Financial Data and Key Metrics Changes - The company reported revenue of RMB 446 million for 2025, representing a 48% year-over-year growth, although the first half was impacted by supply constraints [14][15] - Revenue from Nephicon alone reached RMB 520 million in August 2025, indicating a strong recovery from earlier supply issues [15] - The full-year revenue guidance for 2025 is set between RMB 1.6 billion to RMB 1.8 billion, with Nephicon expected to contribute RMB 1.2 billion to RMB 1.4 billion [16] - The gross margin on a cash basis was 76.4%, slightly lower than 2024 due to price reductions after NRDL inclusion, but expected to recover above 80% in the long run [17] - The non-IFRS net loss was approximately RMB 147 million, down 31% year-over-year, indicating improved operational efficiency [18] Business Line Data and Key Metrics Changes - Nephicon generated RMB 825 million in revenue from January to August 2025, with NRDL coverage achieved in 29 provinces [6][7] - The autoimmune disease franchise, particularly Velsipiti, is in the final stages of NDA review, with expectations for early 2026 approval [9] - XERAVA in the anti-infective franchise showed steady growth, with revenue growth of 37% year-over-year [26] Market Data and Key Metrics Changes - The company plans to expand Nephicon's market coverage to 1,000 hospitals, targeting 30,000 new IGAM patients [22] - The estimated market for IGAM in China includes about 5 million patients, with 100,000 new confirmed cases each year [23] - The ulcerative colitis market is projected to reach RMB 14 billion, with significant unmet medical needs [29] Company Strategy and Development Direction - The company aims to achieve operational profitability in 2025, with a focus on expanding its commercial platform and advancing its R&D pipeline [19][37] - The strategy includes leveraging a combination of commercial execution and in-house discovery to drive growth [72] - The company is also pursuing strategic investments, such as a USD 30.9 million investment in I Mab, to enhance its oncology platform [70] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the strong market potential for Nephicon and Velsipiti, citing robust clinical data and regulatory approvals [81][82] - The company is optimistic about achieving peak sales of RMB 5 billion for Nephicon, supported by a growing patient base and favorable market conditions [80] - Future growth is expected to be driven by multiple near-term catalysts, including upcoming NDA approvals and market expansions [71][72] Other Important Information - The company has made significant progress in its R&D platform, including advancements in mRNA technology and CAR T therapies [48][49] - The company is preparing for pivotal trials in 2026 for its autoimmune renal disease treatments, indicating a strong pipeline for future growth [45][46] Q&A Session Summary Question: Peak sales for Etrasimod - The company raised peak sales estimates for Etrasimod to RMB 5 billion due to strong clinical data and an underdeveloped market with significant unmet needs [80][81] Question: Clinical development plan for EVER-one - The company is finalizing the design for a Phase II basket trial and plans to initiate pivotal studies in 2026, with ongoing regulatory interactions [88][89]

Financial Performance & Outlook - The company reported revenue of RMB 446 million, a 48% year-over-year increase, primarily driven by NEFECON® and XERAVA®[10, 12] - Gross margin was 76.4%, excluding amortization of intangible assets, reflecting NRDL price reduction of NEFECON® in mainland China and product cost optimization[10, 13] - Non-IFRS net loss decreased by 31% year-over-year to RMB 147 million[10] - The company expects full-year revenue to be between RMB 1.6 billion and RMB 1.8 billion, with NEFECON® revenue projected at RMB 1.2 billion to RMB 1.4 billion[10] - The company anticipates achieving operational profitability in the second half of 2025[9, 11] Key Products & Commercialization - NEFECON® revenue reached RMB 825 million from January to August 2025, with full NRDL coverage achieved in target provinces[8, 20] - NEFECON® is projected to generate RMB 1.2 billion to RMB 1.4 billion in revenue for the full year 2025 and RMB 2.4 billion to RMB 2.6 billion in 2026[10, 25] - XERAVA® generated RMB 143 million in revenue in the first half of 2025, a 6% year-over-year increase, with in-market sales up by 37%[32] - VELSIPITY® demonstrated a 51.9% mucosal healing rate with one year of treatment and is estimated to reach peak sales exceeding RMB 5 billion[49, 52] R&D Pipeline & Investments - EVER001 (Civorebrutinib) showed rapid and deep reductions in both Anti-PLA2R and 24h Proteinuria with an excellent safety profile[67] - The company completed a share placement on August 1, 2025, with net proceeds of HKD 1.6 billion[8, 10] - The company increased its strategic investment in I-MAB, becoming its single largest shareholder with 16.1% ownership[8, 116]

Core Viewpoint - The company, CloudTop New Medicine (1952.HK), reported strong mid-year performance for the period ending June 30, 2025, showcasing significant growth in both commercialization and R&D efforts, laying a solid foundation for becoming a leading global Biopharma company [1] Financial Performance - Total revenue for the first half of 2025 reached RMB 446 million, a substantial increase of 48% year-on-year [1] - Operating expenses as a percentage of revenue decreased by 40.1 percentage points, indicating improved operational efficiency [1] - Non-IFRS total loss narrowed significantly by 31%, with a gross margin of 76.4% after excluding non-cash items [1] - The company has a strong cash reserve of RMB 1.6 billion, bolstered by a recent fundraising of HKD 1.553 billion [1] Product Performance - The kidney disease treatment product, Nefukang®, saw impressive sales of RMB 303 million in the first half, an increase of 81% year-on-year [2] - Cumulative sales from January to August reached RMB 825 million, with August alone generating RMB 520 million [2] - The global first fluoroquinolone antibiotic, Yijia®, also showed steady growth with revenue of RMB 143 million, a 6% increase year-on-year [2] Strategic Initiatives - The company is advancing its "dual-wheel drive" strategy, focusing on high-potential products and enhancing its R&D capabilities [3] - The personalized tumor therapeutic vaccine EVM16 has initiated its first human clinical trial in China, with positive preliminary data [3] - The CAR-T project EVM18 is expected to start clinical trials by the end of 2025, with significant progress in its global R&D pipeline [4] Future Outlook - The company aims to achieve annual sales of RMB 1.6 to 1.8 billion and expects to reach operational profitability in the second half of 2025 [1][2] - The strategic focus will remain on the commercialization of Nefukang® and Weishiping®, alongside leveraging AI and mRNA technology platforms for early-stage R&D [5] - The company is targeting a peak sales potential exceeding RMB 25 billion in the future [5]

Core Viewpoint - Cloud-based innovative pharmaceutical company, CloudTop New Medicine, reported strong mid-year performance for the period ending June 30, 2025, showcasing robust growth and a solid foundation for becoming a leading global Biopharma company [1] Financial Performance - Total revenue for the first half of 2025 reached RMB 446 million, a significant increase of 48% year-on-year [1] - Operating expenses as a percentage of revenue decreased by 40.1 percentage points, indicating improved operational efficiency [1] - Non-IFRS total loss narrowed by 31%, with a cash reserve of RMB 1.6 billion, bolstered by a recent fundraising of HKD 1.553 billion [1] Product Performance - The kidney disease treatment product, Nefukang, achieved sales of RMB 303 million in the first half, a remarkable increase of 81% year-on-year [2] - Sales for Nefukang from January to August reached RMB 825 million, with August alone generating RMB 520 million [2] - The antibiotic drug, Yijia, also showed steady growth with sales of RMB 143 million, a 6% increase year-on-year [2] Strategic Initiatives - The company is advancing its "dual-engine" strategy, focusing on both commercialization and R&D to establish a competitive global pipeline [3] - The personalized tumor therapeutic vaccine, EVM16, has initiated its first human clinical trial in China, with positive preliminary data [3] - The CAR-T project, EVM18, is expected to start clinical trials by the end of 2025, while the new generation BTK inhibitor, EVER001, is progressing well in clinical trials [4] Future Outlook - The company aims to achieve annual sales of RMB 1.6 to 1.8 billion and expects to turn operationally profitable in the second half of 2025 [1][2] - The strategic investment in I-Mab enhances the company's global positioning in next-generation tumor immunotherapy [4] - The company targets a sales peak exceeding RMB 25 billion in the future, driven by its innovative platforms and product synergies [5]

Core Viewpoint - The company, Cloudtop New Horizon (01952.HK), reported a significant revenue increase of RMB 144.6 million or 48.0% to RMB 446.1 million for the six months ending June 30, 2025, primarily driven by the growth of its commercialized products, NAI Fukan® and Yijia® [1] Revenue Growth - Revenue growth is attributed to the inclusion of NAI Fukan® in the national medical insurance drug list, which has become a major growth driver [1] - Yijia® continues to deepen its market penetration, contributing to sustained revenue growth [1] - NAI Fukan® successfully launched in Taiwan, marking a significant milestone for the company [1] - The introduction of Weishiping® into the Singapore market in the first half of 2025 highlights the company's progress in expanding international markets and improving drug accessibility [1] Research and Development - R&D expenditure decreased from RMB 253.2 million for the six months ending June 30, 2024, to RMB 195.2 million for the same period in 2025, reflecting strategic resource optimization and a focus on core pipeline breakthroughs [1] - The company achieved multiple R&D milestones in the first half of the year while actively optimizing its R&D strategy [1] - The company is accelerating the development of autologous CAR-T and mRNA platforms to prepare for the next phase of research and clinical trials, while continuing to develop the value of EVER001 (Civorebrutinib) [1]

Core Insights - The company reported a revenue of 446 million, representing a year-on-year growth of 47.96% [1] - Gross profit reached 299 million, an increase of 29.56% compared to the previous year [1] - The loss attributable to shareholders narrowed to 250 million, a reduction of 60.5% year-on-year [1] Revenue Growth Drivers - Revenue growth was primarily driven by the continued expansion of Naisikan and Yijia in commercialized markets [1] - In the Chinese market, Naisikan was included in the national medical insurance drug list, significantly boosting its revenue [1] - Yijia's market penetration continued to deepen, contributing to sustained revenue growth [1] International Market Expansion - Naisikan successfully launched in Taiwan, marking a significant milestone for the company [1] - The company successfully introduced Weishiping to the Singapore market in the first half of 2025, showcasing progress in international market expansion and improving drug accessibility [1]

中国境外市场方面，维适平®于2025年上半年成功引入新加坡市场。该等成就彰显本集团在拓展国际市 场及提升药物可及性方面的进展。 公告称，收益增长主要由于耐赋康®及依嘉®在已商业化市场上持续增长所致。 中国市场方面，耐赋康®获纳入国家医保药品目录，并成为主要增长动力，使耐赋康®截至2025年6月 30日止6个月的收益大幅增加。依嘉®的市场渗透率持续深化，为收益持续增长作出贡献。同时，耐赋 康®在台湾成功上市，达成里程碑。 智通财经APP讯，云顶新耀(01952)发布截至2025年6月30日止6个月中期业绩，该集团取得收益4.46亿 元，同比增长47.96%;毛利2.99亿元，同比增加29.56%;公司拥有人应占亏损2.5亿元，同比收窄60.5%。 ...

香 港 交 易 及 結 算 所 有 限 公 司 及 香 港 聯 合 交 易 所 有 限 公 司 對 本 公 告 的 內 容 概 不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全 部 或 任 何 部 份 內 容 而 產 生 或 因 倚 賴 該 等 內 容 而 引 致 的 任 何 損 失 承 擔 任 何 責 任。 （於開曼群島註冊成立的有限公司） （股份代號：1952） Everest Medicines Limited 雲頂新耀有限公司 截 至2025年6月30日 止 六 個 月 中 期 業 績 公 告 雲 頂 新 耀 有 限 公 司（「本 公 司」）董 事 會（「董 事 會」）宣 佈 本 公 司 及 其 附 屬 公 司 截 至2025年6月30日 止 六 個 月 的 未 經 審 計 中 期 業 績。本 公 告 載 有 本 公 司 2025中 期 報 告 全 文，符 合 香 港 聯 合 交 易 所 有 限 公 司（「聯 交 所」）證 券 上 市 規 則 中 有 關 中 期 業 績 初 步 公 告 附 載 資 料 的 相 關 要 求 ...

Group 1 - The Hong Kong biotechnology stocks experienced a collective decline, with notable drops in several companies [1] - WuXi AppTec (02126) saw a decrease of 12.95%, closing at 4.840 [2] - BioNTech (06952) fell by 12.53%, with a latest price of 13.750 [2] Group 2 - Other companies such as Valiant (09887) and Beihai Kangcheng (01228) also reported significant declines of 9.93% and 9.75% respectively [2] - The decline extended to companies like Saint Noble (02257) and MIRXES (02629), which dropped by 9.64% and 8.43% [2] - Overall, the biotechnology sector is facing downward pressure, impacting multiple firms [1]

Market Overview - The Hong Kong stock market experienced a significant decline in the afternoon, with the Hang Seng Index dropping by 1.27%, losing over 300 points. The Hang Seng China Enterprises Index and the Hang Seng Tech Index fell by 1.4% and 1.47% respectively, with the former barely holding above the 9000-point mark [2] - Major technology stocks, which serve as market indicators, continued to decline in the afternoon. Kuaishou and Meituan fell over 3%, while JD.com dropped by 2.5%. Baidu, NetEase, and Tencent saw declines close to 2%, and Xiaomi fell by 0.56%. Alibaba managed to stay slightly positive [3] Sector Performance - The financial sector, including banks, insurance companies, and Chinese brokerage firms, collectively underperformed, contributing to the overall market decline. The performance of individual stocks continued to be affected by ongoing earnings reports, with property management and real estate stocks experiencing significant drops [3] - Biopharmaceutical stocks faced a collective downturn, particularly in the innovative drug sector, following comments from Trump regarding the rapid imposition of tariffs on pharmaceuticals. This led to notable declines in various biopharma stocks [3] Specific Stock Movements - Several biopharmaceutical companies saw substantial declines, including Kanghao Ya-B (-8.59%), Qiansirui Biotechnology (-7.42%), and Kangfang Biotechnology (-7.10%). Other notable decliners included Xiansheng Pharmaceutical (-6.79%) and Shiyao Group (-6.36%) [3] - In contrast, the rare earth sector remained strong, benefiting from the implementation of supply reforms and multiple catalysts. Apple’s upcoming event on September 9, where the iPhone 17 series is expected to be launched, led to a rise in Apple-related stocks, with Lens Technology (300433) surging nearly 8% and reaching a new high since its listing [4]