摘要 小核酸药物生产成本中，单体占比约 30%-40%，载体占比约 5%，单 体和载体的用量比例约为每克药物需要 40 克单体和 2 克载体。成本控 制的关键在于单体，但商业化阶段对单体纯度要求极高（99%以上）， 与研发阶段（95%-98%）有显著差异。 商业化小核酸药物生产需通过严格的 FDA 质量体系认证，包括质量、生 产、设施设备、实验室检测、仓储及包装六大系统，对硬件（检测设备， 数据完整性）和软件（人员培训，管理体系）均有极高要求，新进入者 需多年准备以符合 GMP 标准。 进入跨国药企（MNC）供应链需通过 FDA 审核及 MNC 的全球质量、 EHS（环保、健康、安全）审计，审计标准由 PSCI 制定，涵盖健康安 全、环境管理、工作条件和商业道德，近年来碳足迹和 eCOVadis 成为 新关注点。 跨国药企对原材料价格敏感度低，更关注产品质量和稳定供应，稳定供 应建立在严格的 EHS 审计基础上。一旦选定供应商，除非发生重大事故， 否则不会轻易更换，因为他们更关注创新而非成本。 小核酸产业链行业大咖分享 20251123 Q&A 小核酸药物生产端整个产业链的价值分布情况如何？ 小核酸药物作为一 ...

Core Viewpoint - The global photoresist market is expected to exceed $15 billion by 2025, with China's market share increasing to 35%, highlighting significant growth potential in the industry [2]. Industry Overview - The photoresist industry is a critical component of high-tech materials, encompassing the entire chain from research and development to production and sales [2]. - In the high-end semiconductor photoresist sector, Japanese companies like JSR and Tokyo Ohka dominate with over 85% market share, while domestic production rates are below 5%, indicating a significant technological and market monopoly [2]. Market Dynamics - The advancement in the photoresist industry is driven by downstream demand, where manufacturers' process improvements necessitate technological iterations in photoresists and raw materials [2]. - Domestic manufacturers are increasingly replacing foreign suppliers and expanding production, creating opportunities for photoresist companies [2]. Supply Chain Components - The upstream of the photoresist supply chain includes raw materials such as resins, monomers, photosensitizers, and solvents; the midstream involves the production and synthesis of photoresists based on formulations; and the downstream includes applications in printed circuit boards, LCDs, and IC chips across various industries [2]. Key Raw Materials - Solvents constitute 50%-90% of photoresist composition, essential for dissolving resins and photosensitizers to create a uniform photoresist solution [3][5]. - Photosensitizers, making up 1%-6% of the composition, are crucial for initiating chemical reactions under specific wavelengths of light, altering the solubility of resins during the development process [3][8]. - Resins account for 10%-40% of photoresist, serving as the inert polymer matrix that binds materials together and determines the basic performance of the photoresist after exposure [3]. Market Players - Domestic companies like Yida Co. hold over 40% market share in electronic-grade PM solvents, while other firms like Xilong Science and Jingrui Electric Materials are also making strides in the solvent sector [7]. - The photosensitizer market is dominated by international players such as BASF and IGM Resins, with a trend of production capacity shifting towards China due to patent expirations and increased domestic demand [10]. Product Types and Applications - Different types of photoresists are used for various exposure wavelengths, with global resin supply primarily monopolized by companies like Sumitomo Chemical and Dow Chemical [11]. - Domestic enterprises such as Shengquan Group and Tongcheng New Materials are making significant advancements in photoresist resin production, with some achieving production capacities exceeding 5,000 tons per year [12]. Upcoming Events - The 2025 TrendBank (Fifth) Photoresist Materials Industry Conference will be held from July 8-10 in Hefei, focusing on new applications, current trends, and in-depth discussions on the photoresist supply chain [13].

Core Viewpoint - Shandong Jiuri Chemical Technology Co., Ltd., a subsidiary of Jiuri New Materials (688199.SH), has been fined by the Binzhou Emergency Management Bureau for failing to ensure that special operation personnel received the required safety training and qualifications before working [1][3]. Company Overview - Jiuri New Materials focuses on the research, production, and sales of photoinitiators, monomers, and other photopolymer materials, as well as semiconductor chemical materials such as photoresists and photosensitive agents. It is listed on the Shanghai Stock Exchange's Sci-Tech Innovation Board under the stock code 688199.SH [4]. - Shandong Jiuri, established in 2010, is a wholly-owned subsidiary of Jiuri New Materials and is recognized as a national high-tech enterprise specializing in photopolymer material development, with an annual production capacity of 5,000 tons [4][6]. Penalty Details - The penalty was issued on April 1, 2025, with a fine of 10,000 yuan (approximately $1,500) for the violation of safety regulations [2][3]. - The violation was based on Article 97(7) of the Production Safety Law of the People's Republic of China, in conjunction with the Shandong Province's administrative penalty discretion guidelines [2][3].