R&D Pipeline and Innovations - The company has established a multi-modal, positive cycle R&D ecosystem focusing on metabolic diseases and respiratory diseases, with 2 innovative drug projects approved for market and several in clinical trials [1][2] - ZSP1601 tablets, targeting metabolic dysfunction-related fatty liver disease (MASH), are the first domestic innovative drug project to complete clinical trials for safety and pharmacokinetics, showing significant potential in reducing liver inflammation markers [1][2] - RAY1225 injection, a long-acting GLP-1 analog, has shown promising results in Phase II trials for obesity and Type 2 diabetes, achieving primary endpoints in both REBUILDING-1 and SHINING-1 trials [2][5] Clinical Trial Results - In the REBUILDING-1 trial, RAY1225 injection demonstrated a dose-dependent weight loss: 3mg, 6mg, and 9mg groups showed weight reductions of -10.05%, -12.98%, and -15.05% respectively, compared to -3.55% in the placebo group [5][7] - The SHINING-1 trial indicated significant reductions in HbA1c levels: -1.68%, -2.06%, and -2.16% for the 3mg, 6mg, and 9mg groups respectively, with the placebo group at -0.33% [8][10] - RAY1225 injection also showed superior results in cardiovascular and metabolic indicators, with significant reductions in uric acid levels compared to the placebo [8] Product Approvals and Market Strategy - The oral antiviral drug, Lai Ruitewei tablets (乐睿灵®), received conditional approval in March 2023 and is included in the national medical insurance directory, enhancing patient access [3] - The company’s innovative drug Angladiwei tablets (安睿威®) was approved in May 2025, showing significant efficacy in alleviating flu symptoms compared to the placebo [4][11] - The company is focusing on building an academic ecosystem and enhancing digital services to improve healthcare delivery and patient trust [14][15] Investment and Future Directions - The company has consistently invested over 10% of its revenue in R&D over the past three years, emphasizing the importance of innovation in its growth strategy [15] - Plans for international collaboration on innovative drugs are underway to expand market opportunities and enhance global brand influence [16][18]

Core Viewpoint - The company has successfully completed the first lock-up period of its 2024 employee stock ownership plan, allowing 45 eligible participants to unlock 30% of the initially granted shares, totaling 1.467 million shares, which represents 0.17% of the company's total share capital [2][7]. Implementation of Employee Stock Ownership Plan - The company held board meetings on June 14, 2024, and July 1, 2024, to approve the implementation of the employee stock ownership plan [2]. - On July 16, 2024, the company transferred 5.551 million shares to the dedicated account for the employee stock ownership plan, which accounted for 0.65% of the total share capital at that time [3]. - The stock ownership plan has three unlocking phases, with the first phase's unlocking conditions met on July 16, 2025 [3][4]. Performance Assessment - The performance assessment for the first lock-up period included company-level targets for revenue and innovation drug development progress [4]. - The company achieved its innovation drug development goals, with significant progress in clinical trials for multiple drugs, resulting in a 100% unlocking ratio for this performance metric [5][6]. - Individual performance assessments for the 45 participants were all rated B+ or above, meeting the criteria for full unlocking [7]. Future Arrangements - Following the unlocking of the first lock-up period, the employee stock ownership management committee will manage the rights of the participants according to the authorized decisions made in the meetings [8]. - The company will adhere to market trading rules and relevant regulations regarding stock transactions [8].

Group 1: Innovative Drug Development - The company has established a multi-mode, positive cycle research and development ecosystem, focusing on metabolic diseases and respiratory diseases, with two innovative drug projects approved for market and several in clinical trials [2][4]. - ZSP1601 tablets, targeting metabolic dysfunction-related fatty liver disease (MASH), have shown significant reduction in liver inflammation markers after four weeks of treatment, indicating potential for improving liver inflammation and fibrosis [2][4]. - RAY1225 injection, a long-acting GLP-1 class drug, has completed Phase II clinical trials for obesity and type 2 diabetes, achieving primary endpoints and demonstrating significant weight loss and metabolic improvements [4][14][18]. Group 2: Clinical Trial Results - RAY1225 injection demonstrated a weight loss of -10.05%, -12.98%, and -15.05% for 3mg, 6mg, and 9mg doses respectively, significantly outperforming the placebo group [14][16]. - The RAY1225 injection also showed a reduction in HbA1c levels of -1.68%, -2.06%, and -2.16% for the same doses, with a notable percentage of participants achieving target HbA1c levels [16][18]. - The clinical trial for the oral antiviral drug, Liratewe tablets, has been approved and included in the national medical insurance directory, providing accessible treatment options for patients [5][6]. Group 3: Safety and Efficacy - The clinical trials for RAY1225 injection reported good safety and tolerability, with low incidence of gastrointestinal adverse effects, similar to previous GLP-1 drug profiles [18]. - The clinical trial for Anglave tablets showed a median flu symptom relief time of 31.72 hours, with no serious adverse events reported, indicating good safety and efficacy in children and adolescents [10][11]. - Anglave tablets demonstrated a significant reduction in flu symptoms compared to placebo, achieving statistical significance in symptom relief and viral load reduction [10][11]. Group 4: Research and Development Investment - The company has consistently invested over 8% of its annual revenue in R&D, with the last three years exceeding 10%, reflecting a commitment to innovation and development [19]. - The R&D strategy includes a diversified matrix of traditional Chinese medicine, innovative drugs, modified new drugs, chemical generics, and raw materials, transitioning from a traditional to an innovative pharmaceutical enterprise [19].

Core Viewpoint - The innovative drug sector is experiencing a bull market, with funds seeking low-priced stocks for potential gains. Zhongsheng Pharmaceutical's stock has seen significant fluctuations, with a recent increase of 9.99% to 16.84 CNY per share, resulting in a market capitalization of 14.33 billion CNY [1][2]. Group 1: Stock Performance - Zhongsheng Pharmaceutical's stock price has increased by over 61% since April 9, 2023, after a decline of more than 70% from its historical high of 40.7 CNY per share in November 2022, reaching a low of 9.65 CNY [8][10]. - The company announced an abnormal stock trading fluctuation, with a cumulative price deviation exceeding 20% over two consecutive trading days [2]. Group 2: Drug Development Pipeline - Zhongsheng Pharmaceutical has two innovative drug projects approved for market, with several others in clinical trials. The RAY1225 injection, a long-acting GLP-1 drug, is undergoing Phase III clinical trials for treating obesity and type 2 diabetes [4]. - The small molecule innovative drug, Anladiwei (安睿威®), for treating influenza A, has been approved by the National Medical Products Administration and is the first drug targeting the PB2 new target, developed under the leadership of academician Zhong Nanshan [4][6]. - The innovative drug ZSP1601 for treating metabolic dysfunction-related fatty liver disease has completed Phase Ib/IIa clinical trials and is moving into Phase IIb trials [8]. Group 3: Financial Performance - In 2024, Zhongsheng Pharmaceutical reported a revenue of 2.467 billion CNY, a year-on-year decline of 5.48%, and a net loss of 299 million CNY, a year-on-year decrease of 213.63% [10]. - For the first quarter of 2024, the company achieved a revenue of 634 million CNY, a slight decline of 1.03%, while net profit increased by 61.06% to 82.61 million CNY [10]. Group 4: Future Outlook - Guangfa Securities projects Zhongsheng Pharmaceutical's EPS for 2025-2027 to be 0.36, 0.45, and 0.54 CNY per share, maintaining a positive outlook on its core business and the progress of its innovative drugs [10].

Group 1: Company Overview and R&D Pipeline - Guangdong Zhongsheng Pharmaceutical Co., Ltd. has established a multi-modal and healthy R&D ecosystem focusing on metabolic diseases and respiratory diseases, with two innovative drug projects approved for market and several in clinical trials [1] - The innovative drug ZSP1601 for treating metabolic dysfunction-related fatty liver disease (MASH) has completed Phase Ib/IIa clinical trials, showing significant reduction in liver inflammation markers [3][15] - The oral antiviral drug Lurivon (brand name: Le Ru Ling®) received conditional approval in March 2023 and is included in the national medical insurance directory, providing affordable treatment options for patients [3] Group 2: Clinical Trial Results - ZSP1601 has shown potential in improving liver inflammation and fibrosis, with results published in Nature Communications [3][15] - The clinical trial for Lurivon demonstrated effectiveness and safety, particularly for elderly and patients with liver and kidney dysfunction, without requiring dosage adjustments [3] - The innovative drug Anglave (brand name: An Rui Wei®) has shown statistically significant improvement in flu symptom relief compared to placebo, with a median symptom relief time of 38.83 hours [4][8] Group 3: Financial and Asset Management - In 2024, the company recorded an asset impairment loss of CNY 546.68 million, impacting the net profit attributable to shareholders by CNY 484.10 million [12] - The company has made provisions for inventory and goodwill impairment losses totaling CNY 201.68 million due to market conditions and policy impacts [12][14] Group 4: Strategic Initiatives and Future Plans - The company plans to enhance its marketing strategy by integrating academic resources and building a network of experts in respiratory and infectious diseases [11] - The company has increased its stake in its subsidiary Zhongsheng Ruichuang to 74.26%, enhancing control over its operations and R&D capabilities [27] - A change in the use of raised funds has been proposed to accelerate the R&D of innovative drugs, specifically RAY1225 injection and Anglave granules [28][30]

Group 1: Product Development and Clinical Trials - The innovative drug Anglavei (brand name: Anruiwei®) has been approved for market release, showing significant efficacy in clinical trials compared to placebo, with a median symptom relief time of 38.83 hours versus 63.35 hours for the placebo group (P<0.001) [5] - Anglavei has demonstrated superior antiviral activity against various strains of influenza, outperforming existing treatments like Oseltamivir and Baloxavir, particularly against resistant strains [4] - The Phase II clinical trial for Anglavei granules in children aged 2-17 showed a median symptom relief time of 31.72 hours, with high-dose and low-dose groups showing times of 28.63 hours and 33.65 hours, respectively [4] Group 2: Safety and Efficacy - No serious adverse events were reported during the clinical trials of Anglavei granules, indicating good safety and tolerability in children and adolescents [7] - The Phase II trial results for Anglavei granules indicated that most adverse reactions were mild and resolved without treatment, confirming the drug's favorable safety profile [7] Group 3: Financial and Asset Management - In 2024, the company recorded an asset impairment loss of CNY 546.68 million, impacting the net profit attributable to shareholders by CNY 484.10 million [10] - The company has taken a cautious approach to asset management, including impairment provisions for inventory and goodwill, totaling CNY 201.68 million for goodwill impairment [10] Group 4: Strategic Initiatives and Market Positioning - The company plans to enhance its marketing strategy for Anglavei by building an academic ecosystem and integrating digital services to improve healthcare solutions [7] - The company has increased its stake in its subsidiary, Zhongsheng Ruichuang, from 61.11% to 74.26% by redeeming shares for CNY 546 million, strengthening control over its innovative drug development [29] Group 5: Research and Development Pipeline - The company has established a robust R&D ecosystem focusing on metabolic and respiratory diseases, with multiple innovative drug projects in various stages of clinical trials [13] - The innovative drug ZSP1601 for treating non-alcoholic steatohepatitis (NASH) has shown promising results in Phase II trials, significantly reducing liver inflammation markers [17] Group 6: New Drug Approvals and Market Impact - The oral antiviral drug Liratewei (brand name: Leruoling®) received conditional approval in March 2023 and is included in the national medical insurance directory, expanding access for patients [14] - RAY1225, a GLP-1 receptor agonist, has shown significant weight loss and glycemic control in Phase II trials, with a notable reduction in HbA1c levels [20]

Financial Performance - In 2024, the company reported a revenue of CNY 246,741.84 million, with a net loss attributable to shareholders of CNY 29,915.71 million, and a net loss of CNY 26,031.27 million after excluding non-recurring gains [2][4] - The decline in performance was attributed to the impact of centralized procurement pricing on the company's core product, the Compound Thrombus-Resolving Series [2] - Non-recurring gains decreased the net profit attributable to shareholders by CNY 3,884.44 million due to litigation-related provisions [2] Asset Impairment - The total asset impairment loss for 2024 was CNY 54,668.07 million, reducing the net profit attributable to shareholders by CNY 48,409.79 million [5][7] - Major impairment factors included inventory write-downs of CNY 5,472.75 million and goodwill impairment of CNY 20,167.71 million related to subsidiaries [5][7] - The company also recognized an impairment loss of CNY 7,916.66 million on intangible assets [5][7] Q1 2025 Performance - In Q1 2025, the company achieved a revenue of CNY 63,426.14 million, a year-on-year decrease of 1.07% [8] - The net profit attributable to shareholders was CNY 8,261.18 million, a year-on-year increase of 61.06% [8] - The net profit after excluding non-recurring gains was CNY 7,843.48 million, reflecting an increase of 8.60% year-on-year [8] R&D Pipeline - The company has established a multi-mode R&D ecosystem focusing on metabolic and respiratory diseases [9] - The innovative drug ZSP1601 for treating metabolic dysfunction-related fatty liver disease has completed Phase Ib/IIa clinical trials, showing significant reductions in liver inflammation markers [9][14] - The oral antiviral drug, Lai Rui Te Wei (乐睿灵®), has been approved for conditional marketing and included in the national medical insurance directory [10] New Drug Developments - The influenza drug Angrawei (安睿威®) has shown positive results in Phase III clinical trials and is under review for market approval [20] - The GLP-1 receptor agonist RAY1225 has completed Phase II trials, demonstrating significant weight loss and glycemic control in participants [15][18] - RAY1225 is expected to be a bi-weekly administered treatment for type 2 diabetes and obesity, with ongoing Phase III trials [15][18]

Core Viewpoint - Guangdong Zhongsheng Pharmaceutical Co., Ltd. reported a decline in revenue and a net loss for 2024, but showed signs of recovery in Q1 2025 with significant profit growth [1][2]. Group 1: Financial Performance - In 2024, the company achieved revenue of 2.467 billion yuan, a year-on-year decrease of 5.48% [1]. - The net profit attributable to shareholders was a loss of 299 million yuan, a shift from profit to loss compared to the previous year [1]. - The loss was primarily due to an asset impairment provision of 547 million yuan, with goodwill, development expenses, and intangible asset impairments accounting for over 90% [1]. - In Q1 2025, the company reported a net profit of 82.61 million yuan, a year-on-year increase of 61.96% [1]. - The net profit attributable to shareholders after deducting non-recurring gains and losses was 78.43 million yuan, up 8.60% year-on-year [1]. Group 2: Strategic Adjustments - The company has developed a mid-term strategic plan focusing on "traditional Chinese medicine as the foundation, innovation as the lead, and concentrating on a specialized pharmaceutical health enterprise" [1]. - Zhongsheng Pharmaceutical actively responded to the policy background of drug procurement, successfully winning bids for its compound thrombus-dissolving series products in 2023 [2]. - The company is building a "volume-cost-fee" collaborative efficiency model around core products to counteract the impact of centralized procurement policies [2]. Group 3: Product Development - The commercialization of innovative drug products and the market expansion of existing chemical drugs are key growth drivers for the company [2]. - The company launched the first independently developed oral antiviral drug for COVID-19, known as Lai Ruitewei tablets (brand name: Le Rui Ling®) [2]. - Unique ophthalmic drugs such as sodium nitroprusside eye drops and pramoxine eye drops have established competitive barriers in the ophthalmology field [2].