Core Viewpoint - The company has not yet achieved profitability and faces significant cumulative losses due to ongoing research and development expenses, despite having several products approved for commercial sale [1][2]. Group 1: Company Overview - The company, Suzhou Zelgen Biopharmaceutical Co., Ltd., has several products included in the medical insurance directory, including Tofacitinib tablets for advanced liver cancer and other conditions [1]. - The company has received approval for the marketing of recombinant human thrombin and Tofacitinib tablets, but these products are still in the market access phase [1][2]. Group 2: Financial Situation - As of June 30, 2025, the company has accumulated losses and may continue to incur losses in the future, which will depend on the success of its drug commercialization and the number of ongoing research projects [2]. - The company has significant reliance on external financing for its working capital, which may pressure its financial situation if expenses exceed available financing [2]. Group 3: Fundraising and Use of Funds - The company raised a total of RMB 2,025.6 million from its initial public offering in 2020, with a net amount of RMB 1,908.22 million after deducting related expenses [8][31]. - In 2021, the company raised RMB 1,199.99 million through a private placement, with a net amount of RMB 1,181.93 million after expenses [9][32]. - As of June 30, 2025, the company has used RMB 1,677.81 million of the initial public offering funds and RMB 406.25 million of the private placement funds [10][15]. Group 4: Risk Factors - The company faces risks related to its ongoing research and development projects, which require substantial investment and may not yield successful outcomes [2][3]. - The company has not declared any cash dividends due to its inability to generate profits, which may negatively impact shareholder returns [2].

Financial Performance - The company reported total operating revenue of approximately 375.65 million, a significant increase from 240.70 million in the same period last year, reflecting a year-on-year growth [3] - The total profit for the period was -77.41 million, slightly improved from -79.49 million year-on-year [3] - The net profit attributable to shareholders was -72.80 million, compared to -66.54 million in the previous year [3] - The net profit after deducting non-recurring gains and losses was -102.64 million, worsening from -72.37 million year-on-year [3] - The net cash flow from operating activities was -17.02 million, a decrease from a positive cash flow of 112.55 million in the same period last year [3] Non-Recurring Gains and Losses - The total non-recurring gains and losses amounted to 29.84 million, with government subsidies contributing 22.82 million and other non-recurring items accounting for 10.24 million, while the tax impact was -3.30 million [1] Shareholder Structure - The top ten shareholders at the end of the first half of 2025 included new entrants such as Huatai Fuhua Innovation Medical Theme Mixed Securities Investment Fund and Ningbo Jingchen Investment Partnership, replacing previous shareholders [52] - The shareholding ratio of China Europe Medical Health Mixed Securities Investment Fund increased, while other funds saw a decrease in their holdings [52] Financial Ratios - As of the end of the first half of 2025, the company's current ratio was 1.9 and the quick ratio was 1.78, indicating a stable liquidity position [48] - The company’s price-to-earnings ratio (TTM) was approximately -200.42, with a price-to-book ratio of about 24.54 and a price-to-sales ratio of approximately 43.24 [3] Asset and Liability Changes - As of mid-2025, cash and cash equivalents decreased by 1.68%, while accounts receivable increased by 22.12% [41] - Long-term borrowings increased by 183.42%, while other payables decreased by 57.26% [44]

Core Viewpoint - Zai Jian Pharmaceutical is recognized as an excellent innovative pharmaceutical company with both sales growth and research achievements, receiving a "buy" rating from Tianfeng Securities [1] Group 1: Commercialization and Product Pipeline - Zai Jian Pharmaceutical has successfully commercialized three key products, including Tofacitinib, Recombinant Human Thrombin, and Gilteritinib, with a fourth product, Recombinant Human Thyroid-Stimulating Hormone, expected to be launched soon [2] - The company is advancing its ZG006 product, a CD3/DLL3/DLL3 tri-antibody, which is in Phase 2 clinical trials and may become the first of its kind to enter Phase 3 trials globally [3] Group 2: Clinical Trial Results - ZG005, a PD-1/TIGIT dual antibody, has shown promising results in cervical cancer trials, with an overall response rate (ORR) of 40.9% and a disease control rate (DCR) of 68.2% in patients who had not previously received immune checkpoint inhibitors [4] Group 3: Financial Forecasts - The company is projected to achieve revenues of 820 million, 1.201 billion, and 1.603 billion RMB from 2025 to 2027, with net profits expected to be -20 million, 121 million, and 282 million RMB respectively, maintaining a "buy" rating [5] - Recent institutional ratings indicate a strong buy sentiment, with eight institutions giving a buy rating and an average target price of 77.18 RMB over the past 90 days [6]

Investment Rating - The report maintains a "Buy" rating for the company [4][7]. Core Insights - The company has successfully commercialized three key drugs and is on the verge of launching a recombinant human thyroid-stimulating hormone [1][15]. - ZG006, a CD3/DLL3/DLL3 tri-antibody, is in Phase 2 clinical trials and is expected to be the first of its kind to enter Phase 3 trials globally [2][41]. - ZG005, a PD-1/TIGIT dual antibody, shows promising clinical trial results for cervical cancer and is actively expanding into multiple indications [3][31]. Financial Projections - Revenue forecasts for 2025 to 2027 are projected at 820 million, 1.201 billion, and 1.603 billion RMB, respectively, with net profits expected to be -20 million, 121 million, and 282 million RMB [4][6]. - The company is expected to achieve significant revenue growth rates, with a projected increase of 53.81% in 2025 [6]. Key Products Overview - The company has launched three key products: - Tofacitinib tablets for advanced liver cancer and radioiodine-refractory differentiated thyroid cancer, which are included in the national medical insurance directory [17][18]. - Recombinant human thrombin for hemostasis, which has shown clear clinical efficacy [21][30]. - JAK inhibitor JAK2 for myelofibrosis, which has been approved for market and is expanding into other indications [31][33]. Clinical Development Highlights - ZG006 has demonstrated significant anti-tumor activity and safety in small cell lung cancer patients during clinical trials [2][40]. - ZG005 has shown a 40.9% objective response rate in cervical cancer patients who had not previously received immune checkpoint inhibitors [3][34]. Market Potential - The market for recombinant human thrombin is expected to grow alongside the increasing number of surgical procedures in China, projected to reach 12.83 million by 2030 [21][25]. - The myelofibrosis drug market is anticipated to grow significantly, with the market size expected to reach 2.93 billion RMB by 2025 [31][32].