| A 股代码：688428 | A 股简称：诺诚健华 | 公告编号：2025-021 | | --- | --- | --- | | 港股代码：09969 | 港股简称：诺诚健华 | | 诺诚健华医药有限公司 2025年股东周年大会决议公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 本次会议是否有被否决议案：无 一、 会议召开和出席情况 （一） 股东大会召开的时间：2025 年 6 月 20 日 | 境外上市外资股股东所持有表决权数量 | 662,195,156 | | --- | --- | | 3、出席会议的股东所持有表决权数量占公司表决权数量的 | 40.7476 | | 比例（%） | | | 普通股股东所持有表决权数量占公司表决权数量的比例 | 40.7476 | | （%） | | | 股股东所持有表决权数量占公司表决权数量的 其中：A | 3.1417 | | 比例（%） | | | 境外上市外资股股东所持有表决权数量占公司表 | 37.6059 | | 决权数量的比例（%） | | ...

董事会薪酬委员会 2025 年 6 月 20 日 诺诚健华医药有限公司（以下简称"公司"）董事会薪酬委员会依据《中华 人民共和国公司法》（以下简称"《公司法》"）、《中华人民共和国证券法》 （以下简称"《证券法》"）、《上市公司股权激励管理办法》（以下简称"《管 理办法》"）、《上海证券交易所科创板股票上市规则》（以下简称"《上市规 则》"）、《科创板上市公司自律监管指南第 4 号——股权激励信息披露》等相 关法律、法规、规范性文件的有关规定，对 2023 年科创板限制性股票激励计划 （以下简称"本激励计划"）首次授予部分第二个归属期及预留授予部分第一个 归属期符合归属条件的激励对象名单进行核查，经核查认为：本次拟归属的 138 名激励对象，符合《管理办法》《上市规则》等法律法规和规范性文件规定的激 励对象条件，符合本激励计划规定的激励对象范围，其作为公司本激励计划激励 对象的主体资格合法、有效。本激励计划首次授予部分第二个归属期及预留授予 部分第一个归属期的归属条件已成就。因此，公司董事会薪酬委员会同意本次归 属名单。 （以下无正文） 诺诚健华医药有限公司 诺诚健华医药有限公司董事会薪酬委员会 关于 202 ...

| | | 诺诚健华医药有限公司 董事会决议公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、 董事会会议召开情况 诺诚健华医药有限公司（以下简称"诺诚健华"或"公司"）于 2025 年 6 月 20 日在公司会议室以现场会议结合通讯方式召开董事会。会议应出席董事 7 人，实 际出席董事 7 人，董事会主席 Jisong Cui（崔霁松）博士担任会议主席。会议的 召集、召开、表决程序符合有关法律、行政法规、部门规章、规范性文件和公司 章程的规定。 二、 董事会会议审议情况 (一) 审议通过《2023 年科创板限制性股票激励计划首次授予部分第二个 归属期及预留授予部分第一个归属期符合归属条件》的议案 根据《上市公司股权激励管理办法》《2023 年科创板限制性股票激励计划》 （以下简称"《激励计划》"）的相关规定和公司 2023 年股东周年大会的授权， 董事会认为公司 2023 年科创板限制性股票激励计划首次授予部分第二个归属期 及预留授予部分第一个归属期规定的归属条件已经成就，本次可归属数量分别为 1,682,250 ...

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Core Viewpoint - ICBC Medical Care Stock (000831) has experienced a decline of 1.27% on June 19, with a latest net value of 2.56 yuan, marking a cumulative drop of 7.84% over five consecutive trading days [1] Group 1: Fund Performance - The fund was established in November 2014, with a total scale of 2.724 billion yuan and a cumulative return of 156.40% since inception [1] - As of the end of 2024, institutional investors hold 0.41 million shares, accounting for 3.55% of total shares, while individual investors hold 11.19 million shares, making up 96.45% of total shares [1] Group 2: Fund Management - Current fund manager Zhao Bei has a master's degree and has been with ICBC Credit Suisse since 2010, serving as the fund manager since November 18, 2014 [2] - The current fund manager Ding Yang holds a doctoral degree and joined ICBC Credit Suisse in December 2017, taking over as fund manager on May 5, 2023 [2] Group 3: Portfolio Holdings - As of March 31, 2025, the top ten holdings of ICBC Medical Care Stock account for a total of 39.79%, with major positions including: - Heng Rui Medicine (8.90%) - WuXi AppTec (5.12%) - Aier Eye Hospital (4.94%) - BeiGene (3.77%) - Zai Lab (3.52%) - New Horizon Health (3.27%) - Mindray Medical (2.80%) - Yuwell Medical (2.76%) - United Imaging Healthcare (2.47%) - Innovent Biologics (2.24%) [3]

Core Viewpoint - The announcement details a change in the shareholding structure of Nuo Cheng Jian Hua Pharmaceutical Co., Ltd, indicating a reduction in the stake held by major shareholders, specifically King Limited and Success Growth Limited, from 8.08% to 7.54% [1][2]. Group 1: Shareholding Changes - The total shareholding percentage of King Limited and Success Growth Limited decreased from 8.08% to 7.54% [1][2]. - The number of shares held by these shareholders reduced from 14,239,205.4 thousand shares to 13,290.0430 thousand shares [1][2]. - The change in shareholding does not trigger mandatory tender offer obligations and does not violate any prior commitments [1]. Group 2: Impact on Company Governance - The primary shareholder has not changed, indicating that the governance structure and ongoing operations of the company will not be significantly affected [2]. - The company will continue to fulfill its information disclosure obligations regarding any future changes in shareholding [2].

诺诚健华医药有限公司 关于持股 5%以上股东权益变动 触及 1%刻度的提示性公告 投资者 King Bridge Investments Limited 及其一致行动人 Success Growth Limited 保证向本公司提供的信息真实、准确、完整，没有虚假记载、误导性陈 述或重大遗漏。 | A | 股代码：688428 | 股简称：诺诚健华 A | 公告编号：2025-020 | | --- | --- | --- | --- | | 港股代码：09969 | | 港股简称：诺诚健华 | | 本公司董事会及全体董事保证公告内容与信息披露义务人提供的信息一致。 重要内容提示： | 权益变动方向 | 比例增加□ | 比例减少√ | | --- | --- | --- | | 权益变动前合计比例 | 8.08% | | | 权益变动后合计比例 | 7.54% | | | 本次变动是否违反已作出的承诺、意 向、计划 | 是□ 否√ | | | 是否触发强制要约收购义务 | 是□ 否√ | | 2、信息披露义务人信息 | 信息披露义务人名称 | | | 投资者身份 | 统一社会信用代码 | | --- | -- ...

Core Viewpoint - The stock price of Innovent Biologics (688428.SZ, 09969.HK) has doubled since the beginning of the year, driven primarily by the strong performance of its flagship product, Oubatinib [1][2]. Group 1: Stock Performance - As of June 18, the A-share price increased from 12.32 CNY to 24.93 CNY, a rise of over 102% [1] - The Hong Kong stock price rose from 6.12 HKD to 13.28 HKD, an increase of nearly 117% [1]. Group 2: Company Overview - Innovent Biologics is a commercial-stage biopharmaceutical company focused on unmet clinical needs in oncology and autoimmune diseases, aiming to develop first-in-class or best-in-class innovative drugs [1]. Group 3: Product Performance - Oubatinib, a second-generation BTK inhibitor, is the company's first commercialized product and is central to its strategy, with ongoing development for multiple blood cancer targets and four autoimmune disease indications, including multiple sclerosis [1]. Group 4: Revenue and Financials - Oubatinib's sales for 2024 are projected at 1 billion CNY, a year-on-year increase of 49.14%, contributing 99% to the company's performance [2]. - Oubatinib's revenue has consistently accounted for over 90% of Innovent's total revenue in recent years, leading to a gradual reduction in losses from 887 million CNY in 2022 to 441 million CNY in 2024 [2]. - In Q1 2025, total revenue grew by 129.9% year-on-year to 380 million CNY, primarily due to Oubatinib's continued growth and a licensing agreement with Prolium [2]. Group 5: Future Outlook - Innovent Biologics plans to increase R&D investment, advance clinical development and commercialization of its pipeline products, expand business collaborations, and leverage artificial intelligence technology, expecting continued revenue growth and reduced losses in 2025 [3].

Core Insights - The 2025 European Hematology Association (EHA) annual meeting showcased nearly 60 clinical research results from four Chinese innovative drug companies, highlighting China's scientific strength in developing innovative therapies for hematological cancers [1] - The collective breakthroughs of these companies at international platforms like ASCO and EHA signify a strategic shift in China's innovative drug industry from "fast following" to "independent innovation" [1] - The EHA annual meeting is a significant academic event in the global hematology field, attracting over 10,000 professionals from more than 100 countries [1] Company Highlights - BeiGene presented four major oral reports at the EHA meeting, demonstrating key breakthroughs in its pipeline for hematological cancer treatments [1] - The next-generation BCL2 inhibitor, Sotorasib, combined with Baiyueze®, achieved total response rates of 96% and 79% for patients with relapsed/refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma, respectively [2] - The potential first-in-class BTK degrader BGB-16673 showed promising early data for treating CLL and Waldenström's macroglobulinemia [2] - Innovent Biologics had 25 studies presented as posters at the EHA meeting, focusing on new BTK inhibitors and BCL2 inhibitors for various lymphomas [2] Research Developments - The combination of Mesutoclax and Obinutuzumab for first-line treatment of CLL/SLL showed a total response rate of 97.6% in a cohort of 42 newly diagnosed patients, with a registration phase III clinical trial now underway [3] - Dizhizhi Pharmaceuticals showcased multiple research advancements covering T-cell and B-cell lymphomas, including the JAK1 inhibitor, Gyrizhe®, which demonstrated effective maintenance treatment in peripheral T-cell lymphoma [3] - Micu Biotech presented 19 new research results on its selective HDAC inhibitor, Sitarabin, across various hematological malignancies, indicating significant tumor response and broad application prospects [4]

Core Insights - The pharmaceutical-themed funds are dominating the performance rankings for the first half of the year, with nine out of the top ten funds being pharmaceutical-focused, led by Huatai-PineBridge Hong Kong Advantage Select A, which achieved a 103.67% return [1][2] - The strong performance of these funds is driven by multiple factors, including breakthroughs in innovative drug development, recovery of liquidity in the Hong Kong stock market, and restructuring of valuation systems through cross-border business development transactions [1][2] Fund Performance - The average return of the top ten actively managed equity funds exceeds 69%, with notable performances from Changcheng Pharmaceutical Industry Select A and Yongying Pharmaceutical Innovation Smart Select A, achieving returns of 87.73% and 79.79% respectively [2] - Huatai-PineBridge Hong Kong Advantage Select A is highlighted as a "doubling fund" for the year, marking a significant achievement in the market [2] Market Dynamics - The pharmaceutical sector is experiencing a "double hit" in profitability and valuation in 2025, with the Hang Seng Hong Kong Stock Connect Innovative Drug Index showing a year-to-date increase of 70.09% [3] - The performance of pharmaceutical funds is significantly influenced by their exposure to Hong Kong stocks, with the Hang Seng Healthcare Index rising by 54.59%, outperforming the A-share innovative drug index, which increased by 24.15% [3] Investment Strategy - Huatai-PineBridge Hong Kong Advantage Select A has benefited from investments in leading companies in the Hong Kong innovative drug and medical device sectors, capitalizing on improved overseas liquidity and favorable industry policies [4] - The introduction of financing channels for unprofitable biotech companies in Hong Kong has allowed competitive biotech firms to enter the market, with many now in advanced stages of research and commercialization [4] Future Outlook - The pharmaceutical industry is expected to maintain long-term investment value driven by demographic aging, consumption upgrades, and technological innovation, although caution is advised regarding potential overvaluation of certain stocks [6] - The current market for innovative drugs is characterized by high valuations and volatility, with expectations for a rebalancing between these factors in the near future [6][7] - The valuation of leading companies and key stocks is anticipated to be reassessed, with a focus on the long-term potential of authorized products and revenue realization from commercial partnerships [7]