Core Viewpoint - 招银国际 maintains a "Buy" rating for 巨子生物 (02367) with a target price of HKD 58.35, despite a weak online sales performance for 可复美 during the first phase of Double Eleven sales [1] Group 1: Financial Performance - 可复美's online revenue is estimated to decline by 10% year-on-year in 2H25, leading to an overall online revenue growth rate of approximately 5% for the year [1] - 可丽金 is expected to achieve a high growth rate of about 40% in online revenue for the year [1] - The company's revenue growth forecast for 2025 is expected to slow down to 12% [1] - The CAGR for 可复美's revenue growth from 2025E to 2027E has been revised down from 26% to 14.5% due to short-term pressures on online sales [1] Group 2: Product Development - 巨子生物's first injectable recombinant collagen product, recombinant type I α1 collagen lyophilized fiber, has been approved for use in facial dermal tissue filling to correct dynamic wrinkles, including frown lines, forehead lines, and crow's feet [1] - The approval marks the completion of the company's product matrix layout for aesthetic injections, post-surgical recovery (dressing), and functional skincare [1] - The company is progressing with the commercialization of injectable products [1] Group 3: Upcoming Products - The company has two additional injectable collagen products in the approval stage: 1. Injectable recombinant collagen filler for moderate to severe neck wrinkles, prioritized for medical device approval by December 2024 [2] 2. Recombinant collagen implant, submitted for registration as a drug-device combination by August 2025, currently under review [2] - The approval of these products will further enrich the company's aesthetic product matrix, covering a range of anti-aging scenarios from forehead to neck and improving skin texture [2]

Group 1 - The core viewpoint of the report is that Zhuhai International maintains a "Buy" rating for Giant Bio (02367) with a target price of HKD 58.35, despite short-term pressures on online sales for Kefu Mei [1] - Kefu Mei's online sales performance during the first phase of Double Eleven was relatively weak, with an estimated year-on-year decline of 10% in online revenue for the second half of 2025, leading to an overall growth rate of approximately 5% for the year [1] - In contrast, Keli Jin is expected to achieve a high growth rate of about 40% in online revenue for the year, while offline business is projected to maintain steady growth [1] Group 2 - The company has adjusted its revenue growth forecast for Kefu Mei from a CAGR of 26% to 14.5% for the years 2025 to 2027 due to the anticipated short-term pressure on online sales [1] - Giant Bio's first injectable recombinant collagen product, recombinant type I α1 collagen lyophilized fiber, has been approved for market launch, aimed at facial dermal tissue filling to correct dynamic wrinkles, including frown lines, forehead lines, and crow's feet [1] - This approval signifies the completion of the company's full product matrix layout for aesthetic injections, post-surgical recovery dressings, and functional skincare [1] Group 3 - The company has two additional injectable collagen products currently in the approval stage: 1) Injectable recombinant collagen filler for moderate to severe neck wrinkles, prioritized for medical device approval by December 2024; 2) Recombinant collagen implant, with a registration application submitted in August 2025 as a drug-device combination, which has been accepted and is under review [2] - The approval of these products is expected to further enrich the company's aesthetic product matrix, covering a range of anti-aging scenarios from forehead to facial and neck areas, addressing dynamic wrinkle improvement to overall skin texture enhancement [2]

Investment Rating - The industry is rated as "Recommended" based on favorable fundamentals and expectations for the industry index to outperform the benchmark index [2][27]. Core Insights - The report highlights the approval of "Recombinant Type III Humanized Collagen Gel" by Jinbo Biotech, marking a significant advancement in the domestic market for recombinant collagen materials, which now covers various formulations including solutions, gels, and solids [1][22]. - The collagen industry is expected to experience a peak in product approvals between 2025 and 2026, with companies like Juzhi Biotech and Chuangjian Medical making significant progress in their product registrations [24]. - The report emphasizes the high market demand for collagen products, particularly in aesthetic applications, driven by the increasing awareness and acceptance of various filler materials [5][11]. Summary by Sections 1. Collagen Filling Products - Various types of facial injectables are categorized into biodegradable and non-biodegradable fillers, with biodegradable fillers further divided into short-acting and long-acting types [8]. - Collagen is a natural protein found in animal tissues, constituting one-third of total body protein, with a significant presence in the skin [10]. 2. Clinical Research on Collagen - Clinical studies on collagen primarily focus on periorbital rejuvenation and skin revitalization, with a growing need for expanded application areas due to increasing aesthetic demands [11]. - The report notes that the use of collagen for periorbital rejuvenation effectively addresses issues like dark circles and fine lines, showcasing its advantages over other materials [11]. 3. Evaluation of Collagen Injection Fillers - The report evaluates the characteristics of collagen fillers, highlighting their immunogenicity, biodegradability, and biocompatibility, which contribute to their safety and effectiveness in clinical applications [14]. - The report also discusses the regulatory landscape, noting that there are currently nine approved collagen injection products in China, with Jinbo Biotech being the sole domestic producer of recombinant collagen [21]. 4. Market Trends and Future Outlook - The report anticipates a surge in collagen product approvals, particularly for recombinant types, as companies navigate the regulatory landscape and enhance their product offerings [24]. - The introduction of innovative technologies, such as self-assembling collagen, is expected to improve product safety and efficacy, further driving market growth [22].