Core Viewpoint - UBS initiated coverage on Zai Lab (ZLAB.US) with a "Buy" rating and a target price of HKD 33.5 based on discounted cash flow (DCF) analysis, highlighting the company's growth potential and undervalued market position [1] Group 1: Company Performance - Zai Lab's stock rose over 2.8% pre-market, reaching USD 26.05 [1] - The core product VYVGART is expected to continue expanding its indications and increasing sales [1] Group 2: Product Pipeline - Several key candidate drugs are anticipated to receive approval, contributing to future growth [1] - The business development opportunities for ZL-1310 (DLL3ADC) and ZL-1503 (IL-13/IL-31R) are seen as significant growth drivers in the near term [1] Group 3: Market Perception - UBS believes the market has overlooked Zai Lab's short-term growth and business development potential [1]

Core Viewpoint - Despite significant business development (BD) agreements exceeding $10 billion, the stock prices of innovative pharmaceutical companies remain sluggish, indicating a disconnect between market expectations and actual performance [1][2]. Group 1: Market Performance - The Hong Kong Stock Connect innovative drug index has declined from over 1240 points on October 9 to 1110 points, reflecting a drop of approximately 10.5% [1][2]. - Notable companies like 信达生物 (Innovent Biologics) have seen their stock prices fall despite announcing major collaborations, with 信达生物's stock dropping 1.96% to 85.2 HKD per share on October 22 [2]. - Over the past month, the innovative drug sector has experienced a 16% decline from a peak of 1326 points on September 8, with several companies like 诺诚健华 (Nocera) and 康诺亚-B (CanSino) seeing stock drops exceeding 19% [2][4]. Group 2: Financial Performance - Many innovative drug companies have reported revenue growth, yet profitability remains a concern, with only four out of the listed companies achieving positive net profits [6][7]. - 康诺亚-B reported a staggering 812.1% year-on-year revenue increase, while other companies like 诺诚健华 and 信达生物 also showed significant revenue growth of over 40% [6][7]. Group 3: Industry Dynamics - The innovative drug sector is characterized by high competition and a high rate of project failure, with a significant percentage of BD agreements facing termination [8]. - The long-term outlook for the Chinese innovative drug industry remains positive, driven by an increase in BD transactions, although the market is becoming increasingly competitive [8][9]. - Analysts suggest that the recent stock price adjustments may be a result of previously overly optimistic expectations regarding BD agreements, and the market may be entering a phase of stabilization [10].

Group 1: Xiaomi Group (01810.HK) - Cathay Securities maintains a "Buy" rating for Xiaomi Group with a target price of HKD 65.7, expecting Q3 vehicle deliveries to approach 109,000 units, indicating operational profitability due to economies of scale [1] - The mobile phone business faces margin pressure due to rising storage costs, but the success of the Xiaomi 17 series in the high-end market is expected to offset some cost pressures [1] Group 2: Anta Sports (02020.HK) - CMB International maintains a "Buy" rating for Anta Sports but lowers the target price to HKD 110.9, citing intensified industry competition and a slowdown in recovery, leading management to revise the annual growth guidance to low single digits [2] - Despite short-term challenges, the long-term potential of the company's multi-brand strategy is still viewed positively [2] -招商证券 (Hong Kong) also maintains a "Buy" rating but reduces the target price to HKD 105.3, highlighting macro uncertainties and competition as factors affecting the brand's growth guidance [3] -浦银国际 lowers the target price to HKD 102.5, noting a cautious promotional strategy for the upcoming "Double Eleven" sales event, while maintaining a positive outlook on the multi-brand global strategy [9] Group 3: Fuyao Glass (06865.HK) - CMB International downgrades Fuyao Glass from "Buy" to "Neutral," citing a significant increase in sales driven by client stockpiling and cost reductions, but anticipates a decline in prices due to rapid inventory rebounds and excess capacity [4] Group 4: Dongyue Group (00189.HK) - Cathay Securities maintains a "Buy" rating for Dongyue Group with a target price of HKD 15.29, projecting a more than 209% year-on-year growth in the refrigerant segment in H1 2025, driven by rising product prices and quota restrictions [5] Group 5: Hengan International (01044.HK) - Cathay Securities maintains a "Buy" rating for Hengan International with a target price of HKD 45.2, noting rapid revenue growth in high-margin products like wet wipes and the potential for profit elasticity due to falling pulp prices [6] Group 6: Global New Material International (06616.HK) - Cathay Securities maintains a "Buy" rating for Global New Material International with a target price of HKD 5.27, highlighting the increase in control over overseas core assets and the expansion of production capacity [7] Group 7: Ping An Good Doctor (01833.HK) -浦银国际 maintains a "Hold" rating for Ping An Good Doctor with a target price of HKD 14.0, reporting a 14% year-on-year revenue growth and a 73% increase in net profit for the first three quarters of 2025 [10] Group 8: Zai Lab (09688.HK) -浦银国际 maintains a "Buy" rating for Zai Lab, noting the promising results of ZL-1310 in small cell lung cancer patients, with a 50% objective response rate and a potential to become an important therapy in the field [11]

Group 1: Market Performance - The Hong Kong Innovative Drug Selected ETF (520690) increased by 0.22%, with the latest price at 0.89 yuan as of October 29, 2025 [3] - The ETF recorded a turnover of 4.25% during the trading session, with a total transaction value of 21.78 million yuan [3] - Over the past year, the average daily transaction volume of the ETF was 120 million yuan [3] Group 2: Clinical Data and Industry Insights - Grail presented initial data from its multi-cancer early detection product Galleri at the 2025 ESMO annual meeting, showing a positive predictive value of 61.6% and a specificity of 99.6% [3] - Among the detected new cancers, 69.3% were in stages I-III, with a tissue origin accuracy of 91.7% [3] - Guosen Securities views this data as a significant milestone in the multi-cancer early detection field, suggesting Galleri could enhance existing screening systems [3] Group 3: Company Earnings and Trends - Over 280 pharmaceutical and biotech companies, including Heng Rui Pharmaceutical and WuXi AppTec, reported strong Q3 results, driven by advancements in R&D pipelines and new drug launches [3] - The overall industry is exhibiting a positive trend characterized by "innovation as a foundation and overseas expansion" [3] Group 4: CDMO Sector Performance - Lonza, a leading overseas CDMO, reported strong Q3 results, maintaining a revenue growth forecast of 20-21% for the year, with core EBITDA margins between 30-31% [4] - Medpace has seen consecutive growth in new orders for two quarters, indicating a recovering financing environment for U.S. small and mid-sized biotech firms [4] - WuXi AppTec exceeded Q3 performance expectations and raised its full-year guidance, further confirming the positive outlook for the CXO industry [4] Group 5: ETF Size and Inflows - The latest size of the Hong Kong Innovative Drug Selected ETF reached 512 million yuan, marking a new high since its inception [4] - The ETF's share count also hit a record high of 574 million shares [4] - In the past five days, the ETF experienced continuous net inflows, with a peak single-day net inflow of 31.48 million yuan, totaling 82.81 million yuan in net inflows [4]

Core Insights - The Hong Kong Innovative Drug ETF (159567) closed down 1.32% with a trading volume of 588 million yuan on October 28, 2024 [1] - The fund was established on January 3, 2024, with an annual management fee of 0.50% and a custody fee of 0.10% [1] - As of October 27, 2024, the fund's latest share count was 8.177 billion shares, with a total size of 6.823 billion yuan, reflecting a significant increase in both share count and size compared to the previous year [1] Fund Performance - The fund's share count increased by 1968.15% and its size increased by 1706.06% from December 31, 2023, when it had 395 million shares and a size of 378 million yuan [1] - The fund has recorded a total trading amount of 22.001 billion yuan over the last 20 trading days, averaging 1.1 billion yuan per day [1] - Year-to-date, the cumulative trading amount is 229.668 billion yuan, with an average daily trading amount of 1.166 billion yuan [1] Fund Management - The current fund manager is Ma Jun, who has managed the fund since its inception, achieving a return of 66.90% during the management period [2] - The top holdings of the fund include companies such as BeiGene, CanSino Biologics, Innovent Biologics, and others, with significant percentages of the portfolio allocated to these stocks [2] - The largest holding is BeiGene, accounting for 10.62% of the portfolio, followed by CanSino Biologics at 10.55% and Innovent Biologics at 10.21% [2]

Core Viewpoint - UBS initiates coverage on Zai Lab with a "Buy" rating and a target price of HKD 33.5, highlighting the company's growth potential in the biopharmaceutical sector [1] Company Overview - Zai Lab has developed into a biopharmaceutical company with eight commercialized products, covering areas such as oncology, immunology, neuroscience, and infectious diseases [1] Product Pipeline - UBS expects the core product VYVGART to continue expanding its indications and increasing sales [1] - Several key candidate drugs are anticipated to receive approval, contributing to future growth [1] - The business development opportunities for ZL-1310 (DLL3ADC) and ZL-1503 (IL-13/IL-31R) are viewed as recent growth drivers [1]

Core Viewpoint - UBS reports that Zai Lab has evolved from a licensing-based business model into a mature biopharmaceutical company with eight commercialized products and a rich product pipeline in oncology, immunology, neuroscience, and infectious diseases [1] Group 1: Company Development - Zai Lab's core product VYVGART is expected to continue expanding its indications and increasing sales [1] - Several key candidate drugs are anticipated to receive approval, contributing to the company's growth [1] Group 2: Business Development Opportunities - The business development opportunities for ZL-1310 (DLL3ADC) and ZL-1503 (IL-13/IL-31R) are seen as key drivers for near-term growth [1] Group 3: Investment Rating - UBS initiates coverage on Zai Lab with a "Buy" rating, setting a target price of HKD 33.5 based on discounted cash flow (DCF) analysis, implying 1x and 1.6x peak sales on an unadjusted and adjusted basis respectively [1] - The market appears to overlook Zai Lab's short-term growth potential, including VYVGART and new product launches, as well as the business development potential of DLL3ADC and ZL-1503 [1]

Core Viewpoint - UBS has initiated coverage on Zai Lab (09688) with a target price of HKD 33.5, indicating a 1x and 1.6x multiple on peak sales, highlighting the market's oversight of the company's short-term growth potential, including VYVGART and new product launches [1] Group 1: Product Potential - UBS believes VYVGART, a first-in-class FcRn drug, has the potential to become a blockbuster in immunology, with peak sales in China projected to reach USD 1.8 billion [2] - Potential blockbuster candidates in the pipeline include Bemarituzumab for gastric cancer, Povetacicept for autoimmune diseases, VRDN-003 for thyroid eye disease, and KarXT for schizophrenia [2] Group 2: Financial Outlook - UBS anticipates that Zai Lab will achieve profitability through revenue growth and operational efficiency improvements, with guidance for non-GAAP operational breakeven by Q4 2025 and for the full year of 2026 [2] - The company expects improved gross margins due to local manufacturing, reduced selling costs from VYVGART's capacity expansion, and potential global product launches [2] - Zai Lab plans to limit R&D spending growth by prioritizing high-value projects, while maintaining moderate growth in sales, general, and administrative expenses [2]

Group 1 - UBS sets a target price of HKD 33.5 for Zai Lab (09688) based on discounted cash flow (DCF) analysis, indicating 1x and 1.6x unadjusted/adjusted peak sales multiples [1] - UBS believes the market is overlooking Zai Lab's short-term growth potential, including the launch of VYVGART and new products, as well as the business development potential of DLL3ADC and ZL-1503 [1] - UBS expects VYVGART to continue expanding its indications and increasing sales, with several key candidate drugs anticipated to receive approval [1] Group 2 - UBS identifies VYVGART as a first-in-class FcRn drug with the potential to become a blockbuster in immunology, predicting peak sales in China to reach USD 1.8 billion [2] - Potential blockbuster candidates include Bemarituzumab for gastric cancer, Povetacicept for autoimmune diseases, VRDN-003 for thyroid eye disease, and KarXT for schizophrenia [2] - Zai Lab is expected to achieve profitability through revenue growth and operational efficiency improvements, with guidance for non-GAAP operational breakeven by Q4 2025 and for the full year 2026 [2] Group 3 - UBS believes that local manufacturing and reduced selling costs due to VYVGART's capacity expansion will improve overall gross margins [2] - The company plans to limit R&D spending growth by prioritizing high-value projects, while sales, general, and administrative expenses are expected to grow moderately [2]

Summary of the Conference Call for ReLi Pharma Company Overview - **Company**: ReLi Pharma - **Focus**: Oncology and Immunology Key Points and Arguments 1. Clinical Data on Soli - In the FURTHER study, Soli demonstrated good safety with only 13% of patients experiencing grade 3 or higher adverse events, significantly lower than other studies reporting 35% to 50% [2][9] - The overall response rate was 60%, with a response rate of 80% in patients with brain metastases who had not received prior radiotherapy [2][9] - The median duration of response was 6.1 months, indicating potential as a treatment for relapsed small cell lung cancer (SCLC) [2][3][9] 2. Development Plans for Soli - ReLi Pharma plans to initiate a registration trial for Soli targeting investigator-selected treatment regimens, with interim data expected in early 2027 [2][10] - The company is also advancing the 19th flight study to explore earlier treatment lines, including combinations with anti-PD-L1 and chemotherapy [2][10] 3. Pipeline Progress - The global innovation pipeline includes Soli for second-line lung cancer treatment and a new generation therapeutic antibody L15O3 for atopic dermatitis, expected to complete Phase I trials by 2026 [4][5] - Other oncology compounds like DL62, O1, RLRC15, and ADC are anticipated to enter clinical trials in 2026 [5] 4. Challenges in Small Cell Lung Cancer - SCLC accounts for about 15% of all lung cancer cases, with over 370,000 new cases globally each year [6] - Approximately 2/3 of patients are diagnosed at an advanced stage, with a median survival time of about 1 year and a high incidence of brain metastases [6] 5. Ideal Target for SCLC - Triangular ligand 3 is expressed in over 85% of SCLC cases and is considered an ideal target due to its low expression in healthy tissues [7][8] 6. Future Regulatory Strategy - ReLi Pharma expects to submit an accelerated approval application for Soli in 2027, with potential approval by late 2027 or early 2028 [11][17] 7. Importance of Efficacy Duration - In single-arm trials, duration of efficacy is deemed more important than progression-free survival (PFS) as it reflects the time patients benefit from the drug [13] 8. Competitive Landscape - ReLi Pharma's registration strategy positions it 1.5 to 2 years ahead of competitors, which is crucial for maintaining a competitive advantage in the market [17] 9. Brain Metastases Treatment - The ability of Soli to penetrate the blood-brain barrier and effectively treat brain metastases is highlighted as a significant advantage, especially for patients with limited treatment options [18] 10. Future Research Directions - ReLi Pharma is exploring combinations with other therapies, including immunotherapy, to enhance treatment efficacy for SCLC and neuroendocrine cancers [19][20] Additional Important Information - The company emphasizes the need for new therapies to improve outcomes in SCLC due to the severe side effects of existing treatments and the urgent demand for effective solutions [6][10]