来源：子弹财经 | 作者 | 张旺 | 编辑 | 蛋总 | | --- | --- | --- | --- | | 美编 | 倩倩 | 审核 | 颂文 | 作为首家适用"第五套标准"登陆科创板的创新药企，泽璟制药曾被视为A股资本市场的一个划时代标 杆。 2020年1月23日，泽璟制药在上交所科创板成功上市，打破了此前A股对未盈利企业的门槛限制。自 此，宝贵的二级市场融资通道开始向一众无营收、无利润的创新药企业开放。 连亏六年仍未上岸 泽璟制药成立于2009年，创始人盛泽林曾在美国从事药物开发，回国后历任上海赛金生物董事、白鹭医 药COO等。 2020年1月，泽璟制药在尚无产品上市、尚无稳定收入来源的情况下，凭借在研管线和技术平台，以第 五套上市标准登陆科创板，开创了中国资本市场支持早期创新药企融资的先河。 泽璟制药的业务布局主要聚焦于肿瘤、自身免疫性疾病及止血领域。公司上市以来，已经从"三无"阶段 成长至商业化阶段。（编者按："三无"即无稳定营收、无持续盈利、无成熟商业化产品。） 2020年上市之初，其营业收入仅为2766万元。2021年，随着核心产品多纳非尼（商品名：泽普生）获批 上市并进入医保目录，公司收 ...

长江商报消息 ●长江商报记者 沈右荣 曾经以"三无"撬开科创板大门的泽璟制药（688266.SH）宣布了一个重磅消息。 泽璟制药的研发取得了初步成果。 根据最新公告，泽璟制药与艾伯维就ZG006（Alveltamig）的全球开发及商业化达成战略合作与许可选 择权协议。艾伯维获得ZG006在大中华区以外地区独家开发与商业化权利。而泽璟制药将保留在大中华 区ZG006的开发与商业化权利。 ZG006是一种新型三特异性 T 细胞结合剂，靶向 DLL3，目前正处于治疗小细胞肺癌及其他 DLL3 表达 恶性肿瘤的临床开发后期阶段。该药物已获得美国食品药品监督管理局（FDA）和中国国家药品监督管 理局（NMPA）的临床试验批准，被 NMPA 药品审评中心认定为复发或进展性晚期小细胞肺癌及DLL3 阳性神经内分泌癌的突破性疗法，并获美国 FDA 授予孤儿药资格认定。 艾伯维是一家以研究为导向的生物制药企业，其全球总部位于美国伊利诺伊州。 2025年的最后一天，泽璟制药发布公告，公司与艾伯维集团控股公司（以下简称"艾伯维"）就ZG006 （Alveltamig）的全球开发及商业化达成战略合作与许可选择权协议，艾伯维获得ZG0 ...

Core Viewpoint - Suzhou Zelgen Biopharmaceutical Co., Ltd. (Zelgen Pharma) has officially submitted its application for listing on the Hong Kong Stock Exchange, aiming to enhance its international brand recognition and support its global business strategy, despite recent actions that raise questions about its commitment to internationalization [1] Financial Performance - Zelgen Pharma has not yet achieved profitability since its IPO on the STAR Market in 2020, but its losses have been decreasing year by year. Revenue for 2022, 2023, and 2024 is reported at 302 million, 386 million, and 533 million yuan respectively, while losses for the same periods are 457 million, 279 million, and 138 million yuan [2] - In the first three quarters of 2025, the company reported revenue of 593 million yuan, a year-on-year increase of 54.49%, with losses amounting to 93.42 million yuan [2] - The company's revenue primarily comes from three approved products, with significant sales expenses that have risen alongside revenue, indicating a focus on market expansion [2] Capital Operations - Zelgen Pharma has engaged in frequent capital operations, raising 2.026 billion yuan during its IPO and an additional 1.2 billion yuan through a private placement in 2023. The company has utilized 1.677 billion yuan of the IPO funds and 406 million yuan of the private placement funds for new drug research projects [3] - The company has also proposed to raise up to 300 million yuan through a simplified procedure for issuing shares to specific investors [3] - A notable portion of the raised funds has been redirected, with 25.38% of IPO funds and 19.88% of private placement funds having their purposes changed [3] Debt Situation - The company's interest-bearing debt has been on the rise, with short-term loans increasing from 391 million yuan in 2022 to 967 million yuan in the first three quarters of 2025, and long-term loans fluctuating during the same period [4] Internationalization Strategy - Despite the importance of internationalization for Zelgen Pharma, the company recently canceled its overseas subsidiary GENSUN, which was seen as a key component of its international strategy. This decision came after the company had previously acquired shares in GENSUN using its own funds [5][6] - GENSUN, established in the U.S. for new drug research, has been unprofitable since its inception, yet the company valued it at approximately 90.28 million USD during acquisitions [6] - The company has reduced its investment in an international clinical trial project, indicating a shift in focus due to competitive pressures in the market [7]

Core Viewpoint - The article discusses the challenges and potential of Zai Lab, a biopharmaceutical company, as it prepares for its IPO in Hong Kong while facing ongoing financial losses and strategic shifts in its international operations [4][5][20]. Group 1: Financial Performance - Zai Lab has reported a revenue increase to 593 million yuan, a year-on-year growth of 54.49%, but still incurred a loss of 93.42 million yuan [8][9]. - The company has experienced continuous losses since its listing, with net losses of 319 million yuan, 451 million yuan, 457 million yuan, 279 million yuan, and 138 million yuan from 2020 to 2024 [14]. - The asset-liability ratio has risen to over 60%, indicating increasing financial risk [3][25]. Group 2: R&D and Product Pipeline - Zai Lab has a unique innovative drug development system with three products already on the market and 14 in the pipeline, including the first domestic targeted drug for liver cancer [10][12]. - Despite the promising product pipeline, the company has been reducing R&D expenditures while sales expenses have been increasing, raising concerns about its long-term sustainability [15][14]. Group 3: International Strategy and Market Position - The company announced plans to issue H shares and pursue an international strategy, but simultaneously canceled its U.S. subsidiary, raising questions about its commitment to overseas expansion [5][22]. - Zai Lab's international revenue has been negligible, with no overseas income reported in recent years, which may affect investor confidence in its global strategy [22][24]. Group 4: Shareholder Dynamics and Market Sentiment - Zai Lab's stock price has fluctuated significantly since its IPO, with a peak of 134.17 yuan per share in July 2025, but has recently declined to 102.8 yuan [17]. - The company has not paid dividends for five consecutive years, which may undermine its valuation as it seeks to list in Hong Kong [6][17]. - Institutional investors play a crucial role in Zai Lab's stock performance, with significant holdings from major funds [18][16]. Group 5: Future Outlook - The company's future success hinges on the commercialization of key products ZG006 and ZG005, as well as the market's willingness to invest in a company that has yet to achieve profitability [27]. - Zai Lab must provide clear and detailed plans to investors regarding its international strategy and financial needs to gain market trust [26][21].

Core Viewpoint - Zejing Pharmaceutical is planning to launch an IPO on the Hong Kong Stock Exchange to enhance its international brand recognition and competitiveness, despite currently being unprofitable and facing financial pressures [1][2][3]. Financial Performance - As of Q3 2025, Zejing's debt-to-asset ratio reached 61.87%, the highest since Q3 2020, significantly exceeding the industry average of 34.36% by 27.51 percentage points [2][5]. - The company's liquidity ratios have declined, with the current ratio falling from 1.953 in Q3 2024 to 1.850 in Q3 2025, and the quick ratio decreasing from 1.831 to 1.721 in the same period [2]. - Operating cash flow has turned negative, with a net cash flow of -16.73 million yuan in the first three quarters of 2025, a 125.11% decrease from 66.65 million yuan in the same period of 2024 [2][5]. Revenue and Profitability - Despite revenue growth from 27.66 million yuan in 2020 to 533 million yuan in 2024, the company continues to report losses, with net losses of 319.2 million yuan in 2020 and narrowing to 93.42 million yuan in the first three quarters of 2025 [5][6]. - Sales expenses have consistently exceeded 50% of revenue, contributing to ongoing losses, with sales expenses rising from 35.07 million yuan in 2020 to 33.20 million yuan in 2025 [6]. Strategic Initiatives - The company aims to accelerate its internationalization strategy, having received FDA clinical trial approvals for multiple products, including ZG0895, which is in the I/II clinical trial phase [9][10]. - Zejing's previous attempt to internationalize through the acquisition of Gensun Pharmaceuticals resulted in continuous losses, leading to the decision to deregister Gensun to streamline operations and reduce costs [10]. Market Context - The global oncology drug market is projected to reach $649.7 billion by 2034, with a compound annual growth rate of 9.0% from 2024 to 2034, indicating significant growth potential for companies in this sector [6]. - The Chinese innovative drug market is experiencing rapid internationalization, with total foreign licensing amounts nearing $100 billion in 2025, highlighting the competitive landscape [7][9].

Core Viewpoint - The company's performance in the first three quarters of 2025 aligns with expectations, showing significant revenue growth driven by key products [1][2]. Revenue Performance - The company reported revenue of 593 million yuan for 1-3Q25, representing a year-on-year increase of 54.49%. The net loss attributable to shareholders was 93.42 million yuan, with 3Q revenue reaching 218 million yuan, up 51.85% year-on-year [1][2]. - Quarterly revenue breakdown for 1-3Q25 shows 168 million yuan in Q1, 208 million yuan in Q2, and 218 million yuan in Q3, with year-on-year growth rates of 54.9%, 57.0%, and 51.9% respectively [2]. Key Growth Drivers - The main contributors to revenue growth include the rapid market uptake of recombinant thrombin following its inclusion in the national medical insurance directory and the commercialization of gilteritinib, which began in June [2]. - The sales of gilteritinib have exceeded 10 million yuan, supported by the company's self-built sales team, and it is expected to participate in medical insurance negotiations this year [2]. Clinical Development Highlights - The company is focusing on the progress and data validation of its potential blockbuster products ZG006 and ZG005, which have shown promising clinical data at various academic conferences [3]. - ZG006 has been selected for oral presentations at the recent ESMO conference, showcasing impressive results in its Phase I trial, with ongoing Phase II data also being presented [3]. - A key registration clinical trial for ZG006 in treating third-line and above small cell lung cancer (SCLC) began patient enrollment in September 2025, and a Phase III trial comparing ZG006 to chemotherapy for second-line SCLC has received regulatory approval [3]. Profit Forecast and Valuation - The company maintains its profit forecasts for 2025 and 2026, with a target price of 145.0 yuan based on DCF valuation, indicating a potential upside of 39.6% from the current stock price [4].

Core Viewpoint - The Chinese innovative drug market is entering a rapid development phase, with local leading companies like Heng Rui benefiting from policy support and industry expansion opportunities [1] Company Performance - Heng Rui Pharmaceutical reported a revenue of 23.188 billion yuan for the first three quarters of 2025, a year-on-year increase of 14.85%, and a net profit of 5.751 billion yuan, up 24.50% [2] - The company has received a total cash dividend of over 9.3 billion yuan, enhancing investor returns [1] - The company has established a differentiated competitive advantage through over 50 billion yuan in R&D investment and has 24 innovative drugs approved for sale in China [1] Industry Trends - The innovative drug sector is experiencing accelerated commercialization and increased business development (BD) transactions, leading to a sustained trend of rapid growth in performance [1] - Other innovative drug companies, such as Zai Lab and DiZhe Pharmaceutical, are also reporting significant revenue growth, with Zai Lab achieving a 54.49% increase in revenue to 593 million yuan [3] - The industry is expected to continue its growth trajectory, supported by favorable national policies and increasing international collaboration [4][5] R&D Focus - Heng Rui's innovative drugs, including Rivoceranib and Darsylis, are addressing unmet clinical needs, contributing to their revenue growth [2] - Zai Lab emphasizes its differentiated product pipeline focusing on oncology and autoimmune diseases, aiming to fill domestic gaps in treatment options [3] - The industry is witnessing a rise in R&D investments, with companies like Yi Fang Bio reporting a total R&D investment of 190 million yuan for the first three quarters of 2025 [4] Future Outlook - Analysts predict a new round of growth for the pharmaceutical sector, particularly in innovative drugs, as the international standing of Chinese innovative drug companies rises [5] - The innovative drug sector is expected to remain a key investment theme in the pharmaceutical industry through 2026, driven by increased BD transactions and international collaborations [5]

Core Viewpoint - The Chinese innovative drug market is entering a rapid development phase, with companies like Heng Rui benefiting from policy support and industry expansion opportunities [1][6]. Company Performance - Heng Rui Pharmaceutical reported a revenue of 23.188 billion yuan for the first three quarters of 2025, a year-on-year increase of 14.85%, and a net profit of 5.751 billion yuan, up 24.50% [2]. - The company has received a total cash dividend of over 9.3 billion yuan, enhancing investor returns [1]. - The company has established a differentiated competitive advantage through over 50 billion yuan in cumulative R&D investment and has 24 innovative drugs approved for sale in China [1][2]. Industry Trends - The innovative drug sector is experiencing accelerated commercialization and increased business development (BD) transactions, leading to a sustained growth trend in performance [1][6]. - Companies like Zejing Pharmaceutical and Dizhe Pharmaceutical are also reporting significant revenue growth, with Zejing achieving a 54.49% increase in revenue to 593 million yuan in the first three quarters of 2025 [3]. - The industry is expected to maintain a positive growth trajectory, supported by favorable national policies and increasing international collaboration [5][6].

Macro Strategy - The core view indicates that actual interest rates remain the key anchor for gold prices, with fluctuations driven by macroeconomic policies and geopolitical factors [1][11] - In November, gold prices are expected to be influenced by geopolitical situations, trade negotiations, and macro policies, with a potential for continued high-level fluctuations [1][11] - The CME interest rate futures suggest a widespread expectation of a 25 basis point rate cut by the Federal Reserve in December, which may support gold prices [1][11] Fixed Income Strategy - The report discusses a trading strategy of "long old bonds and short new bonds" based on the behavior of active bond spreads, which typically exhibit a jump during the switching process [2][12] - The active bond spread trading strategy remains profitable, with the maximum spread observed at 9.8 basis points since 2023, indicating a favorable trading environment [2][12] Food and Beverage Industry - The beer sector is currently viewed as being at a bottoming phase, with expectations for demand recovery driven by macro policy changes and improved fundamentals in 2024 [4][14] - The report highlights that the beer sector's revenue for the first three quarters of 2025 reached 617.26 billion yuan, with a year-on-year growth of 1.99% [4][15] - Key players such as Qingdao Beer and Yanjing Beer are expected to perform well, with a focus on high-growth segments and defensive strategies [4][15] Healthcare Products Industry - The healthcare products sector showed a year-on-year revenue growth of 18% and a net profit increase of 122% in Q3 2025, indicating a positive trend despite individual stock variations [16][17] - Companies like Tongrentang and Minsheng Health are highlighted for their strong performance and growth potential in the healthcare market [16][17] Nonferrous Metals Industry - The report notes that industrial metals are experiencing high-level fluctuations, with copper prices expected to strengthen after a period of consolidation due to supply disruptions and improved macro sentiment [5][19] - Aluminum prices have shown an upward trend, supported by supply stability and increased demand, particularly in the context of geopolitical developments [5][19] Media Industry - The media sector reported a revenue of 1,279 billion yuan in Q3 2025, reflecting a 7% year-on-year increase, with the gaming sector showing particularly strong performance [6][20] - The gaming segment's net profit grew by 76% year-on-year, driven by successful product launches and a stable revenue growth trajectory [6][20]

Core Viewpoint - The report outlines the ongoing supervision and compliance of Suzhou Zejing Biopharmaceutical Co., Ltd. by China International Capital Corporation, emphasizing the company's adherence to regulations and the status of its financial performance in the first half of 2025. Summary by Sections Continuous Supervision Work - The supervising institution has established a comprehensive and effective supervision system and has signed a continuous supervision agreement with the company, clarifying the rights and obligations of both parties during the supervision period [1]. - During the supervision period from January to June 2025, the company did not report any violations or illegal activities [1][2]. - The supervising institution conducted regular communications, site visits, and due diligence to monitor the company's compliance with laws and regulations [1]. Financial Performance - For the first half of 2025, the company reported a revenue of CNY 375.65 million, a 56.07% increase compared to CNY 240.70 million in the same period of 2024 [1]. - The total profit for the same period was a loss of CNY 77.41 million, slightly improved from a loss of CNY 79.49 million in the previous year [1]. - The net loss attributable to shareholders was CNY 72.80 million, compared to a loss of CNY 66.54 million in the previous year [1]. - The cash flow from operating activities showed a significant decline, with a net outflow of CNY 17.02 million, down from an inflow of CNY 112.55 million in the same period last year [1]. Research and Development - The company has a strong focus on R&D, with R&D expenses accounting for 52.31% of its revenue in the first half of 2025, a decrease from 75.26% in the previous year [1]. - The company is actively developing a pipeline of innovative drugs targeting oncology and autoimmune diseases, with several products in various stages of clinical trials [20][21][24]. Competitive Advantages - The company possesses a differentiated product pipeline with several drugs already approved or nearing commercialization, including treatments for advanced liver cancer and thyroid cancer [20][21]. - The company is also exploring new targets and technologies to enhance its product offerings and maintain a competitive edge in the biopharmaceutical industry [22][26]. Risks and Challenges - The company faces significant risks, including the potential for unprofitability, reliance on external financing for R&D, and challenges in clinical trial recruitment and regulatory approvals [3][4][14]. - The competitive landscape in the pharmaceutical industry is intense, with the company needing to adapt to rapid technological changes and regulatory shifts [15][16]. Future Outlook - The company aims to enhance its international presence and collaboration capabilities, leveraging its innovative drug development platforms and established clinical networks [25][26]. - As more products approach commercialization, the company anticipates sustained revenue growth, which will support further R&D investments and strategic initiatives [24][25].