Coagulation Factor Analysis - The report notes a CAGR of 13.6% for human coagulation factor VIII approvals from 2011 to 2024, with Q1 2025 approvals at 163 batches, up 12% [35] - Prothrombin complex concentrate (PCC) approvals increased by 26% year-on-year, totaling 82 batches in Q1 2025 [35] - The report identifies leading companies in the coagulation factor market, which hold significant market shares [43]

公告也分析，因血液制品行业的特殊性，截至目前，血液制品尚未纳入国家级的集采范围（至 2024 年 12 月底，国家 级集采已实施 10 批）。但自 2022 年 1 月起，血液制品集采开始纳入地方性、区域联盟性的集采范围。 在集采政策的大背景下，将促使行业加速结构调整与产业整合，这将为具有产能规模优势、产品管线丰富、血浆综合 利用率高、学术营销能力强、管理效率高的企业提供新的发展契机。华润博雅生物亦会抓住机遇，致力于发展"成为 世界一流血液制品企业"。 4月7日，以卫光生物、派林生物、博雅生物、天坛生物为代表的血制品概念股拉升。 其中，山西证券在近期发布的一份围绕派林生物的研报中指出，静丙、白蛋白需求旺盛，在研第四代静丙、凝血因子 新品种提供长期增长动力。狂免和破免是公司长期优势产品，2023年公司在静丙、白蛋白国内市场占比6.5%、 2.5%，国内进口人血白蛋白占比64.4%，国产替代空间巨大；国内静丙市场扩张及公司新一代静丙后续上市也将持续 带动静丙销售放量。 公司已展现出良好的凝血因子类产品商业化与研发能力，2023年公司人纤维蛋白原、PCC、人凝血因子Ⅷ分别市占 11.9%、3.1%、2.8%，在研人 ...