2025年末将至，距离港股通最新一轮调整考察期结束仅有最后20天时间，这意味着目前已是不少标的"入通"的最后冲刺阶段。 恒生指数和港股通下一轮定期调整时间在明年3月，检讨结果公布时间在2月25日，检讨周期则为2025年1月1日至2025年12月31日。据智通财经APP测算，目 前预计新纳入港股通的标的数量共有31只。除去3只标的将以"A+H"形式获纳入外，剩下28只则有望因满足"入通门槛"获纳入，劲方医药-B(02595)便是其中 之一。 上市以来稳健走势成"入通"关键 目前数据显示，劲方医药在本次检讨周期内的日平均市值为102.96亿港元，较最新的92.42亿港元市值门槛高出超10亿港元。考虑到现已时至12月11日，距离 港股通最新一轮调整考察期结束仅有20天时间，因此劲方医药在保证市值稳定前提下，在新一期港股通调整中顺利入通的概率较大。 从劲方医药上市以来的表现来看，经历上市前期震荡下跌后实现止跌回稳的股价走势无疑是其"冲通"的关键因素。 据智通财经APP观察，9月18日，劲方医药辉立暗盘以40.00港元高开，经过短暂震荡便快速拉升至45.58港元高点，并后续保持中高位震荡以41.22港元报 收，最终收涨 ...

Major Events - Chuangsheng Group-B (06628) announced updated efficacy data for osemitamab triple therapy as a first-line treatment for gastric or gastroesophageal junction adenocarcinoma at ESMO Asia [1] - Strength Development (01277) plans to acquire 100% equity of Taiyuan Shidi for approximately 384 million yuan and acquire Dongzhimen property for a total of 86.33 million yuan [1] - Innovent Biologics (01801) completed a global strategic collaboration with Takeda Pharmaceutical and issued 6.9138 million shares under general authorization [1] - Ascentage Pharma-B (06855) received FDA and EMA approval for global registration of a Phase III clinical trial for Nilotinib as a first-line treatment for Ph+ ALL [1] - Baiao Saitou-B (02315) announced that its business partner IDEAYA received IND approval from the FDA for IDE034 [1] - Jinfang Pharmaceutical-B (02595) initiated a registration clinical trial for GFH375, the world's first oral KRAS G12D inhibitor in a controlled chemotherapy Phase III study [1] - Xixiangfeng Group (02473) signed a business cooperation agreement with Hello Car Rental to develop car rental services in designated cities under a "co-branded store" model [1] - International Commercial Settlement (00147) signed a computer chip sales agreement with Hong Kong Antarctic Light to seize growth opportunities in the IC chip market [1] - CSPC Pharmaceutical Group (01093) received clinical trial approval in the U.S. for a GLP-1/GIP receptor dual agonist injection [1] - MIRXES-B (02629) plans to collaborate with Crystal Technology to build an AI-enabled integrated "diagnosis and treatment" research and industrialization platform [1] - Zhengtong Automobile (01728) intends to invest approximately 816 million yuan to acquire Xiamen Xinda 4S dealership and automotive sales and export business [1] - Guorui Life (00108) plans to acquire 78.3% of Beijing Chunyu Tianxia Software for 269 million yuan [1] - Innovent Biologics (01801) successfully included seven innovative products (including new indications) in the 2025 National Medical Insurance Drug List [1] - Peijia Medical-B (09996) had its registration application for the TaurusNXT® "non-aldehyde cross-linked" transcatheter aortic valve replacement system accepted by the National Medical Products Administration [1] - Fosun Pharma (02196) had new drugs included in the National Medical Insurance Directory and commercial insurance innovative drug directory [1] - Junshi Biosciences (01877) had Tuoyi® new indications and Junshida® included in the National Medical Insurance Directory [1] - Valiant Biotech-B (09887) presented clinical data for LBL-034 at the 67th ASH Annual Meeting [1] - Canfite BioPharma (09926) had all approved indications for five marketed drugs successfully included in the latest National Medical Insurance Drug List [1] - Fuhong Hanlin (02696) had Fuzhuoning® (Citrus Acid Vovizili Capsules) included in the National Medical Insurance Drug List [1] - Green Leaf Pharmaceutical (02186) successfully included five new products in the 2025 National Medical Insurance Drug List or commercial insurance innovative drug directory [1] - Yinnuo Pharmaceutical-B (02591) had its core products included in the National Medical Insurance Drug List [1] Operating Performance - Poly Real Estate Group (00119) reported a contract sales amount of approximately 47.7 billion yuan for the first 11 months, a year-on-year decrease of 8.45% [2] - GAC Group (02238) reported November automobile sales of approximately 179,700 units, a year-on-year decline of 9.72% [2] - Xiehe New Energy (00182) reported an equity power generation of 697.23 GWh in November, a year-on-year increase of 7.77% [2]

这项多中心、开放标签、随机对照的III期试验(GFH375X1301)将在约40家中心开展，计划入组约320例 既往接受至少一种标准系统性治疗的转移性胰腺癌患者。沙利文资料显示2037年全球胰腺癌新发病例将 超过77万人，胰腺癌恶性程度高、预后极差，5年生存率不足10%;目前胰腺癌治疗仍以化疗药物为主， 二线至三线客观缓解率(ORR)仅为10-20%，三线及以上治疗尚无标准治疗方案。科研文献显示近40%胰 腺癌患者存在KRAS G12D突变，而全球尚无相关靶向药获批上市;KRAS G12D突变是晚期PDAC应答率 及总生存期不佳的独立预后标志物，且KRAS G12D突变在调节性T细胞转化过程中发挥关键作用，可促 进形成免疫抑制性肿瘤微环境、并导致患者对免疫检查点抑制剂应答不佳。 劲方医药-B(02595)发布公告，口服KRAS G12D(ON/OFF)抑制剂GFH375治疗经治KRAS G12D突变型转 移性胰腺癌患者的注册性III期试验(GFH375X1301)已在北京大学肿瘤医院启动。目前GFH375开发进度 位于全球口服KRAS G12D抑制剂第一梯队，多项GFH375(于中国境外称VS-7375)单药 ...

劲方首席医学官汪裕博士表示："这是全球首个口服RAS抑制剂治疗胰腺癌的注册性临床研究，这一重 要里程碑体现了劲方临床团队的临床研发和执行能力、以及公司深耕于RAS疗法矩阵的一体化新药开发 实力。GFH375在去年进入临床试验，今年就已获得优秀的单药I/II期研究数据，并在近期进入多项单 药、联合疗法试验，我们期待该产品在这项注册性研究(GFH375X1301)中取得积极结果、早日造福患 者。我们也期待以GFH375为代表的劲方RAS靶向药物在未来实现更多突破，并与公司的恶病质双抗疗 法形成靶向胰腺癌的协同性治疗矩阵。" 智通财经APP讯，劲方医药-B(02595)发布公告，口服KRAS G12D (ON/OFF)抑制剂GFH375治疗经治 KRAS G12D突变型转移性胰腺癌患者的注册性III期试验(GFH375X1301)已在北京大学肿瘤医院启动。 目前GFH375开发进度位于全球口服KRAS G12D抑制剂第一梯队，多项GFH375(于中国境外称VS-7375) 单药和联合疗法正在中国(由劲方主导)及海外(由劲方合作伙伴Verastem Oncology主导)进行临床探索， 包括 GFH375联合化疗(白 ...

这项多中心、开放标签、随机对照的III期试验(GFH375X1301)将在约40家中心开展，计划入组约320例 既往接受至少一种标准系统性治疗的转移性胰腺癌患者。沙利文资料显示2037年全球胰腺癌新发病例将 超过77万人，胰腺癌恶性程度高、预后极差，5年生存率不足10%；目前胰腺癌治疗仍以化疗药物为 主，二线至三线客观缓解率(ORR)仅为10-20%，三线及以上治疗尚无标准治疗方案。科研文献显示近 40%胰腺癌患者存在KRAS G12D突变，而全球尚无相关靶向药获批上市；KRAS G12D突变是晚期 PDAC应答率及总生存期不佳的独立预后标志物，且KRAS G12D突变在调节性T细胞转化过程中发挥关 键作用，可促进形成免疫抑制性肿瘤微环境、并导致患者对免疫检查点抑制剂应答不佳。 格隆汇12月5日丨劲方医药-B(02595.HK)宣布，口服KRAS G12D (ON/OFF)抑制剂GFH375治疗经治 KRAS G12D突变型转移性胰腺癌患者的注册性III期试验(GFH375X1301)已在北京大学肿瘤医院启动。 目前GFH375开发进度位于全球口服KRAS G12D抑制剂第一梯队，多项GFH375(于中国境外 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容引致的任何損失承擔任何責任。 GenFleet Therapeutics (Shanghai) Inc. 勁方醫藥科技（上海）股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：2595） 自願公告 GFH375治療轉移性胰腺癌註冊性臨床試驗在首家研究中心啟動， 為全球首個口服KRAS G12D抑制劑單藥對照化療III期研究 本公告由勁方醫藥科技（上海）股份有限公司（「本公司」或「勁方」，連同其附屬公 司統稱「本集團」）自願刊發，以知會本公司股東及潛在投資者有關本集團最新業 務動態。 本公司董事會欣然宣佈，口服KRAS G12D (ON/OFF)抑制劑GFH375治療經治 KRAS G12D突變型轉移性胰腺癌患者的註冊性III期試驗(GFH375X1301)已在北 京大學腫瘤醫院啟動。目前GFH375開發進度位於全球口服KRAS G12D抑制劑第 一梯隊，多項GFH375（於中國境外稱VS-7375）單藥和聯合療法正在 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年11月30日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 勁方醫藥科技 ( 上海 ) 股份有限公司 （於中華人民共和國註冊成立的股份有限公司, 「本公司」） | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 02595 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 338,029,020 | RMB | | 0.1 RMB | | 33,802,902 | | 增加 / 減少 (-) | | | | | | RMB | | | | 本月底結存 | | | 338,029,020 | RMB | | 0.1 RMB | | 33,802,902 | | 2. 股份分類 | 普通股 | 股份類別 | ...

Core Viewpoint - The article discusses the journey and insights of Lü Qiang, the founder of Jinfang Pharmaceutical, highlighting the challenges and strategies in the innovative drug development landscape in China, particularly focusing on the RAS target and the company's approach to commercialization and investor relations. Group 1: Company Overview - Jinfang Pharmaceutical was founded in August 2017 by Lü Qiang in Shanghai Zhangjiang, capitalizing on the favorable conditions for innovative drug development in China [1] - The company successfully listed on the Hong Kong Stock Exchange, with its stock price increasing over 100% on the first day, but faced a subsequent decline of over 30% due to market adjustments [6] - Jinfang's lead drug, Dabotinib, is set to be the first RAS-targeted drug approved in China by August 2024, marking a significant milestone in the company's pipeline [3] Group 2: R&D Focus and Innovation - Jinfang is heavily invested in the RAS target, which has historically been considered "undruggable," with no approved drugs for over 40 years until Amgen's Lumakras received FDA approval in May 2021 [2] - The company aims to cover 80% to 90% of pancreatic cancer patients with its four RAS drugs, addressing a significant unmet need in the oncology market [11] - Lü Qiang emphasizes the importance of innovation beyond just targeting new mechanisms, advocating for a comprehensive understanding of existing research to drive breakthroughs [7][8] Group 3: Commercialization Strategy - Lü Qiang believes that the era of "single product dominance" is over, and that a product matrix approach is necessary for successful commercialization in the competitive oncology market [12] - The company has opted to partner with larger pharmaceutical firms for commercialization rather than pursuing independent sales, reflecting a strategic decision to leverage collective strengths [10] - Jinfang's strategy focuses on creating a "small but beautiful" commercial portfolio, aligning with clinical market gaps and technological advancements [12] Group 4: Market Dynamics and Future Outlook - The article notes that the Chinese biotech sector is increasingly scrutinized by professional capital, which now values the progress and breadth of R&D pipelines more than before [6] - Lü Qiang acknowledges the challenges of balancing innovation with market demands, indicating that the pressures of entrepreneurship are often underestimated [4] - The article concludes with insights on the evolving landscape of biotech and biopharma, suggesting that both sectors have distinct roles and that the current trend of high financial expectations in business development may require recalibration [13][14]

Core Viewpoint - The company has announced the adoption of its H-share option plan and H-share incentive plan aimed at providing qualified individuals with opportunities to gain equity in the company and to enhance the overall value for shareholders [1] Group 1: H-share Option Plan - The H-share option plan is designed to offer qualified participants, including employees and service providers, the chance to acquire capital equity in the company [1] - The plan aims to encourage qualified individuals to work towards enhancing the company's value and that of its shares [1] Group 2: H-share Incentive Plan - The H-share incentive plan is intended to retain, motivate, and reward qualified individuals by providing flexible compensation, remuneration, and/or benefits [1] - This plan is part of a broader strategy to align the interests of participants with those of the company and its shareholders [1]

Core Viewpoint - The company, Jinfang Pharmaceutical-B (02595), announced the board's resolution to adopt the H-share option scheme and H-share incentive plan on November 24, 2025, aimed at providing qualified individuals with opportunities to gain equity interests in the company and to enhance the overall value for shareholders [1] Group 1 - The H-share option scheme and H-share incentive plan are collectively referred to as the "Share Scheme" [1] - The Share Scheme is designed to encourage qualified individuals, including employee participants, service providers, and related entity participants, to work towards enhancing the company's value and that of its shares [1] - The Share Scheme is expected to retain, incentivize, and reward qualified individuals, providing flexible means of compensation, remuneration, and/or benefits [1]