机构：天风证券 研究员：杨松/曹文清 事件：近日，公司发布2025 年中报。2025H1，公司总收入74.34 亿元，同比增长14.3%；归母净利润为 31.35 亿元，同比增长15.02%。创新药产品收入为61.45 亿元，同比增长22.1%，在总收入中的占比提升 至82.7%。 盈利预测与投资评级 考虑到公司2025 年有多笔大额BD 交易款项到账，我们将2025 年的营业收入从137.41 亿元上调至146.68 亿元，预计2026 年和2027 年的营业收入分别为158.35 亿元和177.79 亿元；将2025 年的归母净利润从 47.46 亿元上调至51.67 亿元，预计2026-2027 年归母净利润分别为53.25 亿元和61.33 亿元。维持"增 持"评级。 风险提示：行业政策风险、市场竞争风险、药物研发失败风险、专利和知识产权风险、销售不及预期风 险 业绩稳健，创新品种持续放量，仿制药业务风险基本出清阿美替尼作为国产首款三代EGFR TKI，销售 增长迅速，适应症持续拓展。 样本医院销售数据显示，从2020 年的1841 万增长到2024 年的17.84 亿元，年度复合增长率为214%， ...

Core Viewpoint - Tianfeng Securities maintains an "overweight" rating for Hansoh Pharmaceutical, adjusting revenue and net profit forecasts for 2025, 2026, and 2027 due to expected large BD transaction payments [1] Group 1: Financial Performance - The revenue forecast for 2025 is raised from 137.41 billion to 146.68 billion RMB, with expected revenues of 158.35 billion and 177.79 billion RMB for 2026 and 2027 respectively [1] - The net profit forecast for 2025 is increased from 47.46 billion to 51.67 billion RMB, with expected net profits of 53.25 billion and 61.33 billion RMB for 2026 and 2027 respectively [1] - In the first half of 2025, total revenue reached 74.34 billion RMB, with a net profit of 31.35 billion RMB [1] Group 2: Product Performance - Revenue from innovative drug products reached 61.45 billion RMB, accounting for 82.7% of total revenue [1] - The metabolic and other fields saw significant growth, with revenue from this segment approximately 14.00 billion RMB, a year-on-year increase of 134.5% [1] - The anti-tumor product portfolio, including Amatinib and Flumatinib, generated revenue of 45.31 billion RMB, remaining stable year-on-year [1] Group 3: Innovation and Clinical Development - Over 40 candidate innovative drugs are undergoing more than 70 clinical trials, with 8 new drugs entering clinical trials in the first half of 2025 [3] - Three drugs have entered Phase III clinical trials, including HS-20137 for psoriasis and HS-20093 and HS-20089 for sarcoma and ovarian cancer respectively [3] - The TYK2 inhibitor HS-10374 is also in Phase III trials, showing low skin toxicity risk [3] Group 4: Market Position and Growth - Amatinib, as the first domestic third-generation EGFR TKI, has seen rapid sales growth, with a compound annual growth rate of 214% from 2020 to 2024 [2] - Amatinib is expanding its indications related to NSCLC, with four approved indications and additional ones expected in 2025 [2] - The drug received approval from the UK MHRA in June 2025, marking Hansoh's first entry into the overseas market [2]

Core Viewpoint - Tianfeng Securities maintains an "overweight" rating for Hansoh Pharmaceutical (03692), adjusting the 2025 revenue forecast from 13.741 billion to 14.668 billion RMB, with expected revenues of 15.835 billion and 17.779 billion RMB for 2026 and 2027 respectively. The net profit forecast for 2025 is raised from 4.746 billion to 5.167 billion RMB, with projections of 5.325 billion and 6.133 billion RMB for 2026 and 2027 respectively [1] Group 1 - In H1 2025, the total revenue of the company reached 7.434 billion RMB, with a net profit of 3.135 billion RMB. Revenue from innovative drug products amounted to 6.145 billion RMB, accounting for 82.7% of total revenue [1] - The revenue from the metabolic and other fields saw significant growth, with the MSD upfront payment received [1] - In H1 2025, the product portfolio in the oncology field, including Amivantamab and Furmonertinib, generated revenue of 4.531 billion RMB, remaining stable year-on-year [1] Group 2 - The sales of Amivantamab, the first domestic third-generation EGFR TKI, have rapidly increased, with a compound annual growth rate of 214% from 2020 to 2024, reaching 1.784 billion RMB in 2024 [2] - Amivantamab has expanded its indications related to NSCLC, with four approved indications and additional approvals expected in 2025 [2] - The company aims to obtain EMA recognition for Amivantamab in overseas markets following its approval by the UK MHRA in June 2025 [2] Group 3 - The company has over 40 candidate innovative drugs undergoing more than 70 clinical trials as of H1 2025 [3] - Eight new innovative drugs entered clinical trials in H1 2025, including HS-20122 (EGFR/c-Met ADC) and HS-10510 (PCSK9) [3] - Three new drugs entered Phase III clinical trials, including HS-20137 (IL-23p19) for psoriasis and two ADCs for bone and soft tissue sarcoma and ovarian cancer, with overseas rights granted to GSK [3]

Investment Rating - The investment rating for the company is "Accumulate" [6] Core Views - The company reported a total revenue of 7.434 billion yuan for H1 2025, representing a year-on-year growth of 14.3%, with a net profit attributable to shareholders of 3.135 billion yuan, up 15.02% year-on-year [1] - Revenue from innovative drug products reached 6.145 billion yuan, showing a year-on-year increase of 22.1%, and accounted for 82.7% of total revenue [1] - The metabolic and other fields saw significant revenue growth, with a 134.5% increase in revenue from related products, amounting to approximately 1.4 billion yuan [2] Summary by Sections Financial Performance - The company adjusted its 2025 revenue forecast from 13.741 billion yuan to 14.668 billion yuan, with expected revenues of 15.835 billion yuan and 17.779 billion yuan for 2026 and 2027, respectively [5] - The net profit forecast for 2025 was raised from 4.746 billion yuan to 5.167 billion yuan, with projections of 5.325 billion yuan and 6.133 billion yuan for 2026 and 2027 [5] Product Development - The company has over 40 candidate innovative drugs undergoing more than 70 clinical trials, with 8 new innovative drugs entering clinical trials in H1 2025 [4] - Three new drugs have entered Phase III clinical trials, including HS-20137 for psoriasis and two ADCs for bone and soft tissue sarcomas and ovarian cancer, with overseas rights granted to GSK [4] Market Position - The sales of the domestic first third-generation EGFR TKI, Amatinib, have grown rapidly, with a compound annual growth rate of 214% from 2020 to 2024, and it is expected to account for about 28% of total sales in 2024 [3] - The company is actively expanding indications related to NSCLC, with multiple approvals and ongoing NDA reviews for new treatment indications [3]

格隆汇8月19日｜石四药集团(2005.HK)公告，公司的吗啉硝唑已获中国国家药品监督管理局批准登记成 为在上市制剂使用的原料药，吗啉硝唑是一种硝基咪唑类抗生素，主要用于治疗厌氧性细菌引起的阑尾 炎和盆腔炎。 ...

Group 1 - The core point of the article is that Sihuan Pharmaceutical Group (02005.HK) has received approval from the National Medical Products Administration of China for its Metronidazole, allowing it to be used as an active pharmaceutical ingredient in marketed formulations [1] Group 2 - Metronidazole is a nitroimidazole antibiotic primarily used for treating anaerobic bacterial infections such as appendicitis and pelvic inflammatory disease [1]

Core Viewpoint - The company Shijiazhuang Fourth Pharmaceutical Group has received approval from the National Medical Products Administration of China for its raw material drug, Metronidazole, to be used in marketed formulations [1] Group 1 - Metronidazole is a nitroimidazole antibiotic primarily used for treating anaerobic bacterial infections such as appendicitis and pelvic inflammatory disease [1]

Core Viewpoint - The announcement by the company indicates that its drug, Metronidazole, has been approved by the National Medical Products Administration of China for use as an active pharmaceutical ingredient in marketed formulations [1] Group 1: Company Information - The company, Shijiazhuang Fourth Pharmaceutical Group, has received regulatory approval for Metronidazole, a nitroimidazole antibiotic [1] - Metronidazole is primarily used for the treatment of anaerobic bacterial infections, specifically appendicitis and pelvic inflammatory disease [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不會就因本公告全部或任何部份內容而產生 或因倚賴該等內容而引致之任何損失承擔任何責任。 自願公告 產品開發的最新進展 石四藥集團有限公司（「本公司」，連同其附屬公司，「本集團」）董事局（「董事局」）欣然公告， 本集團的嗎啉硝唑已獲中國國家藥品監督管理局批准登記成為在上市製劑使用的原料藥。嗎啉 硝唑是一種硝基咪唑類抗生素，主要用於治療厭氧性細菌引起的闌尾炎和盆腔炎。 本公告為本公司自願發佈，目的是使股東及潛在投資者瞭解本集團最新業務發展情況。 承董事局命 執行董事兼公司秘書 周興揚 香港，二零二五年八月十九日 於本公告日期，董事局成員包括執行董事曲繼廣先生、蘇學軍先生、孟國先生、周興揚先生及 曲婉蓉女士，非執行董事劉文軍先生，以及獨立非執行董事王亦兵先生、周國偉先生及姜廣策 先生。 ...