第 1 頁 共 6 頁 v 1.3.0 B. 贖回/購回股份 (擬註銷但截至期終結存日期尚未註銷) (註5及6) FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 百濟神州有限公司 (根據瑞士法律註冊成立的公司) 呈交日期： 2025年8月1日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | 證券代號 (如上市) | 06160 | 說明 | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | ...

| 序号 | 名称 | 港股代码 | ADR换算价(HKD) | 较港股升跌 | 较港股升跌% | AD ADR最新价(美元) | | --- | --- | --- | --- | --- | --- | --- | | 1 | 腾讯控股 | 0 00700 | 550.011 | +0.011 | 0.00% | 70.070 | | 2 | 阿里巴巴-W | 09988 | 118.360 | +2.660 | 2.30% | 120.630 | | 3 | 建设银行 | 00939 | 8.003 | -0.047 | -0.59% | 20.390 | | 4 | 汇丰控股 | 00005 | 96.234 | +0.084 | 0.09% | 61.300 | | 5 | 小米集团-W | 01810 | 52.874 | -0.276 | -0.52% | 33.680 | | 6 | 友邦保险 | 01299 | 73.059 | -0.341 | -0.46% | 37.230 | | 7 | 美团-W | 03690 | 120.489 | -1.111 | -0.91% | 30.700 ...

Core Insights - The Chinese life sciences industry is undergoing rapid transformation driven by policy relaxation, technological innovation, the rise of domestic companies, and the development of specialized real estate ecosystems [9][18][39] - The report "Trends in China's Life Sciences" provides a comprehensive overview of current market dynamics, regulatory changes, and future development directions [9] Policy Environment - Nationally, China has relaxed foreign investment restrictions in gene and cell therapy, allowing foreign-owned hospitals in major cities [10][20] - Local governments in cities like Beijing, Shanghai, and Shenzhen are offering targeted subsidies and fast-track approval processes to support biotechnology development [10][27] Industry Innovation and Company Growth - Chinese life sciences companies are shifting from generic drug production to innovative therapies, with firms like CanSino Biologics and BeiGene leading in CAR-T cell therapy and bispecific antibodies [11][29] - These companies are attracting international investment and licensing agreements, enhancing China's position in the global life sciences sector [11][39] Real Estate Development and Regional Hubs - Innovation hubs such as Suzhou BioBay and Shanghai Zhangjiang Hi-Tech Park provide end-to-end support, including shared laboratories and GMP-compliant facilities [12][35] - Second-tier cities like Chengdu and Ningbo are emerging as new growth centers, expanding the life sciences ecosystem [12][35] Owner Perspective - Real estate developers are adapting to industry-specific needs through light-asset models and flexible leasing arrangements [14][45] - While first-tier cities face saturation, demand remains robust in central and western regions, with a focus on sustainability and compliance [14][45] Tenant Perspective - Life sciences tenants are responding to regulatory reforms and increased compliance requirements, seeking flexibility and proximity to talent and infrastructure [15][46] - The highest demand is for GMP-certified laboratories and modular production facilities, emphasizing location advantages and sustainability certifications [15][46] Future Outlook - Growth opportunities lie in AI-driven drug development, personalized medicine, and advanced therapies, supported by government policies [16][39] - Life sciences real estate is evolving from generic parks to specialized, digitally-enabled facilities with high compliance and flexibility [16][39]

Core Insights - BeiGene has received Priority Medicine (PRIME) designation from the European Medicines Agency (EMA) for its investigational Bruton’s Tyrosine Kinase (BTK) degrader BGB-16673, aimed at treating patients with Waldenström's macroglobulinemia (WM) who have previously been treated with BTK inhibitors [1] - The EMA's Committee for Medicinal Products for Human Use (CHMP) has also issued a positive opinion regarding the orphan drug designation (ODD) application for BGB-16673 for the treatment of WM patients, with a final decision expected in the coming weeks [1]

港股创新药概念多股走强，歌礼制药(01672.HK)、石药集团(01093.HK)涨近3%，中国生物制药 (01177.HK)涨超2%，百济神州(06160.HK)、翰森制药(03692.HK)等跟涨。 ...

1. Report Industry Investment Rating No relevant information provided. 2. Core View of the Report In Q2 2025, the Hong Kong stock market showed a V-shaped trend of sharp decline followed by recovery. The returns of various types of Hong Kong stock funds were positive, and the scale and share of Hong Kong stock funds increased. The stock positions and Hong Kong stock positions of Hong Kong stock funds increased slightly. In terms of heavy - position sectors, there were increases in medicine, finance, and technology, and a decrease in consumption. Among heavy - position stocks, pharmaceutical stocks showed obvious increases, while some Internet platform leaders declined. The scale of some fund companies increased significantly [3]. 3. Summary According to the Table of Contents 3.1 Hong Kong Stock Fund Performance and Scale Development - **Performance**: In Q2 2025, among the main indices tracked by Hong Kong stock funds, the Hang Seng Index and Hang Seng China Enterprises Index rose by 4.42% and 1.9% respectively, outperforming the CSI 300. The Hang Seng Technology Index fell by - 1.70%. The leading indices in terms of gains were the China Securities Hong Kong Stock Connect Innovative Drug Index (25.6%) and the China Securities Hong Kong Stock Connect Non - Banking Financial Index (21.8%). The average returns of various types of Hong Kong stock funds were positive, with "Hong Kong QDII - Active" leading with an average increase of 10.22% [3]. - **Scale and Share**: As of the end of Q2, the total scale of Hong Kong stock funds was 619.134 billion yuan, a quarter - on - quarter increase of 13.54 pct; the total share was 623.83 billion shares, a quarter - on - quarter increase of 7.45 pct. In Q2, the number of newly issued funds was 28, an increase from the previous quarter, but the newly issued scale was 7.517 billion yuan, lower than the previous quarter [3]. 3.2 Hong Kong Stock Fund Positioning Characteristics - **Stock and Hong Kong Stock Positions**: In Q2, the average stock position was 92%, a slight increase from the previous quarter. The stock position of index funds was higher than that of actively managed funds. The average Hong Kong stock position was 85%, an increase from the previous quarter, and the gap between index funds and actively managed funds narrowed in Q2 [3]. - **Heavy - Position Sector Allocation**: Technology (39%) and consumption (25%) ranked first and second in terms of proportion. The sectors with more increases were medicine (+2.27 pct), finance (+2.25 pct), and technology (+1.67 pct), while consumption (-5.97 pct) was significantly reduced [3]. - **Heavy - Position Stock Industry Distribution**: Media ranked first for four consecutive quarters, with a quarter - on - quarter increase of 0.66 pct in Q2; Commerce and Retail ranked second for four consecutive quarters, with a quarter - on - quarter decrease of 3.5 pct; Electronics became the third for two consecutive quarters, with a quarter - on - quarter increase of 0.88 pct. The sector with the highest quarter - on - quarter increase was Medicine and Biology, accounting for 12.42% and a quarter - on - quarter increase of 2.27 pct [3]. - **Individual Stock Level**: The "herding effect" of funds on leading stocks decreased. In terms of the number of funds holding heavy - position stocks, Xiaomi rose one place to become the third, and Sino Biopharmaceutical and Pop Mart entered the top 10 for the first time in four quarters. The concentration of heavy - position stocks decreased, and the proportion of large - cap stocks with a market value of over 80 billion yuan rose to 90% [3]. 3.3 Hong Kong Stock Fund Company Analysis - **Scale Ranking**: In Q2, the top 5 fund companies in terms of scale were Huaxia, E Fund, Fullgoal, GF, and ICBC Credit Suisse, and their total scales increased to varying degrees compared with the previous quarter. Huaxia's Hong Kong stock product scale exceeded 10 billion yuan, and ICBC Credit Suisse's scale increased by 35.45 pct quarter - on - quarter. Among the top 20, the most obvious expansion was by Huatai - PineBridge, with a quarter - on - quarter increase of 91.13 pct, rising four places to the seventh [3]. 3.4 Performance - Oriented Hong Kong Stock Fund Positioning Display and Quarterly Report Views - **Positioning Display**: Some actively managed Hong Kong stock funds in Q2 2025 held stocks that were among the top 50 in terms of gains, such as Rongchang Biologics, Sino Biopharmaceutical, and Innovent Biologics [54]. - **Quarterly Report Views**: Fund managers generally expressed optimism about the development prospects of sectors such as innovative drugs, new consumption, and technology Internet, and adjusted their investment strategies according to market conditions [57][58].

Core Insights - The innovative drug sector has seen significant growth this year, with the China Securities Hong Kong Stock Connect Innovative Drug Index rising over 124% since the beginning of the year, and the Shanghai Stock Exchange Sci-Tech Innovation Board Innovative Drug Index increasing over 80% [2][3] - There is a growing divergence in opinions among fund managers regarding the valuation of innovative drugs, with some expressing caution and suggesting profit-taking, while others remain optimistic about future growth [2][11] Fund Performance - As of July 29, 2023, 16 funds have reported returns exceeding 100%, all heavily invested in the innovative drug sector [5] - The fund managed by Zhang Wei, Huatai-PineBridge Hong Kong Advantage Selection, leads with a 139% return [5] - The total scale of funds focused on innovative drugs has increased from 111 billion yuan to 366 billion yuan this year, marking a growth of over 200% [5] Market Dynamics - The innovative drug sector has attracted significant investor interest, with the scale of the Huatai-PineBridge National Index Hong Kong Stock Connect Innovative Drug ETF rising from less than 700 million yuan to nearly 8 billion yuan in the first half of the year [5] - The innovative drug index has seen a net inflow of 172 billion yuan, making it one of the highest net buying sectors this year [5][6] Valuation Concerns - Some fund managers, like Wan Minyuan from Rongtong Fund, have raised concerns about the high valuations of A-share innovative drug stocks, suggesting that many companies may have reached their peak valuations [11][12] - There is a belief that the current market is experiencing a bubble, with excessive speculation on early-stage clinical drugs [11][12] Long-term Outlook - The innovative drug sector is viewed as a critical area for investment, with expectations of continued growth driven by technological advancements and supportive policies [10][14] - Fund managers emphasize the importance of selecting companies with strong technological capabilities and sustainable clinical value to navigate potential market volatility [2][14]

风险提示：股市有风险，投资需谨慎。 百济神州-U属于生物制药行业，是一家专注于创新型分子靶向和肿瘤免疫治疗药物研发的生物科技公 司。公司主要研发治疗癌症的创新型分子靶向和肿瘤免疫治疗药物。 从资金流向来看，百济神州-U当日主力资金净流出1077.61万元。公司当前总市值为3726.46亿元，流通 市值为278.43亿元。 百济神州-U最新股价为242.00元，较前一交易日下跌1.54%。该股当日成交额达5.50亿元，振幅为 3.71%。 ...

Core Viewpoint - The announcement of HRS-9821 project licensing to GlaxoSmithKline (GSK) by Heng Rui Medicine signifies a growing trend of multinational pharmaceutical companies acquiring innovative drugs from Chinese firms, reflecting a competitive landscape in the Chinese pharmaceutical market [1][5][19]. Group 1: Licensing and Financial Details - Heng Rui Medicine will receive a $500 million upfront payment from GSK, with potential milestone payments reaching up to $12 billion based on successful development, registration, and sales [2]. - The licensing agreement excludes regions such as mainland China, Hong Kong, Macau, and Taiwan, indicating a strategic focus on international markets [1]. - The deal has positively impacted Heng Rui Medicine's stock prices in both A-shares and Hong Kong stocks [4]. Group 2: Market Trends and Acquisitions - In the first half of the year, multinational pharmaceutical companies invested approximately 464.3 billion yuan ($64.5 billion) in acquiring Chinese innovative drugs, indicating a surge in interest [6][19]. - The "buy-buy-buy" strategy adopted by these companies highlights a shift towards acquiring rather than developing new drugs internally [7][20]. - Notable transactions include Pfizer's acquisition of a PD-1/VEGF bispecific antibody from 3SBio for $12.5 billion, marking a record for domestic innovative drug deals [8][10]. Group 3: Characteristics of Transactions - The average transaction amounts are substantial, with many exceeding $1 billion, and the largest deals surpassing $6 billion [15]. - Major pharmaceutical companies involved in these transactions include Pfizer, Roche, and AstraZeneca, all ranked among the top ten global pharmaceutical firms [16]. - The focus of these acquisitions is on high-tech areas such as oncology, autoimmune diseases, and metabolic disorders, showcasing the advanced nature of the Chinese pharmaceutical pipeline [17]. Group 4: Rationale Behind Acquisitions - The high risk and long development timelines associated with innovative drug development make acquisitions a more attractive option for multinational companies [20][22]. - Acquiring innovative drugs allows these companies to quickly fill gaps in their pipelines and respond to competitive pressures in the market [25][27]. - The trend of increasing external procurement from Chinese companies has risen from 10% in 2020 to 29% in 2023, indicating a growing recognition of the value of Chinese innovation [17][19]. Group 5: Advantages of Chinese Innovative Drugs - Chinese innovative drugs are perceived as high-quality and cost-effective compared to similar products in developed markets, making them appealing to multinational companies [36][40]. - The lower costs associated with drug development in China, estimated to be 20-30% of those in the U.S., further enhance the attractiveness of these assets [40]. - The increasing number of new drug approvals and ongoing research pipelines in China positions the country as a significant player in the global pharmaceutical landscape [36][38].

Core Viewpoint - The stock of Baiaosaitu-B (02315) surged over 10% following the announcement of a global licensing agreement for antibody molecules with BeiGene, indicating strong market confidence in the company's growth prospects and collaboration with established partners [1] Company Developments - Baiaosaitu has entered into a global licensing agreement with BeiGene, which includes an upfront payment and potential milestone payments based on development and commercialization, as well as royalties based on net sales [1] - The collaboration builds on an existing relationship where BeiGene had previously obtained a license for Baiaosaitu's RenMice fully human antibody platform, reflecting a deepening partnership [1] Financial Performance - Dongwu Securities reported that Baiaosaitu's operational performance in the first half of the year exceeded expectations, with significant growth in business development (BD) activities [1] - The company is expected to achieve over 40% growth in its antibody BD business and maintain over 40% growth in animal models, with preclinical CRO growth nearing 60%, leading to an overall revenue growth exceeding 40% [1]