Core Viewpoint - BioNTech has successfully completed the initial offering period for the acquisition of CureVac, with approximately 81.74% of CureVac's shares tendered, allowing the company to proceed with the transaction and subsequent reorganization [1][8]. Group 1: Acquisition Details - A total of 184,071,410 shares of CureVac were validly tendered, satisfying the minimum condition for the exchange offer [1][8]. - The subsequent offering period for CureVac shareholders who have not yet tendered their shares will expire at 12:01 a.m. Eastern Time on December 18, 2025 [2][8]. - Following the expiration of the subsequent offering period, non-tendering holders of CureVac shares will receive BioNTech American Depositary Shares (ADSs) or cash in lieu of fractional ADSs as part of the post-offer reorganization [3]. Group 2: Tax Implications and Trading Status - Non-tendering holders of CureVac shares will generally be subject to a 15% Dutch dividend withholding tax when receiving BioNTech ADSs [3]. - Shares held by non-tendering CureVac shareholders will cease to be tradable on any national stock exchange after the completion of the post-offer reorganization [4]. Group 3: Company Background - BioNTech is a global next-generation immunotherapy company focused on developing novel therapies for cancer and other serious diseases, utilizing a diverse portfolio that includes mRNA cancer immunotherapies and targeted therapies [5]. - The company has established collaborations with various global pharmaceutical partners, enhancing its research and development capabilities [5].

Group 1: Sports and Events - Sichuan's "Bashu Xiongjing Cup" will draw on the successful development experience of the "Supert League" to enhance the event system and promote fair competition [1] - The competition is scheduled to take place from June 21 to July 6, 2025, with the finals set for September 5 to September 27, featuring both men's and women's teams in an eleven-a-side format [1] Group 2: Automotive Industry - Xiaopeng Motors aims to be among the first companies to introduce advanced intelligent driving assistance in Hong Kong, with plans for vehicle readiness and software development within two months [3] - The company is looking to leverage Hong Kong as a launchpad for global expansion in the smart driving sector [3] Group 3: Financial Technology - Ant Group's Ant Digital has initiated the application for a stablecoin license in Hong Kong, having already engaged in multiple rounds of discussions with regulators [4] - The establishment of "Ant Xinneng" in collaboration with GCL-Poly is part of Ant's strategy to anchor its global financial presence [4] Group 4: Technology and AI - Scale AI has received a significant new investment from Meta, with CEO Wang Tao stepping down to join Meta while remaining on Scale AI's board [5] - The company is actively seeking a new CTO to strengthen its engineering team [5] Group 5: Market Regulation - The State Administration for Market Regulation reported that over 99.5% of 3,605 batches of frozen beverages passed inspection, indicating a stable improvement in food safety [6] Group 6: Robotics and Elderly Care - The Ministry of Industry and Information Technology and the Ministry of Civil Affairs are launching pilot projects for smart elderly care robots in various settings, with preparations already underway in Hunan [7] Group 7: Corporate Earnings - Adobe reported Q2 revenue of $5.87 billion, exceeding analyst expectations of $5.8 billion, with projected digital media revenue for Q3 between $4.37 billion and $4.4 billion [8] Group 8: Mergers and Acquisitions - BioNTech has signed an agreement to acquire CureVac for $1.25 billion, aimed at enhancing its mRNA cancer immunotherapy research and commercialization efforts [9] Group 9: Stock Market Regulation - The Hong Kong Securities and Futures Commission is considering optimizing the Stock Connect program and adjusting the minimum trading lot size to enhance market liquidity [11][12] Group 10: Real Estate Initiatives - The Guangxi government aims to acquire 25,000 units of existing commercial housing by 2025 as part of its consumption promotion strategy [13]

Financial Data and Key Metrics Changes - In Q1 2025, the company reported total revenues of approximately €183 million, a slight decrease from €188 million in Q1 2024, reflecting expected seasonality in the COVID-19 vaccine market [26] - Research and development expenses increased to €526 million in Q1 2025 from €508 million in the prior year, driven by late-stage clinical studies [26] - The net loss for Q1 2025 was €416 million, compared to a net loss of €350 million in Q1 2024, with a basic and diluted loss per share of €1.73 versus €1.31 in the prior year [27][28] Business Line Data and Key Metrics Changes - The oncology segment is advancing with multiple clinical trials, including BNT327 and mRNA cancer immunotherapies, which are expected to establish new standards of care [10][13] - The COVID-19 vaccine franchise remains a significant revenue driver, although the company is preparing for a variant-adapted vaccine rollout [10][26] Market Data and Key Metrics Changes - The company estimates the second-line market for endometrial cancer to be around 10,000 patients in the US and Europe, indicating a sizable market opportunity [40] - The company is diversifying its manufacturing supply base, currently reliant on a China-based CDMO, to mitigate risks associated with tariffs [40] Company Strategy and Development Direction - The company aims to become a fully integrated biopharmaceutical company with a focus on oncology, particularly through combination therapies that exploit synergistic effects [12][13] - Significant investments are being made in clinical development and commercial capabilities to support the launch of BNT323 in oncology, expected as early as 2026 [35] Management's Comments on Operating Environment and Future Outlook - Management acknowledges 2025 as a transition year, focusing on long-term growth strategies while maintaining financial discipline [28] - The company is actively monitoring potential impacts from tariffs and evolving public sentiment regarding vaccines and mRNA technology [30][31] Other Important Information - The company announced the appointment of a new CFO, Ramon Sapater, effective July 1, 2025, as Jens Holstein prepares for retirement [11][32] - The company plans to present multiple updates from its oncology pipeline at the ASCO Annual Meeting, highlighting its commitment to advancing clinical programs [25][36] Q&A Session Summary Question: Addressable population for endometrial cancer launch - The estimated second-line market in endometrial cancer is about 10,000 patients in the US and Europe, indicating a sizable opportunity [40] Question: Impact of tariffs on manufacturing - Manufacturing for BNT323 is currently supplied by China, with plans to diversify supply bases in the coming years [40] Question: Long-term outlook for NSCLC - The company believes both bispecifics and ADCs will play a role in the evolving NSCLC market, with ongoing development in both areas [47][49] Question: COVID-19 vaccine recommendations - The company is tracking upcoming decisions regarding COVID-19 vaccine recommendations and anticipates that vaccination rates will remain stable [52][54] Question: Differences between bispecifics - The company is focusing on a bispecific with PD-L1, which is expected to be superior in the tumor microenvironment, and is exploring various combinations with ADCs [88][90]

Financial Data and Key Metrics Changes - The company maintained a leading position in the COVID-19 vaccine market with a global market share above 50% [4] - The balance sheet was strengthened through strong financial performance and disciplined cash spending [4] Business Line Data and Key Metrics Changes - The oncology portfolio advanced into late-stage development with 15 ongoing Phase II and Phase III clinical trials [3] - Data was presented on BNT327, a bispecific anti-PD-L1 anti-VEGF antibody, showing high clinical potential across multiple indications [10] Market Data and Key Metrics Changes - The company identified a significant medical need in populations where current treatments do not provide optimal results, particularly in PD-L1 negative tumors [15] - The potential market for BNT327 includes approximately 1.5 million cases annually in PD-L1 positive indications and around 1.4 million cases in PD-L1 negative indications [15] Company Strategy and Development Direction - The vision is to transform cancer medicine into personalized and individualized treatments, leveraging deep genomics, immunology expertise, and AI capabilities [5] - The strategy includes establishing three phases of clinical registration trials for BNT327, focusing on replacing current standards of care and exploring combination therapies [17][18] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the potential of BNT327 to serve as a backbone for immuno-oncology therapy, with expectations for multiple approvals in oncology products across various indications by 2025 [32][33] - The company aims to maintain its leadership in COVID-19 vaccines while advancing its oncology pipeline and preparing for commercialization of upcoming products [32] Other Important Information - The company has developed two platforms for mRNA cancer immunotherapies, focusing on individualized neoantigen-specific immunotherapy and shared tumor antigens [19][20] - Ongoing studies are expected to provide data readouts in 2025 and 2026, with a focus on addressing high medical needs in cancer patients [31] Q&A Session Summary Question: How can the bispecific molecule address populations where PD-1 works well? - Management indicated that data shows encouraging clinical response and progression-free survival (PFS) rates that are better than current standards of care, with ongoing trials outside of China to validate these findings [35] Question: Will the randomized adjuvant colon cancer data support accelerated approval? - Management stated that the study is large and if strong signals are observed, they would be open to discussions with regulators regarding approval [37]