Core Viewpoint - The Chinese innovative pharmaceutical industry is experiencing a significant transformation, marked by increased research breakthroughs, active business development (BD) transactions, and a shift in market perception, moving away from the "me too" label associated with Chinese drugs [1][5][10] Market Performance - The innovative pharmaceutical sector has seen a strong resurgence in the secondary market, with A-share and Hong Kong stock indices rising significantly; A-share innovative drug stocks increased by 34.27% and Hong Kong's innovative drug index surged over 70% from April 8 to June 16 [3] - The sector had previously undergone a four-year adjustment period, with the Hang Seng Innovative Drug Index hitting a historical low in July 2023, down over 70% from July 2021 [3] - The recovery is driven by active BD transactions and the commercialization of innovative drugs, with a notable shift in market sentiment towards the sector [3][4] Business Development Trends - Numerous Chinese innovative drug companies have announced significant BD projects in cutting-edge fields, with notable transactions including a $12.5 billion upfront payment from Pfizer to 3SBio for a PD-1/VEGF dual antibody [5] - The License-out model has become a primary funding source for unprofitable innovative drug companies, with Q1 2025 seeing a record 41 transactions totaling $369.29 billion, surpassing the total for the first half of 2024 [6] - The ability of Chinese companies to leverage their research platforms and enhance capital efficiency is reshaping the traditional high-risk, high-investment model of the industry [6] Commercialization and Profitability - The commercialization of innovative drugs is gaining momentum, with 20 new class 1 innovative drugs approved in the first five months of 2023, marking a five-year high [7] - Companies like BeiGene are expected to achieve positive operating profits by 2025, indicating a shift from the traditional "burning cash" phase to profitability [7][8] - The improved financial health of innovative drug companies enhances their negotiating power in BD transactions, allowing them to demand better terms [8] Competitive Landscape - The competition in the innovative drug sector is intensifying, with a focus on efficiency across the entire drug development chain, from target discovery to commercialization [9] - The majority of BD transactions are concentrated in the oncology sector, particularly in ADC and dual antibody technologies, leading to increased competition and market saturation [9] - Companies are encouraged to innovate and differentiate their products to avoid the pitfalls of homogeneity and to enhance their global competitiveness [9] Challenges Ahead - Despite the progress, the high failure rate in new drug development remains a significant challenge, particularly for early-stage research [10] - There is a growing expectation among investors for innovative drug companies to not only achieve profitability but also to provide stable dividends in the future [10]

Market Overview - On June 16, the Hang Seng Index rose by 0.70%, closing at 24,060.99 points, with a total net inflow of HKD 57.43 billion through the southbound trading channel [1][3] - The total trading volume for the southbound trading was HKD 1,278.17 billion, with a net buy of HKD 57.43 billion [1] Trading Activity - The Shanghai Stock Exchange's southbound trading had a total transaction amount of HKD 779.26 billion, with a net buy of HKD 26.68 billion, while the Shenzhen Stock Exchange had a transaction amount of HKD 498.91 billion and a net buy of HKD 30.75 billion [1] - In the top ten active stocks on the Shanghai Stock Exchange, Xiaomi Group-W had the highest transaction amount of HKD 43.93 billion, followed by Shandong Molong and Alibaba-W with transaction amounts of HKD 40.27 billion and HKD 29.26 billion, respectively [1] Stock Performance - In terms of net buy amounts, China Construction Bank led with a net buy of HKD 11.08 billion, closing with a price increase of 1.97% [1] - Xiaomi Group-W recorded the highest net sell amount of HKD 14.89 billion, while its closing price increased by 4.23% [1] - In the Shenzhen Stock Exchange's top active stocks, Xiaomi Group-W again led with a transaction amount of HKD 34.12 billion, followed by Pop Mart and Meituan-W with transaction amounts of HKD 15.52 billion and HKD 15.46 billion, respectively [2] - Meituan-W had the highest net buy amount of HKD 6.22 billion, closing with a price increase of 0.43%, while Xiaomi Group-W had a net sell of HKD 3.91 billion [2]

Core Insights - On June 16, 2025, Xiaomi Group-W (01810), Shandong Molong (00568), and Alibaba Group-W (09988) were the top three companies by trading volume in the Southbound Stock Connect, with trading amounts of 4.393 billion, 4.027 billion, and 2.926 billion respectively [1] - In the Southbound Stock Connect for the Shenzhen-Hong Kong Stock Connect, Xiaomi Group-W (01810), Pop Mart (09992), and Meituan-W (03690) led the trading volume, with amounts of 3.412 billion, 1.552 billion, and 1.546 billion respectively [1] Southbound Stock Connect (Shanghai-Hong Kong) - Top active companies by trading amount: - Xiaomi Group-W (01810): 4.393 billion, net buy of -1.489 billion - Shandong Molong (00568): 4.027 billion, net buy of 55.0174 million - Alibaba Group-W (09988): 2.926 billion, net buy of 311 million - Pop Mart (09992): 2.646 billion, net buy of 154 million - China Construction Bank (00939): 1.938 billion, net buy of 1.108 billion - Meituan-W (03690): 1.829 billion, net buy of 493 million - Tencent Holdings (00700): 1.802 billion, net buy of -322 million - ZhongAn Online (06060): 1.700 billion, net buy of 215 million - CNOOC (00883): 1.383 billion, net buy of -261 million - Yika (09923): 1.087 billion, net buy of -2.1563 million [2] Southbound Stock Connect (Shenzhen-Hong Kong) - Top active companies by trading amount: - Xiaomi Group-W (01810): 3.412 billion, net buy of -391 million - Pop Mart (09992): 1.552 billion, net buy of -83.2303 million - Meituan-W (03690): 1.546 billion, net buy of 622 million - Alibaba Group-W (09988): 1.457 billion, net buy of -284 million - Tencent Holdings (00700): 1.314 billion, net buy of -298 million - Shandong Molong (00568): 1.162 billion, net buy of 18.7368 million - Innovent Biologics (01801): 1.111 billion, net buy of -285 million - BeiGene (06160): 1.039 billion, net buy of -228 million - Kuaishou-W (01024): 987 million, net buy of -27.6221 million - CanSino Biologics (09926): 904 million, net buy of 20.6 million [2]

Core Insights - The 2025 European Hematology Association (EHA) annual meeting showcased nearly 60 clinical research results from four Chinese innovative drug companies, highlighting China's scientific strength in developing innovative therapies for hematological cancers [1] - The collective breakthroughs of these companies at international platforms like ASCO and EHA signify a strategic shift in China's innovative drug industry from "fast following" to "independent innovation" [1] - The EHA annual meeting is a significant academic event in the global hematology field, attracting over 10,000 professionals from more than 100 countries [1] Company Highlights - BeiGene presented four major oral reports at the EHA meeting, demonstrating key breakthroughs in its pipeline for hematological cancer treatments [1] - The next-generation BCL2 inhibitor, Sotorasib, combined with Baiyueze®, achieved total response rates of 96% and 79% for patients with relapsed/refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma, respectively [2] - The potential first-in-class BTK degrader BGB-16673 showed promising early data for treating CLL and Waldenström's macroglobulinemia [2] - Innovent Biologics had 25 studies presented as posters at the EHA meeting, focusing on new BTK inhibitors and BCL2 inhibitors for various lymphomas [2] Research Developments - The combination of Mesutoclax and Obinutuzumab for first-line treatment of CLL/SLL showed a total response rate of 97.6% in a cohort of 42 newly diagnosed patients, with a registration phase III clinical trial now underway [3] - Dizhizhi Pharmaceuticals showcased multiple research advancements covering T-cell and B-cell lymphomas, including the JAK1 inhibitor, Gyrizhe®, which demonstrated effective maintenance treatment in peripheral T-cell lymphoma [3] - Micu Biotech presented 19 new research results on its selective HDAC inhibitor, Sitarabin, across various hematological malignancies, indicating significant tumor response and broad application prospects [4]

Core Insights - The pharmaceutical-themed funds are dominating the performance rankings for the first half of the year, with nine out of the top ten funds being pharmaceutical-focused, led by Huatai-PineBridge Hong Kong Advantage Select A, which achieved a 103.67% return [1][2] - The strong performance of these funds is driven by multiple factors, including breakthroughs in innovative drug development, recovery of liquidity in the Hong Kong stock market, and restructuring of valuation systems through cross-border business development transactions [1][2] Fund Performance - The average return of the top ten actively managed equity funds exceeds 69%, with notable performances from Changcheng Pharmaceutical Industry Select A and Yongying Pharmaceutical Innovation Smart Select A, achieving returns of 87.73% and 79.79% respectively [2] - Huatai-PineBridge Hong Kong Advantage Select A is highlighted as a "doubling fund" for the year, marking a significant achievement in the market [2] Market Dynamics - The pharmaceutical sector is experiencing a "double hit" in profitability and valuation in 2025, with the Hang Seng Hong Kong Stock Connect Innovative Drug Index showing a year-to-date increase of 70.09% [3] - The performance of pharmaceutical funds is significantly influenced by their exposure to Hong Kong stocks, with the Hang Seng Healthcare Index rising by 54.59%, outperforming the A-share innovative drug index, which increased by 24.15% [3] Investment Strategy - Huatai-PineBridge Hong Kong Advantage Select A has benefited from investments in leading companies in the Hong Kong innovative drug and medical device sectors, capitalizing on improved overseas liquidity and favorable industry policies [4] - The introduction of financing channels for unprofitable biotech companies in Hong Kong has allowed competitive biotech firms to enter the market, with many now in advanced stages of research and commercialization [4] Future Outlook - The pharmaceutical industry is expected to maintain long-term investment value driven by demographic aging, consumption upgrades, and technological innovation, although caution is advised regarding potential overvaluation of certain stocks [6] - The current market for innovative drugs is characterized by high valuations and volatility, with expectations for a rebalancing between these factors in the near future [6][7] - The valuation of leading companies and key stocks is anticipated to be reassessed, with a focus on the long-term potential of authorized products and revenue realization from commercial partnerships [7]

创新药投资手册：从盈利到 BD 爆发，创新药如何投资？ 20250615 摘要 中国创新药行业正经历系统性估值提升，主要受益于 BD 出海的实现， MNC 开始为早期管线产品买单，重塑了估值体系，扭转了过去仅依赖国 内市场买单的局面。 中国创新药行业已达经营拐点，大型生物技术公司如百济神州已展示盈 利趋势，进入盈利窗口期，验证了创新药商业化模式的市场认可度。 MNC 面临专利悬崖，急需通过 BD 引进创新药以填补销售缺口，而中国 创新药研发在过去十年取得显著进展，为 BD 合作提供了高质量的替代 产品。 中国创新药 BD 活动集中在 ADC 和二代 IO 领域，中国企业在 ADC 领域 通过创新设计和改造提升产品有效性并降低毒性，如科伦博泰和应恩生 物处于全球领先地位。 康方生物的 Harmony Two 研究数据引发 MNC 对二代 IO 赛道的关注， 加速了相关布局，并促成了多项大型 BD 交易，如 BMS 与 Biotech 的合 作，总金额超过 90 亿美金。 Q&A 中国创新药行业未来的发展前景如何？ 中国创新药行业正处于经营层面的拐点，今年被认为是扭亏元年。随着更多 Biotech 公司进入盈利窗 ...

Investment Rating - The report maintains an "Accumulate" rating for the pharmaceutical and biotechnology sector [8] Core Insights - The report highlights that the pharmaceutical sector, particularly the innovative drug segment, is experiencing a significant bull market, with the innovation drug index outperforming other indices [2][13] - The report emphasizes the strong liquidity in the market, which has led to increased investment in innovative drugs, particularly those related to PD1 and weight loss drugs [2][15] - Future outlook remains optimistic for 2025, focusing on innovative drugs, new technologies, and restructuring of the supply chain [3][16] Summary by Sections 1. Pharmaceutical Core Insights - The pharmaceutical index increased by 1.40% during the week of June 9-13, outperforming both the ChiNext and CSI 300 indices [13] - The innovative drug index rose by 3.07%, indicating strong market performance [50] 2. MNC Cash and Potential Layouts - MNCs have substantial cash reserves, with major companies like Johnson & Johnson and Merck holding over $10 billion in cash, indicating strong purchasing power for potential business development (BD) opportunities [27][25] - The report analyzes MNC revenue sources, highlighting a focus on oncology, metabolism, and mental health, which are areas of high market potential [25][27] 3. Investment Strategies and Thoughts 3.1 Broad Pharmaceuticals - Innovative drugs are a key focus, with a recommendation to explore opportunities in core stocks and those with BD expectations [3][16] - The report identifies specific companies for investment, including major players in the innovative drug space and smaller market cap stocks with promising pipelines [17][18] 3.2 Generic Drugs - The generic drug sector showed a weekly increase of 5.24%, outperforming the broader pharmaceutical index [59] - Top-performing stocks in the generic sector include Yiming Pharmaceutical and Sai Sheng Pharmaceutical, indicating strong market activity [62] 4. Market Review and Hotspot Tracking - The report notes that innovative drugs are becoming the most attractive sector, with significant price increases observed in several companies due to market catalysts [2][15] - Key events, such as the NMPA's inclusion of a new treatment for cardiovascular disease, are highlighted as important developments in the sector [57]

Core Viewpoint - The A-share pharmaceutical sector, particularly the innovative drug segment, has shown strong performance, with R&D investment becoming a critical variable for company success in a competitive environment [1] Group 1: R&D Investment Overview - The total R&D expenditure of A-share pharmaceutical companies has steadily increased over the past three years, reaching 111.11 billion yuan in 2022, 118.50 billion yuan in 2023, and projected to be 121.01 billion yuan in 2024 [2][3] - The chemical pharmaceutical sector leads in R&D spending, with an expected 2024 expenditure close to 60 billion yuan, followed by the medical device sector at over 23 billion yuan and the biological products sector at 16.87 billion yuan [2][3] Group 2: R&D Intensity - The R&D intensity, measured as the ratio of R&D expenditure to revenue, ranks the biological products sector highest at 13.01%, followed by chemical pharmaceuticals at 10.87% and medical devices at 9.68% for 2024 [4][5] Group 3: Performance of Key Sectors - Despite overall pressure on performance, the chemical pharmaceutical sector has shown consistent growth, with net profits increasing from 21.68 billion yuan in 2022 to 34.44 billion yuan in 2024 [3][14] - The medical device sector has faced significant declines, with net profits dropping from 80.28 billion yuan in 2022 to 33.18 billion yuan in 2024, a nearly 59% decrease [3][14] Group 4: Leading Companies in R&D Investment - Among biological products companies, Changchun High-tech leads with an average R&D investment of 2.26 billion yuan over the past three years, showing a growth of over 60% from 1.66 billion yuan in 2022 to 2.69 billion yuan in 2024 [10][11] - In the chemical pharmaceutical sector, BeiGene has the highest average R&D investment at 12.70 billion yuan, with a significant reduction in losses from 13.64 billion yuan in 2022 to 4.98 billion yuan in 2024 [12][14] - In the medical device sector, Mindray Medical tops the list with an average R&D investment of 3.66 billion yuan, maintaining stable profit growth despite overall sector challenges [16][17]

A股千亿级研发投入行业系列三：医药生物行业连续三年研发投入超千亿元，化学制药研发费用居首业 绩亮眼，龙头百济神州股价最高涨超200%（附表） 每经资本眼记者根据同花顺iFinD数据统计发现，2022年至2024年，A股医药生物行业上市公司合计研 发费用稳步上升，分别为1111.09亿元、1185.02亿元和1210.07亿元。从细分二级行业来看，化学制药板 块的研发总费用目前仍然排在医药生物行业第一位，2024年接近600亿元。最近三年医药生物行业的业 绩增长整体承压，但研发投入最高的化学制药板块实现逆势增长。2022年至2024年，医药生物行业的营 业收入分别为2.47万亿元、2.49万亿元和2.47万亿元，净利润分别为1992.25亿元、1619.33亿元和1411亿 元。从细分二级行业来看，仅化学制药板块业绩的呈现持续增长态势，净利润由2022年的216.84亿元增 长到2024年的344.41亿元。 统计的158家A股化学制药上市公司中，入围最近三年平均研发投入总额TOP10的门槛接近10亿元。其 中，最近三年平均研发投入总额最高的为百济神州，达到127.02亿元。入围最近三年平均研发投入总额 TOP ...

2025年6月13日当天，山东墨龙（维权）(00568)、阿里巴巴-W(09988)、中国海洋石油(00883)位居沪港 通（南向）成交额前3位，成交额分别为75.70 亿元、60.17 亿元、41.42 亿元；小米集团-W(01810)、山 东墨龙(00568)、阿里巴巴-W(09988) 位居深港通（南向）成交额前3位，成交额分别为22.51 亿元、 21.76 亿元、19.46 亿元。 沪港通（南向）十大活跃成交公司 深港通（南向）十大活跃成交公司 | 公司名称 | 成交金额 | 净买入额 | | --- | --- | --- | | 小米集团-W(01810) | 22.51 亿元 | -3.78 亿元 | | 山东墨龙(00568) | 21.76 亿元 | +46.09 万元 | | 阿里巴巴-W(09988) | 19.46 亿元 | -2.69 亿元 | | 美团-W(03690) | 17.76 亿元 | +12.54 亿元 | | 腾讯控股(00700) | 16.34 亿元 | -8.78 亿元 | | 信达生物(01801) | 14.92 亿元 | -3.94 亿元 | | 泡泡玛 ...