上海市方达律师事务所 关于上海奥浦迈生物科技股份有限公司 发行股份及支付现金购买资产并募集配套资金的 补充法律意见书（二） 2025 年 11 月 上海市方达律师事务所 补充法律意见书（二） FANGDA PARTNERS http://www.fangdalaw.com 中国上海市石门一路 288 号 电子邮件 E-mail: email@fangdalaw.com 兴业太古汇香港兴业中心二座 24 楼 电 话 Tel.: +86-21-2208 1166 邮政编码：200041 传 真 Fax.: +86-21-5298 5599 24/F, HKRI Centre Two HKRI Taikoo Hui 288 Shi Men Yi Road Shanghai, PRC 200041 上海市方达律师事务所 关于上海奥浦迈生物科技股份有限公司 发行股份及支付现金购买资产并募集配套资金的 补充法律意见书（二） 致：上海奥浦迈生物科技股份有限公司 上海市方达律师事务所（以下简称"本所"）是具有中华人民共和国境内法 律执业资格的律师事务所。根据上海奥浦迈生物科技股份有限公司（以下简称 "上市公司"或"奥浦迈"） ...

国泰海通证券股份有限公司 关于 上海奥浦迈生物科技股份有限公司 发行股份及支付现金购买资产并募集配套 资金 之 独立财务顾问报告 （修订稿） 独立财务顾问 （三）本独立财务顾问的职责范围并不包括应由上海奥浦迈生物科技股份有 限公司董事会负责的对本次交易事项在商业上的可行性评论，本独立财务顾问并 未参与本次交易条款的磋商和谈判。独立财务顾问报告旨在就本次交易对上海奥 2-1-1 浦迈生物科技股份有限公司的全体股东是否公平、合理，遵循诚实信用、勤勉尽 责的职业准则独立发表意见。 签署日期：二〇二五年十一月 声明与承诺 本部分所使用的简称与本报告"释义"中所定义的简称具有相同含义。 国泰海通证券股份有限公司接受上海奥浦迈生物科技股份有限公司的委托， 担任上海奥浦迈生物科技股份有限公司发行股份及支付现金购买资产并募集配 套资金的独立财务顾问，就该事项向上海奥浦迈生物科技股份有限公司全体股东 提供独立意见，并制作本独立财务顾问报告。 本独立财务顾问报告是依据《中华人民共和国公司法》《中华人民共和国证 券法》《上市公司重大资产重组管理办法》《上市公司并购重组财务顾问业务管 理办法》《公开发行证券的公司信息披露内容与格式准 ...

立信会计师事务所（特殊普通合伙） 关于上海奥浦迈生物科技股份有限公司 发行股份及支付现金购买资产并募集配套资金申请 的审核问询函回复之核查意见 信会师函字[2025]第 ZA490 号 上海证券交易所： 根据贵所出具的《关于上海奥浦迈生物科技股份有限公司发行股份及支付现 金购买资产并募集配套资金的审核问询函》（上证科审（并购重组）〔2025〕24 号）（以下简称"审核问询函"）的要求，立信会计师事务所（特殊普通合伙）（以 下简称"申报会计师"或"会计师"）作为上海奥浦迈生物科技股份有限公司（以 下简称"公司"、"上市公司"或"奥浦迈"）发行股份及支付现金购买资产并募 集配套资金申请的申报会计师，就审核问询函所列问题逐项进行了认真核查与落 实，现就相关问题回复如下。 除非文义另有所指，本问询函回复中的简称与《上海奥浦迈生物科技股份有 限公司发行股份及支付现金购买资产并募集配套资金报告书（草案）》（以下简称 "重组报告书"）中的释义具有相同涵义，若出现合计数值与各分项数值之和尾 数不符的情况，均为四舍五入原因造成。 本问询函回复的字体代表以下含义： | 问询函所列问题 | 黑体（加粗） | | --- | --- ...

近日，本次交易中部分交易对方的合伙企业续期工作已完成，并取得了最新 的营业执照，同时结合上交所进一步审核意见，公司对《重组报告书》中的相关 内容予以修订，形成了《上海奥浦迈生物科技股份有限公司发行股份及支付现金 购买资产并募集配套资金报告书（草案）（申报稿）》（三次修订稿）（以下简称"《重 组报告书》（三次修订稿）"）。 除上述更新修订内容之外，上市公司已对《重组报告书》（三次修订稿）全 文进行了梳理和自查，对本次交易方案无影响。 特此公告。 证券代码：688293 证券简称：奥浦迈 公告编号：2025-106 上海奥浦迈生物科技股份有限公司 关于发行股份及支付现金购买资产并募集配套资金 报告书（草案）修订说明的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 上海奥浦迈生物科技股份有限公司（以下简称"公司"或"上市公司"）拟 通过发行股份及支付现金方式购买澎立生物医药技术（上海）股份有限公司（以 下简称"澎立生物"或"标的公司"）100.00%股权（以下简称"本次发行股份及 支付现金购买资产"），并向不超过 35 名 ...

证券代码：688293 证券简称：奥浦迈 公告编号：2025-105 上海奥浦迈生物科技股份有限公司 关于发行股份及支付现金购买资产并募集配套资金 审核问询函回复（修订稿）的提示性公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 上海奥浦迈生物科技股份有限公司（以下简称"奥浦迈"或"公司"）拟通 过发行股份及支付现金方式购买澎立生物医药技术（上海）股份有限公司（以下 简称"澎立生物"或"标的公司"）100.00%股权（以下简称"本次发行股份及支 付现金购买资产"），并向不超过 35 名特定投资者发行股票募集配套资金（以下 简称"本次募集配套资金"，与本次发行股份及支付现金购买资产合称"本次交 易"）。 2025 年 11 月 26 日 公司于 2025 年 7 月 10 日收到上海证券交易所（以下简称"上交所"）出具 的《关于上海奥浦迈生物科技股份有限公司发行股份及支付现金购买资产并募集 配套资金的审核问询函》（上证科审（并购重组）〔2025〕24 号）（以下简称"《审 核问询函》"）。公司及相关中介机构根据《审核问询 ...

Investment Rating - The report maintains a "Strong Buy" rating for the company with a target price of 69 yuan, reflecting an expected performance exceeding the benchmark index by over 20% in the next six months [2][10][25]. Core Insights - The company reported a revenue of 272 million yuan for the first three quarters of 2025, representing a year-on-year growth of 25.79%. The net profit attributable to the parent company reached 49 million yuan, up 81.48% year-on-year, while the non-recurring net profit was 37 million yuan, increasing by 118.80% [2][9]. - In Q3 2025 alone, the company achieved a revenue of 94 million yuan, marking a 29.80% year-on-year increase, with a net profit of 12 million yuan, which is a significant growth of 283.59% year-on-year [2][9]. - The cell culture product business remains the core pillar of the company's revenue, generating 239 million yuan in the first three quarters of 2025, a 32.56% increase year-on-year. The company continues to invest in product technology optimization, R&D innovation, and market expansion [9][10]. - The CDMO (Contract Development and Manufacturing Organization) business faced challenges, with revenue of 32.58 million yuan in the first three quarters of 2025, showing a slight decline. The company is optimizing internal processes and innovating service models to stabilize and recover this segment [9][10]. - The company has expanded its customer base, serving over 800 domestic and international biopharmaceutical companies and research institutions, with a total of 2,000 clients as of Q3 2025 [9][10]. - Cost control measures have led to an increase in net profit margin to 18.07%, up 5.73 percentage points year-on-year, despite a slight decline in gross margin to 54.57% [9][10]. Financial Summary - The company is projected to achieve total revenue of 381 million yuan in 2025, with a year-on-year growth rate of 28.2%. The net profit attributable to the parent company is expected to reach 71 million yuan, reflecting a substantial growth of 238.1% [5][10]. - Earnings per share (EPS) are forecasted to be 0.63 yuan in 2025, increasing to 1.25 yuan by 2027 [5][10]. - The company maintains a low debt-to-equity ratio of 4.0%, indicating strong financial stability [10].

优化，成就与众不同 Optimization Makes Differences 证券代码：688293 证券简称：奥浦迈 上海奥浦迈生物科技股份有限公司 2025 年第三次临时股东大会 会议资料 二〇二五年十二月 1 三、会议按照会议通知上所列顺序审议、表决议案。 | 2025 | | 年第三次临时股东大会会议须知 3 | | --- | --- | --- | | 2025 | | 年第三次临时股东大会会议议程 6 | | 议案 | 1： | 8 | | 《关于变更公司注册资本、取消监事会、修订<公司章程>并办理工商变更登记的议案》..8 | | | | 议案 | 2： | 10 | | 《关于制定及修订公司部分治理制度的议案》 10 | | | 优化，成就与众不同 Optimization Makes Differences 上海奥浦迈生物科技股份有限公司 2025 年第三次临时股东大会会议须知 为了维护全体股东的合法权益，确保股东大会的正常秩序和议事效率，保证 大会的顺利进行，根据《中华人民共和国公司法》《中华人民共和国证券法》《上 市公司股东会规则》以及《上海奥浦迈生物科技股份有限公司章程》《上海奥 ...

Core Viewpoint - Aopu Mai's stock price has experienced fluctuations, with a current decline of 2.01% and a year-to-date increase of 59.83%, indicating volatility in the market while showing strong annual growth in revenue and profit [1][2]. Company Overview - Aopu Mai Biotechnology Co., Ltd. was established on November 27, 2013, and went public on September 2, 2022. The company is located in Shanghai and specializes in cell culture products and services [1]. - The revenue composition of Aopu Mai is primarily from products (87.34%), followed by services (12.53%) and other sources (0.13%) [1]. Financial Performance - For the period from January to September 2025, Aopu Mai reported a revenue of 272 million yuan, representing a year-on-year growth of 25.79%. The net profit attributable to the parent company was 49.43 million yuan, showing an impressive increase of 81.48% year-on-year [1]. - Since its A-share listing, Aopu Mai has distributed a total of 173 million yuan in dividends [2]. Shareholder Information - As of September 30, 2025, Aopu Mai had 3,682 shareholders, an increase of 14.63% from the previous period. The average number of circulating shares per shareholder rose by 27.96% to 30,838 shares [1]. - Among the top ten circulating shareholders, notable increases were observed in holdings by institutional investors such as China Europe Medical Health Mixed A and ICBC Frontier Medical Stock A [2].

Core Insights - The biopharmaceutical sector experienced a decline of 0.98% on November 18, with He Yuan Bio leading the drop [1] - The Shanghai Composite Index closed at 3939.81, down 0.81%, while the Shenzhen Component Index closed at 13080.49, down 0.92% [1] Stock Performance Summary - Notable gainers included: - Aopu Mai (688293) with a closing price of 58.80, up 3.38% on a trading volume of 15,900 shares and a transaction value of 93.39 million [1] - Jin Hu Ke (688670) at 26.80, up 2.88% with a volume of 116,300 shares and a transaction value of 319 million [1] - Te Bao Bio (688278) at 77.08, up 1.22% with a volume of 10,800 shares and a transaction value of 82.57 million [1] - Notable decliners included: - Bu Yuan Bio (688765) at 79.95, down 3.89% with a volume of 56,800 shares and a transaction value of 458 million [2] - San Sheng Guo Jian (688336) at 67.60, down 3.87% with a volume of 68,100 shares and a transaction value of 469 million [2] - Wo Wu Bio (300357) at 31.77, down 3.23% with a volume of 77,900 shares and a transaction value of 250 million [2] Capital Flow Analysis - The biopharmaceutical sector saw a net outflow of 981 million from institutional investors, while retail investors contributed a net inflow of 819 million [2] - Key stocks with significant capital flow included: - Hua Lan Vaccine (301207) with a net inflow of 48.51 million from institutional investors [3] - Rong Chang Bio (688331) with a net inflow of 23.62 million from institutional investors [3] - Jin Ke (688670) with a net inflow of 5.53 million from institutional investors [3]

Group 1: Company Restructuring and Financial Performance - The company is currently in the process of restructuring, having received an inquiry letter in July and completed the related responses by September. The restructuring report was revised and disclosed on November 11, 2025, and is still under review [1] - For the first three quarters of 2025, the company achieved operating revenue of 271.53 million yuan, a year-on-year increase of 25.79%. The net profit attributable to shareholders was 49.43 million yuan, up 81.48% year-on-year [9] Group 2: Gross Margin and Business Segments - The overall gross margin for the first three quarters has declined compared to 2024, primarily due to structural impacts from two business segments. The gross margin for cell culture products remains stable at 70%-71% [2] - The cell culture product segment generated revenue of 238.60 million yuan, reflecting a significant growth of 32.56% year-on-year, and remains the core revenue driver for the company [3] Group 3: Market Expansion and Client Engagement - The company is successfully engaging with multinational corporations (MNCs) in the U.S., with products being tested by several American pharmaceutical companies. There are over 10 pipelines associated with business development (BD) going overseas [5] - The company has established a U.S. research laboratory in 2024 and is considering building a production base in the U.S. to meet overseas client demands [5] Group 4: Product Pricing and Market Position - The company maintains strong customer loyalty in the antibody drug field, with long-term supply agreements that allow for differentiated pricing based on purchase volume [4] - According to a market research report, the company ranked first among domestic manufacturers of cell culture media for high-end antibody drugs in 2020, indicating a growing market share [8]