FF301 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年8月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 樂普心泰醫療科技（上海）股份有限公司 (「本公司」) 呈交日期: 2025年9月4日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 02291 | 說明 | | | | | | | | | 已發行股份（不包括庫存股份）數目 | | 庫存股份數目 | | 已發行股份總數 | | | 上月底結存 | | | 346,749,997 | | 0 | | 346,749,997 | | 增加 / 減少 (-) | | | 0 | | 0 | | | | 本月底結存 | | | 346,749,997 | | 0 | | 346,749,997 | 第 2 頁 共 10 頁 v 1.1.1 | 1. 股份分類 | 普通股 | ...

Core Viewpoint - The significant drop in the stock price of HeartTech Medical (02291.HK) is primarily attributed to the major share reduction by its controlling shareholder, Lepu Medical (300003.SZ), which has raised concerns among investors despite the company's strong financial performance and product pipeline [3][4][6]. Group 1: Shareholder Actions - Lepu Medical sold 11.14 million shares of HeartTech Medical at a price of 22.79 HKD per share, representing approximately 3.21% of the company's total issued shares [3]. - Following the sale, Lepu Medical retains about 269 million shares, which is approximately 77.54% of the total issued capital, indicating continued confidence in the company [4]. - The transaction amount exceeded 250 million HKD, leading to a significant market reaction with HeartTech Medical's stock dropping 12.75%, resulting in a market value loss of over 1.2 billion HKD [4]. Group 2: Market Impact - The removal of HeartTech Medical from the Hang Seng Biotechnology Index, which reduced its constituent stocks from 50 to 30, may have negatively influenced investor sentiment, prompting further selling pressure [4]. - The stock's trading volume increased significantly, with a total transaction amount of 376 million HKD on the day of the drop, indicating a rush of capital outflow [2]. Group 3: Company Performance - HeartTech Medical reported a revenue of 330 million RMB for the first half of the year, reflecting a year-on-year growth of 32.4%, and a net profit of 182 million RMB, up 29.8% year-on-year [4]. - As of the end of June, the company had cash and cash equivalents totaling 1.32 billion RMB, a 17.8% increase compared to the end of the previous year [4]. - The company has a diverse product portfolio, including 30 marketed products and 28 in various stages of research and development, showcasing its strong pipeline in the cardiac medical device sector [5]. Group 4: Industry Position - HeartTech Medical is recognized as a pioneer in the domestic cardiac medical device field, with recent advancements in innovative products such as the TAVR system, which has been successfully implanted in multiple clinical centers [5][6]. - The company is well-positioned in the structural heart disease treatment market, with a comprehensive product line covering various areas, including congenital heart defect occluders and heart valve products [6]. - The leading technology of the biodegradable occluders positions the company favorably for potential overseas licensing opportunities, given the high costs associated with international clinical research [6].

Market Overview - The Hong Kong stock market failed to maintain its strong performance from the previous day, with all three major indices experiencing a collective adjustment. The Hang Seng Index fell by 1.18% or 304.99 points, closing at 25,524.92 points, with a total trading volume of HKD 31.78 billion. The Hang Seng China Enterprises Index decreased by 1.07% to 9,148.66 points, while the Hang Seng Tech Index dropped by 0.74% to 5,782.24 points [1] Blue-Chip Stocks Performance - CSPC Pharmaceutical Group (01093) led the decline among blue-chip stocks, falling by 4.33% to HKD 10.38, with a trading volume of HKD 1.797 billion, contributing a loss of 6.04 points to the Hang Seng Index. Bank of America Securities reported a 14.3% year-on-year decline in total revenue for CSPC in Q2, with attributable net profit down 24% to RMB 1.1 billion. The firm revised its revenue forecasts for 2025 to 2027 down by 25%, 2%, and 11% respectively [2] Sector Highlights - Large technology stocks mostly declined, with Alibaba down 2.57% and Tencent down 0.81%. Gold stocks surged, with China Gold International rising over 10%. Apple is expected to initiate a three-year innovation cycle, boosting related stocks like Lens Technology, which rose over 5%. Gaming stocks and some new consumption concepts performed well, with Melco International Development up over 9% [3][5] Federal Reserve Insights - Federal Reserve Chairman Jerome Powell indicated rising downside risks in the U.S. labor market, suggesting a potential policy adjustment could be appropriate. This statement is seen as a strong signal for a possible interest rate cut as early as September. The market reacted positively, particularly for precious metals, with expectations for further increases in gold prices [4] Gaming Sector Performance - The gaming sector continued its upward trend, with Melco International Development rising 9.27% to HKD 5.54. According to JPMorgan, Macau's gaming revenue for the first 24 days of August reached MOP 17.65 billion, with a daily average of MOP 735 million, reflecting a 9% increase from the previous week [6] Pharmaceutical Sector Challenges - The pharmaceutical sector faced pressure, with several stocks declining. Notably, CStone Pharmaceuticals (09966) fell 6.74% to HKD 10.24. U.S. President Trump's announcement to drastically reduce drug prices could create significant challenges for the global pharmaceutical industry, presenting both opportunities and risks for Chinese biotech stocks [6] Notable Stock Movements - Double Ended Co. (06960) debuted with a 31.29% increase, closing at HKD 19.05. The company focuses on energy storage solutions in the data and communication sectors, with a projected market share of 11.1% by 2024 [7] - Kingsoft Holdings (03918) reached a new high, rising 17.94% to HKD 5.72, reporting a 16.76% year-on-year revenue increase to USD 342 million [8] - Angelalign Technology (06699) saw a 10.28% increase to HKD 75.1, with a 33.1% year-on-year revenue growth reported [9] - Meitu Inc. (01357) rose 7.9% to HKD 11.47 after being included in the MSCI China Index, with Morgan Stanley expressing confidence in its long-term growth potential [10] - Xintai Medical (02291) experienced a significant drop of 12.75% to HKD 23.96 following a major shareholder's sale of shares [11]

于出售事项后，乐普医疗将继续持有2.6886亿股股份，包括由乐普医疗直接持有的2.6606亿股股份及由 乐普医疗的附属公司北京天地和协科技有限公司持有的280万股股份，占公司于公告日期已发行股本约 77.54%，彰显其对公司的坚定信心。公告强调，乐普医疗对集团的业务运营充满信心，出售事项旨在 提升公司股票的流动性。 智通财经APP获悉，心泰医疗(02291)跌超10%，截至发稿，跌10.78%，报24.5港元，成交额2.83亿港 元。 消息面上，心泰医疗今早公告，董事会已获公司其中一名控股股东乐普(北京)医疗器械股份有限公司(乐 普医疗，其股份于深圳证券交易所创业板上市，证券代码：300003)告知，乐普医疗于8月26日通过大宗 交易出售合共1114万股公司H股，每股价格为22.79港元，占公司于公告日期已发行股份总数的约3.21% (出售事项)。 ...

Core Viewpoint - The stock of HeartTech Medical (02291) has dropped over 10%, currently trading at 24.5 HKD, with a transaction volume of 283 million HKD due to a significant share sale by a major shareholder, Lepu Medical [1] Group 1: Shareholder Activity - Lepu Medical announced the sale of a total of 11.14 million H-shares of HeartTech Medical at a price of 22.79 HKD per share, representing approximately 3.21% of the total issued shares as of the announcement date [1] - After the sale, Lepu Medical will continue to hold 268.86 million shares, which includes 266.06 million shares directly held and 2.8 million shares held by its subsidiary, accounting for about 77.54% of the total issued share capital as of the announcement date [1] Group 2: Company Confidence - The announcement emphasized Lepu Medical's strong confidence in the operational performance of HeartTech Medical, stating that the sale was aimed at enhancing the liquidity of the company's stock [1]

Core Viewpoint - The announcement from HeartTech Medical (02291) indicates that its major shareholder, Lepu Medical (300003), will sell 11.14 million H-shares at a price of HKD 22.79 per share, representing approximately 3.21% of the total issued shares, to enhance liquidity while maintaining a significant ownership stake of 77.54% in the company [1] Group 1 - HeartTech Medical's board has been informed by Lepu Medical about the sale of shares [1] - The sale involves 11.14 million H-shares at a price of HKD 22.79 each [1] - Post-sale, Lepu Medical will hold 268.86 million shares, which includes direct and subsidiary holdings [1] Group 2 - The sale is aimed at improving the liquidity of HeartTech Medical's stock [1] - Lepu Medical expresses strong confidence in the business operations of HeartTech Medical [1] - The ownership stake of Lepu Medical after the sale will be approximately 77.54% of the total issued shares [1]

智通财经APP讯，心泰医疗(02291)发布公告，本公司董事会已获本公司其中一名控股股东乐普(北京)医 疗器械股份有限公司(乐普医疗，其股份于深圳证券交易所创业板上市，证券代码：300003)告知，乐普 医疗于2025年8月26日通过大宗交易出售合共1114万股本公司H股，每股价格为22.79港元，占本公司于 本公告日期已发行股份总数的约3.21%(出售事项)。于出售事项后，乐普医疗将继续持有2.6886亿股股 份，包括由乐普医疗直接持有的2.6606亿股股份及由乐普医疗的附属公司北京天地和协科技有限公司持 有的280万股股份，占本公司于本公告日期已发行股本约77.54%，彰显其对本公司的坚定信心。乐普医 疗对本集团的业务运营充满信心，出售事项旨在提升本公司股票的流动性。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因倚賴 該等內容而引致之任何損失承擔任何責任。 LEPU SCIENTECH MEDICAL TECHNOLOGY (SHANGHAI) CO., LTD.* 樂普心泰醫療科技（上海）股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：2291） 內幕消息 本公司控股股東減持股份 本公告乃由樂普心泰醫療科技（上海）股份有限公司（「本公司」，連同其附屬公 司，「本集團」）根據香港聯合交易所有限公司（「聯交所」）證券上市規則（「上市規 則」）第13.09條及《證券及期貨條例》（香港法例第571章）第XIVA部所訂明的內幕 消息條文（定義見上市規則）而作出。 本公司董事（「董事」）會（「董事會」）已獲本公司其中一名控股股東（定義見上市規 則）樂普（北京）醫療器械股份有限公司（「樂普醫療」，其股份於深圳證券交易所創 業板上市，證券代碼：300003）告知，樂普醫療於2025年8月26日通過大宗交易出 售合共11,140,000股本公司H股，每 ...

Core Viewpoint - HeartTech Medical (02291) reported strong mid-term performance with a revenue of 330 million RMB, representing a year-on-year growth of 32.4%, and a net profit attributable to shareholders of 182 million RMB, up 29.8% [1] Company Performance - The company’s basic earnings per share reached 0.5249 RMB [1] - As of the announcement date, HeartTech Medical has a total of 30 products in the market, including occluders, heart valves, and accessories, with 4 products under registration review and 28 products in various stages of research and development [1] Product Pipeline and Market Position - According to CITIC Securities, HeartTech Medical has a comprehensive layout in the structural heart disease sector, covering products for congenital heart disease occluders, cardioembolic stroke, valves, and heart failure [1] - The company has a rich pipeline in the valve sector, with TAVR products already approved for market [1] - In the aortic and peripheral occluder fields, the company is developing biodegradable aortic occluders [1] Growth Drivers and Future Potential - The company has maintained rapid growth in recent years, primarily driven by the market expansion of new products such as biodegradable occluders [1] - HeartTech Medical's biodegradable occluder technology is at a leading level globally, with independent intellectual property rights [1] - There is potential for strong overseas license-out opportunities for this product series, considering the high costs of overseas clinical research and the company's technological advantages [1]

Core Viewpoint - HeartTech Medical (02291) reported strong mid-term performance with a revenue of 330 million RMB, reflecting a year-on-year growth of 32.4%, and a net profit attributable to shareholders of 182 million RMB, up 29.8% [1] Financial Performance - Revenue reached 330 million RMB, representing a 32.4% increase year-on-year [1] - Net profit attributable to shareholders was 182 million RMB, showing a growth of 29.8% [1] - Basic earnings per share stood at 0.5249 RMB [1] Product Portfolio - The company has a total of 30 marketed products including occluders, heart valves, and accessories [1] - There are 4 products under registration review and preparation, with an additional 28 products in various stages of research and development [1] Market Position and Growth Potential - CITIC Securities highlighted HeartTech Medical's comprehensive layout in the structural heart disease sector, covering areas such as congenital heart disease occluders, stroke, valves, and heart failure [1] - The company has a rich pipeline in the valve sector, with TAVR products already approved for market [1] - HeartTech Medical is positioned in the biodegradable aortic occluder market, which is expected to have strong overseas licensing potential due to its leading technology and proprietary intellectual property [1]