Group 1 - The Hong Kong biotechnology sector experienced a rise on August 5, with notable increases in stock prices for several companies [1] - Gilead Sciences (歌礼制药) saw a surge of over 15% in its stock price [1] - Ascentage Pharma (亚盛医药) increased by more than 9% [1] - Other companies such as Jiahe Biopharma (嘉和生物) and Innovent Biologics (复宏汉霖) rose by over 8% [1] - CanSino Biologics (康希诺生物) and Zai Lab (再鼎医药) experienced increases of over 5% [1]

| | | | 中流国际 (00981.HK) 再鼎医药 (09688.HK) 华虹半导体 | | | --- | --- | --- | --- | --- | | | | 经济数据 | (01347.HK) | | | · 22:00 | · 08:30 | · 04:30 | 中国7月出口年 | 中国7月M2货币 | | 美国6月工厂订 | 中国香港7月标 | 美国至8月1日当 | 駅 | 供应年率 | | 单月率 | 普全球制造业 | 周API原油屋存 | 中国7月进口年 | 中国7月M1货币 | | | PMI | (万桶) | 院 | 供应年率 | | | · 09:45 | · 22:00 | 中国7月贸易帐 | 中国7月M0货币 | | | 中国7月标普全 | 美国7月全球供 | (亿元) | 供应年率 | | | 球服务业PMI | 应链压力指数 | · 00:00 | 中国7月今年迄 | | | · 20:30 | · 22:30 | 中国7月以美元 | 今新增人民币贷 | | | 美国6月贸易帐 | 美国至8月1日当 | 计算贸易帐(亿 | 款(亿元) | | | (亿美元) | 周EI ...

Investment Rating - The report maintains a positive outlook on the pharmaceutical and biotechnology industry, emphasizing the transition from "Made in China" to "Created in China" for innovative drugs [10]. Core Insights - The report highlights that domestic innovative drugs are gaining global competitiveness and are currently in the first and second stages of international expansion, primarily through licensing agreements and partnerships [10][12]. - The report identifies key areas of focus for investment, including PD-(L)1 plus, ADCs, and GLP-1 drugs, which are expected to drive future growth and business development (BD) opportunities [10][51]. Summary by Sections Section 1: Transition from "Manufacturing" to "Innovation" - The policy reforms initiated in 2015 have stimulated a shift from generic to innovative drug development in China, with significant increases in R&D investment since 2018 [19][21]. - The number of First-in-Class (FIC) drugs developed in China has risen from 9 in 2015 to 120 in 2024, indicating a substantial increase in innovation [25][26]. Section 2: Continued BD Opportunities - PD-(L)1 plus is identified as a cornerstone for next-generation cancer treatments, with significant demand and potential for new products [51]. - The report notes that ADCs are transitioning towards more differentiated targets, focusing on unmet clinical needs, with promising candidates like PD-L1, DLL3, and EGFR [51]. - The GLP-1 market is experiencing rapid growth, with a focus on multi-target, oral, combination, and long-acting formulations [51]. Section 3: Investment Recommendations - For PD-(L)1 plus, companies such as Kangfang Biotech, Shansheng Pharmaceutical, and Junshi Biosciences are recommended for investment due to their strong pipelines [5]. - In the ADC space, companies like Fuhong Hanlin and Zai Lab are highlighted for their potential in addressing unmet clinical needs [5]. - In the GLP-1 sector, firms such as Borui Pharmaceutical and Zai Lab are noted for their promising developments [5].

Core Insights - The four key themes in China's innovative pharmaceutical industry this year are blockbuster drugs, IPOs, financing, and international expansion [2] - The industry is experiencing a turning point after years of capital challenges and market fluctuations, leading to a self-driven push for breakthroughs [2] Industry Overview - In Shanghai, the three leading industries reached a scale of 1.8 trillion yuan last year, with the biopharmaceutical sector exceeding 980 billion yuan [2] - This year, the biopharmaceutical industry in Shanghai is expected to surpass 1 trillion yuan, indicating a significant growth trajectory [2] Company Spotlight - Zai Lab, founded in 2014, represents a second entrepreneurial venture for its founding team, who previously established Hutchison China MediTech in Shanghai [2] - The name "Zai" signifies the ambition of "reaching new heights" in their business endeavors [2] - The company has achieved dual listings on the Hong Kong and US stock markets, with a total market capitalization of approximately 30 billion yuan [2]

节目第二集，将走进2014年成立的再鼎医药。它的创始团队此前在上海成功创办了和黄医药，这是他们 在上海的二度创业，再鼎寓意着"再度问鼎"的事业期许。这让人不禁感慨，创业者在上海能够那么如鱼 得水，这座城市生产创新药企的速度又是那么高效。目前，公司已实现港股和美股两地上市，总市值约 300亿元。它在今年能不能站上新的发展拐点，第一财经记者将与之深度对话。 爆款、上市、融资、出海，这是今年中国创新药产业的四大关键词。这些动作绝非一朝一夕的博弈，而 是历经过去数年的资本"寒潮"、行业波动和周期冷暖后，自我倒逼、奋力突围、穿越周期的结果。 把镜头拉回上海。去年上海三大先导产业规模达1.8万亿元，其中生物医药产业规模超9800亿元。今 年，这一数字有望突破万亿大关。行业迎来拐点，企业何尝不是。"上海药圈新拐点"系列报道，将独家 专访三家扎根上海的上市药企掌舵人，共同讲述当全球创新药行业进入"中国时间"，作为上海打造生物 医药产业高地的侧影，他们如何腾挪和突破，迎接属于自己的新拐点。 ...

港股生物医药板块午后走弱，荣昌生物(09995.HK)跌超7%，君实生物(01877.HK)跌超6%，再鼎医药 (09688.HK)、复宏汉霖(02696.HK)等跟跌。 ...

Summary of Key Points Core Viewpoint - The report highlights the top short-selling stocks in the market, indicating significant short-selling activity and potential investor sentiment towards these companies. Group 1: Top Short-Selling Ratios - JD Health (86618) has the highest short-selling ratio at 100.00% [1][2] - Hang Seng Bank (80011) follows with a short-selling ratio of 88.44% [1][2] - SenseTime (80020) has a short-selling ratio of 76.25% [1][2] Group 2: Top Short-Selling Amounts - Xiaomi Group (01810) leads in short-selling amount with 2.209 billion [1][2] - Tencent Holdings (00700) has a short-selling amount of 0.955 billion [1][2] - WuXi AppTec (02359) reports a short-selling amount of 0.698 billion [1][2] Group 3: Top Short-Selling Deviations - Hang Seng Bank (80011) has the highest deviation value at 48.82% [1][2] - JD Health (86618) follows with a deviation value of 45.78% [1][2] - Uni-President China (00220) has a deviation value of 33.70% [1][2]

资料显示，再鼎医药有限公司是一家以患者为中心的、处于商业化阶段的创新型全球生物制药公司,立 足中国、全球运营,致力于为中国及全球的患者提供针对肿瘤、自身免疫性疾病、感染性疾病和中枢神 经系统疾病的同类最优和同类首创药物。公司的使命是成为全球领先的生物制药公司,为中国和世界各 地的患者提供变革性创新药物。再鼎医药的长期目标是成为全球领先的生物制药公司,以中国为基,为全 球患者提供创新疗法。 本文源自：金融界 大事提醒： 8月7日，再鼎医药将于(美东)盘前披露2025财年中报（数据来源于纳斯达克官网，预计披露日期为美国 当地时间，实际披露日期以公司公告为准）。 7月29日，再鼎医药(ZLAB)开盘上涨5.84%，截至21:30，报40.95美元/股，成交212.97万美元，总市值 45.49亿美元。 财务数据显示，截至2025年03月31日，再鼎医药收入总额1.06亿美元，同比增长22.19%；归母净利 润-4843.8万美元，同比增长9.41%。 作者：行情君 ...

智通财经7月28日电，中概股美股盘前多数走高，小马智行、再鼎医药、文远知行涨超4%，阿里巴巴涨 超2%。 ...

Core Insights - The report maintains a positive outlook on small molecule drug conjugates (SMDCs) and related companies, highlighting their potential in cancer treatment due to their ability to enhance efficacy while reducing toxicity [1][5][17] - The report emphasizes the clinical advantages of SMDCs, including better tumor penetration, reduced toxicity to normal cells, and easier control over synthesis and costs compared to antibody-drug conjugates (ADCs) [5][11][12] - The report identifies domestic biopharmaceutical companies, particularly Affinivax, as leaders in the SMDC space, showcasing significant advancements in innovative cancer drug development [5][12][17] Industry Overview - The pharmaceutical and biotechnology sector has shown a relative price-to-earnings (P/E) ratio of 51.14 as of July 25, 2025, which is significantly higher than its historical low of 24.38, indicating a premium valuation compared to the broader market [19] - The report notes that the healthcare sector's valuation is 279% higher than the Shanghai Composite Index, reflecting strong investor interest and confidence in the industry [19] - Recent market performance indicates a 1.90% increase in the pharmaceutical and biotechnology sector from July 21 to July 25, 2025, ranking it 16th among 27 sub-industries [26][29] Company Focus - The report suggests monitoring companies involved in the SMDC space, including Affinivax, and those collaborating with them, such as Innovent Biologics and others, which are expected to benefit from the growing interest in innovative cancer therapies [5][17][18] - Specific companies highlighted for their innovative drug development capabilities include Innovent Biologics, Shunyi Pharmaceutical, and others, which are positioned to capitalize on the advancements in SMDC technology [5][18]