Group 1 - The core message emphasizes the importance of early diagnosis and understanding of Alzheimer's disease, highlighting that many patients remain undiagnosed for an average of two years despite noticeable symptoms [4][8] - There is a common misconception that memory decline is a normal part of aging, which can lead to delays in seeking medical help [5][6] - Cognitive impairment is defined as a broader concept that includes mild cognitive impairment and dementia, aiming to raise awareness for early intervention [7][8] Group 2 - Not all cognitive impairments are Alzheimer's disease; various types of dementia exist, such as frontotemporal dementia and Lewy body dementia, which require different diagnostic approaches [21][19] - Diagnosis of Alzheimer's disease can be complex, as some patients may present atypical symptoms, necessitating comprehensive assessments and advanced imaging techniques like PET scans [22][29] - The article discusses the development of medications that can alleviate symptoms and improve the quality of life for Alzheimer's patients, although it cannot cure the disease [33][34] Group 3 - Caregivers of Alzheimer's patients face significant challenges and stress, often going unrecognized for their contributions and sacrifices [40][41] - The establishment of support groups and caregiver networks is crucial for providing emotional support and resources to those caring for Alzheimer's patients [49][50] - The article highlights the importance of community involvement and the expansion of caregiver support initiatives across various regions to enhance the well-being of both patients and caregivers [60][62]

你刚刚结束了一天的疲惫工作回到家，只想抬起双脚，随便看点电视放空自己。虽然这种不动的状态感 觉像是应得的休息，但其实你的大脑并没有真的"放空"。根据最新研究，它在你放松时消耗的能量，几 乎和你紧张工作时差不多。 澳大利亚蒙纳士大学的神经科学家沙娜·贾马达（Sharna Jamadar）和她的同事们，综合了她所在实验室 以及全球其他研究团队的研究成果，估算了"认知的代谢成本"（metabolic cost of cognition）——也就是 大脑运行到底需要多少能量。令人惊讶的是，他们发现，专注、有目标的思考任务，比休息状态下的大 脑活动仅多消耗大约5%的能量。换句话说，即使我们在专心思考时，大脑的能耗也只比"待机"状态高 出一点点。 我们常觉得集中注意力、深入思考很费脑力，好像消耗了很多能量。但这项新研究支持了一个正在发展 的观点：大脑的主要功能其实是"维持运转"。过去，很多神经科学研究重点放在外显的认知活动上，比 如注意力、解决问题、工作记忆、决策等。但现在越来越清楚的是，在这些显性的思维之下，大脑 的"后台"其实一直在高度活跃。它负责调节身体的主要生理系统，自动调配资源来应对内外环境的变 化，不管是我们 ...

编译丨王聪 编辑丨王多鱼 排版丨水成文 神经精神疾病 具有复杂的病理机制、显著的临床异质性以及漫长的临床前期，这给早期诊断和精准干预策略的制定带来了挑战。 随着大规模多模态神经影像数据集的发展以及人工智能 （AI） 算法的进步，将多模态成像与 AI 技术相结合已成为早期发现神经精神疾病以及为其量身定制个性 化治疗方案的关键途径。 2025 年 5 月 20 日，北京师范大学 舒妮 教授、南京航空航天大学 黄伟杰 副研究员在 Cell 子刊 Cell Reports Medicine 上发表了题为 ： AI-powered integration of multimodal imaging in precision medicine for neuropsychiatric disorders 的综述论文。 在这篇综述中， 作者概述了多模态神经影像技术、人工智能方法以及多模态数据融合策略，强调了基于神经影像数据的多模态人工智能在神经精神疾病精准医疗 中的应用，并探讨了其在临床应用中的挑战、新兴解决方案以及未来的发展方向。 神经精神疾病，例如阿尔茨海默病、自闭症、抑郁症等，如同一幅复杂的拼图：症状多样、病因隐蔽， ...

Group 1: Core Concepts of Antimatter - Antimatter is a mirror image of ordinary matter, where each particle has a corresponding antiparticle with opposite charge [2][3] - The discovery of antimatter dates back to the early 20th century, with significant milestones including the prediction of positrons by Paul Dirac in 1928 and the first observation of positrons by Carl Anderson in 1932 [3] - Recent advancements in antimatter research include the successful observation of antihydrogen-4 by Chinese scientists in 2024, marking a significant breakthrough in the field [3] Group 2: Research Objectives - One primary goal of antimatter research is to address the baryon asymmetry problem, which questions why the universe is predominantly composed of matter despite equal amounts of matter and antimatter being produced during the Big Bang [4] - Another objective is to test the applicability of physical laws to antimatter, particularly the equivalence principle of general relativity, which posits that all objects respond to gravity in the same way [5][6] - A third goal involves studying dark matter and its potential counterpart, "antidark matter," which could provide insights into the origins of observed antimatter in the universe [7] Group 3: Practical Applications - Antimatter has practical applications in medicine, particularly in positron emission tomography (PET), which utilizes positrons for high-precision imaging of metabolic processes in patients [8] - Research on antiprotons has been conducted to explore their effectiveness in cancer treatment, with findings suggesting that antiprotons can more efficiently destroy cancer cells while minimizing damage to healthy cells [9] - Antimatter also holds potential as a clean energy source, with energy density estimates indicating that it could be 10 billion times greater than traditional fossil fuels, making it a candidate for future energy solutions [10] Group 4: Future Prospects - Theoretical applications of antimatter in space travel suggest that antimatter propulsion systems could achieve speeds up to 15% of the speed of light, revolutionizing interstellar exploration [10] - Despite the challenges in producing and storing antimatter, ongoing research aims to overcome these obstacles, potentially leading to significant advancements in both energy and space travel technologies [10]