招商证券国际发布研报称，石药集团(01093)今年二季度收入及净利润均不及预期，反映肿瘤和神经系 统业务线的结构性下行，管理层重申EGFR ADC产品(CPO301/SYS6010)为潜在商业发展(BD)催化剂， 但该行认为市场已消化相关预期。招商证券国际下调集团2025至2026年销售及净利润预测，因公司核心 业务表现乏力及BD预期过高，下调评级至"中性"和目标价至9.3港元(原本12.9港元)。 该行表示，展望未来，石药集团的前景取决于商业合作战略及后期管线商业化情况。市场关注其关键资 产SYS6010。然而，回顾石药过去在1.1类创新药物研发的表现，该行认为其在管线临床进展上落后于 中国其他大型制药及部分生物药公司。 鉴于核心业务环比持续下滑，招商证券国际下调集团今明两年的收入和净利润预测，以反映增长及盈利 前景的短期压力，预计2025财年经历深度调整后，2026财年收入将趋于稳定。目标价调整反映盈利调整 及拆股因素，该行根据成药、管线及传统原料药业务的SOTP估值调整目标价，新目标价为9.3港元，分 别对应今明两年19.4倍、17.9倍市盈率。 ...

Core Viewpoint - The stock price of CSPC Pharmaceutical Group (01093) fell over 7% towards the end of trading, reflecting market concerns following the release of disappointing interim results for the first half of the year [1] Financial Performance - Total revenue for the first half of the year was 13.273 billion RMB, a year-on-year decrease of 18.5% [1] - Profit attributable to shareholders was 2.548 billion RMB, down 15.64% year-on-year [1] Market Reaction - The stock price dropped by 6.45% to 9.7 HKD, with a trading volume of 2.213 billion HKD [1] - The decline in stock price indicates that the market has reacted negatively to the company's financial performance and outlook [1] Analyst Insights - According to a report from CMB International, the second quarter revenue and net profit of CSPC Pharmaceutical did not meet expectations, indicating structural declines in the oncology and neurology business lines [1] - The management reiterated that the EGFR ADC product could be a potential catalyst for business development, but the market has already priced in these expectations [1] - CMB International has lowered its sales and net profit forecasts for 2025 to 2026 due to weak core business performance and overly optimistic business development expectations [1] Future Outlook - The future prospects of CSPC Pharmaceutical depend on its commercial cooperation strategy and the commercialization of its pipeline [1] - Market attention is focused on its key asset SYS6010, but the company has lagged behind other large pharmaceutical and biotech companies in clinical progress for Class 1 innovative drugs [1]

智通财经APP获悉，招商证券国际发布研报称，石药集团(01093)今年二季度收入及净利润均不及预期， 反映肿瘤和神经系统业务线的结构性下行，管理层重申EGFR ADC产品(CPO301/SYS6010)为潜在商业 发展(BD)催化剂，但该行认为市场已消化相关预期。招商证券国际下调集团2025至2026年销售及净利 润预测，因公司核心业务表现乏力及BD预期过高，下调评级至"中性"和目标价至9.3港元(原本12.9港 元)。 该行表示，展望未来，石药集团的前景取决于商业合作战略及后期管线商业化情况。市场关注其关键资 产SYS6010。然而，回顾石药过去在1.1类创新药物研发的表现，该行认为其在管线临床进展上落后于 中国其他大型制药及部分生物药公司。 鉴于核心业务环比持续下滑，招商证券国际下调集团今明两年的收入和净利润预测，以反映增长及盈利 前景的短期压力，预计2025财年经历深度调整后，2026财年收入将趋于稳定。目标价调整反映盈利调整 及拆股因素，该行根据成药、管线及传统原料药业务的SOTP估值调整目标价，新目标价为9.3港元，分 别对应今明两年19.4倍、17.9倍市盈率。 ...

恒生指数、恒生科技指数双双转跌，华润万象生活跌超8.5％，翰森制药、石药集团、申洲国际、李宁 等均跌4％。 (本文来自第一财经) ...

展望未来，石药集团的前景取决于商业合作战略及后期管线商业化情况，市场关注其关键资产 SYS6010。然而，回顾石药过去在1.1类创新药物研发的表现，该行认为其在管线临床进展上落后于中 国其他大型制药及部分生物药公司。 招商证券国际发表研究报告指出，石药集团今年二季度收入及净利润均不及预期，反映肿瘤和神经系统 业务线的结构性下行，管理层重申EGFR ADC产品(CPO301/SYS6010)为潜在商业发展(BD)催化剂，但 该行认为市场已消化相关预期。该行下调集团2025至2026年销售及净利润预测，因公司核心业务表现乏 力及BD预期过高，下调评级至"中性"，目标价从12.9港元下调至9.3港元。 ...

Overview - The demand for antiviral drugs in China is significantly influenced by the number of influenza cases, with the market size reaching 11 billion yuan in 2023, a year-on-year increase of 150% [1][7] - In 2024, the market size is expected to decrease to 8 billion yuan due to a reduction in influenza cases, with oseltamivir accounting for approximately 78% of the market [1][7] Industry Chain - The upstream of the antiviral drug industry includes suppliers of raw materials such as chemical APIs, traditional Chinese medicine materials, and packaging materials, while the midstream consists of antiviral drug manufacturers, and the downstream includes medical institutions, pharmacies, and e-commerce platforms [4] Development Background - The large population base in China leads to a high susceptibility to influenza, with an estimated 8.59 million cases and 19 deaths in 2024, driving demand for antiviral drugs, especially among the elderly [6][7] - Increased health awareness among the public has led to a greater willingness to purchase antiviral medications during flu season [6] Current Market Situation - The antiviral drug market in China is heavily influenced by influenza case numbers, with a significant expansion in 2023 due to a broader and longer-lasting influenza outbreak compared to pre-COVID-19 times [1][7] - The market is projected to contract in 2024 as influenza cases decline [1][7] Competitive Landscape - The antiviral drug market is currently dominated by neuraminidase inhibitors, with oseltamivir being the primary product, facing increasing competition from generic versions after its patent expired [8][9] - As of August 2025, there are 118 approved oseltamivir products from 69 companies, indicating a highly competitive environment [9] Key Companies - **East Sunshine Pharmaceutical**: Holds a 64.8% market share in the oseltamivir market and a 50.5% share in the overall antiviral market, with a revenue of 4.019 billion yuan in 2024 [10] - **Shijiazhuang Pharmaceutical Group**: Focuses on innovative drugs and reported a revenue of 29.01 billion yuan in 2024, with a gross profit margin of 69.97% [11] Development Trends - The rapid mutation of influenza viruses is driving research towards more effective antiviral drugs with lower resistance rates, particularly RNA polymerase inhibitors [11] - The emergence of innovative domestic drugs is expected to enhance China's position in the global antiviral market, with potential for international expansion of products with independent intellectual property rights [11]

Core Viewpoint - Bank of America Securities reports that CSPC Pharmaceutical Group's total revenue for the second quarter decreased by 14.3% year-on-year to 6.3 billion yuan, with attributable net profit declining by 24% to 1.1 billion yuan [1] Revenue and Profit Forecasts - The bank has lowered its revenue forecasts for 2025 to 2027 by 25%, 2%, and 11% respectively due to price reductions of core drugs and an increase in the proportion of revenue from raw material products [1] - The gross margin forecast for 2025 has also been reduced, alongside a 42% decrease in the earnings per share (EPS) forecast for 2025 [1] Future Earnings Projections - However, the bank has raised its EPS forecasts for 2026 and 2027 by 32% and 8% respectively [1] Target Price Adjustment - The target price for CSPC Pharmaceutical Group has been adjusted from 6.9 HKD to 8.1 HKD, while maintaining a "underperform" rating due to the price reductions of major drugs [1]

Core Viewpoint - 招银国际 has raised the target price for 石药集团 (01093) to HKD 12.11, citing continued revenue generation from drug licensing despite a 25% year-on-year decline in core earnings to RMB 12.2 billion for the first half of the year [1][2]. Financial Performance - The core earnings for the second quarter decreased by 22% year-on-year, primarily due to weak sales of 丁苯 (酉太) (NBP), impacted by tighter hospital prescription regulations and the collective procurement of 多美素 and 津优力 [2]. - Management anticipates an improvement in core earnings for the second half of the year, with product sales expected to grow by at least 5% [2]. Licensing and Growth Potential - Since the end of last year, the company has secured six external licensing agreements, with management expecting two more large-scale licenses in the second half, each valued at over USD 5 billion [2]. - The company has established a broad proprietary technology platform, including nanoparticle formulations, antibody-drug conjugates, siRNA, and antibody-fusion proteins, with 40 to 50 assets identified as having licensing potential [2]. - The firm is projected to sustainably generate external licensing revenue in the medium to long term [2].

Core Viewpoint - CStone Pharmaceuticals (01093) reported a 25% year-on-year decline in core earnings to 12.2 billion RMB, aligning with the bank's expectations for the year [1] Financial Performance - The company's core earnings for the second quarter decreased by 22% year-on-year, primarily due to weak sales of NBP, impacted by tighter hospital prescription regulations and the procurement effects of Duomeisu and Jinyouli [1] - Management anticipates an improvement in core earnings for the second half of the year, with product sales expected to grow by at least 5% [1] Target Price and Rating - The bank raised its target price for CStone Pharmaceuticals from HKD 10.08 to HKD 12.11, maintaining a "Buy" rating [1] Licensing Agreements - Since the end of last year, the company has secured six external licensing agreements, with management expecting two more large-scale licenses in the second half, each valued at over USD 5 billion [1] - The company has established a broad proprietary technology platform, including nanoparticle formulations, antibody-drug conjugates, siRNA, and antibody-fusion proteins [1] - Management indicated that 40 to 50 assets have potential for external licensing, suggesting sustainable licensing revenue in the medium to long term [1]

Market Overview - The Hong Kong stock market failed to maintain its strong performance from the previous day, with all three major indices experiencing a collective adjustment. The Hang Seng Index fell by 1.18% or 304.99 points, closing at 25,524.92 points, with a total trading volume of HKD 31.78 billion. The Hang Seng China Enterprises Index decreased by 1.07% to 9,148.66 points, while the Hang Seng Tech Index dropped by 0.74% to 5,782.24 points [1] Blue-Chip Stocks Performance - CSPC Pharmaceutical Group (01093) led the decline among blue-chip stocks, falling by 4.33% to HKD 10.38, with a trading volume of HKD 1.797 billion, contributing a loss of 6.04 points to the Hang Seng Index. Bank of America Securities reported a 14.3% year-on-year decline in total revenue for CSPC in Q2, with attributable net profit down 24% to RMB 1.1 billion. The firm revised its revenue forecasts for 2025 to 2027 down by 25%, 2%, and 11% respectively [2] Sector Highlights - Large technology stocks mostly declined, with Alibaba down 2.57% and Tencent down 0.81%. Gold stocks surged, with China Gold International rising over 10%. Apple is expected to initiate a three-year innovation cycle, boosting related stocks like Lens Technology, which rose over 5%. Gaming stocks and some new consumption concepts performed well, with Melco International Development up over 9% [3][5] Federal Reserve Insights - Federal Reserve Chairman Jerome Powell indicated rising downside risks in the U.S. labor market, suggesting a potential policy adjustment could be appropriate. This statement is seen as a strong signal for a possible interest rate cut as early as September. The market reacted positively, particularly for precious metals, with expectations for further increases in gold prices [4] Gaming Sector Performance - The gaming sector continued its upward trend, with Melco International Development rising 9.27% to HKD 5.54. According to JPMorgan, Macau's gaming revenue for the first 24 days of August reached MOP 17.65 billion, with a daily average of MOP 735 million, reflecting a 9% increase from the previous week [6] Pharmaceutical Sector Challenges - The pharmaceutical sector faced pressure, with several stocks declining. Notably, CStone Pharmaceuticals (09966) fell 6.74% to HKD 10.24. U.S. President Trump's announcement to drastically reduce drug prices could create significant challenges for the global pharmaceutical industry, presenting both opportunities and risks for Chinese biotech stocks [6] Notable Stock Movements - Double Ended Co. (06960) debuted with a 31.29% increase, closing at HKD 19.05. The company focuses on energy storage solutions in the data and communication sectors, with a projected market share of 11.1% by 2024 [7] - Kingsoft Holdings (03918) reached a new high, rising 17.94% to HKD 5.72, reporting a 16.76% year-on-year revenue increase to USD 342 million [8] - Angelalign Technology (06699) saw a 10.28% increase to HKD 75.1, with a 33.1% year-on-year revenue growth reported [9] - Meitu Inc. (01357) rose 7.9% to HKD 11.47 after being included in the MSCI China Index, with Morgan Stanley expressing confidence in its long-term growth potential [10] - Xintai Medical (02291) experienced a significant drop of 12.75% to HKD 23.96 following a major shareholder's sale of shares [11]