Group 1 - The company, Innovent Biologics, announced significant progress in clinical research for its novel TYK2 inhibitor soficitinib, with the completion of patient enrollment for a Phase III registration clinical trial for moderate to severe atopic dermatitis (AD) [1] - The Phase III trial for AD included 579 patients, while the Phase II trial for vitiligo enrolled 162 patients, both trials being randomized, double-blind, and placebo-controlled [1] - Soficitinib is a highly selective oral TYK2 inhibitor developed by the company, targeting various T-cell related autoimmune diseases, with a focus on dermatological conditions such as atopic dermatitis and vitiligo [1] Group 2 - According to WHO, there are approximately 230 million people globally suffering from atopic dermatitis, making it the most burdensome non-fatal skin disease, with nearly 70 million patients in China [2] - The Phase II clinical study of soficitinib for moderate to severe atopic dermatitis achieved multiple efficacy endpoints, demonstrating superior efficacy and safety compared to other treatment modalities [2] - Vitiligo affects around 70 million people globally, characterized by the destruction of skin melanocytes, requiring long-term treatment to control lesion progression and promote repigmentation [2] Group 3 - The CEO of Innovent Biologics emphasized the significant unmet clinical needs for both atopic dermatitis and vitiligo, expressing optimism about the progress of soficitinib in addressing these chronic diseases [2]

Core Viewpoint - The company announced significant progress in the clinical research of its novel TYK2 inhibitor soficitinib (ICP-332), with the completion of patient enrollment for the Phase III registration clinical trial, marking a crucial step in addressing AD disease [1] Group 1: Company Developments - The clinical trial for soficitinib has reached a major milestone with the completion of patient enrollment [1] - Soficitinib is a novel TYK2 inhibitor developed by the company [1] Group 2: Industry Context - TYK2 is a member of the Janus kinase (JAK) family and plays a critical role in the JAK-STAT signaling pathway, which is important in the mechanisms of inflammation [1]

Group 1 - The core viewpoint is that the development of innovative drugs in China is supported by both capital market opportunities and policy reforms [1] - The Hong Kong Stock Exchange and the Sci-Tech Innovation Board have provided a platform for unprofitable companies to list, facilitating the growth of innovative pharmaceuticals over the past decade [1] - Policy support has significantly improved since the reform of the drug review system in 2015, accelerating the development of innovative drugs [1] Group 2 - The return of a large number of overseas Chinese professionals has contributed to the talent pool, further stimulating the growth of the industry [1]

诺诚健华 诺诚健华 分时图 日K线 周K线 月K线 20.52 -0.07 -0.34% 1.41% 0.92% 0.49% 0.00% 0.49% 0.92% 1.41% 20.30 20.40 20.49 20.59 20.69 20.78 20.88 09:30 10:30 11:30/13:00 14:00 15:00 15:30 0 4万 7万 11万 诺诚健华企业传播执行总监陆春华表示："中国创新药的知识产权授权给了国际的MNC公司，今年上半 年的总的对外授权的总金额，已经达到了600亿美元，超过了2024年全年，那尤其在前几年资本市场相 对比较薄弱的情况下，中国创新药通过对外授权获得的资本，足以支撑创新药的发展，因为它几乎超过 了IPO的融资，这几年中国的创新药已经成为这个世界创新的名片。" ...

Core Viewpoint - The article discusses the strategic development goals and initiatives of the company, 诺诚健华, in response to the central economic work meeting's emphasis on expanding domestic demand and optimizing supply in the context of the 2026 economic landscape [1][3]. Group 1: Company Initiatives - The company has achieved significant milestones, including a partnership with Zenas worth over $2 billion, marking a record in the field of self-immune small molecules in China [1]. - Two innovative drugs have been approved for market launch, including the first CD19 monoclonal antibody for treating diffuse large B-cell lymphoma and the first domestically developed TRK inhibitor [2]. - The company plans to launch five to six innovative drugs and develop five to ten differentiated clinical candidates by 2026, aiming to accelerate the globalization process and enhance its core competitiveness in innovative drug development [3]. Group 2: Strategic Development Goals - By 2026, the company aims to leverage "Chinese originality" and a "global vision" to embark on a new decade of growth, focusing on innovation and global market expansion [3]. - The company intends to strengthen its overseas team capabilities and achieve globalization for three to four products, enhancing its core competitiveness in innovative drug development from China to the global market [3]. - The company will maintain a passion for entrepreneurial innovation and a keen insight to drive rapid development in a challenging environment [3].

Core Insights - The article discusses the economic outlook for 2026 and the strategic development goals of companies in response to the central economic work conference's emphasis on expanding domestic demand and optimizing supply [1][2]. Company Developments - In 2025, the company will celebrate its 10th anniversary, marking a significant milestone with multiple "China's first" achievements in the biopharmaceutical sector [7]. - The company has entered into a major collaboration with Zenas worth over $2 billion, setting a record for external licensing in China's small molecule field [7]. - The company has achieved profitability two years ahead of schedule due to significant commercial developments and partnerships [7]. Product Innovations - The company has received approval for two innovative drugs: the first CD19 monoclonal antibody for treating diffuse large B-cell lymphoma (DLBCL) and the first domestically developed next-generation TRK inhibitor [7][8]. - The company is advancing multiple clinical trials for its BCL2 inhibitor Mesutoclax, which has shown significant efficacy in treating various blood cancers [8]. - The company is also progressing with its BTK inhibitor, which has entered phase III clinical trials for several indications, including systemic lupus erythematosus (SLE) and immune thrombocytopenic purpura (ITP) [8]. Strategic Goals for 2026 - The company aims to launch five to six innovative drugs and develop five to ten differentiated clinical candidates, focusing on global expansion and innovation [9][10]. - The company plans to enhance its overseas team capabilities and accelerate its globalization efforts, targeting three to four products for global markets [10]. - The company will maintain a strong entrepreneurial spirit and agility in execution to navigate uncertainties and drive rapid growth [10].

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因依賴該等內容而引致的任何損失承擔任何責任。 InnoCare Pharma Limited 諾誠健華醫藥有限公司 （ 於 開 曼 群 島 註 冊 成 立 的 有 限 公 司 ） （股份代號：9969） 根據2023年股權激勵計劃 授予受限制股份單位 根據上市規則第17.06A條，董事會宣佈於2025年12月31日，本公司根據2023年 股權激勵計劃授予兩名承授人1,400,000份受限制股份單位，相當於本公司於本 公告日期已發行股份總數的約0.08%。 授予受限制股份單位的詳情 授予承授人受限制股份單位的詳情如下： 授出日期： 2025年12月31日 承授人及獲授受限制股份 單位的數目： 授予兩名僱員參與者1,400,000份受限制股份單位。 概無承授人須個別披露。 購買價： 每股香港股份0.178美元（約1.39港元） – 1 – 於授出日期股份的 收市價： (i) 每股香港股份12.3港元；及 (ii) 每股人民幣股份人民幣20.52元（約2 ...

格隆汇12月31日丨诺诚健华(09969.HK)发布公告，2025年12月31日，公司根据2023年股权激励计划授予 两名承授人140万份受限制股份单位，相当于公司于本公告日期已发行股份总数的约0.08%。 ...

格隆汇12月31日丨诺诚健华(09969.HK)发布公告，2025年12月31日，公司根据2023年股权激励计划授予 两名承授人140万份受限制股份单位，相当于公司于本公告日期已发行股份总数的约0.08%。 ...

智通财经APP讯，诺诚健华(09969)发布公告，于2025年12月31日，公司根据2023年股权激励计划授予两 名承授人140万份受限制股份单位，相当于公司于本公告日期已发行股份总数的约0.08%。 ...