格隆汇1月26日丨云顶新耀(01952.HK)公告，董事会欣然宣布，于2026年1月26日，公司全资附属公司云 顶新耀医药贸易(上海)有限公司(作为承租人)与康墣(作为出租人)订立租赁协议以于租期(定义见下文)内 租赁该物业。该物业指中国上海市青浦区香花桥街道新园路1718及1788号康墣生命科学产业园8幢(G 栋)1层至4层。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或 完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚賴該 等內容而引致的任何損失承擔任何責任。 （於開曼群島註冊成立的有限公司） （股份代號：1952） Everest Medicines Limited 雲 頂 新 耀 有 限 公 司 有關租賃協議的關連交易 董事會欣然宣佈，於2026年1月26日，該附屬公司（ 作為承租人 ）與康墣（ 作為出租 人 ）訂立租賃協議以於租期（ 定義見下文 ）內租賃該物業。租賃協議主要條款載列 如下。 租賃協議 – 1 – 日期： 2026年1月26日 訂約方： (i) 該附屬公司（ 作為承租人 ）；及 (ii) 康墣（ 作為出租人 ） 該物業： 中國上海市青浦區香花橋街道新園路1718及1788號康墣生命 科學產業園8幢（ G棟 ）1層至4層（「該物業」） 該物業面積： 11,458.72平方米 該物業用途： 僅限用於研發、生產及加工、配套倉儲用途 租期： 初步為期36個月，自2026年2月1日起至2029年1月31日止， 若任何一方未於初始租期屆滿前六個月發出終 ...

Core Insights - The collaboration between Merck and Moderna on the mRNA cancer vaccine mRNA-4157 has shown promising results, significantly reducing the risk of recurrence or death by 49% in high-risk melanoma patients when combined with the PD-1 inhibitor Keytruda [1][2] - The mRNA-4157 vaccine utilizes a personalized neoantigen therapy mechanism, which designs synthetic mRNA encoding up to 34 neoantigens based on the unique mutations in a patient's tumor DNA [2] - The market potential for mRNA cancer vaccines is substantial, with projections indicating that they could become a new class of cancer immunotherapy, combining accessibility and personalization [4] Company Developments - Moderna plans to increase investment in the oncology sector, with the Phase III clinical trial for mRNA-4157 fully enrolled and expanding its indications beyond melanoma [2] - EVM16, a personalized cancer vaccine developed by the domestic company, has entered human trials, marking a significant milestone in the application of mRNA technology combined with AI for neoantigen selection [3] - The clinical data from EVM16 is expected to be released in the next 6-12 months, with the company aiming to initiate Phase Ib studies thereafter [3] Industry Trends - The success of mRNA-4157 highlights the unmet needs in cancer treatment, with the industry recognizing the potential of mRNA cancer vaccines to address these gaps [4] - The competitive landscape for personalized cancer vaccines is evolving, with domestic companies like EVM16 accelerating their development efforts in response to the advancements made by global players [4]

1月20日，默沙东与莫德纳联合披露的mRNA肿瘤疫苗mRNA-4157(intismeran autogene)联合K药的二期 临床五年随访数据，为全球肿瘤免疫治疗领域注入"强心剂"。受消息影响，莫德纳当天股价上涨2.8%， 随着mRNA产品临床推进，其股价重拾升势，最新价已逼近近一年高点。 这项代号为KEYNOTE-942/mRNA-4157-P201的研究显示，在完全切除后的高危III/IV期黑色素瘤患者 中，mRNA-4157联合PD-1抑制剂帕博利珠单抗(Keytruda)的联合疗法，较Keytruda单药治疗将复发或死 亡风险显著降低49%。 该数据不仅体现疗效显著，更凸显其持久性。此前，该研究在随访两年时数据显示将复发或死亡风险降 低44%，三年时为49%，至第五年随访节点风险降低比例仍维持在49%的高位，有力地支持了mRNA肿 瘤疫苗机制可提供诱导持久免疫应答的科学假设。 尽管PD-1抑制剂已成为多种肿瘤治疗的重要基石，但复发风险依然困扰着相当比例的患者。在此背景 下，"个体化疫苗+免疫检查点抑制剂"的组合方案被视为突破现有治疗瓶颈的癌症治疗重要方向。 作为全球首个获FDA突破性疗法认证的mRN ...

（於開曼群島註冊成立的有限公司） （股份代號：1952） Everest Medicines Limited 雲 頂 新 耀 有 限 公 司 延遲寄發通函 茲提述本公司日期為2025年12月11日的公告（「該公告」），內容涉及有關商業化服 務協議的持續關連交易。除非本公告另有界定或文義另有所指外，本公告所採用 詞彙應與該公告所界定者具有相同涵義。 誠 如 該 公 告所 披 露 ， 一 份 載 有（ 其 中 包 括 ）(a) 商 業 化服 務 協 議 詳 情 ； (b) 獨 立 董 事 委員會致獨立股東的推薦意見；(c)獨立財務顧問致獨立董事委員會及獨立股東的 意見函件；及(d)召開股東特別大會的通告的通函（「通函」），預計將於2026年1月 16日或之前寄發予股東。 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或 完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚賴該 等內容而引致的任何損失承擔任何責任。 吳以芳 香港，2026年1月16日 於本公告日期，董事會包括主席兼執行董事吳以芳先生，執行董事羅永慶先生及何穎先生，非執 行董事傅唯先生、 ...

Summary of Everest Medicines Conference Call Company Overview - **Company Name**: Everest Medicines - **Founded**: 2017 - **Public Listing**: Hong Kong Stock Exchange, 2020 - **Market Capitalization**: Approximately $2 billion - **Employee Count**: About 800 globally, primarily in China - **Business Focus**: Integrated biopharma company with a focus on revenue growth and long-term sustainability through in-licensing and proprietary discovery platforms [2][3] Core Business Strategy - **Revenue Growth**: Aiming for near-term revenue growth while ensuring long-term sustainability through in-house R&D and in-licensing [3][5] - **Product Pipeline**: Focus on renal, autoimmune, infectious disease, and cardiovascular diseases with three commercial products: Nefercon, Zerava, and Valsipidy [4][5] - **Commercialization Platform**: Utilizes an innovative pharmaceuticals commercialization platform called AMMS (A2MS) to effectively market products in China [6][7] Product Highlights - **Nefercon**: - Approved for IgA nephropathy in May 2024 - Price: CNY 5,000 (~$700) per month - Estimated patient population in China: up to 5 million, with an incidence of 100,000 new patients annually - Sales in 2024 (partial year): CNY 350 million; guidance for 2025: CNY 1.2 billion - CNY 1.4 billion (~$200 million) [8][10] - Expected sales in 2026: CNY 2.4 billion - CNY 2.6 billion [10] - **Valsipidy**: - S1P modulator for ulcerative colitis, partnered with Pfizer - Approved in Macau and Singapore; aiming for approval in Mainland China in 2026 [11][12] - **Lyrical**: - PCSK9 inhibitor, expected to file a BLA in China in the first half of 2026 - Anticipated to capture significant market share due to its efficacy and safety profile [13][15] Financial Projections - **CSO Portfolio**: Expected to add CNY 500 million - CNY 600 million in top-line revenue over three years [13] - **Overall Revenue Goal**: Targeting over $2 billion in revenue by 2030 [24] Research and Development - **mRNA Therapeutics**: Significant investment in mRNA capabilities, with a focus on in vivo CAR-T and mRNA cancer vaccines [20][21] - **BTK Inhibitor (EVER001)**: Currently in phase 1B/2A trials for primary membranous nephritis, showing promising results in autoantibody reduction and proteinuria [17][18] Market Position and Future Outlook - **Competitive Advantage**: Emphasis on the ability to commercialize innovative therapeutics effectively in China, which is seen as a scarce capability [6] - **Expansion Plans**: Plans to continue in-licensing products globally and enhance in-house discovery capabilities, particularly in mRNA therapeutics [16][19] Conclusion - Everest Medicines is positioned for significant growth with a robust product pipeline and a strategic focus on commercialization and R&D. The company aims to leverage its innovative platform and market opportunities in China and beyond to achieve its financial and operational goals [24]

Core Viewpoint - The Hong Kong stock market for innovative drug concept stocks has seen a significant rise in early trading, indicating positive investor sentiment in the sector [1] Company Performance - 3SBio (01530.HK) increased by 6.35%, reaching HKD 28.82 [1] - WuXi AppTec (02359.HK) rose by 7.22%, trading at HKD 118.8 [1] - Lepu Biopharma-B (02157.HK) saw a gain of 6.64%, priced at HKD 28.9 [1] - Galenica-B (01672.HK) experienced a 4.09% increase, with shares at HKD 12.97 [1] - Genscript Biotech (01952.HK) grew by 3.97%, valued at HKD 40.84 [1]

Group 1 - The core viewpoint of the articles highlights a significant rise in Chinese innovative pharmaceutical stocks, driven by the upcoming 44th JPMorgan Healthcare Conference, where multiple Chinese companies are set to showcase their products [1][2] - Notable stock performances include a 6.35% increase for 3SBio, a 7.22% increase for WuXi AppTec, and a 6.64% increase for Lepu Biopharma, indicating strong market interest in these companies [1] - The conference serves as a critical platform for domestic pharmaceutical companies to demonstrate their core molecular product capabilities and advance overseas business development collaborations [2] Group 2 - The industry is transitioning back to a phase of global value verification for products, with a focus on global clinical advancements and the release of significant data [2] - Chinese innovative drug valuations have shifted from being perceived as "assets to be bought" to a stage of "global value," reflecting a broader recognition of their potential in the international market [2] - The Chinese pharmaceutical industry has largely completed the transition from old to new growth drivers, with innovative drugs significantly contributing to new growth trajectories for companies [2]

Core Viewpoint - The innovative pharmaceutical stocks have shown significant gains, driven by the upcoming 44th JPMorgan Healthcare Conference, where multiple Chinese innovative drug companies are set to participate [1] Group 1: Stock Performance - Innovent Biologics (01530) increased by 6.35%, trading at HKD 28.82 [1] - WuXi AppTec (02359) rose by 7.22%, trading at HKD 118.8 [1] - Lepu Biopharma-B (02157) saw a rise of 6.64%, trading at HKD 28.9 [1] - Galenica-B (01672) increased by 4.09%, trading at HKD 12.97 [1] - Genscript Biotech (01952) rose by 3.97%, trading at HKD 40.84 [1] Group 2: Conference Participation - The 44th JPMorgan Healthcare Conference is set to begin on January 12, 2026, in San Francisco, with several Chinese innovative drug companies confirming their attendance [1] - Key speakers include WuXi AppTec, WuXi Biologics, and WuXi AppTec's subsidiary, along with innovative drug companies such as BeiGene, Zai Lab, Ascentage Pharma, and Legend Biotech [1] - A total of 17 companies, including Hengrui Medicine, Baillie Gifford, Innovent Biologics, and Rongchang Biologics, will participate in the Asia-Pacific session [1] Group 3: Industry Insights - According to Guojin Securities, the conference serves as a critical platform for domestic pharmaceutical companies to showcase their core molecular product capabilities and advance overseas business development collaborations [1] - The industry is transitioning back to a phase of global value verification for products, with ongoing clinical advancements, significant data releases, and improved competitive dynamics driving multiple rounds of revaluation for product global value and corporate valuations [1] - Huayuan Securities indicates that the Chinese pharmaceutical industry has largely completed the transition from old to new growth drivers, with innovative drugs significantly opening new growth trajectories for companies [1]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年12月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 雲頂新耀有限公司 呈交日期: 2026年1月7日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 01952 | 說明 | 普通股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 500,000,000 | USD | | 0.0001 | USD | | 50,000 | | 增加 / 減少 (-) | | | | | | | USD | | | | 本月底結存 | | | 500,000,000 | USD | | 0.0001 | USD | | 50,000 | 本月底法定/註冊股本總額： U ...