香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準 確性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部份內容而產生 或因倚賴該等內容而引致的任何損失承擔任何責任。 CSPC PHARMACEUTICAL GROUP LIMITED 石 藥 集 團 有 限 公 司 石 藥 集 團 有 限 公 司（「 本 公 司 」， 連 同 其 附 屬 公 司 統 稱「 本 集 團 」）董 事 會（「 董 事 會 」）欣 然 宣 布，本集團開發的度普利尤單抗注射液（「該產品」）已獲中華人民共和國國家藥品監督管理 局批准，可在中國開展臨床試驗。 該產品是一種靶向IL -4Rα的重組全人源單克隆抗體藥物，為達必妥®的生物類似藥，按照 治療用生物製品3.3類申報，適用於治療成人中重度特應性皮炎。 該產品的研發遵循生物類似藥相關研究指南。藥學及非臨床研究結果顯示，該產品與原研 參照藥在質量、安全性和有效性方面高度相似，支持開展後續臨床研究。 代表董事會 石藥集團有限公司 主席 蔡東晨 香港，2025年8月19日 於 本 公 告 日 期 ， 董 事 會 包 括 執 行 董 事 蔡 東 晨 先 ...

智通财经APP获悉，8月13日,信达生物（01801）、中国人寿（02628）、友邦保险（01299）南向资金 净流入金额位列市场前三，分别净流入8.35 亿、4.03 亿、3.73 亿 盈富基金（02800）、恒生中国企业（02828）、安踏体育（02020）南向资金净流出金额位列市场前 三，分别净流出-66.79 亿、-25.84 亿、-7.82 亿 | 股票名称 | 净流入(元)↓ | 净流入比 | 收盘价 | | --- | --- | --- | --- | | 信达生物(01801) | 8.35 亿 | 33.64% | 95.000（+8.82%） | | 中国人寿(02628) | 4.03 亿 | 21.25% | 22.800（+0.71%） | | 友邦保险(01299) | 3.73 亿 | 13.36% | 76.400（+3.03%） | | 理想汽车-W(02015) | 3.65 亿 | 13.55% | 97.150（+3.30%） | | 石药集团(01093) | 2.57 亿 | 14.56% | 10.720（+6.77%） | | 中国生物制药(01177) | ...

Group 1 - The company has entered into a global exclusive licensing agreement with Madrigal Pharmaceuticals, Inc. for SYH2086, covering development, production, and commercialization, with potential total payments of up to $2.075 billion, including an upfront payment of $120 million and milestone payments based on annual net sales [1] - SYH2086 is in the preclinical stage and has complete intellectual property rights, with expectations for significant growth in the weight loss and MASH fields following the licensing agreement [1] - The management anticipates potential upfront and milestone payments from ongoing negotiations for three other projects, including SYS6010 (EGFR-ADC), could total around $5 billion [1] Group 2 - The company continues to increase its R&D investment, with 2024 R&D expenses projected to reach ¥5.191 billion (up 7.5% year-over-year), accounting for 21.9% of its revenue from prescription drugs, which is industry-leading [2] - As of the end of Q1 2025, the company has 24 projects in critical II/III clinical phases and 9 projects under review for market approval, indicating a robust pipeline [2] - The company is expected to achieve multiple new drug approvals and data readouts throughout the year, maintaining a strong position in business development [2] Group 3 - The company is recognized as a leading domestic pharmaceutical firm with ample cash reserves, transitioning from traditional pharmaceuticals to innovation [2] - The net profit forecasts for 2025 and 2026 have been revised down to ¥4.92 billion and ¥5.25 billion, respectively, reflecting a decrease of 24.9% and 23.9% from previous estimates [2] - The current valuation is considered attractive due to the expected orderly market entry of significant products, maintaining a "buy" rating [2]

智通财经APP讯，石药集团(01093)发布公告，公司附属公司石药创新制药股份有限公司(石药创新)于截 至2025年6月30日止六个月取得营业收入10.50亿元(人民币，下同)，同比增长7.99%;归属于上市公司股 东的净亏损274.6万元，上年同期净利润1.37亿元;基本每股亏损0.0020元。 ...

石药集团(01093)发布公告，公司附属公司石药创新制药股份有限公司(石药创新)于截至2025年6月30日 止六个月取得营业收入10.50亿元(人民币，下同)，同比增长7.99%;归属于上市公司股东的净亏损274.6 万元，上年同期净利润1.37亿元;基本每股亏损0.0020元。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準 確性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部份內容而產生 或因倚賴該等內容而引致的任何損失承擔任何責任。 CSPC PHARMACEUTICAL GROUP LIMITED 石 藥 集 團 有 限 公 司 （股份代號：1093） （於香港註冊成立之有限公司） 石藥創新製藥股份有限公司 截至2025年6月30日止六個月之未經審核財務資料 按深圳證券交易所之相關規定，石藥集團有限公司（「本公司」）附屬公司石藥創新製藥股份有 限公司（「石藥創新」），其股份於深圳證券交易所創業板上市（ 股票代碼：300765 ））已於2025 年8月15日發佈其截至2025年6月30日止六個月的未經審核中期報告（「2025年中期報告」）於深 圳 證 券 交 易 所 網 站 資 訊 披 露 頁 面 http: / / www.szse.cn / disclosure / listed / notice / index.html 。 石藥創新之財務資料乃根據中國企業會計準則編製。 本 公 告 附 錄（「 附 錄 」）所 載 石 藥 創 ...

Investment Rating - The report maintains a "Buy" rating for the company, indicating an expected investment return exceeding the market benchmark by more than 15% over the next 6-12 months [7]. Core Insights - The company has entered a global exclusive licensing agreement with Madrigal Pharmaceuticals for SYH2086, which includes potential payments totaling up to $2.075 billion, comprising an upfront payment of $120 million and milestone payments based on annual net sales [2]. - The company is focusing on innovation and transformation, with a strong pipeline of new drugs expected to be approved within the year, alongside multiple data readouts and business development (BD) opportunities [5]. - The company is actively negotiating three potential transactions, including SYS6010 (EGFR-ADC), with a total potential value of approximately $5 billion [3]. Summary by Sections Business Development and Innovation - The oral GLP-1 drug SYH2086 is in the preclinical stage and has complete intellectual property rights, with Madrigal being a leading company in the MASH field, suggesting significant global growth potential [3]. - The company has a robust R&D investment, with R&D expenses projected to reach 5.191 billion yuan in 2024, representing a year-over-year increase of 7.5% and accounting for 21.9% of the revenue from proprietary drugs [4]. Financial Forecasts - The company is projected to have a net profit of 4.916 billion yuan in 2025, with a decrease in profit estimates for 2025 and 2026 by 24.9% and 23.9%, respectively, due to new product development costs [5]. - The estimated earnings per share (EPS) for 2025 is 0.43 yuan, with a price-to-earnings (P/E) ratio of 22x for 2025, indicating an attractive valuation given the expected orderly launch of key products [5]. Market Position and Performance - The company is recognized as a leading domestic pharmaceutical firm with ample cash reserves, positioning it well for future growth and innovation [5]. - The total market capitalization is approximately 120.404 billion HKD, with a recent trading price of 10.45 HKD per share [7].

Group 1 - The core viewpoint of the article highlights the performance and strategic focus of the company, CSPC Pharmaceutical Group, which has seen a stock price increase of 2.01% to HKD 10.66 per share with a trading volume of HKD 302 million as of August 15 [1] - CSPC Pharmaceutical Group is a Hong Kong-listed pharmaceutical company primarily engaged in the production of finished drugs and active pharmaceutical ingredients, with a core development strategy centered on innovative drugs targeting various therapeutic areas including neurological diseases, oncology, anti-infection, and cardiovascular diseases [1] - As of the first quarter of 2025, CSPC Pharmaceutical Group reported total revenue of HKD 7.015 billion and a net profit of HKD 1.478 billion [1] Group 2 - The company is set to disclose its interim report for the fiscal year 2025 on August 22 [2]

Summary of Key Points from the Conference Call on China Healthcare Industry Overview - The conference focused on the **China Healthcare** sector, particularly the pharmaceutical and biotech industries, highlighting the attractive investment landscape in the Asia Pacific region [2][5][6]. Core Insights and Arguments - **Growth Projections**: The global pharmaceutical market is expected to grow at a **CAGR of 5.7%** from 2023 to 2028, while the Chinese pharmaceutical market is projected to grow at a **CAGR of 7.7%** during the same period [9][12]. - **Market Dynamics**: The Chinese pharmaceutical market is characterized by a significant reliance on imported products, particularly in the albumin segment, where **60-70%** of the market is composed of imports [34]. - **Out-licensing Trends**: There has been a notable increase in out-licensing activities, with over **$50 billion** in deals recorded in 2024, driven by narrowing innovation gaps and emerging complex modalities [41][42]. - **Regulatory Environment**: The plasma industry in China faces high entry barriers, with only **<30 plasma fractionators** currently operating, leading to a market consolidation trend [33][34]. Important Developments - **Upcoming Events**: Key sector events include the **CSCO 2025** and **WCLC 2025** conferences, which are expected to influence stock performance in the pharmaceutical and biotech sectors [6][8]. - **Pipeline Assets**: Several companies, including Hengrui and CSPC, have significant pipeline assets with upcoming drug approvals and trial progress expected in **2H25** [32][27]. Potential Risks and Challenges - **Supply Constraints**: The Chinese plasma market is underdeveloped compared to global standards, with a limited variety of plasma derivatives available [34]. - **Market Competition**: The top five plasma companies dominate approximately **60%** of the market, indicating a highly consolidated competitive landscape [33]. Additional Insights - **Investment Sentiment**: The overall sentiment towards the China healthcare sector remains positive, with analysts highlighting the potential for significant returns driven by innovation and market expansion [2][41]. - **Technological Advancements**: The introduction of recombinant human albumin (rHSA) is expected to disrupt the albumin market, potentially capturing **~10%** of the total market share [35]. This summary encapsulates the key points discussed during the conference call, providing a comprehensive overview of the current state and future outlook of the China healthcare sector.

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準 確性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部份內容而產生 或因倚賴該等內容而引致的任何損失承擔任何責任。 代表董事會 石藥集團有限公司 主席 蔡東晨 香港，2025年8月12日 於 本 公 告 日 期 ， 董 事 會 包 括 執 行 董 事 蔡 東 晨 先 生 、 張 翠 龍 先 生 、 王 振 國 先 生 、 潘 衛 東 先 生、王懷玉先生、李春雷博士、姚兵博士、蔡鑫先生及陳衛平先生；及獨立非執行董事王 波先生、CHEN Chuan先生、王宏廣教授、歐振國先生、羅卓堅先生及李泉女士。 （於香港註冊成立之有限公司） （股份代號：1093） 董事會召開日期 石藥集團有限公司（「本公司」）宣布，本公司董事會（「董事會」）會議將於2025年8月22日（ 星 期五 ）舉行，藉以（ 其中包括 ）批准本公司及其附屬公司截至2025年6月30日止6個月之未經 審核中期業績。 CSPC PHARMACEUTICAL GROUP LIMITED 石 藥 集 團 有 限 公 司 ...