Core Viewpoint - 康乐卫士 has made significant progress in the application for the market approval of its trivalent HPV vaccine following the successful completion of the on-site inspection by the National Medical Products Administration [1] Group 1 - 康乐卫士 and its subsidiary, 康乐卫士 (昆明) 生物技术有限公司, received a notification from the National Medical Products Administration on July 23 regarding the on-site inspection for drug registration [1] - The company has recently passed the on-site inspection for its trivalent HPV vaccine, which is based on E. coli [1] - The successful completion of the registration inspection lays a solid foundation for the approval of the trivalent HPV vaccine for market launch [1]

证券代码：833575 证券简称：康乐卫士 公告编号：2025-093 北京康乐卫士生物技术股份有限公司 关于三价 HPV 疫苗通过注册现场核查的公告 本公司及董事会全体成员保证公告内容的真实、准确和完整，没有虚假 记载、误导性陈述或者重大遗漏，并对其内容的真实性、准确性和完整性承 担个别及连带法律责任。 申请分类：上市许可申请 注册分类：预防用生物制品 1.4 类 申请人：康乐卫士（昆明）生物技术有限公司 公司自主研发的三价 HPV 疫苗主要用于预防 HPV 16/18/58 型持续感染及由 此引起的癌前病变和宫颈癌等疾病。除全球主要高危型别 HPV 16 和 18 型外， 公司三价 HPV 疫苗还覆盖了东亚地区诱发宫颈癌的第三大高危型别 HPV 58 型。 相较于目前已上市的二价和四价 HPV 疫苗可为 70%的宫颈癌提供保护，三价 HPV 疫苗将对东亚地区女性宫颈癌的保护范围提高至 78%。 公司三价 HPV 疫苗于 2024 年 8 月完成Ⅲ期保护效力临床试验期中分析揭盲， 结果符合预期；于 2025 年 3 月被国家药品监督管理局药品审评中心纳入优先审 评品种名单；于 2025 年 4 月递交上市许 ...

Market Overview - The biopharmaceutical sector experienced a decline of 0.21% on September 25, with Nossland leading the drop [1] - The Shanghai Composite Index closed at 3853.3, down 0.01%, while the Shenzhen Component Index closed at 13445.9, up 0.67% [1] Stock Performance - Notable gainers in the biopharmaceutical sector included: - Aopu Mai (688293) with a closing price of 62.85, up 7.42% and a trading volume of 30,600 [1] - Rongchang Biotech (688331) closed at 108.50, up 3.43% with a trading volume of 89,200 [1] - Baipusais (301080) closed at 62.16, up 3.43% with a trading volume of 43,500 [1] - Major decliners included: - Nossland (430047) closed at 22.99, down 3.69% with a trading volume of 57,000 [2] - Wufan Biotech (301393) closed at 53.12, down 3.42% with a trading volume of 24,600 [2] - Kexing Pharmaceutical (688136) closed at 38.75, down 3.34% with a trading volume of 53,500 [2] Capital Flow - The biopharmaceutical sector saw a net outflow of 207 million yuan from institutional investors, while retail investors contributed a net inflow of 45.07 million yuan [2] - Notable capital flows included: - Rongchang Biotech (688331) with a net inflow of 1.021 billion yuan from institutional investors [3] - Junshi Biosciences (688180) with a net inflow of 35.36 million yuan from institutional investors [3] - Aopu Mai (688293) with a net inflow of 9.41 million yuan from institutional investors [3]

中国经济网北京9月23日讯 康乐卫士(833575.BJ)今日收报12.98元，跌幅11.76%，总市值36.47亿 元。目前该股处于破发状态。 康乐卫士于2023年3月15日在北交所上市，发行价为42.00元，该股上市首日开盘破发，截至收盘报 35.52元，跌幅15.43%。 康乐卫士在北交所发行数量7,000,000股（不含超额配售选择权）；8,050,000股（全额行使超额配售 选择权后），保荐机构（主承销商）为中信证券股份有限公司，保荐代表人胡朝峰、赵洞天，联席主承 销商为国信证券股份有限公司。 超额配售选择权行使前，康乐卫士募集资金总额为29,400.00万元，扣除发行费用2,737.59万元（不 含增值税）后，募集资金净额为26,662.41万元。公司募集资金净额比原计划少3,337.59万元。2023年2月 28日公司招股书显示，康乐卫士拟募集资金30,000.00万元，用于HPV疫苗研发项目、昆明生产基地代建 回购项目。 康乐卫士发行费用总额为2,737.59万元（超额配售选择权行使前）；3,008.02万元（若超额配售选择 权全额行使后），其中中信证券、国信证券获得承销保荐费1,902.83 ...

值得一提的是，康乐卫士9月23日盘中最低触及12.88元/股，股价创下年内新低。东方财富显示，今年 以来，康乐卫士股价累计跌幅为21.78%，同期大盘累计上涨48.46%。 北京商报讯（记者 丁宁）9月23日，康乐卫士（833575）股价大跌，截至午间收盘，康乐卫士报12.93 元/股，跌幅为12.1%。 ...

Market Overview - The Shanghai Composite Index fell by 1.23% today, with a trading volume of 1,083.14 million shares and a transaction value of 17,135.39 billion yuan, an increase of 26.47% compared to the previous trading day [1]. Industry Performance - Among the industries, the banking sector had the highest increase, up by 2.15%, with Nanjing Bank leading at a rise of 4.30% [1]. - The computer, social services, and comprehensive sectors experienced the largest declines, down by 3.74%, 3.73%, and 3.57% respectively [1][2]. Detailed Industry Data - **Banking**: +2.15%, transaction value 315.69 billion yuan, up 126.85% from the previous day, led by Nanjing Bank (+4.30%) [1]. - **Coal**: -0.02%, transaction value 103.20 billion yuan, up 34.02%, led by Antai Group (-5.22%) [1]. - **Utilities**: -0.28%, transaction value 229.25 billion yuan, up 23.66%, led by Jingyuntong (-5.99%) [1]. - **Oil & Petrochemicals**: -0.50%, transaction value 60.02 billion yuan, up 20.24%, led by Yueyang Xingchang (-4.60%) [1]. - **Transportation**: -0.91%, transaction value 224.70 billion yuan, up 20.14%, led by Jushen Co. (-9.87%) [1]. - **Food & Beverage**: -1.10%, transaction value 205.01 billion yuan, up 31.81%, led by Ziyan Food (-5.40%) [1]. - **Construction & Decoration**: -1.12%, transaction value 252.99 billion yuan, up 18.05%, led by Yabo Co. (-6.56%) [1]. - **Household Appliances**: -1.30%, transaction value 315.39 billion yuan, up 10.99%, led by Greer (-8.21%) [1]. - **Power Equipment**: -1.48%, transaction value 1,861.78 billion yuan, up 44.25%, led by Daqian Energy (-7.29%) [1]. - **Automotive**: -1.52%, transaction value 1,037.23 billion yuan, up 20.58%, led by Shanghai Wumao (-9.93%) [1]. - **Textiles & Apparel**: -1.58%, transaction value 128.03 billion yuan, up 15.04%, led by Sanfu Outdoor (-5.97%) [1]. - **Agriculture, Forestry, Animal Husbandry, and Fishery**: -1.65%, transaction value 121.46 billion yuan, up 11.51%, led by Aonong Biological (-6.99%) [1]. - **Non-Bank Financials**: -1.72%, transaction value 431.67 billion yuan, up 55.06%, led by Yalian Development (-5.63%) [1]. - **Environmental Protection**: -1.75%, transaction value 151.27 billion yuan, up 35.24%, led by Henghe Co. (-10.64%) [1]. - **Construction Materials**: -2.28%, transaction value 116.54 billion yuan, up 18.34%, led by Gongyuan Co. (-6.75%) [1]. - **Nonferrous Metals**: -2.36%, transaction value 761.40 billion yuan, up 20.71%, led by Tengyuan Cobalt (-6.04%) [1]. - **Media**: -2.36%, transaction value 390.38 billion yuan, up 24.71%, led by Jinyi Film (-8.95%) [1]. - **Beauty & Personal Care**: -2.50%, transaction value 30.26 billion yuan, up 30.69%, led by Huaye Fragrance (-4.78%) [1]. - **Defense & Military**: -2.52%, transaction value 384.06 billion yuan, up 22.18%, led by ST Sicor (-11.43%) [1]. - **Telecommunications**: -2.54%, transaction value 1,124.99 billion yuan, up 29.44%, led by Dekeli (-14.18%) [1]. - **Electronics**: -2.56%, transaction value 3,735.81 billion yuan, up 19.69%, led by Zhixin Electronics (-10.74%) [1]. - **Machinery Equipment**: -2.65%, transaction value 1,391.63 billion yuan, up 24.55%, led by Huizhong Co. (-10.29%) [1]. - **Basic Chemicals**: -2.66%, transaction value 645.44 billion yuan, up 13.75%, led by Dingjide (-7.52%) [1]. - **Steel**: -2.78%, transaction value 68.00 billion yuan, down 2.07%, led by Shougang Co. (-5.26%) [1]. - **Light Industry Manufacturing**: -2.80%, transaction value 174.20 billion yuan, up 4.62%, led by Haotaitai (-10.01%) [1]. - **Pharmaceuticals & Biotechnology**: -3.02%, transaction value 805.28 billion yuan, up 33.02%, led by Kangle Weishi (-12.10%) [1]. - **Real Estate**: -3.17%, transaction value 252.56 billion yuan, up 13.91%, led by Electronic City (-9.86%) [1]. - **Commerce & Retail**: -3.57%, transaction value 38.87 billion yuan, up 81.17%, led by Nanjing Business Travel [2]. - **Social Services**: -3.73%, transaction value 151.27 billion yuan, up 0.36%, led by Yunnan Tourism (-10.01%) [2]. - **Computers**: -3.74%, transaction value 1,426.22 billion yuan, up 34.17%, led by ST Chuangyi (-19.97%) [2].

Core Viewpoint - Kang Le Wei Shi (833575.BJ) has experienced a significant decline in stock price since its listing, currently trading at 14.71 yuan, down 6.9%, indicating a state of underperformance since its initial public offering (IPO) [1] Group 1: Stock Performance - The stock opened at 35.52 yuan on its first trading day, reflecting a drop of 15.43% from the IPO price of 42.00 yuan [1] - As of the latest close, the stock is in a state of "破发" (below the issue price) [1] Group 2: IPO Details - Kang Le Wei Shi issued 7,000,000 shares initially, with a total of 8,050,000 shares if the overallotment option is fully exercised [1] - The total funds raised before the exercise of the overallotment option amounted to 29,400,000 yuan, with a net amount of 26,662.41 million yuan after deducting issuance costs of 2,737.59 million yuan [1] - The company aimed to raise 30,000,000 yuan for HPV vaccine research and the construction of a production base in Kunming [1] Group 3: Underwriting Fees - The total underwriting fees before the exercise of the overallotment option were 1,902.83 million yuan, which would increase to 2,173.25 million yuan if the overallotment option is fully exercised [2]

Market Overview - On September 22, the biopharmaceutical sector experienced a slight decline of 0.15%, with Kanglaosheng leading the drop [1] - The Shanghai Composite Index closed at 3828.58, up 0.22%, while the Shenzhen Component Index closed at 13157.97, up 0.67% [1] Stock Performance - Notable gainers in the biopharmaceutical sector included: - Aipumai (688293) with a closing price of 58.70, up 9.90% on a trading volume of 47,100 shares and a turnover of 267 million yuan [1] - Baipusais (301080) closed at 61.75, up 5.05% with a trading volume of 38,300 shares and a turnover of 231 million yuan [1] - Muli Pharmaceutical (603087) closed at 73.60, up 3.76% with a trading volume of 182,000 shares and a turnover of 134.2 million yuan [1] - Conversely, the following stocks saw significant declines: - Kanglaosheng (833575) closed at 14.71, down 6.90% with a trading volume of 90,400 shares and a turnover of 137 million yuan [2] - Kexing Pharmaceutical (688136) closed at 40.54, down 3.20% with a trading volume of 47,600 shares and a turnover of 194 million yuan [2] - Changchun High-tech (000661) closed at 122.10, down 2.49% with a trading volume of 102,800 shares and a turnover of 1.265 billion yuan [2] Capital Flow - The biopharmaceutical sector saw a net outflow of 473 million yuan from institutional investors, while retail investors contributed a net inflow of 418 million yuan [2] - The following stocks had notable capital flows: - Ganli Pharmaceutical (603087) had a net inflow of 58.16 million yuan from institutional investors [3] - Rongchang Biotechnology (688331) saw a net inflow of 43.73 million yuan from institutional investors [3] - ZhiXiangJinTai (688443) had a net inflow of 6.53 million yuan from retail investors [3]

据天眼查APP显示，北京康乐卫士生物技术股份有限公司成立于2008年04月14日。注册资本28094万人 民币。（数据宝） 9月18日康乐卫士大宗交易一览 | 成交量 （万股） | 成交金额 （万元） | 成交价格 （元） | 相对当日 收盘价折溢价 | 买方营业部 | 卖方营业部 | | --- | --- | --- | --- | --- | --- | | | | | （%） | | | | 100.00 | 1594.00 | 15.94 | -1.91 | 中信建投证券股份有限公 司北京东三环中路证券营 | 中信证券华南股份有限 公司昆明青年路证券营 | | | | | | 业部 | 业部 | 注：本文系新闻报道，不构成投资建议，股市有风险，投资需谨慎。 （原标题：康乐卫士9月18日大宗交易成交1594.00万元） 康乐卫士（833575）9月18日大宗交易平台出现一笔成交，成交量100.00万股，成交金额1594.00万元， 大宗交易成交价为15.94元，相对今日收盘价折价1.91%。该笔交易的买方营业部为中信建投证券股份有 限公司北京东三环中路证券营业部，卖方营业部为中信证券华南股份有限公司昆 ...

每经讯，2025年9月18日，北交所上市公司康乐卫士（833575，收盘价：16.25元）发生一笔大宗交易，成交价15.94元/股，成交 数量100万股，成交金额1594万元，折价1.91%。买入营业部是中信建投证券股份有限公司北京东三环中路证券营业部，卖出营 业部是中信证券华南股份有限公司昆明青年路证券营业部。 （记者 曾健辉） 免责声明：本文内容与数据仅供参考，不构成投资建议，使用前核实。据此操作，风险自担。 每日经济新闻 ...