Core Viewpoint - Nocare Biopharma's stock has experienced fluctuations, with a year-to-date increase of 92.83% but a recent decline of 6.55% over the past five trading days [1] Company Overview - Nocare Biopharma, established on November 3, 2015, and listed on September 21, 2022, is based in Beijing and focuses on the research, production, and commercialization of biopharmaceuticals, particularly in oncology and autoimmune diseases [1] - The company's revenue composition includes 87.67% from drug sales, 12.04% from technology licensing, and 0.15% each from testing and research services [1] Financial Performance - For the period from January to September 2025, Nocare Biopharma reported revenue of 1.115 billion yuan, reflecting a year-on-year growth of 59.85%, while the net profit attributable to shareholders was -64.41 million yuan, an increase of 76.61% year-on-year [2] Shareholder Information - As of September 30, 2025, the number of shareholders increased by 8.66% to 16,500, with an average of 0 circulating shares per person [2] - The top ten circulating shareholders include several new entrants, such as Wanjiayou Xuan and Ping An Healthcare, while some previous shareholders have exited the list [3]

Core Viewpoint - Nocera Biopharma's stock has experienced fluctuations, with a year-to-date increase of 95.03% but a recent decline of 4.77% over the past five trading days [1] Company Overview - Nocera Biopharma, established on November 3, 2015, and listed on September 21, 2022, is based in Beijing and focuses on the research, production, and commercialization of biopharmaceuticals, particularly in oncology and autoimmune diseases [1] - The company's revenue composition includes 87.67% from drug sales, 12.04% from technology licensing, and 0.15% each from testing and research services [1] Financial Performance - For the period from January to September 2025, Nocera Biopharma reported a revenue of 1.115 billion yuan, reflecting a year-on-year growth of 59.85%, while the net profit attributable to shareholders was -64.41 million yuan, an increase of 76.61% compared to the previous period [2] Shareholder Information - As of September 30, 2025, the number of shareholders increased by 8.66% to 16,500, with an average of 0 circulating shares per shareholder [2] - The top ten circulating shareholders include several new entrants, such as Wan Jia You Xuan and Ping An Medical Health, while some previous shareholders have reduced their holdings [3]

Core Insights - The company reported a 60% year-on-year revenue growth for the first three quarters of 2025, reaching 1.12 billion yuan, with a net loss of 64 million yuan, narrowing by 77% compared to the previous year [1] - The core product, Oubatinib, saw a 46% increase in sales to 1.01 billion yuan in the first three quarters, with third-quarter sales reaching 373 million yuan, reflecting a 35% year-on-year growth and a 14% quarter-on-quarter growth [1][2] - Research and development expenses for the first three quarters amounted to 676 million yuan, a 10% increase year-on-year, while sales expenses rose by 41% to 386 million yuan, with a sales expense ratio decreasing by 4.7 percentage points to 35% [1] Product Performance - Oubatinib's sales accelerated due to the approval for 1L CLL/SLL indications and increased contributions from MZL, leading to an upward revision of the 2025 sales target from over 35% to over 40% [2] - The company has initiated commercialization of Tanshizhuo monoclonal antibody for r/r DLBCL, approved in May 2025, and is conducting two registration studies for mesutoclax [2] Pipeline Development - The company plans to submit a new drug application for ITP indications for Oubatinib in the first half of 2026 and expects to read out IIb phase data for SLE by the end of 2025 [3] - The early-stage pipeline includes various technology platforms, with plans to submit 5-7 IND applications targeting malignancies and autoimmune diseases by 2026 [3] Financial Outlook - The earnings forecast for 2025 has been revised from a loss of 0.19 yuan per share to a profit of 0.09 yuan, with similar upward adjustments for 2026 and 2027 [4] - The target price has been increased from 11.8 HKD to 19.0 HKD, indicating a potential upside of 25% [4]

瑞银发表研究报告指，诺诚健华第三季业绩大致符合预期，收入按年增长38%至3.84亿元，与市场及该 行预测的3.83亿及3.87亿元相若。期内净亏损达3400万元，略逊于市场预期的蚀2700万元。核心产品奥 布替尼第三季销售额按年增约34%至3.69亿元，增长维持强劲，公司维持2025年奥布替尼销售按年增长 35%以上的指引，意味第四季销售将达到约3.41亿元。瑞银指，随着与Zenas合作的首付款入账，诺诚健 华预计今年可实现盈亏平衡，计及与Zenas合作的首付款影响，将今年每股盈利预测上调至0.05元，明 年每股盈利预测下调93%至0.06元，目标价由25.8港元下调至23.6港元，维持"买入"评级。 ...

Core Viewpoint - UBS's research report indicates that Innovent Biologics' Q3 performance largely met expectations, with a year-on-year revenue growth of 38% to 384 million yuan, aligning closely with market and UBS forecasts of 383 million and 387 million yuan respectively [1] Financial Performance - The net loss for the period reached 34 million yuan, slightly worse than the market expectation of a loss of 27 million yuan [1] - Core product, Obinutuzumab, saw Q3 sales increase approximately 34% year-on-year to 369 million yuan, maintaining strong growth [1] - The company maintains its guidance for Obinutuzumab sales to grow over 35% year-on-year by 2025, implying Q4 sales will reach around 341 million yuan [1] Earnings Forecast - With the recognition of the upfront payment from the collaboration with Zenas, Innovent Biologics expects to achieve breakeven this year [1] - The earnings per share forecast for this year has been raised to 0.05 yuan, while the forecast for next year has been reduced by 93% to 0.06 yuan [1] - The target price has been adjusted down from 25.8 HKD to 23.6 HKD, while maintaining a "Buy" rating [1]

Core Insights - The company, Innovent Biologics, has announced that it will achieve breakeven in 2025, two years ahead of schedule, driven by strong commercialization performance and strategic licensing deals [1][3][10] Financial Performance - For the first three quarters of 2025, the company reported total revenue of 1.12 billion yuan, a year-on-year increase of 59.8% [2] - Revenue from the key BTK inhibitor, Oubatinib, rose by 45.8% year-on-year to 1.01 billion yuan, surpassing the total revenue of the previous year [2] - The company's loss for the first three quarters narrowed significantly by 74.8% to 70 million yuan, attributed to strong revenue growth and strict cost management [3] Strategic Initiatives - The company has successfully executed a significant licensing deal worth over $2 billion, aimed at accelerating the internationalization of Oubatinib [4][5] - The management has raised the full-year sales guidance to at least a 40% year-on-year increase based on the strong performance in the first three quarters [2] Research and Development - The company has over 10 research pipelines, with several in Phase III clinical trials, which will benefit from the strong cash flow generated by its operations [1][3] - In addition to Oubatinib, the company has developed multiple research barriers, including a new generation BCL2 inhibitor, Mesutoclax, which has shown an 84.0% overall response rate in difficult-to-treat patients [7][8] Market Positioning - The company is positioning itself for global expansion, leveraging partnerships to enhance its market presence and profitability [4][5] - The collaboration with Zenas, a U.S.-based biotech, is expected to create synergies in the treatment of multiple sclerosis, targeting a market worth nearly $30 billion [6][8] Future Outlook - The company aims to enter a rapid development phase, with plans to push five to six innovative drugs for approval and three to four products for global markets [9][10] - The strategic focus has shifted from a single product explosion to a multi-driver approach, indicating a robust pipeline and potential for market revaluation [10]

证券日报网讯诺诚健华11月17日在互动平台回答投资者提问时表示，截至2025年10月31日公司A股股东 户数约为1.88万户。 ...

Investment Rating - The report maintains a "Buy" rating for InnoCare Pharma [8][16] Core Insights - InnoCare Pharma's revenue for the first three quarters of 2025 increased by 60% year-on-year, reaching RMB 1.12 billion, with a net loss of RMB 64 million, which is a 77% year-on-year reduction [5][12] - The company has raised its sales target for its key product, orelabrutinib, from over 35% year-on-year growth to over 40% for 2025, following strong sales performance [6][13] - The company has a robust pipeline for both liquid tumors and autoimmune diseases, with several products in various stages of development [7][14][15] Financial Performance - For the first three quarters of 2025, orelabrutinib sales reached RMB 1.01 billion, a 46% increase year-on-year, with third-quarter sales of RMB 373 million, reflecting a 35% year-on-year and 14% quarter-on-quarter growth [5][12] - Research and development expenses for the first three quarters of 2025 were RMB 676 million, a 10% increase year-on-year, while selling expenses rose by 41% to RMB 386 million [5][12] - As of September 2025, the company had approximately RMB 7.76 billion in cash on hand [5][12] Future Outlook - The company plans to submit a New Drug Application (NDA) for orelabrutinib for the treatment of ITP in the first half of 2026 and expects to read out phase IIb data for SLE by the end of 2025 [7][14] - InnoCare Pharma anticipates submitting 5-7 IND applications targeting malignant tumors and autoimmune diseases in 2026 [15]

Investment Rating - The report maintains a "Buy" rating for the company [1][7][15] Core Insights - The company has raised its 2025 sales target from a year-on-year growth of over 35% to over 40% due to strong sales performance of its key product, orelabrutinib, which saw a 46% year-on-year increase in sales to RMB 1.01 billion in the first three quarters of 2025 [4][5][12] - The company reported a revenue of RMB 1.12 billion for the first nine months of 2025, reflecting a 60% year-on-year growth, with a net loss of RMB 64 million, which is a 77% reduction compared to the previous year [4][11] - The company has a robust pipeline in both oncology and autoimmune diseases, with several products in various stages of development, including orelabrutinib and ICP-332 [5][6][13][14] Financial Performance - For the first three quarters of 2025, the company recorded a revenue of RMB 1.12 billion, with a net loss of RMB 64 million, and a third-quarter revenue of RMB 384 million, marking a 38% year-on-year increase [4][11] - Research and development expenses for the first three quarters were RMB 676 million, a 10% increase year-on-year, while selling expenses rose by 41% to RMB 386 million [4][11] - The company had approximately RMB 7.76 billion in cash as of September 2025, providing a solid financial foundation for ongoing and future projects [4][11] Sales and Product Development - Orelabrutinib's sales reached RMB 373 million in the third quarter of 2025, with a year-on-year growth of 35% and a quarter-on-quarter growth of 14% [5][12] - The company is advancing its autoimmune pipeline, with plans to submit a new drug application for orelabrutinib for ITP in the first half of 2026 and to read out phase IIb data for SLE by the end of 2025 [6][13] - The company expects to submit 5-7 IND applications targeting malignant tumors and autoimmune diseases in 2026, indicating a strong early-stage pipeline [14]

InnoCare Pharma (9969.HK) Earnings Review Summary Company Overview - **Company**: InnoCare Pharma (9969.HK) - **Industry**: Biotechnology Key Financial Highlights - **3Q Orela Sales**: Rmb383 million, representing a **39% year-over-year (y/y)** increase and **18% quarter-over-quarter (q/q)** growth, compared to **4% q/q** in 2Q25 [1] - **Net Loss**: Reduced to **-Rmb34 million** from **-Rmb48 million** in 2Q25, with slower growth in Selling, General and Administrative (SG&A) expenses at **19% y/y** [1] - **2025 Guidance**: Management raised orela sales growth guidance to **40% y/y** from the previous **35% y/y** [1] Growth Drivers - **Hospital Coverage**: Expansion in low-tier markets contributed to sales growth [1] - **MZL Growth**: Solid growth in MZL accounted for approximately **40%** of new patient acquisitions [1] - **Future Sales Momentum**: Expected continued growth in orela sales in 2026E at **28% y/y**, driven by newly reimbursed 1L CLL/SLL indication [1] New Product Development - **Tafasitamab**: Targeting the self-pay market with expected sales of **Rmb100 million to Rmb200 million** in 2026 [1] - **Immunology Pipeline**: Ongoing development with multiple catalysts: - **ICP-332**: Phase 3 data on AD expected by week 16 and phase 2 data for vitiligo in mid-2026 [3] - **ICP-488**: Phase 3 trial for psoriasis aiming for patient enrollment completion by year-end 2025 [3] - **Orelabrutinib**: Phase 2b data for SLE to be released in 4Q25 [3] Profitability Outlook - **Profitability Expectations**: Management anticipates turning profitable in 2025 post-Zenas deal, with core business profits expected by 2027 [2] - **R&D Expenses**: Projected at nearly **Rmb1 billion** for 2025, with a **15% y/y** growth expected for 2026 [2] - **Selling Expenses**: Anticipated growth of **35%-40% y/y** in 2026 to support the commercial launch of ITP indication in 2027 [2] Price Target and Risks - **12-Month Price Target**: Revised to **HK$24.54** for H-Share and **Rmb47.28** for A-Share, reflecting an **upside of 61.8%** and **86.6%** respectively [9][11] - **Key Risks**: Include R&D risks for clinical assets, uncertainties in pricing, potential entry of generic ibrutinib in 2027, and below-expected progress in global expansion [10] Conclusion - InnoCare Pharma shows strong sales growth and a promising pipeline, with management optimistic about future profitability and market expansion. The raised guidance and ongoing clinical trials position the company favorably within the biotechnology sector.