GlucaPharm is developing GEP44, a novel, patented peptide (similar in function to Ozempic®, Wegovy®, Mounjaro®, but with reduced risk of adverse events) discovered by researchers at Syracuse University.Vancouver, British Columbia--(Newsfile Corp. - February 23, 2026) - SureNano Science Ltd. (CSE: SURE) (OTCQB: SURNF) ("SureNano" or the "Company") is pleased to announce that it has completed the acquisition of GlucaPharm Inc. ("GlucaPharm"), a next-generation glucagon-like peptide ("GLP") pharmaceutical com ...

Core Insights - PharmaTher Holdings Ltd. is pursuing Health Canada approval for generic semaglutide, aiming for commercialization following regulatory approval [1][4] - The expiration of regulatory exclusivity for semaglutide in Canada in January 2026 opens the market for generic competition [2] - The Canadian market for semaglutide generated approximately C$2.9 billion in sales in 2025, with potential growth in the broader GLP-1 receptor agonist market estimated at US$6.5 billion by 2033 [3] Company Strategy - PharmaTher's initiative focuses on speed-to-market, reliable supply, and broad dose coverage for generic semaglutide [4][7] - The company plans to leverage its experience from FDA approval of ketamine to execute its strategy for semaglutide [4] - A sterile injectable manufacturing strategy will be employed, utilizing a cost-effective, high-quality manufacturer with regulatory compliance [7] Market Context - The demand for semaglutide is increasing, and affordable access along with reliable supply will be critical in the Canadian market [4] - The transition in Canada's semaglutide market is seen as pivotal, with growing demand for generic options [2][4]

Core Insights - Skye Bioscience, Inc. presented findings on nimacimab, a potential first-in-class monoclonal antibody for obesity treatment, at a recent conference, highlighting its efficacy and safety profile when combined with other therapies [1][2][4] Group 1: Nimacimab's Mechanism and Efficacy - Nimacimab is designed to be a peripherally-restricted CB1 receptor inhibitor, minimizing neuropsychiatric side effects associated with previous CB1-targeting drugs [3] - The studies indicated that nimacimab, when combined with lower doses of incretin agonists, could maintain a favorable safety profile while achieving significant efficacy [2][6] - In combination with suboptimal doses of tirzepatide, nimacimab resulted in weight loss of 39% and 46% respectively, demonstrating its additive effects [6] Group 2: Long-term Treatment and Maintenance - The weight loss effects of nimacimab were durable even after treatment discontinuation, with a significant reduction in weight rebound (approximately 80% blunted) [6] - Nimacimab can serve as a maintenance therapy following the discontinuation of tirzepatide, enhancing weight loss outcomes [6] Group 3: Clinical Development and Strategy - Skye is conducting a Phase 2a clinical trial for nimacimab in obesity, assessing its combination with a GLP-1R agonist (Wegovy®) [4] - The company's strategy focuses on developing next-generation therapeutics that modulate G-protein coupled receptors, aiming for clinical and commercial differentiation [4]

Strategy and Focus - Novo Nordisk focuses on innovation-driven opportunities within core therapeutic areas[9, 13] - The company's strategy centers on leading in Obesity, Diabetes, and related comorbidities[10, 14] Market Needs and Opportunities - There is a significant unmet need within Diabetes, with >550 million people living with T1D or T2D and ~7% of diabetes prescriptions are for a GLP-1[11, 15] - A significant unmet need exists within Obesity, with >900 million people living with obesity and only ~2% are treated with branded Anti-Obesity Medications (AOMs)[11, 15] - Select related comorbidities include >800 million people living with MASH, 250 million with CVD, and >500 million with CKD[11, 15] Key Priorities for 2026 - Accelerate commercial execution, including the launch of Wegovy® pill in the US and roll out of semaglutide 7.2 mg, and expand Direct-to-Patient and cash channels[18] - Reinforce organizational focus through organizational set-up & culture coming out of transformation and resource allocation towards growth opportunities[18] - Strengthen the R&D pipeline by progressing late-stage pipeline and bringing several new obesity & diabetes assets into the clinic[18] Forward-Looking Statements - The company's statements may contain forward-looking statements relating to operating, financial, and sustainability performance[3] - These statements are based on current plans, estimates, opinions, views, and projections, but actual results may differ materially due to risks, uncertainties, and assumptions[4]

Group 1 - The consensus among domestic and foreign institutions is that the Chinese stock market will continue to rise in 2026, driven by factors such as AI innovations, anti-involution policies, and improved corporate earnings [1] - Morgan Stanley and Citibank maintain an overweight rating on the Chinese market, while Goldman Sachs predicts a 38% increase in the Chinese stock market by the end of 2027, primarily due to corporate earnings growth of 14% and 12% in 2026 and 2027, respectively [1] - The national pension fund, exceeding 7.7 trillion yuan, will enter a long-term assessment phase to promote long-term investments and improve risk control and asset allocation [1] Group 2 - In January 2026, 71 new public funds are scheduled for issuance, indicating a growing expectation for new capital entering the market [2] - Over 20 A-share listed companies disclosed merger and acquisition announcements, with Zhongwei Company planning to acquire a 64.69% stake in Hangzhou Zhonggui [2] - China surpassed the US in the number of new drug approvals, with 76 innovative drugs approved in 2025, marking a historical high [3] Group 3 - The software and information technology service industry in China saw a revenue increase of 13.3% year-on-year, exceeding 13 trillion yuan, with software product revenue accounting for over 20% of total industry revenue [4] - The Supreme People's Court of China made a favorable ruling regarding the patent of semaglutide, which is significant for the pharmaceutical company Novo Nordisk [5] - The company anticipates a low single-digit negative impact on global sales growth in 2026 due to the expiration of the semaglutide patent in some markets [5] Group 4 - Tianjin 712 Mobile Communication Co., Ltd. and Chengdu Startronic Microelectronics Co., Ltd. both initiated listing guidance on January 4, 2026 [6][7] - Blue Arrow Aerospace's IPO application has been accepted, with a planned fundraising of 7.5 billion yuan [8] - Former senior executive of Hengrui Medicine, Zhou Yunshu, has joined Xiansheng Pharmaceutical as president [8]

Core Insights - GoodRx has launched two major initiatives to enhance the availability of FDA-approved GLP-1 medications [1] - The first initiative is GoodRx for Weight Loss, a telemedicine subscription service connecting consumers with licensed healthcare providers for affordable weight management treatment [1] - The second initiative, in partnership with Novo Nordisk, introduces a new cash price of $199 per month for Ozempic® [1]

Core Insights - Novo Nordisk has reached an agreement with the U.S. Administration to lower drug prices for semaglutide medicines starting in 2026, enhancing patient access and affordability in Medicare Part D and Medicaid [1][2] - A pilot program will be initiated to cover anti-obesity medicines under Medicare Part D, benefiting a majority of beneficiaries [1][3] - The company anticipates a direct, negative low single-digit impact on global sales growth in 2026 due to this agreement [3] Company Overview - Novo Nordisk is a leading global healthcare company founded in 1923, headquartered in Denmark, focusing on chronic diseases, particularly diabetes [5] - The company employs approximately 78,500 people across 80 countries and markets its products in around 170 countries [5] - Novo Nordisk's B shares are listed on Nasdaq Copenhagen, and its ADRs are listed on the New York Stock Exchange [5]

Financial Performance & Strategic Aspirations - For the first nine months of 2025, Novo Nordisk reported sales growth of 15% at Constant Exchange Rates (CER)[11] - Operating profit growth was 10% at CER, impacted by restructuring costs of 9 billion DKK[11, 68] - The company anticipates annualised savings of approximately 8 billion DKK for reinvestment in future growth[17] - Novo Nordisk is transforming with aim to meet future patient needs and allow for investment in growth opportunities[16] Market & Therapeutic Focus - Obesity care sales reached 59.9 billion DKK, reflecting a 41% increase at CER[11] - Rare disease sales amounted to 14.3 billion DKK, a 13% increase at CER[11] - Diabetes value market share stood at 31.6%, a decrease of 2.3 percentage points[11] - The company aims to strengthen its diabetes leadership, targeting a global value market share exceeding one-third[72] Pipeline & Innovation - Novo Nordisk is progressing its pipeline, including US approval for Rybelsus® CV indication and Wegovy® MASH indication[11] - The company agreed to acquire Akero, including a phase 3 MASH asset, and proposed the acquisition of Metsera, Inc for up to 10 billion USD[11, 47] - Cagrilintide 2.4 mg will be investigated in RENEW phase 3 programme with potential to be the first amylin on the market[58]

Core Viewpoint - Skye Bioscience, Inc. is set to discuss its Q3 2025 financial results and business updates in a conference call on November 10, 2025, following the release of its financial results after market close [1][2] Company Overview - Skye Bioscience is a clinical-stage biotechnology company focused on developing new therapeutic pathways for obesity and metabolic health disorders through next-generation molecules that modulate G-protein coupled receptors [3] - The company is conducting a Phase 2 clinical trial for nimacimab, an antibody that inhibits CB1, and is also assessing its combination with a GLP-1R agonist (Wegovy®) [3] Upcoming Events - A live webcast of the conference call will be available on the Skye Investor Relations website, along with the earnings press release and financial tables [2] - Skye will present at the Stifel 2025 Healthcare Conference in New York on November 13, 2025, and will be available for one-on-one meetings [2]

Core Insights - The financial report for the first nine months of 2025 shows robust sales growth, but the company has narrowed its guidance due to lower growth expectations for GLP-1 treatments [2][4] Financial Performance - Net sales reached DKK 229.9 billion, a 12% increase compared to DKK 204.7 billion in the same period of 2024, with a 15% growth at constant exchange rates (CER) [2][4] - Operating profit increased by 5% to DKK 95.9 billion, with a 10% growth at CER, impacted by one-off restructuring costs of approximately DKK 9 billion [2][4] - Net profit rose by 4% to DKK 75.5 billion, with diluted earnings per share increasing by 4% to DKK 16.99 [2][4] Sales Breakdown - Sales in US Operations increased by 12% in Danish kroner and 15% at CER, while International Operations saw a 13% increase in Danish kroner and 16% at CER [4] - Sales within Diabetes and Obesity care grew by 12% to DKK 215.7 billion, driven by a 37% increase in Obesity care sales to DKK 59.9 billion and a 7% increase in GLP-1 diabetes sales [4] Research and Development - The US FDA approved Wegovy® for the treatment of MASH, and the company announced the acquisition of Akero Therapeutics, adding a potential first-and-best-in-class asset [4] - The phase 3 development of cagrilintide for weight management has been initiated, with the potential to be the first amylin monotherapy treatment on the market [4] Future Outlook - For the full-year 2025, sales growth is now expected to be between 8-11% at CER, with operating profit growth projected at 4-7% at CER, reflecting a negative impact of around DKK 8 billion from the company-wide transformation [4] - The guidance narrowing is attributed to lowered growth expectations for GLP-1 treatments within diabetes and obesity [4]