Core Viewpoint - Zai Ding Pharmaceutical (09688) announced that its partner Amgen will stop the FORTITUDE-102 clinical trial due to insufficient efficacy based on interim analysis requested by the data monitoring committee [1] Group 1 - The FORTITUDE-102 trial was evaluating the combination of bemarituzumab with chemotherapy and nivolumab for first-line gastric cancer [1] - The announcement was made during Amgen's Q3 2025 earnings call on November 4, 2025 [1]

Core Viewpoint - The company Zai Lab (09688) announced that its partner Amgen will halt the FORTITUDE-102 clinical trial due to insufficient efficacy observed in a preliminary analysis mandated by the data monitoring committee [1] Group 1 - The FORTITUDE-102 trial was assessing the combination of bemarituzumab with chemotherapy and nivolumab for first-line gastric cancer treatment [1] - The announcement was made during Amgen's Q3 2025 earnings call scheduled for November 4, 2025 [1]

Zai Lab Limited 再鼎醫藥有限公司* 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不會對因本公告全部或任何部分內容而產生或因 倚賴該等內容而引致的任何損失承擔任何責任。 本公司將繼續與安進公司密切合作，並在適當時提供進一步的更新。 承董事會命 再鼎醫藥有限公司 董事、董事長兼首席執行官 杜瑩 （於開曼群島註冊成立的有限公司） （股份代號：9688） 內幕消息 關於安進公司貝瑪妥珠單抗 1b/3 期臨床研究 FORTITUDE-102 的更新 本公告乃由再鼎醫藥有限公司（「本公司」）根據香港聯合交易所有限公司證券上市 規則（「上市規則」）第 13.09(2)(a)條及香港法例第 571 章證券及期貨條例第 XIVA 部 項下內幕消息條文（定義見上市規則）而作出。 本公司的合作夥伴及該研究申辦方安進公司，於 2025 年 11 月 4 日在其 2025 年第三季 度財報發佈會期間宣佈，評估貝瑪妥珠單抗聯合化療及納武利尤單抗用於一線胃癌的 1b/3 期臨床研究 FORTITUDE-102，由於根據資料監查委員會的要求所做的 ...

Core Insights - Morgan Stanley increased its stake in Zai Lab (09688) by acquiring 611,105 shares at a price of HKD 20.5592 per share, totaling approximately HKD 12.5638 million [1] - Following this acquisition, Morgan Stanley's total shareholding in Zai Lab reached approximately 123 million shares, representing an ownership percentage of 11.00% [1]

Core Insights - Zai Lab Limited will participate in two investor conferences in November and December 2025, including the Jefferies Global Healthcare Conference and Citi's 2025 Global Healthcare Conference [1] Company Overview - Zai Lab Limited is a research-based, commercial-stage biopharmaceutical company operating in China and the United States, focusing on innovative products in oncology, immunology, neuroscience, and infectious diseases [2] Upcoming Events - The Jefferies Global Healthcare Conference will take place on November 19, 2025, at 8:30 AM GMT in London, and the Citi's 2025 Global Healthcare Conference will occur on December 2, 2025, at 1:00 PM ET in Miami, Florida [1] - Live webcasts of these events will be available on Zai Lab's Investor Relations page, with archived replays accessible for up to 90 days [1] Financial Reporting - Zai Lab is set to announce its third quarter 2025 financial results and recent corporate updates on November 6, 2025, before the U.S. equity markets open [6]

Core Viewpoint - The Hong Kong Innovative Drug ETF (159567) has shown significant growth in both share volume and fund size since its inception, indicating strong investor interest and market performance [1][2]. Group 1: Fund Performance - As of October 31, 2024, the Hong Kong Innovative Drug ETF (159567) closed with a gain of 5.46% and a trading volume of 3.327 billion yuan [1]. - The fund's share volume increased by 1968.65% from 3.95 million shares at the end of 2023 to 81.79 million shares by October 30, 2024 [1]. - The fund's size grew by 1650.00%, from 378 million yuan to 6.612 billion yuan during the same period [1]. Group 2: Liquidity - Over the last 20 trading days, the cumulative trading amount for the fund reached 23.202 billion yuan, with an average daily trading amount of 1.16 billion yuan [1]. - Year-to-date, the cumulative trading amount for the fund is 234.346 billion yuan, averaging 1.172 billion yuan per day over 200 trading days [1]. Group 3: Fund Management - The current fund manager, Ma Jun, has managed the Hong Kong Innovative Drug ETF (159567) since its inception, achieving a return of 64.72% during the management period [2]. - The fund's top holdings include companies such as BeiGene, CanSino Biologics, Innovent Biologics, and others, with significant percentages of the portfolio allocated to these stocks [2].

Core Viewpoint - UBS initiated coverage on Zai Lab (ZLAB.US) with a "Buy" rating and a target price of HKD 33.5 based on discounted cash flow (DCF) analysis, highlighting the company's growth potential and undervalued market position [1] Group 1: Company Performance - Zai Lab's stock rose over 2.8% pre-market, reaching USD 26.05 [1] - The core product VYVGART is expected to continue expanding its indications and increasing sales [1] Group 2: Product Pipeline - Several key candidate drugs are anticipated to receive approval, contributing to future growth [1] - The business development opportunities for ZL-1310 (DLL3ADC) and ZL-1503 (IL-13/IL-31R) are seen as significant growth drivers in the near term [1] Group 3: Market Perception - UBS believes the market has overlooked Zai Lab's short-term growth and business development potential [1]

Core Viewpoint - Despite significant business development (BD) agreements exceeding $10 billion, the stock prices of innovative pharmaceutical companies remain sluggish, indicating a disconnect between market expectations and actual performance [1][2]. Group 1: Market Performance - The Hong Kong Stock Connect innovative drug index has declined from over 1240 points on October 9 to 1110 points, reflecting a drop of approximately 10.5% [1][2]. - Notable companies like 信达生物 (Innovent Biologics) have seen their stock prices fall despite announcing major collaborations, with 信达生物's stock dropping 1.96% to 85.2 HKD per share on October 22 [2]. - Over the past month, the innovative drug sector has experienced a 16% decline from a peak of 1326 points on September 8, with several companies like 诺诚健华 (Nocera) and 康诺亚-B (CanSino) seeing stock drops exceeding 19% [2][4]. Group 2: Financial Performance - Many innovative drug companies have reported revenue growth, yet profitability remains a concern, with only four out of the listed companies achieving positive net profits [6][7]. - 康诺亚-B reported a staggering 812.1% year-on-year revenue increase, while other companies like 诺诚健华 and 信达生物 also showed significant revenue growth of over 40% [6][7]. Group 3: Industry Dynamics - The innovative drug sector is characterized by high competition and a high rate of project failure, with a significant percentage of BD agreements facing termination [8]. - The long-term outlook for the Chinese innovative drug industry remains positive, driven by an increase in BD transactions, although the market is becoming increasingly competitive [8][9]. - Analysts suggest that the recent stock price adjustments may be a result of previously overly optimistic expectations regarding BD agreements, and the market may be entering a phase of stabilization [10].

Group 1: Xiaomi Group (01810.HK) - Cathay Securities maintains a "Buy" rating for Xiaomi Group with a target price of HKD 65.7, expecting Q3 vehicle deliveries to approach 109,000 units, indicating operational profitability due to economies of scale [1] - The mobile phone business faces margin pressure due to rising storage costs, but the success of the Xiaomi 17 series in the high-end market is expected to offset some cost pressures [1] Group 2: Anta Sports (02020.HK) - CMB International maintains a "Buy" rating for Anta Sports but lowers the target price to HKD 110.9, citing intensified industry competition and a slowdown in recovery, leading management to revise the annual growth guidance to low single digits [2] - Despite short-term challenges, the long-term potential of the company's multi-brand strategy is still viewed positively [2] -招商证券 (Hong Kong) also maintains a "Buy" rating but reduces the target price to HKD 105.3, highlighting macro uncertainties and competition as factors affecting the brand's growth guidance [3] -浦银国际 lowers the target price to HKD 102.5, noting a cautious promotional strategy for the upcoming "Double Eleven" sales event, while maintaining a positive outlook on the multi-brand global strategy [9] Group 3: Fuyao Glass (06865.HK) - CMB International downgrades Fuyao Glass from "Buy" to "Neutral," citing a significant increase in sales driven by client stockpiling and cost reductions, but anticipates a decline in prices due to rapid inventory rebounds and excess capacity [4] Group 4: Dongyue Group (00189.HK) - Cathay Securities maintains a "Buy" rating for Dongyue Group with a target price of HKD 15.29, projecting a more than 209% year-on-year growth in the refrigerant segment in H1 2025, driven by rising product prices and quota restrictions [5] Group 5: Hengan International (01044.HK) - Cathay Securities maintains a "Buy" rating for Hengan International with a target price of HKD 45.2, noting rapid revenue growth in high-margin products like wet wipes and the potential for profit elasticity due to falling pulp prices [6] Group 6: Global New Material International (06616.HK) - Cathay Securities maintains a "Buy" rating for Global New Material International with a target price of HKD 5.27, highlighting the increase in control over overseas core assets and the expansion of production capacity [7] Group 7: Ping An Good Doctor (01833.HK) -浦银国际 maintains a "Hold" rating for Ping An Good Doctor with a target price of HKD 14.0, reporting a 14% year-on-year revenue growth and a 73% increase in net profit for the first three quarters of 2025 [10] Group 8: Zai Lab (09688.HK) -浦银国际 maintains a "Buy" rating for Zai Lab, noting the promising results of ZL-1310 in small cell lung cancer patients, with a 50% objective response rate and a potential to become an important therapy in the field [11]

Group 1: Market Performance - The Hong Kong Innovative Drug Selected ETF (520690) increased by 0.22%, with the latest price at 0.89 yuan as of October 29, 2025 [3] - The ETF recorded a turnover of 4.25% during the trading session, with a total transaction value of 21.78 million yuan [3] - Over the past year, the average daily transaction volume of the ETF was 120 million yuan [3] Group 2: Clinical Data and Industry Insights - Grail presented initial data from its multi-cancer early detection product Galleri at the 2025 ESMO annual meeting, showing a positive predictive value of 61.6% and a specificity of 99.6% [3] - Among the detected new cancers, 69.3% were in stages I-III, with a tissue origin accuracy of 91.7% [3] - Guosen Securities views this data as a significant milestone in the multi-cancer early detection field, suggesting Galleri could enhance existing screening systems [3] Group 3: Company Earnings and Trends - Over 280 pharmaceutical and biotech companies, including Heng Rui Pharmaceutical and WuXi AppTec, reported strong Q3 results, driven by advancements in R&D pipelines and new drug launches [3] - The overall industry is exhibiting a positive trend characterized by "innovation as a foundation and overseas expansion" [3] Group 4: CDMO Sector Performance - Lonza, a leading overseas CDMO, reported strong Q3 results, maintaining a revenue growth forecast of 20-21% for the year, with core EBITDA margins between 30-31% [4] - Medpace has seen consecutive growth in new orders for two quarters, indicating a recovering financing environment for U.S. small and mid-sized biotech firms [4] - WuXi AppTec exceeded Q3 performance expectations and raised its full-year guidance, further confirming the positive outlook for the CXO industry [4] Group 5: ETF Size and Inflows - The latest size of the Hong Kong Innovative Drug Selected ETF reached 512 million yuan, marking a new high since its inception [4] - The ETF's share count also hit a record high of 574 million shares [4] - In the past five days, the ETF experienced continuous net inflows, with a peak single-day net inflow of 31.48 million yuan, totaling 82.81 million yuan in net inflows [4]